Abstract: A polymorphic form of 5-[4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzyl]-thiazolidine-2, 4-dione, maleic acid salt (the “Polymorph”) characterized in that it provides: (i) an infra red spectrum containing peaks at 1763, 912, 856 and 709 cm−1; and/or (ii) a Raman spectrum containing peaks at 1762, 1284, 912 and 888 cm−1; and/or (iii) a solid-state 13C nuclear magnetic resonance spectrum containing peaks at 111.0, 113.6, 119.8, 129.1, 130.9, 131.8, 134.7, 146.5, 152.7, 157.5, 169.5, 171.0, 178.7 ppm; and/or (v) an X-ray powder diffraction (XRPD) pattern which gives calculated lattice spacings at 5.87, 5.30, 4.69, 4.09, 3.88, 3.61, 3.53 and 3.46 Angstroms; a process for preparing such a compound, a pharmaceutical composition containing such a compound and the use of such a compound in medicine.
Abstract: Promoters and a process for isolating a promoter capable of driving fruit-specific expression of DNA sequences in transgenic blackcurrant and other non-climacteric fruit.
Type:
Application
Filed:
May 4, 2004
Publication date:
October 14, 2004
Applicant:
SmithKline Beecham p.l.c.
Inventors:
Mary Rose Woodhead, Mark Andrew Taylor, Rex Michael Brennan
Abstract: A method for the treatment of hyperglycaemia wherein plasma glucose levels in the range of from >126 mg/dl to 140 mg/dl, which method comprises administering an effective nontoxic and pharmaceutically acceptable amount of an insulin sensitiser, to a mammal in need thereof.
Type:
Application
Filed:
April 13, 2004
Publication date:
September 30, 2004
Applicant:
SmithKline Beecham p.l.c.
Inventors:
Robin Edwin Buckingham, Stephen Alistair Smith
Abstract: A process for the preparation of methyl 2-(3-chloropropoxy)-indole-3-carboxylate, which comprises reacting a 3-chloro-3-carboxylate indole compound with 3-chloropropanol in the presence of an acid having a pKa of from 0 to 2.
Abstract: A method for the treatment of diabetes mellitus and conditions associated with diabetes mellitus in a mammal, which method comprises administering an effective non-toxic and pharmaceutically acceptable amount of an insulin sensitiser and a sub-maximal amount of an insulin secretagogue, to a mammal in need thereof; and a pharmaceutical composition for use in such method.
Type:
Application
Filed:
March 15, 2004
Publication date:
September 9, 2004
Applicant:
SmithKline Beecham p.l.c.
Inventors:
Robin Edwin Buckingham, Stephen Alistair Smith
Abstract: 3,4-Dihydro-N-[[1-(3-hydroxybutyl-4-piperidinyl]methyl]-2H-[1,3]oxazino[3,2-&agr;]indole-10-carboxamide and its use as 5-HT4 receptor antagonist for example in the treatment or prophylaxis of gastrointestinal disorders, cardiovascular disorders and CNS disorders.
Abstract: A method for the treatment of diabetes mellitus, especially Type II diabetes and the cardiac conditions associated with diabetes mellitus in a mammal such as a human, which method comprises administering an effective non-toxic and pharmaceutically acceptable amount of an insulin sensitizer, such as Compound (I), and an agent used in the treatment of the cardiac conditions associated with diabetes mellitus.
Abstract: Chimeric, humanized and other RANK-L MAbs, derived from high affinity neutralizing MAbs, pharmaceutical compositions containing same, methods of treatment and diagnostics are provided.
Abstract: Pyrimidinone compounds of formula (I) are inhibitors of the enzyme Lp-PLA2 and of use in therapy, in particular for treating atherosclerosis.
Type:
Application
Filed:
February 11, 2004
Publication date:
August 26, 2004
Applicant:
SmithKline Beecham p.l.c.
Inventors:
Ashley Edward Fenwick, Deirdre Mary Bernadette Hickey, Robert John Ife, Colin Andrew Leach, Ivan Leo Pinto, Stephen Allan Smith
Abstract: Chimeric, humanized and other IL-5 mAbs, derived from high affinity neutralizing mAbs, pharmaceutical compositions containing same, methods of treatment and diagnostics are provided.
Inventors:
Robert S. Ames, Edward Robert Appelbaum, Irwin M. Chaiken, Richard M. Cook, Mitchell Stuart Gross, Stephen Dudley Holmes, Lynette Jane McMillan, Timothy Wayne Theisen
Abstract: A method for inserting a cassette into a nucleic acid molecule to produce a modified nucleic acid molecule, e.g., a nucleic acid-cassette fusion, is described. The method involves the use of polymerase chain reaction, thereby permitting precise targeting of the desired site in the molecule, but does not require ligation. Also described is the use of this method for high throughput screening the resulting modified nucleic acid molecules.
Abstract: The use of [R-(Z)]-&agr;-(methoxyimino)-&agr;-(1-azabicyclo[2.2.2]oct-3-yl)acetonitrile or a pharmaceutically acceptable salt thereof for the treatment of anxiety.
Type:
Application
Filed:
January 8, 2004
Publication date:
July 29, 2004
Applicant:
SmithKline Beecham p.l.c
Inventors:
Joanne Bright, Nick Harrington, Naheed Mirza, Kelly Stanhope
Abstract: Chimeric, humanized and other IL-18 mAbs, derived from high affinity neutralizing mAbs, pharmaceutical compositions containing same, methods of treatment and diagnostics are provided.
Type:
Application
Filed:
January 22, 2004
Publication date:
July 22, 2004
Applicant:
SmithKline Beecham Corporation and SmithKline Beecham p.l.c.
Inventors:
Sherin S. Abdel-Meguid, Yen Sen Ho, Stephen D. Holmes, Alexander H. Taylor
Abstract: Acidic oral compositions having reduced tooth erosion characteristics, especially acid beverages such as fruit juice drink concentrates, or oral healthcare products such as mouthwashes, are prepared by adding a calcium compound to the acid composition so that the mol ratio of calcium to acid ranges from 0.3 to 0.8, and the pH of the composition, if necessary after adjustment with an alkali, is from 3.5 to 4.5.