Patents Assigned to Spectrum Dynamics LLC
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Patent number: 8036731Abstract: An ingestible device, adapted to travel in the gastrointestinal tract and perform a diagnostic image of tissue therein, is provided. The diagnostic image may comprise diagnostic information as a function of time, or diagnostic information as a function of distance traveled within the gastrointestinal tract. An imaging method by depth calculations is provided, based on the attenuation of photons of different energies, which are emitted from the same source, coupled with position monitoring.Type: GrantFiled: July 10, 2003Date of Patent: October 11, 2011Assignee: Spectrum Dynamics LLCInventors: Yoav Kimchy, Roni Amrami, Yona Bouskila, Udi Antebi, Nick Sidorenko, Gal Ben-David, Yoel Zilberstein
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Patent number: 8000773Abstract: A method of imaging, including receiving radioactive radiation from a body; reconstructing a 3D SPECT image of a distribution of radiation in at least one voxel of said body; and reconstructing a dynamic change in radiation in said voxel, as an updated image, at a rate of faster than one change per 5 minutes, wherein said reconstructed image is a clinically useful image including a resolution of 10 mm or better for a voxel volume of at least 5 cm in diameter and a contrast to background ratio of radiation of at least 2:1.Type: GrantFiled: October 31, 2007Date of Patent: August 16, 2011Assignee: Spectrum Dynamics LLCInventors: Benny Rousso, Shlomo Ben-Haim, Michael Nagler, Omer Ziv, Ran Ravhon, Dalia Dickman, Yoel Zilberstein, Eli Dichterman, Simona Ben-Haim, Shankar Vallabhajosula, Daniel Berman, Zohar Bronshtine, Ziv Popper, Nir Weissberg, Nathaniel Roth, Haim Melman
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Patent number: 7968851Abstract: A method of reconstruction of a radioactive emission image. The method comprises providing a first system of voxels for a region of interest, obtaining radioactive-emission data from the region of interest, performing a first reconstruction, based on the radioactive-emission data and the first system of voxels, to obtain a first image, correcting the first system of voxels, by aligning voxel boundaries with object boundaries, based on the first image; thus obtaining a second system of voxels, and performing a second reconstruction, based on the radioactive-emission data and the second system of voxels, thus obtaining a second image.Type: GrantFiled: March 22, 2010Date of Patent: June 28, 2011Assignee: Spectrum Dynamics LLCInventors: Benny Rousso, Omer Ziv, Michael Nagler, Shlomo Ben-Haim
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Patent number: 7970455Abstract: An ingestible pill platform for colon imaging is provided, designed to recognize its entry to the colon and expand in the colon, for improved imaging of the colon walls. On approaching the external anal sphincter muscle, the ingestible pill may contract or deform, for elimination. Colon recognition may be based on a structural image, based on the differences in diameters between the small intestine and the colon, and particularly, based on the semilunar fold structure, which is unique to the colon. Additionally or alternatively, colon recognition may be based on a functional image, based on the generally inflammatory state of the vermiform appendix. Additionally or alternatively, pH, flora, enzymes and (or) chemical analyses may be used to recognize the colon. The imaging of the colon walls may be functional, by nuclear-radiation imaging of radionuclide-labeled antibodies, or by optical-fluorescence-spectroscopy imaging of fluorescence-labeled antibodies.Type: GrantFiled: May 19, 2005Date of Patent: June 28, 2011Assignee: Spectrum Dynamics LLCInventors: Yoel Zilberstein, Michael Nagler, Benny Rousso, Izhar Halahmi
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Publication number: 20110112856Abstract: A method for managing a plurality of medical imaging procedures. The method comprises associating a machine readable tag with each of a plurality of patients designated for a plurality of medical imaging procedures, monitoring a progress of at least one of the plurality of patients in a respective the medical imaging procedure, and managing at least one medical imaging resource for performing the plurality of medical imaging procedures according to the progress.Type: ApplicationFiled: July 13, 2009Publication date: May 12, 2011Applicant: Spectrum Dynamics LLCInventors: Benny Rousso, Yoel Zilberstein, Haim Melman, Shlomo Ben-Haim
