Abstract: The disclosed subject matter relates to a device, system and method for locating and repairing a pulmonary air leak in a patient.

Abstract: Provided is a method including obtaining time-series data; computing a transform of the time-series data; performing, with a complex clipping algorithm, a complex clipping operation of the transform of the time-series data to obtain a clipped data representation of the transform; classifying, using a classifier, the time-series data based on the clipped data representation; and storing a result of the classifying in memory.

Abstract: Disclosed herein are ladder polymers comprising fused aromatic and non-aromatic rings. Also disclosed are the manufacture and use of these ladder polymers, e.g., in separation membranes, such as membrane for gas separation.

Abstract: A method of determining a number of a solution constituent includes introducing a first number of solution constituents to a first test location, establishing a first binding environment for the introduced first number of solution constituents, creating a first residual number of solution constituents by binding a first plurality of solution constituents, establishing a second binding environment for the first residual number of solution constituents, creating a second residual number of solution constituents by binding a second plurality of solution constituents from the first residual number of solution constituents, obtaining a first signal associated with the bound first plurality of solution constituents, obtaining a second signal associated with the bound second plurality of solution constituents, and determining a second number of a constituent of interest based upon the obtained first signal and the obtained second signal.

Abstract: A precise measurement of the immunological receptor diversity present in a sample is obtained by sequence analysis. Samples of interest are generally complex, comprising more than 102, 103, 104, 105, 106, 107, 108, 109, 1010, 1011, 1012 or more different sequences for a receptor of interest. Immunological receptors of interest include immunoglobulins, T cell antigen receptors, and major histocompatibility receptors. The specific composition of immunological receptor sequence variations in the sample can be recorded and output. The composition is useful for predictive, diagnostic and therapeutic methods relating to the immune capabilities and history of an individual. Such predictions and diagnoses are used to guide clinical decisions.

Abstract: Mitofusin modulatory peptides are described which may function as activators or inhibitors of mitochondrial fusion. The sequences and compositions comprising the sequences are useful for treating diseases or disorders associated with mitofusin 1 (Mfn1) and/or mitofusin 2 (Mfn2) and mitochondrial dysfunction. Methods of treatment, pharmaceutical formulations and methods of identifying compounds that mimic the activity of the peptides for use in screening assays are also described.

Abstract: Compounds, pharmaceutical compositions, and methods of using such compounds and compositions to treat or prevent Alzheimer's disease and related tauopathies through the inhibition of USP-9X and/or enhancement of SCF(?-TrCP).

Abstract: A method of detecting a biomarker in one embodiment includes identifying a quantity of biomolecule types in a sample, exposing the sample to a plurality of test sites, wherein the number of test sites in the plurality of test sites is equal to or greater than the identified quantity of biomolecule types, establishing, for each of the plurality of test sites, a respective test environment, wherein the test environment for each of the plurality of test sites is different from the test environment for each of the other of the plurality of test sites, obtaining a detection signal associated with each of the plurality of test sites, and determining the concentration of one of the biomolecule types based upon the obtained detection signals.

Abstract: The invention provides a non-invasive technique for the differential detection of multiple genotypes and/or mutations for a plurality of target genes in a biological sample containing genetic material from different genomic sources. Methods are conducted using multiplex amplification of a plurality of target sequences from the biological sample, and sequencing is used to detect and enumerate genetic mutations and chromosomal abnormalities at the single nucleotide level.

Abstract: Systems and methods for representing and diagnosing interaction sequences in accordance embodiments of the invention are disclosed.

Abstract: A method and system are disclosed for estimating internal position information of a target in real-time based on a single gantry-mounted x-ray imager and a respiratory signal. The x-ray imaging is done periodically to limit radiation dosage. Initial parameters for the estimation model are determined in a pre-treatment session using four dimensional computed tomography (4D CT) in combination with a respiratory signal acquired from the patient. The model parameters are updated during treatment based on the periodic x-ray image data and the respiratory signal.

