Patents Assigned to SmithKline Beecham p.l.c.
  • Process for the fermentative preparation of clavam derivatives whereby the levels of ammonia and urea in the fermentation medium are kept low
    Patent number: 6235506
    Abstract: Improved methods for the preparation of clavams by fermentation of a clavam-producing organism in a suitable medium wherein the ammonium levels are kept low so as to avoid repression of enzymes, particularly urease, are disclosed.
    Type: Grant
    Filed: September 29, 1999
    Date of Patent: May 22, 2001
    Assignee: SmithKline Beecham, p.l.c.
    Inventors: Brian Peter Valentine, Paul Alan Jeffkins, William Henry Holms, David Michael Mousdale
  • Arginyl tRNA synthetase polynucleotides
    Patent number: 6232097
    Abstract: The invention provides argS polypeptides and DNA (RNA) encoding argS polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing argS polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: August 6, 1997
    Date of Patent: May 15, 2001
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham p.l.c.
    Inventor: Elizabeth Jane Lawlor
  • Skin wash compositions comprising triclocarban and surfactants
    Patent number: 6224886
    Abstract: The compositions of the present invention are useful for the topical delivery of a wide variety of active ingredients. These compositions are particularly useful for treating conditions such as acne and its attendant skin lesions, blemishes, and other imperfections. These compositions are nonirritating to the skin and also provide skin feel benefits. These compositions can be in the form of leave-on products and products that are rinsed or wiped from the skin after use.
    Type: Grant
    Filed: December 15, 1998
    Date of Patent: May 1, 2001
    Assignee: SmithKline Beecham p.l.c.
    Inventors: Lynda Rosemary Charlton, Juliet Teresa McGillycuddy
  • Pharmaceutical compositions
    Patent number: 6218380
    Abstract: A new antibacterially active agent has been isolated from Streptomyces clavuligerus. This new compound which is designated clavulanic acid has the formula (I): In addition to being a broad spectrum antibiotic of medium potency, clavulanic acid and its salts and esters have the ability to enhance the effectiveness of &bgr; lactam antibiotics against many &bgr;-lactamase producing bacteria.
    Type: Grant
    Filed: August 15, 1991
    Date of Patent: April 17, 2001
    Assignee: SmithKline Beecham p.l.c.
    Inventors: Martin Cole, Thomas Trevor Howarth, Christopher Reading
  • Method of promoting smoking cessation
    Patent number: 6218421
    Abstract: A method for promoting smoking cessation, which method comprises administrating an effective, non-toxic amount of ropinirole or a pharmaceutically acceptable salt or solvate thereof to a human in need thereof. Said ropinirole is preferably administered orally or transdermally. Also provided is a medicament for use in smoking cessation that comprises ropinirole. Said medicament may be a tablet for oral use or a transdermal patch containing ropinirole.
    Type: Grant
    Filed: July 1, 1999
    Date of Patent: April 17, 2001
    Assignee: SmithKline Beecham p.l.c.
    Inventor: Stephen Eldon King
  • Use of a combination of amoxycillin and clavulanate in the manufacture of a medicament for the treatment drug-resistant Streptococcus pneumoniae
    Patent number: 6214359
    Abstract: Infections potentially caused by DRSP may be treated by a method, which comprises administering to an adult or older child patient a pharmaceutical formulation comprising from 800 to 1100 mg amoxycillin and from 100 to 150 mg clavulanate in a weight ratio between 6:1 and 10:1 inclusive, in combination with a pharmaceutically acceptable carrier or excipient, three times a day (tid).
    Type: Grant
    Filed: November 5, 1999
    Date of Patent: April 10, 2001
    Assignee: SmithKline Beecham p.l.c.
    Inventor: Richard Peregrine Bax
  • Pyrrolidine and thiazole derivatives with metallo-beta-lactamase inhibitory properties
    Patent number: 6211212
    Abstract: A method of treatment of bacterial infections in humans or animals which comprises administering, in combination with a &bgr;-lactam antibiotic, a therapeutically effective amount of an amino acid derivative or a pharmaceutically acceptable salt, solvate or in vivo hydrolysable ester thereof.
