Patents Assigned to SmithKline Beecham p.l.c.
  • Blackcurrant promoters and genes
    Publication number: 20040203053
    Abstract: Promoters and a process for isolating a promoter capable of driving fruit-specific expression of DNA sequences in transgenic blackcurrant and other non-climacteric fruit.
    Type: Application
    Filed: May 4, 2004
    Publication date: October 14, 2004
    Applicant: SmithKline Beecham p.l.c.
    Inventors: Mary Rose Woodhead, Mark Andrew Taylor, Rex Michael Brennan
  • Process for the preparation of an indole derivative
    Publication number: 20040192911
    Abstract: A process for the preparation of methyl 2-(3-chloropropoxy)-indole-3-carboxylate, which comprises reacting a 3-chloro-3-carboxylate indole compound with 3-chloropropanol in the presence of an acid having a pKa of from 0 to 2.
    Type: Application
    Filed: April 5, 2004
    Publication date: September 30, 2004
    Applicant: SmithKline Beecham p.l.c.
    Inventors: Michael Fedouloff, John Bryce Strachan
  • Use of thiazolidinediones for the treatment of hyperglycaemia
    Publication number: 20040192737
    Abstract: A method for the treatment of hyperglycaemia wherein plasma glucose levels in the range of from >126 mg/dl to 140 mg/dl, which method comprises administering an effective nontoxic and pharmaceutically acceptable amount of an insulin sensitiser, to a mammal in need thereof.
    Type: Application
    Filed: April 13, 2004
    Publication date: September 30, 2004
    Applicant: SmithKline Beecham p.l.c.
    Inventors: Robin Edwin Buckingham, Stephen Alistair Smith
  • Novel method of treatment
    Publication number: 20040176373
    Abstract: A method for the treatment of diabetes mellitus, especially Type II diabetes and the cardiac conditions associated with diabetes mellitus in a mammal such as a human, which method comprises administering an effective non-toxic and pharmaceutically acceptable amount of an insulin sensitizer, such as Compound (I), and an agent used in the treatment of the cardiac conditions associated with diabetes mellitus.
    Type: Application
    Filed: March 18, 2004
    Publication date: September 9, 2004
    Applicant: SmithKline Beecham p.l.c.
    Inventor: Robin Edwin Buckingham
  • 3,4-Dihdro-N-[[1-(3-hydroxybutyl)-4-piperidinyl]methyl]-2H-[1,3]oxazino[3,2-a]indole-10-carboxamide as 5-HT(4) receptor antagonist
    Publication number: 20040176370
    Abstract: 3,4-Dihydro-N-[[1-(3-hydroxybutyl-4-piperidinyl]methyl]-2H-[1,3]oxazino[3,2-&agr;]indole-10-carboxamide and its use as 5-HT4 receptor antagonist for example in the treatment or prophylaxis of gastrointestinal disorders, cardiovascular disorders and CNS disorders.
    Type: Application
    Filed: March 16, 2004
    Publication date: September 9, 2004
    Applicant: SmithKline Beecham p.l.c.
    Inventors: Frank Hossner, David Austin Ryan
  • Treatment of diabetes with thiazolidinedione and sulphonylurea
    Publication number: 20040176420
    Abstract: A method for the treatment of diabetes mellitus and conditions associated with diabetes mellitus in a mammal, which method comprises administering an effective non-toxic and pharmaceutically acceptable amount of an insulin sensitiser and a sub-maximal amount of an insulin secretagogue, to a mammal in need thereof; and a pharmaceutical composition for use in such method.
    Type: Application
    Filed: March 15, 2004
    Publication date: September 9, 2004
    Applicant: SmithKline Beecham p.l.c.
    Inventors: Robin Edwin Buckingham, Stephen Alistair Smith
  • Anti-RANK ligand monoclonal antibodies useful in treatment of RANK ligand mediated disorders
    Publication number: 20040171117
    Abstract: Chimeric, humanized and other RANK-L MAbs, derived from high affinity neutralizing MAbs, pharmaceutical compositions containing same, methods of treatment and diagnostics are provided.
    Type: Application
    Filed: December 17, 2003
    Publication date: September 2, 2004
    Applicants: SmithKline Beecham Corporation, SmithKline Beecham p.l.c.
    Inventors: Mark A. Tornetta, Raymond W. Sweet, Alemseged Truneh, Trevor A. Wattam
  • Pyrimidinone compounds
    Publication number: 20040167142
    Abstract: Pyrimidinone compounds of formula (I) are inhibitors of the enzyme Lp-PLA2 and of use in therapy, in particular for treating atherosclerosis.
    Type: Application
    Filed: February 11, 2004
    Publication date: August 26, 2004
    Applicant: SmithKline Beecham p.l.c.
    Inventors: Ashley Edward Fenwick, Deirdre Mary Bernadette Hickey, Robert John Ife, Colin Andrew Leach, Ivan Leo Pinto, Stephen Allan Smith
  • Recombinant IL-5 antagonists useful in treatment of IL-5 mediated disorders
    Publication number: 20040156850
    Abstract: Chimeric, humanized and other IL-5 mAbs, derived from high affinity neutralizing mAbs, pharmaceutical compositions containing same, methods of treatment and diagnostics are provided.
    Type: Application
    Filed: November 4, 2003
    Publication date: August 12, 2004
    Applicants: SmithKline Beecham Corporation, SmithKline Beecham p.l.c.
