Abstract: Described herein is a novel, mitochondrial encoded, open reading frame, that leads to the production of a new mitochondrial peptide. Residing within the ND-Two subunit, a specific small nucleotide polymorphism disrupts expression of this mitochondrial peptide, and is correlated with an increase in obesity and diabetes, particularly in certain ethnic populations. In vitro administration of the peptide increases insulin secretion, decreases fat accumulation and improves glucose uptake in muscle cell. Antibodies generated against the peptide can be used for detecting peptide deficiency, in addition to SNP detection, supporting diagnostic approaches. In vivo studies further revealed that administration of the peptide improves glucose tolerance, thereby providing a new therapeutic avenue for a novel diabetes therapy and decreases bodyweight, thus serving as a novel obesity therapy. Generation of synthetic analogs further enhance or abrogated activity relative to the natural peptide.

Abstract: Computer systems and computer implemented methods are presented for designing and making vaccines to pathogens, particular viral pathogens. Vaccine compositions for COVID-19 are also disclosed, as well as method of using the same.

Abstract: Devices, computer-readable media, and methods for making a cache admission decision regarding a video chunk are described. For instance, a processing system including at least one processor may obtain a request for a first chunk of a first video, determine that the first chunk is not stored in a cache, and apply, in response to the determining that the first chunk is not stored in the cache, a classifier to predict whether the first chunk will be re-requested within a time horizon, where the classifier is trained in accordance with a set of features associated with a plurality of chunks of a plurality of videos. When it is predicted via the classifier that the first chunk will be re-requested within the time horizon, the processing system may store the first chunk in the cache.

Abstract: A hybrid processing fabric for doing training and inference on neural networks comprises heterogeneous computational resources for performing both arithmetic and logic operations such that some layers of the neural network are implemented with arithmetic multiply-and-accumulate processing elements whereas other layers are implemented with fixed-function logic processing elements. Support circuitry including memory, data transformation modules, and I/O interfaces are also included in the fabric. A compiler is introduced to optimize and map high level descriptions of the neural network model to the said hybrid fabric.

Abstract: An organic flow battery having a positive electrode electrolyte containing organic compounds with extended conjugation and/or cyclic side chains is provided. The flow battery includes a positive electrode and a positive electrode electrolyte including first solvent and a first redox couple. The positive electrode electrolyte flows over and contacting the positive electrode. The first redox couple includes a first organic compound and a reduction product of the first organic compound. The flow battery also includes a negative electrode and a negative electrode electrolyte including a second solvent and a second redox couple. The negative electrode electrolyte flows g over and contacts the positive electrode. Typically, an ion exchange membrane is interposed between the positive electrode and the negative electrode Characteristically, the first organic compound resists crossover through the ion exchange membrane.

Abstract: Arrangements and techniques for providing organic emissive layers are provided, in which the emissive layer includes a first dopant having a dissociative energy level. A second dopant in the emissive layer provides a solid state sink energy level, to which doubly excited excitons and/or polarons may transition instead of to the dissociative energy level, thereby decreasing the undesirable effects of transitions to the dissociative energy level.

Abstract: Acenes, such as aza-acenes are attractive materials for organic semiconductors, specifically for n-type materials. There are disclosed new derivatives of acenes that are fabricated using novel synthesis. For example, the disclosed fabrication strategies have allowed for the first time new aza-tetracene and aza-pentacene derivatives. The HOMO and LUMO energy levels of these materials are tunable through appropriate substitution and as predicted, deepened. There are also disclosed organic photosensitive devices comprising at least one aza-acene such as aza-tetracene and aza-pentacene.

Abstract: A hippocampal prosthesis for bypassing a damaged portion of a subject's hippocampus and restoring the subject's ability to form long-term memories. The hippocampal prosthesis includes a first set of hippocampal electrodes configured to receive an input signal from at least one of the subject's hippocampus or surrounding cortical region. The hippocampal prosthesis includes a processing device having a memory and one or more processors operatively coupled to the memory and to the first set of hippocampal electrodes. The processing device being configured to generate an output signal based on the input signal received from the first set of hippocampal electrodes. The hippocampal prosthesis includes a second set of hippocampal electrodes operatively coupled to the one or more processors and configured to receive and transmit the output signal to the subject's hippocampus.

Abstract: A lacrimal tear flow measurement device, and methods of manufacture and use, are described that includes a polymer microcapillary tube or similar structure having at least one end coated on the outside with soft silicone rubber and one end treated on the inside to be hydrophobic. The hydrophobic end keeps liquid from escaping or entering that end while allowing air to pass. The rest of the tube's insides may be hydrophilic or a neutral hydrophobe. As a Schirmer's test strip replacement, the entrance end of the device can be touched to the lacrimal lake of a patient's eye to collect suck up, or merely collect, tear fluid within the collection tube for weighing, volume measurement, or other analysis. Long-term collection devices for wear between doctors' visits can have a bypass channel allowing liquid to flow back onto the eye.

Abstract: The present invention provides an advancement in the art of cardiac pacemakers. The invention provides a novel and unobvious pacemaker system that comprises at least one pacemaker and that is, to a large extent, self-controlled, allows for long-term implantation in a patient, and minimizes current inconveniences and problems associated with battery life. The invention further includes a mechanism in which at least two pacemakers are implanted in a patient, and in which the pacemakers communicate with each other at the time of a given pacing or respiratory event, without any required external input, and adjust pacing parameters to respond to the patient's need for blood flow. The invention further provides a novel design for a pacemaker in which the pacemaker electrode is connected to the pacemaker body by a lead that is configured to allow the pacemaker to lie parallel to the epicardial surface and to reduce stress on the pacemaker and heart tissue.

