Patents Assigned to SmithKline Beecham p.l.c.
  • DivIB
    Patent number: 5955304
    Abstract: The invention provides DivIB polypeptides and DNA (RNA) encoding such DivIB, particularly those of S. aureus, and a procedure for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing such DivIB for the treatment of infection, to screen for antagonists against such DivIB, diagnostic assays for detecting disease.
    Type: Grant
    Filed: April 9, 1997
    Date of Patent: September 21, 1999
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham p.l.c.
    Inventors: John Edward Hodgson, David John Payne, Stewart Campbell Pearson
  • Fibronectin binding protein polypeptides
    Patent number: 5955078
    Abstract: A monoclonal antibody (Mab), or a fragment thereof, that binds to one or more epitopes of a matrix binding protein and an isolated D1-D4 polypeptide (SEQ ID NO. 6, 7, and 8) from a Staphylococcus aureus Fbp and their use in the prevention of adhesion of bacteria, in particular gram positive bacteria, to extracellular matrix proteins on in-dwelling devices or to matrix proteins in wounds.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: September 21, 1999
    Assignee: Smithkline Beecham p.l.c.
    Inventors: Martin Karl Russel Burnham, Ian Chopra, Ian Alfred Critchley, David Justin Charles Knowles
  • Use of granisetron for the treatment of postoperative nausea and vomiting
    Patent number: 5952340
    Abstract: The present invention is directed to a method for the treatment of post-operative nausea and vomiting wherein granisetron is administered to a patient in need thereof.
    Type: Grant
    Filed: May 23, 1996
    Date of Patent: September 14, 1999
    Assignee: SmithKLine Beecham p.l.c.
    Inventors: Gareth John Sanger, Philip Timothy Davey, Christopher Stuart Dott
  • Desiccating container for moisture-sensitive material
    Patent number: 5947274
    Abstract: The present invention is to a container, particularly for moisture sensitive materials, having a container body of a substantially atmospheric moisture-impermeable material and incorporating a solid element which is made at least in part of a desiccating polymer and which is in contact with the atmosphere inside the container.
    Type: Grant
    Filed: February 20, 1997
    Date of Patent: September 7, 1999
    Assignee: SmithKline Beecham p.l.c.
    Inventors: Charles Bernard Taskis, Simon Joseph Holland, Paul John Whatmore
  • DNA strand resolution
    Patent number: 5948642
    Abstract: The invention provides DNA strand resolution polypeptides and DNA (RNA) encoding DNA strand resolution polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing DNA strand resolution polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: September 2, 1997
    Date of Patent: September 7, 1999
    Assignee: Smithkline Beecham p.l.c.
    Inventors: Michael Terence Black, John Edward Hodgson, David Justin Charles Knowles, Raymond Winfield Reichard, Richard Oakley Nicholas, Martin Karl Russel Burnham, Julie M Pratt, Martin Rosenberg, Judith M Ward, Michael Arthur Lonetto, Patrick Vernon Warren
  • RsbW-1 encoding nucleic acids
    Patent number: 5942419
    Abstract: RsbW-1 polypeptides and DNA (RNA) encoding such RsbW-1 and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such RsbW-1 for the treatment of infection, particularly bacterial infections. Antagonists against such RsbW-1 and their use as a therapeutic to treat infections, particularly bacterial infections are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to the presence of RsbW-1 nucleic acid sequences and the polypeptides in a host. Also disclosed are diagnostic assays for detecting polynucleotides encoding SigB operon and for detecting the polypeptide in a host.
    Type: Grant
    Filed: September 26, 1997
    Date of Patent: August 24, 1999
    Assignee: SmithKline Beecham p.l.c.
    Inventors: Andrew P Fosberry, Elizabeth J Lawlor, Richard O Nicholas
  • Pharmaceutical formulations
    Patent number: 5939066
    Abstract: A pharmaceutical formulation comprises, in combination with a penem of formula (I): ##STR1## in which: R.sup.1 is hydrogen or an organic substituent group;R.sup.2 is a fused bicyclic heterocyclic ring system of general formula: ##STR2## wherein R.sup.4 and R.sup.5 are independently hydrogen or one or more substituents replacing hydrogen atoms in the ring system shown; m is 2 or 3; p is zero, 1 or 2; and R.sup.3 is hydrogen, a salt-forming cation or an ester-forming group; and the symbol =/= indicates that the double bond may be in either the E or Z configuration; and a pharmaceutically acceptable carrier; a .beta.-lactam antibiotic selected from the group consisting of ceftazidime, cefotaxime, amoxycillin, and piperacillin, and pharmaceutically acceptable derivatives thereof.
