Patents Assigned to St. Louis University
  • Patent number: 9457180
    Abstract: A clamp for clamping a brain electrode extending through a burr hole formed in a skull of a patient. The clamp includes a first retainer element having a flange extending around an outer end for engaging an outer table of the skull and a jaw extending across the inner end. The clamp includes a second retainer element shaped complementarily to the first retainer element. The second retainer element has a flange extending around an outer end for engaging the outer table of the skull and a jaw extending across the inner end for cooperating with the jaw of the first retainer to clamp the electrode. The clamp has a cap for maintaining the jaws of the first and second retainer elements in cooperation to clamp the electrode adjacent an inner table of the skull. The cap includes an opening for receiving the electrode to hold the electrode against movement.
    Type: Grant
    Filed: December 10, 2012
    Date of Patent: October 4, 2016
    Assignee: St. Louis University
    Inventor: Richard D. Bucholz
  • Patent number: 8872768
    Abstract: An input device for use in controlling medical equipment controlled by a mouse. The device includes an elastic finger cot having an interior sized and shaped for selectively receiving and retaining a user's finger. The device has a light emitting diode for emitting a beam of light to illuminate a selected surface and a light sensor for sensing a light reflected from the selected surface to detect movement of the sensor and finger cot relative to the surface and producing a signal corresponding to the detected movement. The device includes a transmitter for receiving the signal from the light sensor corresponding to the detected movement and generating an electromagnetic signal corresponding to the light sensor signal for receipt by the medical equipment. A power supply connected to the diode, the sensor, and the transmitter provides power. The medical equipment views the input device as the mouse controlling the medical equipment.
    Type: Grant
    Filed: April 16, 2012
    Date of Patent: October 28, 2014
    Assignee: St. Louis University
    Inventor: Richard D. Bucholz
  • Patent number: 8859151
    Abstract: Disclosed is an improved biofuel cell having a cathode comprising a dual function membrane, which contains an oxygen oxidoreductase enzyme immobilized within a buffered compartment of the membrane and an electron transport mediator which transfers electrons from an electron conducting electrode to the redox reaction catalyzed by the oxygen oxidoreductase enzyme. The improved biofuel cell also has an anode that contains an oxidoreductase enzyme that uses an organic fuel, such as alcohol, as a substrate. An electric current can flow between the anode and the cathode.
    Type: Grant
    Filed: August 31, 2004
    Date of Patent: October 14, 2014
    Assignee: St. Louis University
    Inventors: Shelley D. Minteer, Sabina Topcagic, Becky Treu
  • Patent number: 8721538
    Abstract: A surgical distractor for distracting tissue of a patient to access structure underlying the tissue of the patient. The distractor includes a tube having a distal end adapted for insertion in tissue, a proximal end opposite the distal end, an exterior surface adapted for contacting the tissue, and an interior surface opposite the exterior surface defining a hollow interior extending between the distal end and the proximal end for accessing structure underlying the tissue when the distal end is inserted in the tissue. The distractor is adjustable from a reduced configuration, in which the tube has a reduced width sized for inserting the distal end in the tissue, and an expanded configuration, in which the tube has an expanded width greater than the reduced width sized to provide the hollow interior with a size sufficient for accessing the structure underlying the tissue.
    Type: Grant
    Filed: January 26, 2011
    Date of Patent: May 13, 2014
    Assignee: St. Louis University
    Inventor: Richard D. Bucholz
  • Patent number: 8626953
    Abstract: A system used by a local health care facility to communicate with a remote health care facility via a data communication network. A controller at the local health care facility controls communication on the data communication network, including data communicated between the local health care facility and the remote health care facility. One or more devices located at the local health care facility transmit data to the remote health care facility via the data communication network. Additionally, the one or more devices receive control data via the data communication network and perform one or more functions in response to the received control data.
    Type: Grant
    Filed: March 2, 2007
    Date of Patent: January 7, 2014
    Assignee: St. Louis University
    Inventor: Richard D. Bucholz
  • Publication number: 20130245421
    Abstract: Devices having the capability to both locate and retrieve objects are disclosed. More particularly, the present disclosure relates to devices having a probe comprising an ultrasound detector for locating and a grasper for retrieving objects from a medium. The present disclosure further relates to devices having a probe comprising an electromagnetic detector for locating and a grasper for retrieving metallic objects from a medium. Devices of the present disclosure are specifically adapted for use as medical devices for locating and retrieving a foreign body in a subject in need.
