Patents Assigned to Societe de Conseils de Recherches et
  • NOVEL IMIDAZOLE DERIVATIVES, PREPARATION AND USER THEREOF AS MEDICINE
    Publication number: 20090186930
    Abstract: The invention concerns novel imidazole derivatives of general formula (I), wherein Z? and Z represent different variable groups. Said products have an antitumoral activity. The invention also concerns pharmaceutical compositions containing said products and their use for preparing antitumoral medicine.
    Type: Application
    Filed: April 26, 2007
    Publication date: July 23, 2009
    Applicant: Societe de Conseils de Recherches et D' Applications Scientifiques (S.C.R.A.S.)
    Inventors: Anne-Marie Liberatore, Dennis Bigg, Dominique Pons, Grégoire Prevost
  • Derivatives of 2-(iminomethyl)amino-phenyl, their preparation, their use as medicaments and the pharmaceutical compositions containing them
    Patent number: 7553976
    Abstract: The invention relates to new derivatives of 2-(iminomethyl)amino-phenyl which are NO synthase inhibitors and can trap reactive oxygen species. These compounds can notably be used for the treatment of stroke, of neurodegenerative diseases and of ischemic or hemorragic cardiac of cerebral infarctions.
    Type: Grant
    Filed: January 22, 2008
    Date of Patent: June 30, 2009
    Assignee: Societe de Conseils de Recherches et d'Applications (S.C.R.A.S.)
    Inventors: Pierre Etienne Chabrier De Lassauniere, Serge Auvin, Dennis Bigg, Michel Auquet, Jeremiah Harnett
  • Somatostatin antagonists
    Patent number: 7550423
    Abstract: The invention features somatostatin antagonists having a D-amino acid at the second residue.
    Type: Grant
    Filed: November 13, 2003
    Date of Patent: June 23, 2009
    Assignees: The Administrators of the Tulane Educational Fund, Societe de Conseils de Recherches et d'Applications Squentifiques, S.A.S.
    Inventors: David H. Coy, Barry Morgan, William Murphy
  • G-PROTEIN INHIBITOR
    Publication number: 20090137596
    Abstract: A subject of the invention is a product comprising at least one Cdc25 phosphatase inhibitor in combination with at least one other anti-cancer agent for a therapeutic use which is simultaneous, separate or spread over time in the treatment of cancer.
    Type: Application
    Filed: October 7, 2008
    Publication date: May 28, 2009
    Applicant: Societe de Conseils de Recherches et D'Applications Scientifiques (S.C.R.A.S.)
    Inventors: Gregoire PREVOST, Marie-Christine Brezak Pannetier, Christian Diolez
  • BENZOOXAZOLE-4,7-DIONE, DERIVATIVES AND THEIR USE AS CDC25 PHOSPHATE INHIBITORS
    Publication number: 20090131428
    Abstract: The invention concerns the use as cdc25 phosphatase inhibitors, in particular cdc25-C phosphatase, and CD45 phosphatase, of compounds of general formula (I), wherein: W represents O or S. In accordance with the invention, the compounds of general formula (I) can in particular be used for preparing a medicine for cancer treatment.
    Type: Application
    Filed: October 6, 2008
    Publication date: May 21, 2009
    Applicant: Societe de Conseils de Recherches et D'Applications Scientifiques (S.C.R.A.S.)
    Inventors: Marie-Odile Galcera Contour, Olivier Lavergne, Marie-Christine Brezak Pannetier, Gregoire Prevost
  • Imidazole derivatives, their preparation and their use as medicaments
    Patent number: 7534805
    Abstract: Novel imidazole compounds of the formula wherein the substituents are as defined in the application having antitumoral activity and use thereof.
    Type: Grant
    Filed: May 26, 2004
    Date of Patent: May 19, 2009
    Assignee: Societe de Conseils de Recherches Et d'Applications Scientifiques (S.C.R.A.S.)
    Inventors: Dennis Bigg, Anne-Marie Liberatore, Dominique Pons
  • PTH2 receptor selective compounds
    Patent number: 7531621
    Abstract: This invention relates to a series of PTH and PTHrP analogues that selectively bind to PTH2 receptors and as such may be useful in treating abnormal CNS functions; abnormal pancreatic functions; divergence from normal mineral metabolism and homeostasis; male infertility; regulation of abnormal blood pressure; and hypothalmic disease.
    Type: Grant
    Filed: May 3, 1999
    Date of Patent: May 12, 2009
    Assignees: Societe de Conseils de Recherches et d'Applications Scientifiques S.A.S., Beth Israel
    Inventors: Zheng Xin Dong, Michael Chorev, Michael Rosenblatt
  • GLP-1 pharmaceutical compositions
    Patent number: 7521527
    Abstract: The present invention is directed to peptide analogues of glucagon-like peptide-1, the pharmaceutically-acceptable salts thereof, to methods of using such analogues to treat mammals and to pharmaceutical compositions useful therefor comprising said analogues.
