Patents Assigned to Southern Research Institute
  • Preparation of thioarabinofuranosyl compounds and use thereof
    Publication number: 20060287320
    Abstract: Patients suffering from cancer are treated by being administered a compound represented by the following formula: wherein each R individually is H or an aliphatic or aromatic acyl group; A is selected from the group consisting of wherein X is selected from the group consisting of hydrogen, fluorine, alkoxy, alkyl, haloalkyl, alkenyl, haloalkenyl, alkynyl, amino, monoalkylamino, dialkylamino, cyano and nitro. The above compounds also inhibit DNA replication in mammalian cells.
    Type: Application
    Filed: August 24, 2006
    Publication date: December 21, 2006
    Applicant: Southern Research Institute
    Inventors: John Secrist, Kamal Tiwari, John Montgomery, William Hinds
  • 4?-thio-L-xylo furanosyl nucleosides, precursors thereof, preparation and use thereof
    Patent number: 7148223
    Abstract: Compounds represented by the formula 1: A is selected from the group consisting of wherein each R individually is H or acyl, Y is X, N3, NH2, monoalkylamino, or dialkylamino; Z is O or S; and X is selected from the group consisting of hydrogen, halo, hydroxy, alkoxy, alkyl, haloalkyl, alkenyl, haloalkenyl, alkynyl, amino, monoalkylamino, dialkylamino, thioaryl, thioalkyl, allylamino, cyano and nitro; tautomers thereof; and pharmaceutically acceptable salts thereof are provided along with methods for their fabrication. Various of these compounds can be used as anticancer agents, or antiviral agents or to inhibit DNA replication.
    Type: Grant
    Filed: January 31, 2005
    Date of Patent: December 12, 2006
    Assignee: Southern Research Institute
    Inventors: John A. Secrist, III, Kamal N. Tiwari, John A. Montgomery
  • Pyridomorphinans, thienomorphinans and use thereof
    Publication number: 20060264452
    Abstract: Compounds represented by the formulae: wherein each of Y, X and R individually is selected from the group consisting of hydrogen, hydroxy, halo, CF3, NO2, CN, NH2, COR1 and CO2R2 wherein R1 is selected from the group consisting of alkyl, aryl, alkaryl, and NH2, and R2 is selected from the group consisting of alkyl, aryl and aralkyl, and provided that at least one of Y, X and R is other than H; and pharmaceutically acceptable salts thereof are provided. Compounds of the above formula are useful as analgesics for treating pain, as immunomodulators and for treating drug abuse.
    Type: Application
    Filed: July 25, 2006
    Publication date: November 23, 2006
    Applicant: Southern Research Institute
    Inventor: Subramaniam Ananthan
  • Thioarabinofuranosyl compounds and use thereof
    Patent number: 7138385
    Abstract: Patients suffering from cancer are treated by being administered a compound represented by the following formula: wherein each R individually is H or an aliphatic or aromatic acyl group; A is selected from the group consisting of wherein X is selected from the group consisting of hydrogen, fluorine, alkoxy, alkyl, haloalkyl, alkenyl, haloalkenyl, alkynyl, amino, monoalkylamino, dialkylamino, cyano and nitro. The above compounds also inhibit DNA replication in mammalian cells.
    Type: Grant
    Filed: September 13, 2004
    Date of Patent: November 21, 2006
    Assignee: Southern Research Institute
    Inventors: John A. Secrist, III, Kamal N. Tiwari, John A. Montgomery
  • Derivatives of 4-demethylpenclomedine, use thereof and preparation thereof
    Patent number: 7122563
    Abstract: Thiocarbonate and thiocarbamate derivatives of 4-demethylpenclomedine are provided along with pharmaceutical compositions containing them and use for treating cancer. A method for preparing the derivatives is also provided.
    Type: Grant
    Filed: February 1, 2005
    Date of Patent: October 17, 2006
    Assignee: Southern Research Institute
    Inventor: Robert F. Struck
  • Pyridomorphinans, thienomorphinans and use thereof
    Patent number: 7105675
    Abstract: Compounds represented by the formulae: wherein each of Y, X and R individually is selected from the group consisting of hydrogen, hydroxy, halo, CF3, NO2, CN, NH2, COR1 and CO2R2 wherein R1 is selected from the group consisting of alkyl, aryl, alkaryl, and NH2, and R2 is selected from the group consisting of alkyl, aryl and aralkyl, and provided that at least one of Y, X and R is other than H; and pharmaceutically acceptable salts thereof are provided. Compounds of the above formula are useful as analgesics for treating pain, as immunomodulators and for treating drug abuse.