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Patent number: 7872235Abstract: An electronic storage medium that comprises at least one radiopharmaceutical identity, SPECT measured values of at least one radiopharmaceutical kinetic parameter of a flow rate across a tissue membrane, for the radiopharmaceutical, and a set of instructions for associating the at least one radiopharmaceutical kinetic parameter with a disease signature.Type: GrantFiled: January 15, 2006Date of Patent: January 18, 2011Assignee: Spectrum Dynamics LLCInventors: Benny Rousso, Dalia Dickman, Michael Nagler, Shankar Vallabhajosula
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Patent number: 7838838Abstract: An imaging system is provided for radioimaging a region of interest (ROI) of a subject. The system includes a housing, a support structure, which is movably coupled to the housing, and at least one motor assembly, coupled to the housing and the support structure, and configured to move the support structure with respect to the housing. The system also includes at least two detector assemblies, fixed to the support structure, and comprising respective radiation detectors and angular orientators. A control unit drives the motor assembly to position the support structure in a plurality of positions with respect to the housing, and, while the support structure is positioned in each of the plurality of positions, drives the orientators to orient the respective detectors in a plurality of rotational orientations with respect to the ROI, and to detect radiation from the ROI at the rotational orientations. Other embodiments are also described.Type: GrantFiled: September 17, 2009Date of Patent: November 23, 2010Assignee: Spectrum Dynamics LLCInventors: Benny Rousso, Shlomo Ben-Haim, Haim Melman, Michael Nagler, Yoel Zilberstien, Sajed Haj-Yahya
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Patent number: 7826889Abstract: a system for calculating a position of a radioactivity emitting source in a system-of-coordinates, the system comprising (a) a radioactive emission detector; (b) a position tracking system being connected to and/or communicating with the radioactive emission detector; and (c) a data processor being designed and configured for receiving data inputs from the position tracking system and from the radioactive emission detector and for calculating the position of the radioactivity emitting source in the system-of-coordinates.Type: GrantFiled: December 4, 2000Date of Patent: November 2, 2010Assignee: Spectrum Dynamics LLCInventors: Gal Ben David, Yoel Zilberstien, Yoav Kimchy, Roni Amrani
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Publication number: 20100245354Abstract: A dynamic SPECT camera is provided, comprising, a plurality of single-pixel detectors, a timing mechanism, in communication with each single-pixel detector, configured for enabling time-binning of the radioactive emissions impinging upon each single-pixel detector to time periods not greater than substantially 30 seconds, and a position-tracker, configured for providing information on the position and orientation of each detecting unit, with respect to the overall structure, substantially at all times, during the individual motion, the dynamic SPECT camera being configured for acquiring a tomographic reconstruction image of a region of interest of about 15×15×15 cubic centimeters, during an acquisition time of 30 seconds, at a spatial resolution of at least 10×10×10 cubic millimeter. The dynamic camera is configured for very short damping time, and may further acquire images in a stationary mode, with no motion.Type: ApplicationFiled: March 22, 2010Publication date: September 30, 2010Applicant: Spectrum Dynamics LLCInventors: Benny Rousso, Omer Ziv, Michael Nagler, Shlomo Ben-Haim
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Publication number: 20100142774Abstract: A method for analyzing a functional map of at least one tissue of a patient. The method comprises managing a plurality of functional maps each being associated with a plurality of first biological activity indications, receiving a functional map which is associated with a plurality of second biological activity indications, identifying a matching set of the managed functional maps by matching between the plurality of first and second biological activity indications, and using the matching set for a member of a group consisting of: an image data acquisition, a diagnosis of the received functional map, a classification of the received functional map.Type: ApplicationFiled: December 20, 2007Publication date: June 10, 2010Applicant: Spectrum Dynamics LLCInventors: Shlomo Ben-Haim, Benny Rousso