    Type: Grant
    Filed: January 26, 1998
    Date of Patent: August 17, 1999
    Assignee: SmithKline Beecham p.l.c.
    Inventors: Kenneth Coleman, Jane Elizabeth Neale
  • ribA
    Patent number: 5932701
    Abstract: The invention provides ribA polypeptides and polynucleotides encoding ribA polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ribA polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: November 25, 1997
    Date of Patent: August 3, 1999
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham p.l.c.
    Inventors: Michael Terence Black, Jason Craig Fedon, John Edward Hodgson, David Justin Charles Knowles, Michael Arthur Lonetto, Anna Lisa Kosmatka, Richard Oakley Nicholas, Leslie Marie Palmer, Lisa Kathleen Shilling, Robert King Stodola, Richard Lloyd Warren
  • DNA encoding recombinant IL4 antibodies useful in treatment of IL4 mediated disorders
    Patent number: 5928904
    Abstract: Chimeric and humanized IL4 MAbs derived from high affinity MAbs, pharmaceutical compositions containing same, and methods of treatment are provided.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: July 27, 1999
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham P.L.C.
    Inventors: Stephen D. Holmes, Mitchell Stuart Gross, Daniel R. Sylvester
  • Pharmaceutical compositions containing granisetron and dexamethasone
    Patent number: 5929059
    Abstract: A method of treatment of nausea and vomiting is disclosed which comprises administering to a human or animal subject granisetron and an antiemetic corticosteroid.
    Type: Grant
    Filed: July 28, 1997
    Date of Patent: July 27, 1999
    Assignee: SmithKline Beecham p.l.c.
    Inventors: Gareth John Sanger, Christopher Stuart Dott
  • Container
    Patent number: 5927354
    Abstract: A dispenser for pourable fluids comprising a container for fluid, in the neck of the container there being a holder for a drinking cup, at least one passage in the neck allowing fluid to pass from the container along the neck past the holder toward the mouth opening, removeably mounted in the holder a drinking cup, having an open top, a removeable closure for the mouth opening, such that inversion or agitation of the dispenser causes fluid to pass from the container through the passages(s) into the drinking cup, and re-inversion or cessation of agitation, to an upright orientation results in the retention of a volume of the fluid in the drinking cup.
    Type: Grant
    Filed: March 18, 1997
    Date of Patent: July 27, 1999
    Assignee: Smithkline Beecham P.L.C.
    Inventor: Harry Flewitt
  • Pyridil carboxamides as 5HT2B/2C receptor antagonists
    Patent number: 5922733
    Abstract: Novel heterocyclic compounds having pharmacological activity, processes for their preparation, to compositions containing them and to their use in the treatment of CNS disorders are disclosed.
    Type: Grant
    Filed: June 30, 1997
    Date of Patent: July 13, 1999
    Assignee: SmithKline Beecham p.l.c.
    Inventors: Ian Thomson Forbes, Graham Elgin Jones, Francis David King, Peter Ham, David Thomas Davies, Angela Moghe
  • Compounds
    Patent number: 5919904
    Abstract: The invention provides Response Regulator polypeptides and DNA (RNA) encoding Response Regulator polypetides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing Response Regulator polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: January 16, 1998
    Date of Patent: July 6, 1999
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham p.l.c.
    Inventor: Nicola Gail Wallis
  • Process for the production of 2H-1-benzopyrans
    Patent number: 5919953
    Abstract: There is provided a 2-stage process for making 2H-1-benzopyrans wherein an alpha,beta-unsaturated aldehyde is reacted with an alkanol or an alkane-diol in the presence of a dehydrating compound which is an orthoformate and an aluminum oxide/silicon oxide catalyst to form an aliphatic acetal, which is then condensed in a second stage with a phenol in the presence of base in an organic solvent.
