Abstract: The invention pertains to a compound of formula (I), one of its pharmaceutically acceptable salts, or a composition comprising thereof, for use in the prevention or treatment of glucose intolerance related conditions, insulin deficit related conditions, nonalcoholic fatty liver disease and/or obesity.

Abstract: A microfluidic print head of a printer has a distal face, an injection channel, a suction channel, a groove, and a light source or an optical waveguide. The injection channel is configured to inject an ink onto a substrate and leads onto the distal face by an injection opening The suction channel is configured to suck up the ink and leads onto the distal face by a suction opening. The groove is defined on the distal face and into which the suction opening leads.

Abstract: A THz laser source includes a first generator suitable for emitting at least one first light emission and one second light emission of frequencies that are multiples of a first reference frequency; a second generator suitable for emitting at least one first light emission and one second light emission of frequencies that are multiples of a second reference frequency different from the first reference frequency; the THz laser source furthermore comprises a nonlinear crystal suitable for forming, from the first light emissions emitted by each of the first and second generators, a THz light emission generated by difference-frequency generation, of frequency comprised between 0.3 THz and 10 THz; and at least one first frequency-stabilizing module allowing the frequency of one of the second emissions emitted by one of the first and second generators to be stabilized to an atomic transition.

Abstract: A method is provided for detecting a fluorescent species that is reversibly photoswitchable at high frequency, and more precisely to a method for detecting at least one reversibly photoswitchable fluorescent species, including a step consisting in illuminating a sample containing a reversibly photoswitchable fluorescent species with a first illuminating light beam, of wavelength ?1, and periodically modulated at an angular frequency ?, and with a second illuminating light beam of wavelength ?2 different from ?1, which is periodically modulated at the angular frequency ?, the second illuminating light beam being modulated in antiphase with respect to the first illuminating light beam.

Abstract: Provided herein is a method for synthesizing polynucleic acids, comprising the steps of (a) providing an acidic solution substantially free of nucleic acid polymerase and lipids, but containing mononucleotides and a monovalent salt; (b) drying and resolubilizing the mixture of step (a) a plurality of times; and (c) recovering polynucleic acids from a resolubilized mixture of step (b). In certain aspects, the method further uses a low pH, e.g. about 3; it can utilize monophosphates, such as AMP rather than ATP; and it can be used with a polynucleotide template to form a sequence at least partially complementary to said template. Thus, both single-stranded and double-stranded polynucleic acids are provided. Ammonia salts have been used to obtain RNA lengths from 10 to 300 nucleotides after 16 half hour cycles and an effective temperature includes between 80° C. and 100° C.

Abstract: The invention relates to 20-hydroxyecdysone and the derivatives thereof, for use in the treatment of genetic myopathies.

Abstract: Probenecid or a pharmaceutical acceptable salt thereof for use in the treatment of a neurological disorder in a subject in need thereof, wherein administration of probenecid or a pharmaceutical acceptable salt thereof controls clinical or electrographic seizures in the subject. Preferably, the neurological disorder is an epileptic disease, disorder or condition.

Abstract: A regenerative material in the connective tissues (such as bone, dentin or pulp) regeneration field. More precisely, a connective tissue regenerative material, preferably a bone, dentin or pulp regenerative material, including: a porous polymer matrix having interconnected pores; and non-hydrated calcium silicate particles; wherein: the polymer matrix is anhydrous; the non-hydrated calcium silicate particles have a d50 granulometry, preferably ranging from 0.05 ?m to less than the average diameter size of the pores of the matrix; and the non-hydrated calcium silicate particles being coated on the inside walls of the pores of the matrix. Also, a method for preparing the connective tissue regenerative material and uses of the regenerative materials, such as in the dental field; especially, for providing regenerative materials with improved biomechanical and osteoinductive properties (i.e.

Abstract: The invention concerns a method for preparing an extract from a preparation of approximately 90% pure 20-hydroxyecdysone that comprises the following steps: g) Hot dissolution of approximately 90% pure 20-hydroxyecdysone in methanol, filtration and partial concentration, h) Addition of 1 to 5 volumes of acetone, i) Cooling to a temperature of between 0 and 5° C. while stirring, j) Filtration of the obtained precipitate, k) Successive rinses with acetone and water, and l) Drying.