    Type: Grant
    Filed: December 16, 2004
    Date of Patent: April 21, 2009
    Assignee: Societe de Conseils de Recherches et d'Applications Scientifiques, S.A.S.
    Inventors: Zheng Xin Dong, Roland Cherif-Cheikh
  • BENZOTHIAZOLE- AND BENZOOXAZOLE-4,7-DIONE, DERIVATIVES AND THEIR USE AS CDC25 PHOSPHATE INHIBITORS
    Publication number: 20090082345
    Abstract: The invention concerns the use as cdc25 phosphatase inhibitors, in particular cdc25-C phosphatase, and CD45 phosphatase, of compounds of general formula (I), wherein: W represents O or S. In accordance with the invention, the compounds of general formula (I) can in particular be used for preparing a medicine for cancer treatment.
    Type: Application
    Filed: October 3, 2008
    Publication date: March 26, 2009
    Applicant: Societe de Conseils de Recherches et D'Applications Scientifiques (S.C.R.A.S.)
    Inventors: Marie-Odile GALCERA CONTOUR, Olivier Lavergne, Marie-Christine Brezak Pannetier, Gregoire Prevost
  • Method for synthesis of 2,5-dioxane-1,4-diones
    Patent number: 7504524
    Abstract: The invention relates to a novel method for the synthesis of 2,5-dioxane-1,4-diones having formula (I), comprising the oxidation of the ketone function of a cyclic compound having formula (II), wherein R1, R2, R3 and R4 independently represent the hydrogen atom, halo, (C2-C6) alkenyl, (C3-C7)cycloalkyl, cyclohexenyl and a radical having formula —(CH2)m—V—W.
    Type: Grant
    Filed: July 25, 2005
    Date of Patent: March 17, 2009
    Assignee: Societe de Conseils de Recherches Et d'Applications Scientifiques
    Inventors: Didier Bourissou, Blanca Martin-Vaca, Frédéric Ben, Magalie Graullier, Roland Cherif-Cheikh, Martin Montes
  • Derivatives of benzimidazole and imidazo-pyridine and their use as medicaments
    Patent number: 7501524
    Abstract: A compound of the formula wherein the substituents are as defined in the specification and pharmaceutical salts thereof having a good affinity for sub-types of melanocortin receptors making them useful for treating diseases in which such receptors are included such as pain, inflammatory conditions, etc.
    Type: Grant
    Filed: August 11, 2004
    Date of Patent: March 10, 2009
    Assignee: Societe de Conseils de Recherches et d'Applications Scientifiques (S.C.R.A.S.)
    Inventors: Lydie Poitout, Valerie Brault, Carole Sackur, Pierre Roubert, Pascale Plas
  • Derivatives of benzimidazole and their use as medicaments
    Patent number: 7501525
    Abstract: A subject of the present Application is novel derivatives of benzimidazole and imidazo-pyridine which have a good affinity for certain sub-types of melanocortin receptors, in particular the MC4 receptors. They are particularly useful for treating pathological conditions and diseases in which one or more melanocortin receptors are involved. The invention also relates to pharmaceutical compositions containing said products.
    Type: Grant
    Filed: January 31, 2008
    Date of Patent: March 10, 2009
    Assignee: Societe de Conseils de Recherches et d'Applications Scientifiques (S.C.R.A.S.)
    Inventors: Lydie Poitout, Valerie Brault, Carole Sackur, Pierre Roubert, Pascale Plas
  • Benzothiazole- and benzooxazole-4,7-dione, derivatives and their use as cdc25 phosphate inhibitors
    Patent number: 7495021
    Abstract: The invention concerns the use as cdc25 phosphatase inhibitors, in particular cdc25-C phosphatase, and CD45 phosphatase, of compounds of general formula (I), wherein: W represents O or S. In accordance with the invention, the compounds of general formula (I) can in particular be used for preparing a medicine for cancer treatment.
    Type: Grant
    Filed: August 31, 2007
    Date of Patent: February 24, 2009
    Assignee: Societe de Conseils de Recherches et d'Applications Scientifiques (S.C.R.A.S.)
    Inventors: Marie-Odile Galcera Contour, Olivier Lavergne, Marie-Christine Brezak Pannetier, Grégoire Prevost
  • Imidazopyridine derivatives as melancortin receptor agonists
    Patent number: 7495009
    Abstract: Derivatives of imidazopyridine which have a good affinity for certain sub-types of melanocortin receptors, in particular MC4 receptors and are useful for treating pathological states and diseases in which one or more melanocortin receptors are involved and pharmaceutical compositions containing said products.