    Type: Grant
    Filed: August 11, 1998
    Date of Patent: July 6, 1999
    Assignee: SmithKline Beecham p.l.c.
    Inventors: Pierre Bossard, Michael Gottsponer, Frances Finney
  • Biphenylamide derivatives as 5HT.sub.1D antagonists
    Patent number: 5919932
    Abstract: Biphenyl amide derivatives as 5HT.sub.1D antagonists, processes for their preparation, pharmaceutical compositions containing them and their use for the treatment of CNS disorders.
    Type: Grant
    Filed: October 7, 1997
    Date of Patent: July 6, 1999
    Assignee: SmithKline Beecham p.l.c.
    Inventors: Laramie Mary Gaster, Keith Raymond Mulholland
  • Process for epoxidising prochiral olefins and a catalyst therefor and intermediates for making the catalyst
    Patent number: 5916975
    Abstract: A process for enantioselectively epoxidising a prochiral olefin, which process comprises reacting a prochiral olefin with a source of oxygen in the presence of a salen catalyst and a source of an electron donating ligand, characterized in that the donor ligand is isoquinoline N-oxide or a compound having donor ligand activity and having substantially the same solubility characteristics as isoquinoline N-oxide.
    Type: Grant
    Filed: August 5, 1996
    Date of Patent: June 29, 1999
    Assignee: SmithKline Beecham p.l.c.
    Inventors: David Bell, Frances Finney, Robin Patrick Attrill, David Miller, Gillian Turner
  • Process for preparing enantiomers of carbazole derivatives as 5-HT.sub.1 -like agonists
    Patent number: 5917054
    Abstract: A (+) or (-) enantiomer of a compound of formula (I) wherein R.sup.4 is methyl or ethyl, or a salt, solvate or hydrate thereof, processes for preparing said compounds and pharmaceutical compositions containing them. Compounds of formula (+) are 5-HT.sub.1 -like agonists.
    Type: Grant
    Filed: January 6, 1997
    Date of Patent: June 29, 1999
    Assignee: SmithKline Beecham p.l.c.
    Inventors: Gary Thomas Borrett, John Kitteringham, Roderick Alan Porter, Mark Ralph Shipton, Mythily Vimal, Rodney Christopher Young
  • Treatment of a latent infection of herpes virus
    Patent number: 5916893
    Abstract: A method for the treatment of latent infection of herpesviruses in mammals, including humans, which method comprises administering to the mammal in need of such treatment, an effective amount of a compound of formula (A): ##STR1## or a bioprecursor, or a pharmaceutically acceptable salt, phosphate ester and/or acyl derivative of either of the foregoing.
    Type: Grant
    Filed: April 25, 1997
    Date of Patent: June 29, 1999
    Assignee: SmithKline Beecham p.l.c.
    Inventors: Hugh John Field, Alana Maureen Thackray, Teresa Helen Bacon, David Sutton, Richard Anthony Vere Hodge
  • Process and apparatus for cell sorting
    Patent number: 5914262
    Abstract: A method of distinguishing between microorganisms having different attributes comprises the steps of: encapsulating one or more cells within a polymeric bead; incubating the cell(s) within the bead in a growth-supporting medium for a time period sufficient for multiplication of viable cells within the bead; then non-invasively physically examining the bead or the adjacent vicinity of the bead for physical characteristics associated with the differing attributes of cells within the bead. Various forms of apparatus for carrying out the process are descried.
    Type: Grant
    Filed: June 21, 1996
    Date of Patent: June 22, 1999
    Assignee: SmithKline Beecham p.l.c.
    Inventors: Donald Bruce Atherton MacMichael, David Drake, Stephen Adrian Arlington, Ian David Normansell, John Kenneth Addicott, Moira Sloan Divers, John Spencer Stovold
  • Recombinant IL4 antibodies useful in treatment of IL4 mediated disorders
    Patent number: 5914110
    Abstract: Chimeric and humanized IL4 MAbs derived from high affinity MAbs, pharmaceutical compositions containing same, and methods of treatment are provided.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: June 22, 1999
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham p.l.c.
    Inventors: Stephen D. Holmes, Mitchell Stuart Gross, Daniel R. Sylvester