Abstract: The present invention relates to a system and device (1000) for controlling hydroelastic surface waves and to the use thereof. In particular, the invention relates to a system for controlling hydroelastic waves propagating over the surface of a liquid (1), the controlling system comprising a floating composite structure (10) having at least two zones Z1 and Z2 the respective bending coefficients D1 and D2 and/or the shapes of which are adapted to control the propagation of the hydroelastic waves, and for which it is possible to define an index ni, i being equal to 1 or 2, similar to the refractive index of an optical medium. The controlling system thus allows the propagation of the hydroelastic waves to be able to be controlled by applying the laws of geometric optics.

Abstract: The present invention relates to a method for producing a positive electrode composite material comprising at least one Na-based positive electrode active material and Na3P for a battery using sodium ions as electrochemical vector, to a positive electrode comprising such a positive electrode composite material, and to the Na-ion battery comprising such a positive electrode.

Abstract: Fluorescent labeling of proteins. In particular, membrane-impermeant fluorogenic chromophores being capable of binding reversibly a functional derivative of a Photoactive Yellow Protein (PYP), or a functional fragment thereof, for fluorescently labeling biological molecules of interest, preferably proteins of interest. Especially, 4-hydroxybenzylidene-rhodanine (HBR) analogs of formula (II) as membrane-impermeant fluorogenic chromophores.

Abstract: The present invention concerns, in particular, a method for obtaining a product with magnetocaloric effect from a single piece of material having a magnetic phase transition, the method comprising irradiation of at least one part of the material with ions, the irradiation being carried out with a suitable flux so that, after the irradiation, the material has various magnetic phase transition temperatures in the various parts of the material.

Abstract: The present invention relates to a method for preparing a fibrillar collagen matrix, which is advantageously transparent or composite, suitable for being used as a biomaterial, in particular as a corneal substitute.

Abstract: The invention relates to a device and a method to assist with the operation of an instrument by means of said device, the device and the method using leverage effects in order to calculate the data relative to any point of an instrument axis, instead of using low-accuracy sensors. Other improvements are also described that allow higher-quality usage performance for the operator, which reduces the risk of errors and simplifies the operations.

Abstract: The present invention relates to methods and devices to consolidate memory and/or cognitive functions by monitoring brain rhythms and delivering a stimulus at an appropriate stage of sleep cycle.

Abstract: A method of controlling the display of images in the form of a pixel array, includes for a pixel of the array, asynchronous information representing events concerning the pixel is received, a first activation of the pixel is actuated at an activation time determined by a first event of the asynchronous information, and at least a second activation of the pixel is actuated in order to repeat the first activation of the pixel at respective times defined by a refresh sequence.

Abstract: The present invention is related to a method for identifying in a given semantic graph of linked concepts a set of concepts matching the content of a text, the semantic graph of linked concepts being stored in at least one equipment connected to a network, the methods comprising of the following steps: inputting a sample text in natural language at a workstation connected to the network; performing a semantic analysis of the sample text to extract a set of initial concepts belonging to the given semantic graph; accessing the equipment to identify a list of candidate concepts in the given semantic graph, the candidate concepts being the concepts of the semantic graph within a given maximum distance according to a given distance function away from an initial concept; calculating for each candidate concept a proximity score representative of the distances between the candidate concept and each initial concept; identifying as matching concepts the candidate concepts with the highest proximity score.

Abstract: A method for generating an indicator or biomarker of colour perception in a mammalian subject, where the method may include submitting the mammalian subject to a multicoloured dynamic stimulus comprising displaying, on a display device. The method may include controlling a change over time of at least one of the two colours of the multicolour pattern when displaying the dynamic multicolour stimulus, to vary the displayed luminance of this colour (usually several times). The method may include acquiring, by using an image acquisition device, an oscillatory response of a pupil of the mammalian subject. The method may include generating, from the acquired response, a signal representative of the power of the pupil's oscillatory response as a function of the change over time of at least one of the two colours when displaying the dynamic multicoloured stimulus.

Abstract: The invention relates to compounds of formula (I), particularly for the use thereof as a medicament, especially in the treatment or prevention of neurogenerative disorders. The invention also relates to the methods for producing said compounds, and to the pharmaceutical compositions containing same.