    Type: Grant
    Filed: August 17, 1999
    Date of Patent: April 3, 2001
    Assignee: SmithKline Beecham p.l.c.
    Inventors: John Hargreaves Bateson, Desmond John Best
  • Benzopyrans and their use as therapeutic agents
    Patent number: 6211211
    Abstract: This invention relates to substituted benzopyran amides useful in treating certain medical conditions and to processes for preparing these compounds.
    Type: Grant
    Filed: April 7, 1998
    Date of Patent: April 3, 2001
    Assignee: SmithKline Beecham p.l.c.
    Inventors: Wai Ngor Chan, Mervyn Thompson, John Morris Evans
  • Process for expoxidizing prochiral olefins and a catalyst therefor and intermediates for making the catalyst
    Patent number: 6211107
    Abstract: This invention relates to the catalyst (III) and intermediates for its preparation in which M is a transition metal ion; A is a counter-ion if required; B, B′, and E and E′ are independently selected from the group consisting of hydrogen aryl, C1-6alkyl, silyl or aryl-C1-6 alkyl in which any aryl or alkyl moiety is optionally substituted or B′ and B or E′ and E together form a C2-6 polymethylene link; with the proviso that only one of the carbons marked with an asterisk if a chiral center; R1, R2, R3, R4, R5, R6, R7, R8, R9 and R10 are independently hydrogen, alkyl or alkoxy
    Type: Grant
    Filed: August 27, 1998
    Date of Patent: April 3, 2001
    Assignee: SmithKline Beecham p.l.c.
    Inventors: David Bell, Frances Finney, Robin Patrick Attrill, David Miller, Gillian Turner
  • Biologically active peptide of ob protein
    Patent number: 6187751
    Abstract: The present invention provides a protein fragment of the ob protein, being an active site of the protein. The active site is suitably provided by the ob protein when it is in the form of a four helix bundle structure, particularly that having an up-up down-down topology. In particular, the active site is formed from one or more amino acids selected from one or more of the four helices forming the secondary stucture of the ob protein, especially a protein fragment consisting of amino acid residues 26 to 39, 74 to 88, 93 to 113 or 142 to 161. The compounds of the invention arc considered to be capable of regulating the physiological activity of the ob protein and are therefor of potential use in the treatment of nutritional and metabollic disorders, particularly obesity and diabetes in the case of agonists and anorexia and cachexia in the case of antagonists.
    Type: Grant
    Filed: September 9, 1999
    Date of Patent: February 13, 2001
    Assignee: SmithKline Beecham p.l.c.
    Inventors: Richard Anthony Godwin Smith, Lee James Beeley
  • Tubby 2 polypeptides
    Patent number: 6187908
    Abstract: Tubby 2 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing Tubby 2 polypeptides and polynucleotides in the design of protocols for the treatment of diabetes, obesity, and atherosclerosis, among others, and diagnostic assays for such conditions.
    Type: Grant
    Filed: November 25, 1997
    Date of Patent: February 13, 2001
    Assignee: SmithKline Beecham, P.L.C.
    Inventors: Jonathan Alexander Terrett, Tania Tamson Testa, Israel Simon Gloger, Stephen A. Hughes, Trudy Rachel Doe
  • Process to increase the production of clavam antibiotics
    Patent number: 6171814
    Abstract: A process for increasing the amount of clavam produced by an organism having both a clavam pathway or a portion thereof and a cephalosporin pathway or a portion thereof by interfering with the conversion of L-lysine to L-&agr;-aminoadipic acid in the cephalosporin pathway. Plasmids containing a defective LAT (lysine amino transferase) gene and organisms containing such plasmids are also provided.
    Type: Grant
    Filed: May 11, 1998
    Date of Patent: January 9, 2001
    Assignees: SmithKline Beecham p.l.c., The Governors of the University of Alberta
    Inventors: William Henry Holms, Ashish Sudhakar Paradkar, Roy Henry Mosher
  • Clavulanic acid extraction process
    Patent number: 6172221
    Abstract: A back extraction process in which beta-lactam antibiotics or clavulanic acid is extracted from an organic solvent phase into an aqeous medium phase, using a mixing region in which the phases are mixed rapidly under high turbulence and shear stress.