Abstract: Systems and methods for generating scheduling options in consideration of space and resource constraints in accordance with embodiments of the invention are disclosed. One embodiment of the invention includes a scheduling application that configures the processor to generate a project schedule from a TODO list comprising a plurality of construction operations, where the construction operations comprise at least one specific space requirements within a construction site, resource requirements, and a duration time.

Abstract: Various methods for tracking and recognition with rotation invariant feature descriptors are provided. One example method includes generating an image pyramid of an image frame, detecting a plurality of interest points within the image pyramid, and extracting feature descriptors for each respective interest point. According to some example embodiments, the feature descriptors are rotation invariant. Further, the example method may also include tracking movement by matching the feature descriptors to feature descriptors of a previous frame and performing recognition of an object within the image frame based on the feature descriptors. Related example methods and example apparatuses are also provided.

Abstract: Motion artifacts and patient dose during 4D CT imaging are reduced by adaptive control of data acquisition. The respiration signal (310) and CT data acquisition (340) are linked, such that ‘bad’ data from erratic breathing cycles that cause artifacts is not acquired by pausing CT data acquisition (360) when erratic breathing is detected, and not resuming CT data acquisition until steady-state respiration is resumed. Training data is used to develop a tolerance envelope for a respiratory signal such that for erratic breathing cycles the respiratory signal is not within the tolerance envelope (330).

Abstract: Methods, apparatuses, and computer program products are herein provided for providing a REVV system that is configured to provide an MVS that is operable on a mobile terminal. One example method may include causing a plurality of vector word residuals to be aggregated for at least one visual word using local feature descriptors extracted from an image. The method may further include causing the dimensionality of the aggregated at least one vector word residual for each visual word to be reduced by using a classification aware linear discriminant analysis. The method may further include computing, using a processor, a weighted correlation for at least one compact image signature that is binarized from the aggregated at least one vector word residual when compared to a list of candidates. The method may further include determining a ranked list of candidates based on the computed weighted correlation.

Abstract: The disclosure relates to methods and materials useful for polymerizing a monomer. In one embodiment, for example, the disclosure provides a method for polymerizing a monomer containing a plurality of electrophilic groups, wherein the method comprises contacting the monomer with a nucleophilic reagent in the presence of a guanidine-containing catalyst. The methods and materials of the disclosure find utility, for example, in the field of materials science.

Abstract: A deliverable four dimensional (4D) intensity modulated radiation therapy (IMRT) planning method is disclosed, for delivery using a linear accelerator with a dynamic multi-leaf collimator (DMLC). A 4D computed tomography (CT) scan is used for segmenting tumor anatomy on a reference phase of periodic motion of the tumor. Deformable registration of the 4D CT data is used to generate corresponding anatomical structures on other phases. Preferably, the collimator for each beam position is aligned using the gross tumor volume (GTV) centroid motion corresponding to the periodic motion of the tumor, as determined from the two dimensional (2D) projection of a given beam position. A deliverable IMRT plan is created on the 4D CT image set in which the MLC leaf positions and beam on/off status can vary as a function of respiratory phase by solving a four dimensional optimization problem. The mechanical constraints of the MLC leaves are included in the optimization.

Abstract: The disclosure relates to methods and materials useful for depolymerizing a polymer. In one embodiment, for example, the disclosure provides a method for depolymerizing a polymer containing electrophilic linkages, wherein the method comprises contacting the polymer with a nucleophilic reagent in the presence of a guanidine-containing compound. The methods and materials of the disclosure find utility, for example, in the field of waste reclamation and recycling.

Abstract: Surface plasmon resonance (SPR) microscopy systems, methods of making SPR microscopy systems, methods of measuring and detecting the presence of one or more compounds present in a sample using the SPR microscopy system, and the like, are disclosed. In an embodiment, a surface plasmon resonance (SPR) microscopy system can include an integrated microfluidic chip that includes a plurality of layers, an SPR imaging system, and a pressure manifold to actuate flow control components in the integrated microfluidic chip.

Abstract: Recombinant adeno-associated viral (AAV) capsid proteins are provided. Methods for generating a library of recombinant adeno-associated viral capsid proteins are also provided.