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Patent number: 7705316Abstract: A dynamic SPECT camera is provided, comprising, a plurality of single-pixel detectors, a timing mechanism, in communication with each single-pixel detector, configured for enabling time-binning of the radioactive emissions impinging upon each single-pixel detector to time periods not greater than substantially 30 seconds, and a position-tracker, configured for providing information on the position and orientation of each detecting unit, with respect to the overall structure, substantially at all times, during the individual motion, the dynamic SPECT camera being configured for acquiring a tomographic reconstruction image of a region of interest of about 15×15×15 cubic centimeters, during an acquisition time of 30 seconds, at a spatial resolution of at least 10×10×10 cubic millimeter. The dynamic camera is configured for very short damping time, and may further acquire images in a stationary mode, with no motion.Type: GrantFiled: November 9, 2006Date of Patent: April 27, 2010Assignee: Spectrum Dynamics LLCInventors: Benny Rousso, Omer Ziv, Michael Nagler, Shlomo Ben-Haim
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Publication number: 20100021378Abstract: Protocols for radioimaging an event or disorder are provided. An exemplary protocol comprises a method of radioimaging a myocardial perfusion, the method comprising in sequence: (a) administering to a subject about 3 mCi Tl201 thallous chloride; (b) allowing said subject to rest; (c) radioimaging a heart of said subject; (d) subjecting said subject to a physical stress; (e) administering to said subject at a peak of said physical stress about 20-30 mCi Tc99m sestamibi; and (f) radioimaging said heart of said subject, thereby radioimaging a myocardial perfusion.Type: ApplicationFiled: July 19, 2007Publication date: January 28, 2010Applicant: Spectrum Dynamics LLCInventors: Benny Rousso, Dalia Dickman, Shlomo Ben-Haim, Simona Ben Haim
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Patent number: 7652259Abstract: Imaging apparatus, is provided, comprising a first device, for obtaining a first image, by a first modality, selected from the group consisting of SPECT, PET, CT, an extracorporeal gamma scan, an extracorporeal beta scan, x-rays, an intracorporeal gamma scan, an intracorporeal beta scan, an intravascular gamma scan, an intravascular beta scan, and a combination thereof, and a second device, for obtaining a second, structural image, by a second modality, selected from the group consisting of a three-dimensional ultrasound, an MRI operative by an internal magnetic field, an extracorporeal ultrasound, an extracorporeal MRI operative by an external magnetic field, an intracorporeal ultrasound, an intracorporeal MRI operative by an external magnetic field, an intravascular ultrasound, and a combination thereof, and wherein the apparatus further includes a computerized system, configured to construct an attenuation map, for the first image, based on the second, structural image.Type: GrantFiled: November 4, 2003Date of Patent: January 26, 2010Assignee: Spectrum Dynamics LLCInventors: Yoav Kimchy, Roni Amrami, Yoel Zilberstein
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Publication number: 20090304582Abstract: Protocols for radioimaging an event or disorder are provided. An exemplary protocol comprises a method of radioimaging a myocardial perfusion, the method comprising in sequence: (a) administering to a subject about 3 mCi Tl201 thallous chloride; (b) allowing said subject to rest; (c) radioimaging a heart of said subject; (d) subjecting said subject to a physical stress; (e) administering to said subject at a peak of said physical stress about 20-30 mCi Tc99m sestamibi; and (f) radioimaging said heart of said subject, thereby radioimaging a myocardial perfusion.Type: ApplicationFiled: July 19, 2006Publication date: December 10, 2009Applicant: SPECTRUM DYNAMICS LLCInventors: Benny Rousso, Dalia Dickman, Yael Nir, Michael Nagler, Zohar Bronshtine, Shankar Vallabhajosula, Shlomo Ben-Haim, Simona Ben-Haim
