Patents Assigned to SmithKline Beecham Corporation
  • Method for preparing a physiologically active IL-18 polypeptide
    Patent number: 7442526
    Abstract: The present invention provides a method for producing physiologically active human Interleukin-18 (“IL-18”).
    Type: Grant
    Filed: April 11, 2006
    Date of Patent: October 28, 2008
    Assignee: SmithKline Beecham Corporation
    Inventors: Kyung O. Johanson, Robert B. Kirkpatrick, Allan R. Shatzman, Yen Sen Ho, Patrick McDevitt
  • Triphenylethylene compounds as selective estrogen receptor modulators
    Patent number: 7442833
    Abstract: Compounds of formula (I): with a variety of therapeutic uses, more particularly novel prodrugs that are particularly useful for delivering a parent compound for selective estrogen receptor modulation.
    Type: Grant
    Filed: October 4, 2004
    Date of Patent: October 28, 2008
    Assignee: SmithKline Beecham Corporation
    Inventors: John Fred Eaddy, III, Dennis Heyer, Amarjit Sab Randhawa, Vicente Samano, John Albert Ray, Subba Reddy Katamreddy, Michael Tolar Martin, Michael Scott McClure
  • Diazepine compounds as ligands of the melanocortin 1 and/or 4 receptors
    Patent number: 7442693
    Abstract: There is provided novel diazepines that function as agonists at the melanocortin 4 receptor and as agonists at the melanocortin 1 receptor, pharmaceutical compositions containing them, methods for their use in treatment, and processes for their preparation.
    Type: Grant
    Filed: May 27, 2005
    Date of Patent: October 28, 2008
    Assignee: SmithKline Beecham Corporation
    Inventors: Jerzy Ryszard Szewczyk, Jason Daniel Speake, Douglas McCord Sammond, Ronald George Sherrill
  • Compounds Having Activity at Nk3 Receptor and Uses Thereof in Medicine
    Publication number: 20080261945
    Abstract: The present invention relates to compounds of formula (I), a pharmaceutically acceptable salt, solvate or prodrug thereof: wherein R1 is phenyl optionally substituted by 1, 2 or 3 halogen atoms which halogen atoms may be the same or different; R2 is C1-6alkyl, C3-6cycloalkyl or acetyl; X is oxygen or sulphur; a is 1, 2 or 3; b is 0 or 1; c is 0, 1 or 2; R3 is hydrogen or C1-6alkyl; R4 is hydrogen, C1-6alkyl, haloC1-6alkyl, C1-4alkoxyC1-6alkyl, C3-6cycloalkyl or C3-6cycloalkylC1-6alkyl; R5 is hydrogen; or R5 and R3, together with the interconnecting atoms, form a 4, 5 or 6 membered ring; R6 is phenyl or thienyl, either of which is optionally substituted by 1, 2 or 3 halogen atoms, which atoms may be the same or different; and z is 0, 1 or 2; wherein when z is 1 or 2, Z is a halogen atom, and wherein when z is 2 the halogen atoms may be the same or different.
    Type: Application
    Filed: November 10, 2005
    Publication date: October 23, 2008
    Applicant: SMITHKLINE BEECHAM CORPORATION
    Inventors: Paul William Smith, Paul Adrian Wyman
  • Thiazole derivatives for treating PPAR related disorders
    Patent number: 7439259
    Abstract: The present invention provides combinations of compounds of formula (I) and other therapeutic agents for the treatment of PPAR related diseases.
    Type: Grant
    Filed: August 17, 2006
    Date of Patent: October 21, 2008
    Assignee: SmithKline Beecham Corporation
    Inventors: Rodolfo Cadilla, Romain Luc Marie Gosmini, Millard Hurst Lambert, III, Michael Lawrence Sierra
  • Substances and their uses
    Patent number: 7438913
    Abstract: Polypeptides capable of binding human IL-13 and/or of binding human IL-4 in the presence of IL-4 R? can be used in medicine, in diagnosis and in screening for agonists/antagonist of IL-13/IL-4. One such polypeptide is shown in FIG. 1.
    Type: Grant
    Filed: September 29, 2003
    Date of Patent: October 21, 2008
    Assignee: SmithKline Beecham Corporation
    Inventors: Jean-Yves Bonnefoy, Jean-François Gauchat
  • Chemical Compounds
    Publication number: 20080255124
    Abstract: This invention relates to non-steroidal compounds that are modulators of androgen, glucocorticoid, mineralocorticoid, and progesterone receptors, and also to the methods for the making and use of such compounds.