    Inventors: Robert S. Ames, Edward Robert Appelbaum, Irwin M. Chaiken, Richard M. Cook, Mitchell Stuart Gross, Stephen Dudley Holmes, Lynette Jane McMillan, Timothy Wayne Theisen
  • Compounds
    Patent number: 6770657
    Abstract: The invention relates to novel isoquinolines and their use as anticonvulsant and in the treatment of a variety of disorders.
    Type: Grant
    Filed: September 11, 2002
    Date of Patent: August 3, 2004
    Assignee: Smithkline Beecham p.l.c.
    Inventors: John David Harling, Mervyn Thompson
  • Methods for producing modified nucleic acid molecules
    Patent number: 6770462
    Abstract: A method for inserting a cassette into a nucleic acid molecule to produce a modified nucleic acid molecule, e.g., a nucleic acid-cassette fusion, is described. The method involves the use of polymerase chain reaction, thereby permitting precise targeting of the desired site in the molecule, but does not require ligation. Also described is the use of this method for high throughput screening the resulting modified nucleic acid molecules.
    Type: Grant
    Filed: November 5, 2001
    Date of Patent: August 3, 2004
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham p.l.c.
    Inventors: Alison F. Chalker, David J. Holmes, Robert Dwayne Lunsford, James Yigong Ge
  • Method of treatment
    Publication number: 20040147583
    Abstract: The use of [R-(Z)]-&agr;-(methoxyimino)-&agr;-(1-azabicyclo[2.2.2]oct-3-yl)acetonitrile or a pharmaceutically acceptable salt thereof for the treatment of anxiety.
    Type: Application
    Filed: January 8, 2004
    Publication date: July 29, 2004
    Applicant: SmithKline Beecham p.l.c
    Inventors: Joanne Bright, Nick Harrington, Naheed Mirza, Kelly Stanhope
  • Recombinant IL-18 antagonists useful in treatment of IL-18 mediated disorders
    Publication number: 20040141964
    Abstract: Chimeric, humanized and other IL-18 mAbs, derived from high affinity neutralizing mAbs, pharmaceutical compositions containing same, methods of treatment and diagnostics are provided.
    Type: Application
    Filed: January 22, 2004
    Publication date: July 22, 2004
    Applicant: SmithKline Beecham Corporation and SmithKline Beecham p.l.c.
    Inventors: Sherin S. Abdel-Meguid, Yen Sen Ho, Stephen D. Holmes, Alexander H. Taylor
  • Novel compounds
    Publication number: 20040142964
    Abstract: The invention relates to novel isoquinolines and their use as anticonvulsants and in the treatment of a variety of disorders.
    Type: Application
    Filed: January 12, 2004
    Publication date: July 22, 2004
    Applicant: SmithKline Beecham p.l.c.
    Inventors: John David Harling, Mervyn Thompson
  • Resorufin derivatives as substrates for CYP3A4
    Patent number: 6762034
    Abstract: Resorufin derivative as a substance for cytochrome P450 enzyme.
    Type: Grant
    Filed: January 2, 2002
    Date of Patent: July 13, 2004
    Assignee: SmithKline Beecham p.l.c.
    Inventors: Jacqueline Carol Bloomer, Richard Leonard Elliott, Colin Andrew Leach
  • 7-Alkoxycoumarins as CYP2C9 substrates and activity assay
    Patent number: 6756209
    Abstract: Coumarin derivatives as substrates for cytochrome P450 enzyme.
    Type: Grant
    Filed: June 11, 2001
    Date of Patent: June 29, 2004
    Assignee: SmithKline Beecham p.l.c.
    Inventors: Ramesh B. Bambal, Richard Leonard Elliott
  • Liquid oral compositions comprising a calcium compound and an acidulant
    Publication number: 20040120986
    Abstract: Acidic oral compositions having reduced tooth erosion characteristics, especially acid beverages such as fruit juice drink concentrates, or oral healthcare products such as mouthwashes, are prepared by adding a calcium compound to the acid composition so that the mol ratio of calcium to acid ranges from 0.3 to 0.8, and the pH of the composition, if necessary after adjustment with an alkali, is from 3.5 to 4.5.
    Type: Application
    Filed: December 10, 2003
    Publication date: June 24, 2004
    Applicant: SmithKline Beecham p.l.c
    Inventor: David Myatt Parker
  • Use of glucose uptake enhancer for reducing post-ischemic injury of the heart
    Publication number: 20040110800
    Abstract: A method for reducing post-ischaemic injury of the heart and/or improving the functional recovery of the heart following myocardial ischaemia which method comprises administration of an effective, non-toxic amount of a glucose uptake enhancer to a human or non-human mammal in need thereof.
    Type: Application
    Filed: December 2, 2003
    Publication date: June 10, 2004
    Applicant: SmithKline Beecham p.l.c. & SmithKline Beecham Laboratoires Pharmaceutiques
    Inventors: Antoine Michel Alain Bril, Robin Edwin Buckingham, Nassirah Khandoudi
  • Piperazine derivatives as 5-HT1B antagonists
    Patent number: 6747030
    Abstract: Piperazine derivatives of formula(1), processes for their preparation, pharmaceutical compositions containing them in the treatment of CNS and other disorders and in their use in therapy as 5-HT1B antagonists are disclosed herein.
    Type: Grant
    Filed: March 25, 2002
    Date of Patent: June 8, 2004
    Assignee: SmithKline Beecham p.l.c.
    Inventors: Howard Marshall, Mervyn Thompson, Paul Adrian Wyman
  • Capsule link
    Patent number: D493518
    Type: Grant
    Filed: November 26, 2002
    Date of Patent: July 27, 2004
    Assignee: SmithKline Beecham p.l.c.
    Inventors: Stephen Mark McAllister, Brian Hewitt