    Type: Grant
    Filed: October 27, 2005
    Date of Patent: September 12, 2006
    Assignee: Southern Research Institute
    Inventor: Subramaniam Ananthan
  • DERIVATIVES OF 4-DEMETHYLPENCLOMEDINE, USE THEREOF AND PREPARATION THEREOF
    Publication number: 20060173051
    Abstract: Thiocarbonate and thiocarbamate derivatives of 4-demethylpenclomedine are provided along with pharmaceutical compositions containing them and use for treating cancer. A method for preparing the derivatives is also provided.
    Type: Application
    Filed: February 1, 2005
    Publication date: August 3, 2006
    Applicant: Southern Research Institute
    Inventor: Robert Struck
  • Mutant purine nucleoside phosphorylase proteins and cellular delivery thereof
    Patent number: 7037718
    Abstract: The present invention provides a procaryotic host cell stably transformed or transfected by a vector including a DNA sequence encoding for mutant purine nucleoside phosphorylase or hydrolase. The transformed or transfected procaryotic host cell can be used in combination with a purine substrate to treat tumor cells and/or virally infected cells. The present invention provides nucleotide sequences encoding mutant E. coli derived purine nucleoside phosphorylase proteins which can be used in conjunction with an appropriate substrate to produce toxins which impair abnormal cell growth. The invention provides for delivery of the toxin by generation within target cells or by administration and delivery to the cells from without.
    Type: Grant
    Filed: October 26, 2001
    Date of Patent: May 2, 2006
    Assignees: Cornell Research Foundation, Inc., Southern Research Institute, The UAB Research Foundation
    Inventors: Steven E. Ealick, William B. Parker, John A. Secrist, III, Eric J. Sorscher
  • Pyridomorphinans, thienomorphinans and use thereof
    Patent number: 7015326
    Abstract: Compounds represented by the formulae: wherein each of Y, X and R individually is selected from the group consisting of hydrogen hydroxy, halo, CF3, NO2, CN, NH2, COR1 and CO2R2 wherein R1 is selected from the group consisting of alkyl, aryl, alkaryl, and NH2, and R2 is selected from the group consisting of alkyl aryl, and aralkyl, and provided that at least one of Y, X and R in formula I is other than hydrogen; and pharmaceutically acceptable salts thereof are provided along with uses as immunodulaters and/or treating for drug abuse and/or as analegesics for treating pain.
    Type: Grant
    Filed: August 14, 2000
    Date of Patent: March 21, 2006
    Assignee: Southern Research Institute
    Inventor: Subramaniam Ananthan
  • Pyridomorphinans, thienomorphinans and use thereof
    Publication number: 20060047119
    Abstract: Compounds represented by the formulae: wherein each of Y, X and R individually is selected from the group consisting of hydrogen, hydroxy, halo, CF3, NO2, CN, NH2, COR1 and CO2R2 wherein R1 is selected from the group consisting of alkyl, aryl, alkaryl, and NH2, and R2 is selected from the group consisting of alkyl, aryl and aralkyl, and provided that at least one of Y, X and R is other than H; and pharmaceutically acceptable salts thereof are provided. Compounds of the above formula are useful as analgesics for treating pain, as immunomodulators and for treating drug abuse.
    Type: Application
    Filed: October 27, 2005
    Publication date: March 2, 2006
    Applicant: Southern Research Institute
    Inventor: Subramaniam Ananthan
  • Methods for synthesizing 2-chloro-9-(2-deoxy-2-fluoro-B-D-arabinofuranosyl)-9H-purin-6-amine
    Publication number: 20050288500
    Abstract: 2-Chloro-9-(2-deoxy-2-fluoro-?-D-arabinofuranosyl)-9H-purin-6-amine is synthesized by reacting a 2-chloro-6-substituted purine with a protected and activated 2-deoxy-2-fluoro-D-arabinofiranose; and reacting with a base such as ammonia to provide 2-chloro-9-(2-deoxy-2-fluoro-?-D-arabinofuranosyl)-9H-purin-6-amine. When the purine reactant is substituted in the 6 position with a halogen, a reaction step with an alkoxide is carried out prior to the reaction with ammonia.