    Type: Application
    Filed: October 13, 2005
    Publication date: October 16, 2008
    Applicant: Smithkline Beecham Corporation
    Inventors: Philip Stewart Turnbull, Andrew Lamont Larkin, Istvan Kaldor, Rodolfo Cadilla, David John Cowan, Eugene Stewart
  • Inhibitors of Akt Activity
    Publication number: 20080255143
    Abstract: Invented are novel 1H-imidazo[4,5-c]pyridin-2-yl compounds, the use of such compounds as inhibitors of protein kinase B activity and in the treatment of cancer and arthritis.
    Type: Application
    Filed: July 28, 2004
    Publication date: October 16, 2008
    Applicant: SMITHKLINE BEECHAM CORPORATION
    Inventors: Dirk A. Heerding, Tammy J. Clark, David Harold Drewry, Jack Dale Leber, Igor Safonov, Dennis S. Yamashita
  • Morpholinyl and pyrrolidinyl analogs
    Patent number: 7432258
    Abstract: The present invention relates to 4?-[(1R)-1-[[(6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin- 4-yl)acetyl](methyl)amino]-2-(4-morpholinyl)ethyl]-4-biphenylcarboxylic acid and its pharmaceutically acceptable salts, pharmaceutical compositions containing them, and their use as antagonists of urotensin II.
    Type: Grant
    Filed: July 20, 2007
    Date of Patent: October 7, 2008
    Assignee: SmithKline Beecham Corporation
    Inventors: Krista B. Goodman, Michael J. Neeb, Clark A. Sehon, Andrew Q. Viet, Gren Z. Wang
  • Method and apparatus for loading a container with a product
    Patent number: 7426815
    Abstract: There is provided a method of loading a container with a defined quantity of product which comprises the steps of a) closing off a perforation in a perforated plate; b) directing powder into said closed-off perforation by the action of a first leveller blade moveable in a sweeping path relative to the perforated plate; and c) transferring the contents of the perforation to said container, and an apparatus for achieving such method.
    Type: Grant
    Filed: May 18, 2000
    Date of Patent: September 23, 2008
    Assignee: Smithkline Beecham Corporation
    Inventors: Alan Anthony Wilson, Phillip William Farr, Marcus Edward Pike
  • Polynucleotides encoding human tumor necrosis factor receptor-like2
    Patent number: 7427492
    Abstract: The present invention relates to novel members of the Tumor Necrosis Factor family of receptors. The invention provides isolated nucleic acid molecules encoding a human TR2 receptor and two splice variants thereof. TR2 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TR2 receptor activity. Also provided are diagnostic methods for detecting disease states related to the aberrant expression of TR2 receptors. Further provided are therapeutic methods for treating disease states related to aberrant proliferation and differentiation of cells which express the TR2 receptors.
    Type: Grant
    Filed: October 30, 1996
    Date of Patent: September 23, 2008
    Assignees: Human Genome Sciences, Inc., SmithKline Beecham Corporation
    Inventors: Jian Ni, Craig A. Rosen, Reiner L. Gentz
  • 4-Amino-2,3-disubstituted thieno[2,3-d]pyrimidines and pharmacetical compositions thereof
    Patent number: 7427623
    Abstract: Furo- and thienopyrimidine derivatives, which are useful as TIE-2 and/or VEGFR-2 inhibitors are described herein. The described invention also includes methods of making such furo- and thienopyrimidine derivatives as well as methods of using the same in the treatment of hyperproliferative diseases.
    Type: Grant
    Filed: September 10, 2002
    Date of Patent: September 23, 2008
    Assignee: SmithKline Beecham Corporation
    Inventors: Jerry Leroy Adams, Deborah Lynne Bryan, Yanhong Feng, Shinichiro Matsunaga, Yutaka Maeda, Yasushi Miyazaki, Masato Nakano, Jean-Philippe Rocher, Hideyuki Sato, Marcus Semones, Domingos J. Silva, Jun Tang
  • Heteroaryl substituted biphenyl derivatives as p38 kinase inhibitors
    Patent number: 7425555
    Abstract: Compounds of formula (I): are inhibitors of p38 kinase and are useful in the treatment of conditions or disease states mediated by p38 kinase activity or mediated by cytokines produced by the activity of p38.