    Type: Application
    Filed: September 6, 2012
    Publication date: September 19, 2013
    Applicant: ST. LOUIS UNIVERSITY
    Inventors: Charles Hiram Andrus, Patrick Christopher Andrus, Virginia E. Foster, Peddada Krishi
  • Patent number: 8415059
    Abstract: Bioanodes, biocathodes, and biofuel cells comprising an electron conductor, at least one anode enzyme or cathode enzyme, and an enzyme immobilization material. The anode enzyme is capable of reacting with a fuel fluid to produce an oxidized form of the fuel fluid, and capable of releasing electrons to the electron conductor. The cathode enzyme is capable of reacting with an oxidant to produce water, and capable of gaining electrons from the electron conductor. The enzyme immobilization material for both the anode enzyme and the cathode enzyme is capable of immobilizing and stabilizing the enzyme, and is permeable to the fuel fluid and/or the oxidant.
    Type: Grant
    Filed: November 2, 2006
    Date of Patent: April 9, 2013
    Assignee: St. Louis University
    Inventors: Shelley D. Minteer, Becky L. Treu, Rodica Duma
  • Publication number: 20120173155
    Abstract: The present invention generally relates to a computer-implemented method for predicting a response of a virus to antiviral therapy, and finds particular use in predicting a response of a Hepatitis C or Hepatitis B virus isolated from a patient.
    Type: Application
    Filed: December 30, 2011
    Publication date: July 5, 2012
    Applicant: ST. LOUIS UNIVERSITY
    Inventors: Rajeev Aurora, John Tavis
  • Publication number: 20110275902
    Abstract: A surgical distractor for distracting tissue of a patient to access structure underlying the tissue of the patient. The distractor includes a tube having a distal end adapted for insertion in tissue, a proximal end opposite the distal end, an exterior surface adapted for contacting the tissue, and an interior surface opposite the exterior surface defining a hollow interior extending between the distal end and the proximal end for accessing structure underlying the tissue when the distal end is inserted in the tissue. The distractor is adjustable from a reduced configuration, in which the tube has a reduced width sized for inserting the distal end in the tissue, and an expanded configuration, in which the tube has an expanded width greater than the reduced width sized to provide the hollow interior with a size sufficient for accessing the structure underlying the tissue.
    Type: Application
    Filed: January 26, 2011
    Publication date: November 10, 2011
    Applicant: ST. LOUIS UNIVERSITY
    Inventor: Richard D. Bucholz
  • Publication number: 20110014549
    Abstract: Bioanodes, biocathodes, and biofuel cells comprising an electron conductor, at least one anode enzyme or cathode enzyme, and an enzyme immobilization material. The anode enzyme is capable of reacting with a fuel fluid to produce an oxidized form of the fuel fluid, and capable of releasing electrons to the electron conductor. The cathode enzyme is capable of reacting with an oxidant to produce water, and capable of gaining electrons from the electron conductor. The enzyme immobilization material for both the anode enzyme and the cathode enzyme is capable of immobilizing and stabilizing the enzyme, and is permeable to the fuel fluid and/or the oxidant.
    Type: Application
    Filed: November 2, 2006
    Publication date: January 20, 2011
    Applicant: ST. LOUIS UNIVERSITY
    Inventors: Shelley D. Minteer, Becky L. Treu, Rodica Duma
  • Publication number: 20100196393
    Abstract: There are disclosed agents that inhibit Blood Brain Barrier Proteins (BBBP). Such agents are useful in controlling agents entering and exiting the CNS. This allows for drugs to be more effective and/or allowing side effects of the drugs to be lowered.
    Type: Application
    Filed: April 23, 2008
    Publication date: August 5, 2010
    Applicant: ST. LOUIS UNIVERSITY
    Inventors: William A. Banks, Vijaya B. Kumar, Thomas Darling, Robert Clayton
  • Patent number: 7741283
    Abstract: Disclosed are compositions and methods useful in the regulation of cell proliferation. The invention provides TGF-? (transforming growth factor ?) and IGFBP-3 (insulin like growth factor binding protein 3) as ligands that engage LRP (low density lipoprotein receptor-related protein), heretofore known as T?R-V (TGF-? receptor V) and IGFBP-3 receptor, to effect a change in the phosphorylation and activation status of IRS (insulin receptor substrate) proteins. Compositions comprising TGF-? or IGFBP-3 and LRP or IRS protein are useful in the inhibition of cell proliferation and in the treatment of various diseases associated with unregulated cell proliferation.
    Type: Grant
    Filed: October 15, 2004
    Date of Patent: June 22, 2010
    Assignee: St. Louis University
    Inventor: Jung Huang
  • Patent number: 7723473
    Abstract: This invention is drawn to methods of using peptide-based antagonists of TGF-beta to facilitate the healing of cutaneous wounds that includes burns, lacerations and scrapes. The administration of peptide TGF-beta antagonists to wounds results in reduced scarring, wound contraction and deposition of extracellular matrix components, and increased rates of re-epithelialization during wound healing.