    Type: Grant
    Filed: March 29, 2004
    Date of Patent: February 24, 2009
    Assignee: Societe de Conseils de Recherches et d'Applications Scientifiques (S.C.R.A.S.)
    Inventors: Lydie Poitout, Valérie Brault, Carole Sackur, Pierre Roubert, Pascale Plas
  • Benzimidazole derivatives and their use as GnRH antagonists
    Patent number: 7495110
    Abstract: A subject of the present application is new benzimidazole derivatives of formula in which A, Y, R1, R2, R3 and R4 represent different variable groups. These products have an antagonist activity of GnRH (Gonadotropin-Releasing Hormone). The invention also relates to pharmaceutical compositions containing said products and their use for the preparation of a medicament.
    Type: Grant
    Filed: December 20, 2002
    Date of Patent: February 24, 2009
    Assignee: Societe de Conseils de Recherches et d'Applications Scientifiques (S.C.R.A.S.)
    Inventors: Lydie Poitout, Valérie Brault, Eric Ferrandis, Christophe Thurieau
  • Heterocarpine, a plant-derived protein with anti-cancer properties
    Patent number: 7494969
    Abstract: A method of treating cancer dependent on growth factor GHRH in warm-blooded animals in need thereof with an isolated protein extended for Pilocarpus Heterophyllus.
    Type: Grant
    Filed: August 25, 2003
    Date of Patent: February 24, 2009
    Assignee: Societe de Conseils de Recherches et d'Applications Scientifiques (S.C.R.A.S.)
    Inventors: Eric Ferrandis, Beng Poon Teng, Christine Sohier, Christophe Thurieau
  • AMIDINE DERIVATIVES AND THEIR APPLICATIONS AS A MEDICAMENT
    Publication number: 20090018120
    Abstract: The invention concerns amidine derivatives of general formula (I) exhibiting an inhibitory activity of calpains and/or a trapping activity of reactive forms of oxygen.
    Type: Application
    Filed: October 18, 2006
    Publication date: January 15, 2009
    Applicant: Societe de Conseils de Recherches et D'Applications Scientifiques
    Inventors: Serge Auvin, Dennis Bigg, Pierre-Etienne Chabrier De Lassauniere, Bernadette Pignol
  • Derivatives of amidines, their preparation, their use as medicaments and the pharmaceutical compositions containing them
    Patent number: 7473779
    Abstract: Novel derivatives of amidines of formula wherein the substituents are defined as in the specification which are useful for inhibiting activity on NO-synthase enzymes producing nitrogen mono oxide and/or trapping the reactive oxygen species (ROS) making them useful for treating various diseases.
    Type: Grant
    Filed: September 12, 2003
    Date of Patent: January 6, 2009
    Assignee: Societe de Conseils de Recherches et d'Applications Scientifiques (S.C.R.A.S.)
    Inventors: Serge Auvin, Pierre-Etienne Chabrier de Lassauniere, Jeremiah Harnett, Dominique Pons, Gérard Ulibarri
  • 2-hydroxytetrahydrofuran derivatives and use thereof as medicaments
    Patent number: 7465721
    Abstract: A hydroxytetrahydrofuran of formula wherein A is with the substituents as defined in the specification, having a calpain inhibiting activity and/or an activity which traps the reactive oxygen species useful for treating inflammatory and immunological diseases, cardio-vascular and cerebro-vascular diseases, disorders of the central or peripheral nervous system, osteoporosis, muscular dystrophy, proliferative diseases, cataract, rejection reactions following organ transplants and autoimmune and viral diseases.
    Type: Grant
    Filed: December 8, 2004
    Date of Patent: December 16, 2008
    Assignee: Societe de Conseils de Recherches et d'Applications Scientifiques (S.C.R.A.S.)
    Inventors: Serge Auvin, Pierre-Etienne Chabrier de Lassauniere
  • Analogs of parathyroid hormone
    Patent number: RE40850
    Abstract: The present invention is directed to peptide analogues of fragment of parathyroid hormone (PTH) or parathyroid hormone-related protein (PTHrP), a method of using said analogues alone or in combination with a bisphosphonate or calcitonin to treat osteoporosis and pharmaceutical compositions comprising said analogues alone or in combination with a bisphosphonate or calcitonin.
    Type: Grant
    Filed: September 19, 2006
    Date of Patent: July 14, 2009
    Assignee: Societe de Conseils de Recherches et d'Applications Scientifiques, S.A.S.
    Inventor: Zheng Xin Dong