Abstract: A system for determining orientation of a guide sheath introduced by a bronchoscope or similar device. An example system includes a display device, a scope device and a guide sheath. The guide sheath includes a window occupying a predefined circumferential sector of a distal end of the guide sheath and a plurality of markings configured to visually indicate location/orientation and/or distance of the window.

Abstract: Disclosed embodiments include apparatuses, systems, and methods for positioning electrodes within a body. In an illustrative embodiment, an apparatus for slidably moving multiple features relative to a sheath insertable into a body and positionable relative to a reference point includes a primary actuator configured to move a primary electrode to a first position. A secondary actuator is configured to move a secondary electrode to a second position. A shrouding device is configured to selectively prevent access to the secondary actuator until the primary actuator has been manipulated to extend the primary electrode to the first position.

Abstract: Disclosed embodiments include apparatuses, systems, and methods for positioning electrodes within a body. In an illustrative embodiment, an apparatus for slidably moving multiple features relative to a sheath inserted into a body and positioned relative to a reference point includes a primary actuator configured to move a primary electrode, a secondary actuator configured to move a secondary electrode, and a control mechanism. The control mechanism is configured to selectively prevent movement of at least one of the primary actuator based on a position of the secondary actuator and of the secondary actuator based on a position of the primary actuator and lock positions of the primary actuator and the secondary actuator.

Abstract: Disclosed embodiments include apparatuses, systems, and methods for positioning electrodes within a body. In an illustrative embodiment, an apparatus for slidably moving multiple features relative to a sheath inserted into a body and positioned relative to a reference point includes a primary actuator configured to move a primary electrode, a secondary actuator configured to move a secondary electrode, and a control mechanism. The control mechanism is configured to selectively prevent movement of at least one of the primary actuator based on a position of the secondary actuator and of the secondary actuator based on a position of the primary actuator and lock positions of the primary actuator and the secondary actuator.

Abstract: Disclosed embodiments include apparatuses, systems, and methods for positioning electrodes within a body. In an illustrative embodiment, an apparatus for slidably moving multiple features relative to a sheath inserted into a body and positioned relative to a reference point includes a primary actuator configured to move a primary electrode, a secondary actuator configured to move a secondary electrode, and a control mechanism. The control mechanism is configured to selectively prevent movement of at least one of the primary actuator based on a position of the secondary actuator and of the secondary actuator based on a position of the primary actuator and lock positions of the primary actuator and the secondary actuator.

Abstract: Disclosed embodiments include apparatuses, systems, and methods for positioning electrodes within a body. In an illustrative embodiment, an apparatus for slidably moving multiple features relative to a sheath inserted into a body and positioned relative to a reference point includes a primary actuator configured to move a primary electrode, a secondary actuator configured to move a secondary electrode, and a control mechanism. The control mechanism is configured to selectively prevent movement of at least one of the primary actuator based on a position of the secondary actuator and of the secondary actuator based on a position of the primary actuator and lock positions of the primary actuator and the secondary actuator.

Abstract: Disclosed embodiments include apparatuses, systems, and methods for positioning electrodes within a body. In an illustrative embodiment, an apparatus for slidably moving multiple features relative to a sheath inserted into a body and positioned relative to a reference point includes a primary actuator configured to move a primary electrode, a secondary actuator configured to move a secondary electrode, and a control mechanism. The control mechanism is configured to selectively prevent movement of at least one of the primary actuator based on a position of the secondary actuator and of the secondary actuator based on a position of the primary actuator and lock positions of the primary actuator and the secondary actuator.

Abstract: Embodiments disclosed herein are directed to devices, methods, and systems for the treatment of tissue using energy delivery. Specifically, certain embodiments may utilize a thermochemical reaction between at least two reagents where a first reagent has been preloaded into a catheter while a limiting reagent is circulated through the catheter to react with the first reagent. The resulting chemical reaction may be exothermic or endothermic, and a heat transfer fluid may be used to exchange energy between the chemical reaction and surrounding tissue.

Abstract: Embodiments of a simulated valve device can be used to determine whether a valve device would fit within a particular airway. The simulated valve device can include a shaft having at least one strut extending radially therefrom. The strut and at least part of the shaft can be surrounded by a membrane for viewing through a bronchoscope. In some embodiments, the membrane can include markings for viewing by a user.

Abstract: Devices and methods for measuring size of airways to lung are disclosed. A light-based endoluminal sizing device can comprise a centering tool, a light source, and a marker. A size of an airway can be approximated or determined based on a distance between the marker and the light source when light from the light source intersects the marker at an interface between the marker and the airway wall. In some cases, the size of the airway can be approximated from observing an intersection between a light pattern and the airway wall.

