Abstract: This disclosure provides compounds, pharmaceutical compositions, and methods of use for the prevention and treatment of inflammatory diseases or degenerative diseases including neurodegenerative diseases. Embodiments of the present disclosure provide compounds related to very long chain polyunsaturated fatty acids, pharmaceutical compositions containing the provided compounds, and methods of treating a subject with a condition or disease using provided compounds or pharmaceutical compositions.

Abstract: A system for additively manufacturing a build part. The system includes a build platform configured for disposition within a resin tank, and a light source configured to cure a layer of resin. The layer of resin is disposed adjacent to a pre-cure build surface of the build part. The system also includes a constrained surface located between the build platform and the light source and configured to form a boundary for the layer of resin disposed between the constrained surface and the pre-cure build surface. The constrained surface is configured to vibrate to reduce a separation force required to separate the constrained surface from a post-cure build surface of the build part. The system also includes a vibratory source configured to vibrate the constrained surface.

Abstract: Thymidine analogues, 5-substituted 2?-deoxy-2?-[18F]fluoro-arabinofuranosyluracil derivatives, are promising positron emission tomography (PET) tracers being evaluated for noninvasively imaging cancer cell proliferation and/or reporter gene expression. We report the radiosynthesis of 2?-deoxy-2?-[18F]fluoro-5-methyl-1-?-d-arabinofuranosyluracil ([18F]FMAU) and other 2?-deoxy-2?-[18F]fluoro-5-substituted-1-?-d-arabinofuranosyluracil analogues using 1,4-dioxane to replace the currently used 1,2-dichloroethane. Compared to 1,2-dichloroethane, 1,4-dioxane is analyzed as a better solvent in terms of radiosynthetic yield and toxicity concern. The use of a less toxic solvent allows for the translation of the improved approach to clinical production. The new radiolabeling method can be applied to an extensive range of uses for 18F-labeling of other nucleoside analogues.

Abstract: This application provides, inter alia, antibodies or antigen-binding fragments thereof, targeting cell surface GRP78 expressed on tumor cells, tumor endothelial cells, and tumor initiating cancer cells. These anti-GRP78 antibodies, or antigen-binding fragments thereof, have a high affinity for GRP78 and are less immunogenic compared to their unmodified parent antibodies in a given species, e.g., a human, and function to inhibit GRP78. Importantly, these isolated novel antibodies and antigen-binding fragments thereof, attenuate PI3K signaling and promote apoptosis in tumor cells, while leaving normal cells unaffected. The antibodies and antigen-binding fragments are useful for UPR-targeted cancer therapeutic treatments.

Abstract: Methods and systems of monitoring and controlling thermal therapy treatments. One method includes determining, with an electronic processor, a propagation constant for a plurality of waveports. The method also includes modeling an object within an imaging cavity using a sparse mesh model. The method also includes determining a simulated impedance of the object based on the model of the object. The method also includes calibrating the simulated impedance with a theoretical impedance numerically calculated for the object. The method also includes determining a distribution of an electric field and a distribution of a magnetic field for a mode in a conformal modeled waveport based on the calibrated impedance and the model of the object. The method also includes exciting the plurality of waveports to generate the determined distribution of the electric field and the distribution of the magnetic field.

Abstract: Described herein are bisphosphonate quinolone compounds, conjugates and pharmaceutical formulations thereof that can include a bisphosphonate and a quinolone, where the quinolone can be releasably coupled to the bisphosphonate. Also provided herein are methods of making and methods of using the bisphosphonate quinolone compounds, conjugates and pharmaceutical formulations thereof.

Abstract: A federated learning environment includes a central coordinator that is responsible to orchestrate execution of the federated learning environment, and a plurality of clients jointly that trains machine learning and deep learning models on client computing devices without sharing their local private datasets. The clients only share their locally trained model parameters with the central coordinator. Model parameters are encrypted before sharing with the controller. The central coordinator aggregates local models and computes a new global model in encrypted space. This process repeats for a number of synchronization periods or asynchronously until specific convergence criteria are met. A federated learning marketplace is established to incentivize data providers to join federations through a revenue-sharing model, and to facilitate the use of machine-learning models to organizations outside of the federation.

Abstract: A method assessing tissue morphology using machine learning includes a step of training a machine learnable device to predict the status of a diagnostic feature in stained tissue samples. The machine learnable device is trained with a characterized set of digital images of stained tissue samples. Each digital image of the characterized set has a known status for the diagnostic feature and an extracted feature map provides values for a extracted feature over an associated 2-dimensional grid of spatial locations. A step of inputting the set of extracted feature maps is inputted into the machine learnable device to form associations therein between the set of extracted feature maps to and the known status for the diagnostic feature to form a trained machine learnable device. The status for the diagnostic feature of a stained tissue sample of unknown status for the diagnostic feature is predicted from the trained machine learnable device.

Abstract: The disclosure provides for single amplification and double amplification methods for preparing nucleic acid samples for sequencing.

Abstract: A method for preferential system identification (PSID) for modeling neural dynamics of a brain includes extracting behaviorally relevant latent brain states via a projection of future behavior onto past neural activity. The method further includes identifying, based on the extracted latent brain states, model parameters for a linear state space dynamic model of neural activity. An extension of PSID includes accounting for an effect of external inputs to the brain by using oblique projections along the external inputs instead of orthogonal projections. PSID may be extended to apply to any primary signals and secondary signals in place of the neural activity and the behavior. In some embodiments, the extracting and the identifying may be performed using a numerical optimization of recurrent neural networks (RNN) instead of the projection.

