Abstract: The present invention is directed to certain 2'-fluoro, 2-substituted purine nucleosides which are toxic to cancerous cell lines.

Abstract: The present invention relates to an enzyme reagent ticket for conducting diagnostic or serological tests. More particularly, the present invention relates to an enzyme reagent device which allows for a low-cost, disposable, rapid and convenient system for use in the determination of various components in test fluids, and to a diagnostic kit including the device according to the present invention for conducting certain immunochemical, diagnostic or serological testing.

Abstract: A confocal optical microscopy system for storing and retrieving optical information recorded in multiple layers in an optical disk. The invention includes a system utilizing the principle of confocal optical microscopy for accurately focusing a light beam onto a plane of a layer within a multi-layer disk. Optical information is thereby retrieved from the layer within the multi-layer disk. The invention also includes a method for recording optical data onto the multi-layer disk which comprises stacked multiple layers of transparent material having a distribution of discrete areas of metal film deposited between the layers. The distribution of metal film represents the recorded optical information.

Abstract: An apparatus and method for performing ultrasonic spectroscopy provides for rapid evaluation of test materials with good amplitude, balanced response at all test frequencies. A swept frequency signal is generated which is applied to a transmit transducer coupled to a test part. A receive transducer provides a detected signal that is fully digitized for real-time or post signal processing. The created swept frequency signal can be equalized from data obtained from direct coupling between transmit and receive transducers. The resultant data is analyzed for amplitude and/or phase information as a function of frequency and can be used to analyze filter characteristics, identify resonances, characterize material signatures and many other applications.

Abstract: 2'-Deoxy-4'-thio-ribonucleosides, intermediates in their production, and their use as antiviral and anticancer agents are disclosed.

Abstract: The present invention provides for the preparation and use of ribo- and deoxyribo-nucleosides and polynucleotide analogs. The polynucleotide analogs are made of polynucleosides which contain sulfonate and sulfonamide linkages.

Abstract: An antiphlogistic, analgesic, antipyretic parenteral preparation is disclosed comprising diclofenac, its salt, or both, a surfactant, cosurfactant, water, having a pH of 3-10, and optionally comprising an oily component, that can exhibit sustained therapeutic levels of diclofenac in plasma.

Abstract: 2',3'-dideoxy-4'-thioribonucleosides useful as antiviral agents in the treatment and prevention of AIDS are disclosed. In accordance with one aspect of the invention there are provided compounds of the formula ##STR1## where X.dbd.H, N.sub.3 or F, and B is a member selected from the group consisting of pyrimidine, 5-azapyrimidine, 6-azapyrimidine, 3-deazapyrimidine, purine, 3-deazapurine, 7-deazapurine, 8-azapurine, and 2-azapurine bases. The intermediate 1-O-acetyl-5-O-t-butyldiphenylsilyl-4-thio-2,3-dideoxyribofuranose is useful in the production of certain of the 2',3'-dideoxy-4'-thioribonucleosides. Other intermediates include the 4-thio-2,3-dideoxyribofuranose having different hydroxyl protecting groups and leaving groups.

Abstract: A method of microencapsulating an agent to form a microencapsulated product, having the steps of dispersing an effective amount of the agent in a solvent containing a dissolved wall forming material to form a dispersion, combining the dispersion with an effective amount of a continuous process medium to form an emulsion that contains the process medium and microdroplets having the agent, the solvent and the wall forming material and adding rapidly the emulsion to an effective amount of an extraction medium to extract the solvent from the microdroplets to form the microencapsulated product.

Abstract: A method and apparatus for measuring the tensile strength of aggregate material comprising a device in which a layer of dust is applied to a metal electrode, and an electric field is applied in such a way as to induce a charge (negative or positive) on the outer surface of the dust layer. The electric field is then increased until particles break away from the upper surface as a result of the electrostatic force acting on the induced charge. From the balance of forces between the electrostatic (which is easily calculated from the configuration and applied voltage) and the cohesive attraction between the particles, the tensile force of the dust layer is determined. The breakaway point may be observed directly, or it may be detected by a photoelectric device designed to respond to light scattered by the particles as they are lofted from the surface. Alternatively, the breakaway point may be detected by sensing an electric current concomitant with the ejection of surface charge residing in the lofted particles.

Abstract: The present invention is directed to certain 2'-fluoro, 2-substituted purine nucleosides which are toxic to cancerous cell lines.

Abstract: A method has been discovered for the control of arthropod pests which comprises treating the pest with an effective amount of selected fluorocarbons.

Abstract: The present invention relates to polymeric microspheres as injectable, drug-delivery systems for use to deliver bioactive agents to sites within the central nervous system, and for the stimulation of nerve fiber growth by implanting such microspheres within the central nervous system of a patient.

Abstract: Apparatus and process to achieve improved performance with a dry scrubbing flue gas desulfurization (FGD) system. The process consists of injecting sorbent slurry into flue gas from fossil fuel combustion, cooling the flue gas containing the injected slurry and collecting the slurry solids, reaction products, and fly ash in a filter. The apparatus comprises means for cooling the flue gas between the slurry injecting means and the filter.

Abstract: Polyester and cellulosic contaminants are removed from the surfaces of polyolefins by contacting the polyolefins with an aqueous composition of alkali metal hydroxide and/or alkaline earth metal hydroxide; and with an oxidizing agent.

Abstract: Copolymers from a hydroxy acid and a polycarboxylic component, method of preparation thereof, and use thereof are provided.

Abstract: 2'3'-dideoxy-4'-thioribonucleosides useful as antiviral agents in the treatment and prevention of AIDS are disclosed. In accordance with one aspect of the invention there are provided compounds of the formula ##STR1## where X=H, N.sub.3 or F, and B is a member selected from the group consisting of pyrimidine, 5-azapyrimidine, 6-azapyrimidine, 3-deazapyrimidine, purine, 3-deazapurine, 7-deazapurine, 8-azapurine, and 2-azapurine bases.The intermediate 1-O-acetyl-5-O-t-butyldiphenylsilyl-4-thio-2,3-dideoxyribofuranose useful in the production of certain of the 2',3'-dideoxy-4'-thioribonucleosides is also disclosed.

Abstract: There are disclosed 3-substituted and 3,3-disubstituted all-trans-4-oxoretinoic acids and 3-substituted and 3,3-disubstituted 13-cis-4-oxoretinoic acids and their lower alkyl esters.

Abstract: Substituted 1-(benzyloxy)adenosines and the use of substituted 1-(benzyloxy)adenosines and adenosine-N.sup.1 -oxides in the prevention and treatment of vaccinia virus infections are disclosed.

Abstract: 1,2-dihydropyrido[3,4-b]pyrazines are provided which possess antimitotic activity. The compounds have the structure: ##STR1## wherein R is a lower alkyl group and OR.sub.1 is a member selected from the group consisting of aryl-alkyl ethers having from seven to about 20 carbon atoms, alkyl carbamates having from one to about 12 carbon atoms, the alkyl portion of which may be substituted with a halogen atom, e.g., chlorine, fluorine, bromine or iodine; aryl-alkyl carbamates having from about seven to about 20 carbon atoms, aryl carbamates having from about six to about 20 carbon atoms, aryl-alkyl esters having from about 7 to about 20 carbon atoms, aryl esters having from about six to about 20 carbon atoms, alkylthiocarbamates having from about one to about 12 carbon atoms, aryl-alkylthiocarbamates having from about seven to about 20 carbon atoms, and arylthiocarbamates having from about six to about 20 carbon atoms.