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Patent number: 7601966Abstract: An imaging system is provided for radioimaging a region of interest (ROI) of a subject. The system includes a housing, a support structure, which is movably coupled to the housing, and at least one motor assembly, coupled to the housing and the support structure, and configured to move the support structure with respect to the housing. The system also includes at least two detector assemblies, fixed to the support structure, and comprising respective radiation detectors and angular orientators. A control unit drives the motor assembly to position the support structure in a plurality of positions with respect to the housing, and, while the support structure is positioned in each of the plurality of positions, drives the orientators to orient the respective detectors in a plurality of rotational orientations with respect to the ROI, and to detect radiation from the ROI at the rotational orientations. Other embodiments are also described.Type: GrantFiled: June 28, 2007Date of Patent: October 13, 2009Assignee: Spectrum Dynamics LLCInventors: Shlomo Ben-Haim, Haim Melman, Michael Nagler, Benny Rousso, Yoel Zilberstien, Sajed Haj-Yahya
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Publication number: 20090201291Abstract: A method for reconstructing a radioactive emission image of an overall volume having first and second volumetric regions, each volumetric region having respectively independent dynamic characteristics. The method comprises the following steps: a) obtaining radioactive emissions from the overall volume, including the volumetric regions, b) reconstructing an initial radioactive emission image of the volumetric region according to the radioactive emissions, c) segmenting the initial radioactive emission image to delineate the first and second volumetric regions, and d) separately reconstructing the first and the second volumetric regions according to the respectively independent dynamic characteristics.Type: ApplicationFiled: December 28, 2006Publication date: August 13, 2009Applicant: Spectrum dynamics LLCInventors: Omer Ziv, Ran Ravhon, Eli Dichterman, Leonid Gluhovsky, Shiomo Ben-Haim, Benny Rousso
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Publication number: 20090190807Abstract: A method for stabilizing the reconstruction of an imaged volume is presented. The method includes the steps of performing an analysis of the reliability of reconstruction of a radioactive-emission density distribution of the volume from radiation detected over a specified set of views, and defining modifications to the reconstruction process and/or data collection process to improve the reliability of reconstruction, in accordance with the analysis.Type: ApplicationFiled: July 19, 2006Publication date: July 30, 2009Applicant: SPECTRUM DYNAMICS LLCInventors: Benny Rousso, Eli Dichterman, Omer Ziv, Shlomo Ben-Haim
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Publication number: 20090152471Abstract: A dynamic SPECT camera is provided, comprising, a plurality of single-pixel detectors, a timing mechanism, in communication with each single-pixel detector, configured for enabling time-binning of the radioactive emissions impinging upon each single-pixel detector to time periods not greater than substantially 30 seconds, and a position-tracker, configured for providing information on the position and orientation of each detecting unit, with respect to the overall structure, substantially at all times, during the individual motion, the dynamic SPECT camera being configured for acquiring a tomographic reconstruction image of a region of interest of about 15×15×15 cubic centimeters, during an acquisition time of 30 seconds, at a spatial resolution of at least 10×10×10 cubic millimeter. The dynamic camera is configured for very short damping time, and may further acquire images in a stationary mode, with no motion.Type: ApplicationFiled: November 9, 2006Publication date: June 18, 2009Applicant: Spectrum Dynamics LLCInventors: Benny Rousso, Omer Ziv, Michael Nagler, Shlomo Ben-Haim
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Publication number: 20090112086Abstract: A device for registering prostate images, the device comprises an elongate element suitable for insertion into a body passageway, the elongate element comprising at least one marker readable by an ultrasound probe and at least one marker readable by a gamma camera.Type: ApplicationFiled: October 29, 2007Publication date: April 30, 2009Applicant: Spectrum Dynamics LLCInventor: Haim Melman
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Publication number: 20090078875Abstract: Radioimaging methods, devices and radiopharmaceuticals therefor.Type: ApplicationFiled: October 31, 2007Publication date: March 26, 2009Applicant: Spectrum Dynamics LLCInventors: Benny Rousso, Shiomo Ben-Haim, Michael Nagler, Omer Ziv, Ran Ravhon, Dalia Dickman, Yoel Zilberstein, Eli Dichterman, Simona Ben-Haim, Shankar Vallabhajosula, Daniel Berman, Zohar Bronshtine, Ziv Popper, Nir Weissberg, Nathaniel Roth, Haim Melman