Patents Assigned to Spectrum Dynamics LLC
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Patent number: 10964075Abstract: A method for reconstructing a radioactive emission image of an overall volume having first and second volumetric regions, each volumetric region having respectively independent dynamic characteristics. The method comprises the following steps: a) obtaining radioactive emissions from the overall volume, including the volumetric regions, b) reconstructing an initial radioactive emission image of the volumetric region according to the radioactive emissions, c) segmenting the initial radioactive emission image to delineate the first and second volumetric regions, and d) separately reconstructing the first and the second volumetric regions according to the respectively independent dynamic characteristics.Type: GrantFiled: October 16, 2016Date of Patent: March 30, 2021Assignee: Spectrum Dynamics LLCInventors: Omer Ziv, Ran Ravhon, Eli Dichterman, Leonid Gluhovsky, Shlomo Ben-Haim, Benny Rousso
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Publication number: 20170039738Abstract: A method for reconstructing a radioactive emission image of an overall volume having first and second volumetric regions, each volumetric region having respectively independent dynamic characteristics. The method comprises the following steps: a) obtaining radioactive emissions from the overall volume, including the volumetric regions, b) reconstructing an initial radioactive emission image of the volumetric region according to the radioactive emissions, c) segmenting the initial radioactive emission image to delineate the first and second volumetric regions, and d) separately reconstructing the first and the second volumetric regions according to the respectively independent dynamic characteristics.Type: ApplicationFiled: October 16, 2016Publication date: February 9, 2017Applicant: Spectrum Dynamics LLCInventors: Omer ZIV, Ran RAVHON, Eli DICHTERMAN, Leonid GLUHOVSKY, Shlomo BEN-HAIM, Benny ROUSSO
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Patent number: 9470801Abstract: A method for reconstructing a radioactive emission image of an overall volume having first and second volumetric regions, each volumetric region having respectively independent dynamic characteristics. The method comprises the following steps: a) obtaining radioactive emissions from the overall volume, including the volumetric regions, b) reconstructing an initial radioactive emission image of the volumetric region according to the radioactive emissions, c) segmenting the initial radioactive emission image to delineate the first and second volumetric regions, and d) separately reconstructing the first and the second volumetric regions according to the respectively independent dynamic characteristics.Type: GrantFiled: December 28, 2006Date of Patent: October 18, 2016Assignee: Spectrum Dynamics LLCInventors: Omer Ziv, Ran Ravhon, Eli Dichterman, Leonid Gluhovsky, Shlomo Ben-Haim, Benny Rousso
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Publication number: 20160253826Abstract: A method for reconstructing a radioactive emission image of an overall volume having first and second volumetric regions, each volumetric region having respectively independent dynamic characteristics. The method comprises the following steps: a) obtaining radioactive emissions from the overall volume, including the volumetric regions, b) reconstructing an initial radioactive emission image of the volumetric region according to the radioactive emissions, c) segmenting the initial radioactive emission image to delineate the first and second volumetric regions, and d) separately reconstructing the first and the second volumetric regions according to the respectively independent dynamic characteristics.Type: ApplicationFiled: December 28, 2006Publication date: September 1, 2016Applicant: Spectrum dynamics LLCInventors: Omer Ziv, Ran Ravhon, Eli Dichterman, Leonid Gluhovsky, Shiomo Ben-Haim, Benny Rousso
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Patent number: 8894974Abstract: A method for treating a human patient is provided, including administering a radiolabeled form of a therapeutic agent to the patient at a first substantially non-therapeutically-effective dose, wherein pharmacological activity of the therapeutic agent is not due to radioactivity of the therapeutic agent. The method also includes determining information related to a biodistribution of the radiolabeled form of the therapeutic agent in the patient by performing a radioimaging procedure on the patient. Responsively to the information, a decision is made whether or not to treat the patient by administering the therapeutic agent to the patient. If the decision is made to treat the patient, the patient is treated by administering the therapeutic agent to the patient at a second therapeutically-effective dose. If the decision is made not to treat the patient, treatment of the patient with the therapeutic agent is withheld. Other embodiments are also described.Type: GrantFiled: May 11, 2007Date of Patent: November 25, 2014Assignee: Spectrum Dynamics LLCInventors: Benny Rousso, Chalom Bruno Sayada