    Type: Grant
    Filed: April 29, 2003
    Date of Patent: September 16, 2008
    Assignee: SmithKline Beecham Corporation
    Inventors: Richard Martyn Angell, Paul Bamborough, Ian Robert Baldwin, Anne-Marie Li-Kwai-Cheung, Timothy Longstaff, Suzanne Joy Merrick, Kathryn Jane Smith, Stephen Swanson, Ann Louise Walker
  • Process
    Patent number: 7425639
    Abstract: An improved process for preparing arylethanoldiamines is described. Compounds of this type are known to be useful as agonists at a typical beta-adrenoceptors (also known as beta-3-adrenoceptors).
    Type: Grant
    Filed: December 17, 2001
    Date of Patent: September 16, 2008
    Assignee: SmithKline Beecham Corporation
    Inventors: Jason William Beames Cooke, Bobby Neal Glover, Ronnie Maxwell Lawrence, Matthew Jude Sharp, Maria Fumiko Tymoschenko
  • Solid dispersion compositions
    Patent number: 7423004
    Abstract: Disclosed is a water-dispersible solid composition of a sparingly water-soluble compound in a particulatable lipidic carrier, methods for the preparation and use of the same. The compositions of this intention provide improved solubility and dissolution characteristics and enhanced bioavailability of the sparingly soluble compound.
    Type: Grant
    Filed: January 30, 2004
    Date of Patent: September 9, 2008
    Assignee: SmithKline Beecham Corporation
    Inventors: Kamlesh H. Patel, Raviraj S. Pillai
  • Tetrahydrocarbazole derivatives and their pharmaceutical use
    Patent number: 7419997
    Abstract: The present invention relates to novel compounds that are useful in the treatment of human papillomaviruses, and also to the methods for the making and use of such compounds.
    Type: Grant
    Filed: June 7, 2004
    Date of Patent: September 2, 2008
    Assignee: SmithKline Beecham Corporation
    Inventors: Sharon Davis Boggs, Kristjan S Gudmundsson
  • Thrombopoietin mimetics
    Patent number: 7414040
    Abstract: Invented are non-peptide TPO mimetics. Also invented are novel processes and intermediates used in the preparation of the presently invented compounds. Also invented is a method of treating thrombocytopenia, in a mammal, including a human, in need thereof which comprises administering to such mammal an effective amount of a selected hydroxy-1-azobenzene derivative.
    Type: Grant
    Filed: June 6, 2003
    Date of Patent: August 19, 2008
    Assignee: SmithKline Beecham Corporation
    Inventor: Dirk A. Heerding
  • Protease inhibitors
    Patent number: 7405209
    Abstract: The present invention provides 4-amino-azepan-3-one protease inhibitors and pharmaceutically acceptable salts, hydrates and solvates thereof which inhibit proteases, including cathepsin K, pharmaceutical compositions of such compounds, novel intermediates of such compounds, and methods for treating diseases of excessive bone loss or cartilage or matrix degradation, including osteoporosis; gingival disease including gingivitis and periodontitis; arthritis, more specifically, osteoarthritis and rheumatoid arthritis; Paget's disease; hypercalcemia of malignancy; and metabolic bone disease, comprising inhibiting said bone loss or excessive cartilage or matrix degradation by administering to a patient in need thereof a compound of the present invention.
    Type: Grant
    Filed: June 14, 2005
    Date of Patent: July 29, 2008
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham p.l.c.
    Inventors: Robert Wells Marquis, Jr., Yu Ru, Daniel Frank Veber, Maxwell David Cummings, Scott Kevin Thompson, Dennis Shinji Yamashita
  • Substituted quinoline compounds for use as selective estrogen receptor modulator
    Patent number: 7405303
    Abstract: The present invention relates to novel compounds of formula (I) with a variety of therapeutic uses, more particularly novel substituted quinoline compounds particularly useful for selective estrogen receptor modulation.
    Type: Grant
    Filed: February 22, 2005
    Date of Patent: July 29, 2008
    Assignee: SmithKline Beecham Corporation
    Inventors: William Joel Hoekstra, Aaron Bayne Miller, William John Zuercher, Harikrishna Suryakant Patel
  • GENES ASSOCIATED WITH SCHIZOPHRENIA
    Publication number: 20080176239
    Abstract: Genes associated with schizophrenia are identified. Methods of screening small molecule compounds for use in treating schizophrenia are described.
    Type: Application
    Filed: January 8, 2008
    Publication date: July 24, 2008
    Applicant: SMITHKLINE BEECHAM CORPORATION
    Inventors: Stephanie Chissoe, Margaret G. Ehm, Pamela St. Jean