    Type: Application
    Filed: August 16, 2005
    Publication date: December 29, 2005
    Applicant: Southern Research Institute
    Inventors: John Montgomery, Anita Fowler, John Secrist
  • Recombinant bacterial cells for delivery of PNP to tumor cells
    Patent number: 6958318
    Abstract: The present invention provides a procaryotic host cell stably transformed or transfected by a vector including a DNA sequence encoding for purine nucleoside phosphorylase or hydrolase. The transformed or transfected procaryotic host cell can be used in combination with a purine substrate to treat tumor cells and/or virally infected cells.
    Type: Grant
    Filed: July 18, 2002
    Date of Patent: October 25, 2005
    Assignees: The UAB Research Foundation, Southern Research Institute
    Inventors: Eric J. Sorscher, William B. Parker, William Waud, Vijayakrishna K. Gadi, Leonard L. Bennett, Jr.
  • Method for synthesizing 2-chloro-9-(2-fluoro-?-D-arabinofuranosyl)-9H-purin-6-amine
    Patent number: 6949640
    Abstract: 2-Chloro-9-(2-deoxy-2-fluoro-?-D-arabinofuranosyl)-9H-purin-9-amine is synthesized by reacting a 2-chloro-6-substituted purine with a protected and activated 2-deoxy-2-fluoro-D-arabinofuranose; and reacting with a base such as ammonia to provide 2-chloro-9-(2-deoxy-2-fluoro-?-D-arabinofuranosyl)-9H-purin-6-amine. When the purine reactant is substituted in the 6 position with a halogen, a reaction step with an alkoxide is carried out prior to the reaction with ammonia.
    Type: Grant
    Filed: February 16, 2001
    Date of Patent: September 27, 2005
    Assignee: Southern Research Institute
    Inventors: John A. Montgomery, Anita T. Fowler, John A. Secrist, III
  • 4?-thio-L-xylofuranosyl nucleosides, precursors thereof, preparation and use thereof
    Patent number: 6914061
    Abstract: Compounds represented by the formula 1: A is selected from the group consisting of wherein each R individually is H or acyl, Y is X, N3, NH2, monoalkylamino, or dialkylamino; Z is O or S; and X is selected from the group consisting of hydrogen, halo, hydroxy, alkoxy, alkyl, haloalkyl, alkenyl, haloalkenyl, alkynyl, amino, monoalkylamino, dialkylamino, thioaryl, thioalkyl, allylamino, cyano and nitro; tautomers thereof; and pharmaceutically acceptable salts thereof are provided along with methods for their fabrication. Various of these compounds can be used as anticancer agents, or antiviral agents or to inhibit DNA replication.
    Type: Grant
    Filed: September 9, 2002
    Date of Patent: July 5, 2005
    Assignee: Southern Research Institute
    Inventors: John A. Secrist, III, Kamal N. Tiwari, John A. Montgomery
  • Automatic conformal window sizing in a video imaging system
    Patent number: 6911998
    Abstract: An apparatus and method for generating a conformal window in a video tracking system. Each of the lines within the conformal window comprises a sub-window which is resized for each frame of video signal. The composite window comprising all the sub-windows is also resized vertically for each frame. The target image sub-windows are divided into left and right edge regions and a central region and are processed based on the density of pixels in the sub-window for each new frame. The target image is apportioned vertically into top and bottom regions and a central region, and lines of target image detail are processed to delineate new top, bottom and central regions for each subsequent frame of video signal. The resized window gradually assumes an orientation which conforms to the target image orientation.