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Patent number: 8586932Abstract: A method of radioactive-emission-measurement. The method comprises providing a camera for the detection of single emissions, which defines proximal and distal ends. The camera is configured for enabling a reconstruction of a volumetric image having a line spread function of less than 7 mm Full Width Half Maximum (FWHM) when given a substantially line source of radioactive emission, with an activity of 5 mCi, within a region-of-interest volume, at a distance of at least 100 mm from said distal end, with air being substantially the only operating medium. The method further comprises detecting at least 1 of every 5000 photons, emitted from at least one radioactive-emission source, located within a certain region-of-interest volume, using the camera, and reconstructing a volumetric radioactive-emission image from the detected photons.Type: GrantFiled: May 9, 2007Date of Patent: November 19, 2013Assignee: Spectrum Dynamics LLCInventors: Benny Rousso, Shlomo Ben-Haim, Michael Nagler, Omer Ziv, Ran Ravhon, Dalia Dickman, Yoel Zilberstein, Eli Dichterman, Simona Ben-Haim, Shankar Vallabhajosula, Daniel Berman, Zohar Bronshtine, Ziv Popper, Nir Weissberg, Nathaniel Roth, Haim Melman
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Patent number: 8571881Abstract: Apparatus is provided for use with at least one labeled radiopharmaceutical agent, the apparatus including a container (22) containing the at least one labeled radiopharmaceutical agent, and a portable computer-communicatable data carrier (120, 24) associated with the container (22), the data carrier (120, 24) containing imaging protocol information for use with the at least one labeled radiopharmaceutical agent. Other embodiments are also described.Type: GrantFiled: May 17, 2007Date of Patent: October 29, 2013Assignee: Spectrum Dynamics, LLCInventors: Benny Rousso, Shlomo Ben-Haim, Haim Melman, Zohar Bronshtine, Yoel Zilberstien, Michael Nagler, Dalia Dickman, Einav Omer
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Patent number: 8527294Abstract: Apparatus is provided for use with at least one labeled radiopharmaceutical agent, the apparatus including a container (22) containing the at least one labeled radiopharmaceutical agent, and a portable computer-communicatable data carrier (120, 24) associated with the container (22), the data carrier (120, 24) containing imaging protocol information for use with the at least one labeled radiopharmaceutical agent. Other embodiments are also described.Type: GrantFiled: May 17, 2007Date of Patent: September 3, 2013Assignee: Spectrum Dynamics, LLCInventors: Benny Rousso, Shlomo Ben-Haim, Haim Melman, Zohar Bronshtine, Yoel Zilberstien, Michael Nagler, Dalia Dickman, Einav Omer
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Patent number: 8521253Abstract: A device for registering prostate images, the device comprises an elongate element suitable for insertion into a body passageway, the elongate element comprising at least one marker readable by an ultrasound probe and at least one marker readable by a gamma camera.Type: GrantFiled: October 29, 2007Date of Patent: August 27, 2013Assignee: Spectrum Dynamics LLCInventor: Haim Melman
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Patent number: 8489176Abstract: A system for calculating a position of a radioactivity emitting source in a system-of-coordinates, the system comprising (a) a radioactive emission detector; (b) a position tracking system being connected to and/or communicating with the radioactive emission detector; and (c) a data processor being designed and configured for receiving data inputs from the position tracking system and from the radioactive emission detector and for calculating the position of the radioactivity emitting source in the system-of-coordinates.Type: GrantFiled: August 21, 2000Date of Patent: July 16, 2013Assignee: Spectrum Dynamics LLCInventors: Gal Ben-David, Yoel Zilberstien, Yoav Kimchy
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Patent number: 8445851Abstract: Radioimaging methods, devices and radiopharmaceuticals therefor.Type: GrantFiled: October 31, 2007Date of Patent: May 21, 2013Assignee: Spectrum Dynamics LLCInventors: Benny Rousso, Shlomo Ben-Haim, Michael Nagler, Omer Ziv, Ran Ravhon, Dalia Dickman, Yoel Zilberstein, Eli Dichterman, Simona Ben-Haim, Shankar Vallabhajosula, Daniel Berman, Zohar Bronshtine, Ziv Popper, Nir Weissberg, Nathaniel Roth, Haim Melman
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Publication number: 20130114792Abstract: A system of performing a volumetric scan. The system comprises a surface of positioning a patient in a space parallel thereto, a plurality of extendable detector arms each the detector arm having a detection unit having at least one radiation detector, and an actuator which moves the detection unit along a linear path, and a gantry which supports the plurality of extendable detector arms around the surface so that each the linear path of each respective the extendable detector arm being directed toward the space.Type: ApplicationFiled: December 24, 2012Publication date: May 9, 2013Applicant: Spectrum Dynamics LLCInventor: Spectrum Dynamics LLC
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Patent number: 8423125Abstract: Radioimaging methods, devices and radiopharmaceuticals therefor.Type: GrantFiled: October 31, 2007Date of Patent: April 16, 2013Assignee: Spectrum Dynamics LLCInventors: Benny Rousso, Shlomo Ben-Haim, Michael Nagler, Omer Ziv, Ran Ravhon, Dalia Dickman, Yoel Zilberstein, Eli Dichterman, Simona Ben-Haim, Shankar Vallabhajosula, Daniel Berman, Zohar Bronshtine, Ziv Popper, Nir Weissberg, Nathaniel Roth, Haim Melman
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Patent number: 8338788Abstract: A system of performing a volumetric scan. The system comprises a surface of positioning a patient in a space parallel thereto, a plurality of extendable detector arms each the detector arm having a detection unit having at least one radiation detector, and an actuator which moves the detection unit along a linear path, and a gantry which supports the plurality of extendable detector arms around the surface so that each the linear path of each respective the extendable detector arm being directed toward the space.Type: GrantFiled: June 3, 2010Date of Patent: December 25, 2012Assignee: Spectrum Dynamics LLCInventors: Yoel Zilberstein, Nathaniel Roth, Benny Rousso, Shlomo Ben-Haim