Abstract: Provided is a compound having Formula I where rings A and B are independently a five-membered or six-membered, carbocyclic or heterocyclic ring, each of which is optionally aromatic; together with nitrogen atoms bonded to ring A and ring B, ring W is a 5-membered N-heterocyclic carbene; and the remaining variables are as defined herein.

Abstract: Zebrafish are a powerful model for investigating cardiac repair due to their unique regenerative abilities, scalability, and compatibility with many genetic tools. However, characterizing the regeneration process in live adult zebrafish hearts has proved challenging because adult fish are opaque and explanted hearts in conventional culture conditions experience rapid declines in morphology and physiology. To overcome these limitations, we fabricated a fluidic device for culturing explanted adult zebrafish hearts with constant media perfusion that is also compatible with live imaging. Unlike hearts cultured in dishes for one week, the morphology and calcium activity of hearts cultured in the device for one week were largely similar to freshly explanted hearts.

Abstract: Methods and systems for building and maintaining model(s) of a physical process are disclosed. One method includes receiving training data associated with a plurality of different data sources, and performing a clustering process to form one or more clusters. For each of the one or more clusters, the method includes building a data model based on the training data associated with the data sources in the cluster, automatically performing a data cleansing process on operational data based on the data model, and automatically updating the data model based on updated training data that is received as operational data. For data sources excluded from the clusters, automatic building, data cleansing, and updating of models can also be applied.

Abstract: For methane activation, various sulfonation systems using SO3 or H2SO4 have been well studied, however, sulfur dioxide (SO2), a preliminary source of SO3 and H2SO4, has not been used successfully. Herein, we report a novel methane sulfonation method to produce methanesulfonic acid (MSA) utilizing sulfur dioxide by a free radical mechanism. In the presence of H2O2 as a radical initiator, the reaction of SO2 and O2 in trifluoroacetic acid (TFAOH) furnished trifluoroacetylsulfuric acid (TFAOSO3H), which served as the radical propagator to facilitate H-abstraction of methane at low temperatures. In typical reactions, sulfur dioxide was incorporated into MSA in 75% with high selectivity at 60° C.

Abstract: A method for traffic prediction of a road network includes receiving past traffic information corresponding to multiple locations on the road network. The method further includes determining, by a processor and based on the past traffic information, temporal characteristics of the past traffic information corresponding to changes of characteristics over time and spatial characteristics of the past traffic information corresponding to interactions between locations on the road network. The method further includes predicting predicted traffic information corresponding to a later time based on the determined temporal and spatial characteristics of the past traffic information. The method further includes receiving detected additional traffic information corresponding to the later time.

Abstract: This disclosure presents distributed and decentralized synchronization for wireless transceivers. The disclosed system, device, and method achieve sub-nanosecond synchronization using low-cost commercial off the shelf software defined radios. By providing a decentralized mechanism that does not rely on a hierarchical master-slave structure, networks constructed as disclosed are robust to sensor drop-out in contested or harsh environments. Such networks may be used to create phased array radars and communication systems without requiring wired connections to distribute a common clock or local oscillator reference.

Abstract: Methods, systems, devices and apparatuses for generating a high-quality MRI image from under-sampled or corrupted data The image reconstruction system includes a memory. The memory is configured to store multiple samples of biological, physiological, neurological or anatomical data that has missing or corrupted k-space data and a deep learning model or neural network. The image reconstruction system includes a processor coupled to the memory. The processor is configured to obtain the multiple samples. The processor is configured to determine the missing or corrupted k-space data using the multiple samples and the deep learning model or neural network. The processor is configured to reconstruct an MRI image using the determined missing or corrupted k-space data and the multiple samples.

Abstract: A sliding window is used in a projection-based stereolithographic process to more quickly deliver uncured resin after each curing pass. The sliding window may be configured in different patterns, and includes features for delivering resin and exposing resin to curing radiation. The window screen divides the stereolithographic building area divided into two portions, a light exposure portion for resin curing and a liquid resin refilling portion. The light exposure portion is used to selectively solidify liquid resin, while the liquid resin refilling portion is used to quickly refill liquid resin in order to build additional layers. During the layer fabrication process, a mask image is projected to the tank; however, the projection light only passes through the light exposure portion of the window screen.

Abstract: To identify novel agents to treat carbapenem-resistant Acinetobacter baumannii. the Inventors used a nutrient-depleted medium with serum to mimic the in vivo environment. In RPMI with serum, the screen identified rifabutin (RBT) as being 133-fold more potent than rifampin (RIF) against A. baumannii, with MICs of 0.031 ?g/ml and 4 ?g/ml respectively. No difference in RBT vs. RIF activity was observed when MHII was used as the culture media. RBT possesses markedly superior in efficacy to RIF in murine models of lethal iv and pneumonia models of infection with a hyper-virulent, clinical lung and blood isolate of extreme-drug resistant (XDR) A. baumannii. In both models, RBT significantly improved survival and lowered bacterial burden compared to RIF. RBT is a promising, novel therapeutic option for A. baumannii infections.

Abstract: The present invention provides a method for encoding a video signal based on an Edge Adaptive Graph-Based Transform (EA-GBT) including detecting a step edge or a ramp edge from a residual signal; generating a graph signal based on at least one of the step edge or the ramp edge; obtaining an EA-GBT coefficient by performing the EA-GBT for the graph signal; quantizing the EA-GBT coefficient; and entropy-encoding the quantized EA-GBT coefficient.