    Type: Grant
    Filed: May 11, 2006
    Date of Patent: May 25, 2010
    Assignee: St. Louis University
    Inventor: Jung San Huang
  • Patent number: 7709134
    Abstract: Microfluidic biofuel cells comprising a bioanode and/or a biocathode are formed using microfluidic principles and soft lithography. The enzymes utilized in the redox reactions at the bioanode and/or the biocathode are stabilized in a micellar or inverted micellar structure. The biofuel cell is used to produce high power densities.
    Type: Grant
    Filed: January 19, 2005
    Date of Patent: May 4, 2010
    Assignee: St. Louis University
    Inventors: Shelley D. Minteer, Robert S. Martin, Christine M. Moore
  • Publication number: 20100041123
    Abstract: Disclosed are bioanodes comprising a quaternary ammonium treated NafionĀ® polymer membrane and a dehydrogenase incorporated within the treated NafionĀ® polymer. The dehydrogenase catalyzes the oxidation of an organic fuel and reduces an adenine dinucleotide. The ion conducting polymer membrane lies juxtaposed to a polymethylene green redox polymer membrane, which serves to electro-oxidize the reduced adenine dinucleotide. The bioanode is used in a fuel cell to produce high power densities.
    Type: Application
    Filed: October 8, 2009
    Publication date: February 18, 2010
    Applicant: St. Louis University
    Inventors: Shelley D. Minteer, Niki L. Akers, Christine M. Moore
  • Publication number: 20090305113
    Abstract: Bioanodes, biocathodes, and biofuel cells comprising an electron conductor, at least one anode enzyme A) or cathode enzyme, and an enzyme immobilization material. The anode enzyme is capable of reacting with a fuel fluid to produce an oxidized form of the fuel fluid, and capable of releasing electrons to the electron conductor. The cathode enzyme is capable of reacting with an oxidant to produce water, and capable of gaining electrons from the electron conductor. The enzyme immobilization material for both the anode enzyme and the cathode enzyme is capable of immobilizing and stabilizing the enzyme, and is permeable to the fuel fluid and/or the oxidant.
    Type: Application
    Filed: November 2, 2006
    Publication date: December 10, 2009
    Applicant: ST. LOUIS UNIVERSITY
    Inventors: Shelley D. Minteer, Becky L. Treu, Rodica Duma
  • Publication number: 20090304676
    Abstract: The present application provides methods and compositions for improving cognitive function and enhancing mental performance in subjects, including those suffering from memory deficiencies, by regulating the activity of beta amyloid (A?) in the brain of such subjects.
    Type: Application
    Filed: November 10, 2006
    Publication date: December 10, 2009
    Applicant: ST. LOUIS UNIVERSITY
    Inventors: Vijaya B. Kumar, William A. Banks, John E. Morley
  • Publication number: 20090136827
    Abstract: Bioanodes, biocathodes, biofuel cells, immobilized enzymes and immobilization materials comprising a micellar hydrophobically modified polysaccharide are disclosed. In particular, the micellar hydrophobically modified polysaccharide can be a hydrophobically modified chitosan or a hydrophobically modified alginate.
    Type: Application
    Filed: November 2, 2006
    Publication date: May 28, 2009
    Applicant: ST. LOUIS UNIVERSITY
    Inventors: Shelley D. Minteer, Tamara L. Klotzbach, Rodica Duma
  • Publication number: 20070208833
    Abstract: A system used by a local health care facility to communicate with a remote health care facility via a data communication network. A controller at the local health care facility controls communication on the data communication network, including data communicated between the local health care facility and the remote health care facility. One or more devices located at the local health care facility transmit data to the remote health care facility via the data communication network. Additionally, the one or more devices receive control data via the data communication network and perform one or more functions in response to the received control data.
    Type: Application
    Filed: March 2, 2007
    Publication date: September 6, 2007
    Applicant: St. Louis University
    Inventor: Richard Bucholz
  • Publication number: 20070161074
    Abstract: Provision of a method for accurate diagnosis of mucopolysaccharidoses, including determining the level of glycosaminoglycan in a biological sample with high sensitivity and with ease.
    Type: Application
    Filed: December 27, 2006
    Publication date: July 12, 2007
    Applicants: DAIICHI PHARMACEUTICAL CO., LTD., St. Louis University
    Inventors: Shunji Tomatsu, Toshihiro Oguma