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Patent number: 8280124Abstract: A method is described for identifying an optimal, or preferred set of views for radioactive-emission measurements of a body structure, based on modeling the body structure, in terms of its geometry and radioactive emission distribution, obtaining different sets of views of the model, and scoring the different sets of views, with a scoring function, using information theoretic measures, for example, for uniformity, reliability and separability in reconstruction. The preferred set of views may then be applied in imaging the in-vivo body structure, that has been modeled.Type: GrantFiled: June 1, 2005Date of Patent: October 2, 2012Assignee: Spectrum Dynamics LLCInventors: Eli Dichterman, Ran Ravhon, Michael Nagler
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Publication number: 20120172699Abstract: A method for predefining a set of radioactive-emission measurement views, for radioactive-emission imaging after an administration of a radiopharmaceutical, the method being tailored to a specific body structure and optimized with respect to the information gained about the body structure and based on modeling body-structure, based on its geometry and anatomical constraints, which limit accessibility to the body structure.Type: ApplicationFiled: January 8, 2012Publication date: July 5, 2012Applicant: Spectrum Dynamics LLCInventors: Michael NAGLER, Eli DICHTERMAN, Yoel ZILBERSTEIN, Ran RAVHON, Omer ZIV, Benny ROUSSO, Shlomo BEN-HAIM
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Publication number: 20120106820Abstract: A method for stabilizing the reconstruction of an imaged volume is presented. The method includes the steps of performing an analysis of the reliability of reconstruction of a radioactive-emission density distribution of the volume from radiation detected over a specified set of views, and defining modifications to the reconstruction process and/or data collection process to improve the reliability of reconstruction, in accordance with the analysis.Type: ApplicationFiled: January 9, 2012Publication date: May 3, 2012Applicant: Spectrum Dynamics LLCInventors: Benny ROUSSO, Eli Dichterman, Omer Ziv, Shlomo Ben-Haim
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Patent number: 8111886Abstract: A method for stabilizing the reconstruction of an imaged volume is presented. The method includes the steps of performing an analysis of the reliability of reconstruction of a radioactive-emission density distribution of the volume from radiation detected over a specified set of views, and defining modifications to the reconstruction process and/or data collection process to improve the reliability of reconstruction, in accordance with the analysis.Type: GrantFiled: July 19, 2006Date of Patent: February 7, 2012Assignee: Spectrum Dynamics LLCInventors: Benny Rousso, Eli Dichterman, Omer Ziv, Shlomo Ben-Haim
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Patent number: 8094894Abstract: Systems, methods, and probes are provided for functional imaging by radioactive-emission-measurements, specific to body structures, such as the prostate, the esophagus, the cervix, the uterus, the ovaries, the heart, the breast, the brain, and the whole body, and other body structures. The nuclear imaging may be performed alone, or together with structural imaging, for example, by x-rays, ultrasound, or MRI. Preferably, the radioactive-emission-measuring probes include detectors, which are adapted for individual motions with respect to the probe housings, to generate views from different orientations and to change their view orientations. These motions are optimized with respect to functional information gained about the body structure, by identifying preferred sets of views for measurements, based on models of the body structures and information theoretic measures.Type: GrantFiled: December 1, 2006Date of Patent: January 10, 2012Assignee: Spectrum Dynamics LLCInventors: Michael Nagler, Eli Dichterman, Yoel Zilberstein, Ran Ravhon, Omer Ziv, Benny Rousso, Shlomo Ben-Haim
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Patent number: 8055329Abstract: An ingestible device, adapted to travel in the gastrointestinal tract and perform a diagnostic image of tissue therein, is provided. The diagnostic image may comprise diagnostic information as a function of time, or diagnostic information as a function of distance traveled within the gastrointestinal tract. Specifically, the ingestible device may be arranged to perform a diagnostic image of nuclear radiation of a radiophamaceutical, scintillation of a scintillation liquid, responsive to nuclear radiation of a radiophamaceutical, optical fluorescence of a fluorescing-pharmaceutical or of bare gastrointestinal-tract tissue, infrared radiation of the gastrointestinal-tract tissue, temperature-differences along the gastrointestinal-tract, impedance, ultrasound reflection, magnetic resonance, and a combination thereof. The ingestible device may be adapted for general screening of a large population, on the one hand, and for specific diagnoses of suspected pathologies, on the other.Type: GrantFiled: January 22, 2002Date of Patent: November 8, 2011Assignee: Spectrum Dynamics LLCInventors: Yoav Kimchy, Roni Amrami, Yona Bouskila, Udi Antebi