Abstract: An airway measurement/estimation device may comprise a sizing shaft at least partially disposable with a bronchoscope. The sizing shaft may comprise a plurality of bristles of known lengths such that when the sizing shaft is inserted into a patient's airway, and viewed through a bronchoscope, the size or diameter of the airway may be approximated based at least in part on the size of the bristles in relation to the size of the airway.

Abstract: Devices and methods for occluding airways in at least one direction are disclosed. In some cases, the devices include anchoring mechanisms configured to keep an operative portion of the device (e.g., a valve) in position along a length of a lumen in which the device is deployed. The anchoring mechanisms can include anchors configured to settle into the lumen walls with little or no axial movement of the operative portion of the device. In some embodiments, the anchoring mechanisms include a secondary set of anchors configured to engage with the lumen wall to reduce, inhibit, or prevent axial movement of the operative portion of the device when the primary anchors settle into the walls of the lumen.

Abstract: Embodiments of a sizing device that can be used to measure the size of airways lumens, such as those connected to lungs. The sizing device can have different expandable elements in order to accurately and consistently measure the particular dimensions of a lumen. In some embodiments, markings viewable by a user can be used to determine the particular size.

Abstract: Systems, methods, and devices for providing real-time imaging of tissue sampling. An ultrasound probe is received with a first lumen of a catheter and a tissue sampling device is received with a second lumen of the catheter. The catheter is received within a working channel of a bronchoscope. The ultrasound probe is a radial ultrasound probe that generates real-time ultrasound images of the tissue sampling device and surrounding tissue.

Abstract: Systems and devices for minimally invasively treating an air leak in a lung comprise the steps of detecting an air leak in a lung; locating an airway in fluid communication with the air leak, introducing a bronchoscope into a patient's airway to a position adjacent the target section and occluding an airway upstream of the air leak for a period of time. The airway occlusion device is preferably removed after the air leak has substantially permanently healed. The occluding device may be a one-way valve. The occluding device may also comprise strut members and anchors that penetrate an airway wall.

Abstract: An intra-bronchial device placed and anchored in an air passageway of a patient to collapse a lung portion associated with the air passageway. The device includes a support structure, an obstructing member carried by the support structure that reduces ventilation to the lung portion by preventing air from being inhaled into the lung portion, and at least one anchor carried by the support structure that anchors the obstruction device within the air passageway. The anchor may engage the air passageway wall by piercing or friction, include a stop dimensioned for limiting the piercing of the air passageway wall, and may be releasable from the air passageway for removal of the intra-bronchial device. The anchors may be carried by a peripheral portion of the support structure, or by a central portion of the support structure. The obstructing member may be a one-way valve.

Abstract: Embodiments disclosed herein relate to devices implantable into a human lung, for example to reduce the volume of air trapped in a diseased portion of the lung to prevent inhalation while permitting expiration out of the diseased portion. In some embodiments, the device comprises a distal portion with an anchor system that may anchor the device into tissue of an air passageway wall, and the distal portion may be connected to a proximal portion via a flexible portion that permits the distal portion to articulate substantially with respect to the proximal portion, such that the distal portion and the proximal portion may be non-collinear along a longitudinal axis of the distal portion. This may facilitate implantation of the device into a non-linear air passageway.

Abstract: An apparatus and method deploy a self-expandable bronchial obstruction device in an air passageway. The apparatus includes a catheter configured to be passed down the trachea. The apparatus further includes a capsule for housing the self-expandable bronchial obstruction device in a sterile environment. The capsule is configured to be advanced down the catheter. The capsule further includes a tubular extension. The capsule has a breakable seam so as to release the bronchial obstruction device in the air passageway upon a proximal force being exerted upon the bronchial obstruction device. The method includes guiding a conduit down a trachea into the air passageway. The method further includes advancing a capsule having a bronchial device therein down an internal lumen of the conduit into the air passageway. The method further includes releasing the bronchial device from the capsule. The method further includes deploying the bronchial device into the air passageway.

Abstract: An air passageway obstruction device includes a frame structure and a flexible membrane overlying the frame structure. The frame structure is collapsible upon advancement of the device into the air passageway, expandable into a rigid structure upon deploying in the air passageway and recollapsible upon removal from the air passageway. The flexible membrane obstructs inhaled air flow into a lung portion communicating with the air passageway. The device may be removed after deployment in an air passageway by recollapsing the device and pulling the device proximally through a catheter.

Abstract: A resection device and method permits safe and efficient encapsulation, isolation and resection of body tissue. The device includes a sheath of flexible and severable material configured to receive the body tissue to be resectioned as it is drawn therein. The sheath may be expandable and held in an expanded condition as the body tissue to be resectioned is drawn into the sheath. Thereafter, the sheath is permitted to collapse about the body tissue to contain and constrict the body tissue. Once the body tissue to be resectioned is disposed in the sheath, the sheath is severed to resection the body tissue.