    Type: Grant
    Filed: May 7, 2002
    Date of Patent: June 28, 2005
    Assignee: Southern Research Institute
    Inventor: John M. Wiseman
  • 4'-Thio-L-xyloy furanosyl nucleosides, precursors thereof, preparation and use thereof
    Publication number: 20050130969
    Abstract: Compounds represented by the formula 1: A is selected from the group consisting of wherein each R individually is H or acyl, Y is X, N3, NH2, monoalkylamino, or dialkylamino; Z is O or S; and X is selected from the group consisting of hydrogen, halo, hydroxy, alkoxy, alkyl, haloalkyl, alkenyl, haloalkenyl, alkynyl, amino, monoalkylamino, dialkylamino, thioaryl, thioalkyl, allylamino, cyano and nitro; tautomers thereof; and pharmaceutically acceptable salts thereof are provided along with methods for their fabrication. Various of these compounds can be used as anticancer agents, or antiviral agents or to inhibit DNA replication.
    Type: Application
    Filed: January 31, 2005
    Publication date: June 16, 2005
    Applicant: Southern Research Institute
    Inventors: John Secrist, Kamal Tiwari, John Montgomery
  • Preparation of thioarabinofuranosyl compounds and use thereof
    Patent number: 6870052
    Abstract: Patients suffering from cancer are treated by being administered a compound represented by the following formula: wherein each R individually is H or an aliphatic or aromatic acyl group; A is selected from the group consisting of wherein X is selected from the group consisting of hydrogen, fluorine, alkoxy, alkyl, haloalkyl, alkenyl, haloalkenyl, alkynyl, amino, monoalkylamino, dialkylamino, cyano and nitro. The above compounds also inhibit DNA replication in mammalian cells.
    Type: Grant
    Filed: April 7, 2003
    Date of Patent: March 22, 2005
    Assignee: Southern Research Institute
    Inventors: John A. Secrist, III, Kamal N. Tiwari, John A. Montgomery
  • Thioarabinofuranosyl compounds and use thereof
    Publication number: 20050038025
    Abstract: Patients suffering from cancer are treated by being administered a compound represented by the following formula: wherein each R individually is H or an aliphatic or aromatic acyl group; A is selected from the group consisting of wherein X is selected from the group consisting of hydrogen, fluorine, alkoxy, alkyl, haloalkyl, alkenyl, haloalkenyl, alkynyl, amino, monoalkylamino, dialkylamino, cyano and nitro. The above compounds also inhibit DNA replication in mammalian cells.
    Type: Application
    Filed: September 13, 2004
    Publication date: February 17, 2005
    Applicant: SOUTHERN RESEARCH INSTITUTE
    Inventors: John Secrist, Kamal Tiwari, John Montgomery
  • Cascade impactor and jet plate for same
    Patent number: 6685759
    Abstract: A sampling system and method for sampling particulate matter from a high-temperature, high-pressure gas stream. A cyclone sampler for use at high temperatures and pressures, and having threadless sacrificial connectors is disclosed. Also disclosed is an improved cascade impactor including jet plates with integral spacers, and alignment features provided for aligning the jet plates with their associated collection substrates. An activated bauxite alkali collector is disclosed, and includes an alumina liner. The sampling system can be operated remotely or locally, and can be permanently installed or configured as a portable system.
    Type: Grant
    Filed: July 11, 2002
    Date of Patent: February 3, 2004
    Assignee: Southern Research Institute
    Inventors: Robert S. Dahlin, William E. Farthing, Edward C. Landham, Jr.
  • Full flow mechanical fail safe
    Patent number: 6655259
    Abstract: A full-flow mechanical failsafe is composed of a cylindrical shell having a movable sealing plug therein, for attachment to a reaction tube of a fluid treatment system, such as a gas clean up system in a power plant. The sealing plug rests on locking spheres within the shell during normal operation. Upon reaction tube failure or breakage, the flow of fluid will be substantially increased, causing an increase in upward pressure against the sealing plug, forcing it upward off the spheres and into a sealing contact with a flow aperture, shutting off fluid flow. The spheres move downward into a locking position upon movement of the sealing plug, to secure the sealing plug in its upward sealing position. The failsafe can be used in fluid flow control systems other than fluid filtering systems, such as oil or gas pipelines, and can be used to prevent improper reverse fluid flow.
    Type: Grant
    Filed: March 1, 2002
    Date of Patent: December 2, 2003
    Assignee: Southern Research Institute
    Inventor: Todd R. Snyder