    Type: Grant
    Filed: August 27, 1997
    Date of Patent: January 9, 2001
    Assignee: SmithKline Beecham p.l.c.
    Inventor: Simon Ruddick
  • Compounds
    Patent number: 6165771
    Abstract: The HE2NW40 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing HE2NW40 polypeptides and polynucleotides in therapy, and diagnostic assays for such.
    Type: Grant
    Filed: June 1, 1998
    Date of Patent: December 26, 2000
    Assignee: SmithKline Beecham, P.L.C.
    Inventors: Nicola Anne Burgess, Helen Elizabeth Clinkenbeard, Christopher Donald Southan
  • Histidine kinase
    Patent number: 6165992
    Abstract: The invention provides Histidine kinase polypeptides and polynucleotides encoding Histidine kinase polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing Histidine kinase polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: May 20, 1998
    Date of Patent: December 26, 2000
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham p.l.c.
    Inventors: Sanjoy Biswas, John P Throup, Nicola G Wallis, Magdalena Zalacain
  • Use of an antagonist of PPAR.alpha. and PPAR.gamma. for the treatment of syndrome X
    Patent number: 6166049
    Abstract: A method for the treatment or prophylaxis of Syndrome X in a human or non-human mammal is disclosed. The method comprises the administration of an effective, non-toxic and pharmaceutically effective amount of an agonist of PPAR.alpha. and PPAR.gamma., or a pharmaceutically acceptable derivative thereof, to a human or non-human mammal in need thereof.
    Type: Grant
    Filed: September 10, 1998
    Date of Patent: December 26, 2000
    Assignee: SmithKline Beecham P.L.C.
    Inventor: Stephen Alistair Smith
  • HLDAT86 polynucleotides
    Patent number: 6165751
    Abstract: HLDAT86 (Wnt-4) polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing HLDAT86 (Wnt-4) polypeptides and polynucleotides in the design of protocols for the treatment of kidney disorders, cancer, cardiac and vascular disease, inflammatory disorders, Alzheimers disease, schizophrenia and mood disorders., among others, and diagnostic assays for such conditions.
    Type: Grant
    Filed: April 28, 1998
    Date of Patent: December 26, 2000
    Assignee: SmithKline Beecham P.L.C.
    Inventor: Michael R Barnes
  • Spiro piperidine derivatives as 5HT1D receptor antagonists
    Patent number: 6166034
    Abstract: Novel spiro piperdine derivatives of formula (I), in which P.sup.1, P.sup.2, R.sup.1, R.sup.2, R.sup.2 ', R.sup.3, m, A, E, G, X, Y, R.sup.7, R.sup.8, R.sup.9 and R.sup.10 have the meanings defined in claim 1 are described, as well as their use for preparing medicaments which have 5HT1D receptor antagonist activity.
    Type: Grant
    Filed: May 8, 1998
    Date of Patent: December 26, 2000
    Assignee: SmithKline Beecham p. l. c
    Inventor: Francis David King
  • Tryptophanyl tRNA synthetase polypeptides of streptococcus
    Patent number: 6165759
    Abstract: The invention provides Tryptophanyl tRNA Synthetase polypeptides and DNA (RNA) encoding Tryptophanyl tRNA Synthetase polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing Tryptophanyl tRNA Synthetase polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: October 30, 1998
    Date of Patent: December 26, 2000
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham p.l.c.
    Inventor: Elizabeth Jane Lawlor
  • Bicyclic aryl or a bicyclic heterocyclic ring containing compounds having a combined 5HT.sub.1A, 5HT.sub.1B and 5HT.sub.1D receptor antagonistic activity
    Patent number: 6159979
    Abstract: Novel bicyclic aryl/bicyclic heterocyclic ring containing compounds having a combined 5HT.sub.1A, 5HT.sub.1B and 5HT.sub.1D receptor antagonistic activity are provided.
    Type: Grant
    Filed: October 15, 1999
    Date of Patent: December 12, 2000
    Assignee: SmithKline Beecham p.l.c.
    Inventors: Laramie Mary Gaster, Paul Adrian Wyman