Abstract: This disclosure provides a method of synthesis of 4?-thioribose NAD+ and analogues thereof, using an efficient chemoenzymatic approach. Also provided are methods of inhibiting the CD38 enzyme and compounds including 4?-thioribose NAD+ and compounds related thereto.

Abstract: To identify novel agents to treat carbapenem-resistant Acinetobacter baumannii. the Inventors used a nutrient-depleted medium with serum to mimic the in vivo environment. In RPMI with serum, the screen identified rifabutin (RBT) as being 133-fold more potent than rifampin (RIF) against A. baumannii, with MICs of 0.031 ?g/ml and 4 ?g/ml respectively. No difference in RBT vs. RIF activity was observed when MHII was used as the culture media. RBT possesses markedly superior in efficacy to RIF in murine models of lethal iv and pneumonia models of infection with a hyper-virulent, clinical lung and blood isolate of extreme-drug resistant (XDR) A. baumannii. In both models, RBT significantly improved survival and lowered bacterial burden compared to RIF. RBT is a promising, novel therapeutic option for A. baumannii infections.

Abstract: A method for measuring water exchange across the blood-brain barrier includes acquiring diffusion weighted (DW) arterial spin labeling (ASL) magnetic resonance imaging (MRI) signals. The method further includes determining optimal parameters to separate labeled water in capillary and brain tissue compartments. The method further includes estimating water exchange rate across the blood-brain barrier based on the DW ASL MRI signals and the optimal parameters, using a total generalized variation (TGV) regularized single-pass approximation (SPA) modeling algorithm.

Abstract: Disclosed herein are methods and compositions for the identification of viability enhancing cell features and substrate features as they relate to post-cryopreservation survival of substrate seeded cells. Embodiments of the present invention further involve identification of cell features to manufacture a supernatant that is useful for cell culturing and treatment of various diseases.

Abstract: An OLED device comprises a substrate, a first electrode positioned over the substrate, a second electrode positioned over the first electrode, at least one emissive layer positioned between the first and second electrodes in a first region of the OLED device, and a multilayer dielectric reflector stack, comprising a plurality of dielectric reflector layers positioned between the substrate and the first electrode, wherein the multilayer dielectric reflector stack is configured to form an optical cavity with the emissive layer having a Purcell Factor of at least 3.

Abstract: According to various embodiments, a cellular architecture for enhanced privacy regarding identity and location of a computing device is disclosed. The architecture includes a privacy gateway connected to the core packet forwarding gateway, where the privacy gateway is configured to authenticate the computing device while hiding the identity of the computing device by verifying authentication tokens that represent units of access. The architecture further includes an over-the-air (OTA) gateway configured to select an international mobile subscriber identity (IMSI) from a pool of valid IMSIs and deliver the selected IMSI to a subscriber identity module (SIM) card of the computing device, where the SIM card periodically shuffles the pool of valid IMSIs.

Abstract: Provided herein are methods to improve transport or uptake of an avermectin compound in a cell or tissue expressing an efflux transporter P-glycoprotein (Pgp) by co-administering an effective amount of the avermectin compound and a Ppg inhibitor to the cell or tissue. The method also provides improved efficiency transport or uptake of an avermectin compound in the cell or tissue. The methods can be used therapeutically to treat Alcohol Use Disorder.

Abstract: Conformable and wearable sensors with integrated on-chip gate for the detection of biomolecules, chemicals, and other substrates and applications thereof are provided. Biosensor chips can be built with In2O3 nanoribbon field-effect transistors. Biosensor chips can conform to features of a human body, enabling ability for individuals to wear a biosensor.

Abstract: Described herein are nanoparticle bound self-antigens as an immune and vaccine formulations to elicit self-regulations and reduce atherosclerosis. The use of apolipoprotein B100 (ApoB-100) peptide P210 was investigated in self-assembling peptide amphiphile micelles (P210-PAM) as a vaccine formulation to reduce atherosclerosis in ApoE?/? mice. Demonstrated herein, P210 provided T cell activation and memory response in peripheral blood mononuclear cells of human subjects with atherosclerotic cardiovascular disease, and dendritic cell uptake of P210-PAM and its co-staining with major histocompatibility complex class I (MHC-I) molecules supported its use as an immunogenic composition. In ApoE?/? mice, immunization with P210-PAM dampened P210-specific CD4+ T cell proliferative response and CD8+ T cell cytolytic response, modulated macrophage phenotype, and significantly reduced aortic atherosclerosis. P210-PAM immunization also reduced atherosclerosis in chimeric mice with human MHC-I allele.

Abstract: Novel channel estimation techniques that can be performed solely in the analog domain are provided. The techniques use continuous analog channel estimation (CACE), periodic analog channel estimation (PACE), and multiantenna frequency shift reference (MAFSR). These techniques provide sufficient channel knowledge to enable analog beamforming at the receiver while significantly reducing the estimation overhead. These schemes involve transmission of a reference tone of a known frequency, either continuously along with the data (CACE, MAFSR) or in a separate phase from data (PACE). Analysis of the methods show that sufficient receiver beamforming gain can be achieved in sparse channels by building the beamformer using just the amplitude and phase estimates of the reference tone from each receiver antenna.