Patents Assigned to Stanford University
  • Patent number: 10774382
    Abstract: A precise measurement of the immunological receptor diversity present in a sample is obtained by sequence analysis. Samples of interest are generally complex, comprising more than 102, 103, 104, 105, 106, 107, 108, 109, 1010, 1011, 1012 or more different sequences for a receptor of interest. Immunological receptors of interest include immunoglobulins, T cell antigen receptors, and major histocompatibility receptors. The specific composition of immunological receptor sequence variations in the sample can be recorded and output. The composition is useful for predictive, diagnostic and therapeutic methods relating to the immune capabilities and history of an individual. Such predictions and diagnoses are used to guide clinical decisions.
    Type: Grant
    Filed: August 31, 2018
    Date of Patent: September 15, 2020
    Assignee: The Board of Trustees of the Leland Stanford University Junior University
    Inventors: Stephen R. Quake, Joshua Weinstein, Ning Jiang, Daniel S. Fisher
  • Patent number: 10578610
    Abstract: Mitofusin modulatory peptides are described which may function as activators or inhibitors of mitochondrial fusion. The sequences and compositions comprising the sequences are useful for treating diseases or disorders associated with mitofusin 1 (Mfn1) and/or mitofusin 2 (Mfn2) and mitochondrial dysfunction. Methods of treatment, pharmaceutical formulations and methods of identifying compounds that mimic the activity of the peptides for use in screening assays are also described.
    Type: Grant
    Filed: September 20, 2017
    Date of Patent: March 3, 2020
    Assignees: Washington University, Stanford University
    Inventors: Daria Mochly-Rosen, Gerald W. Dorn, II
  • Publication number: 20190154834
    Abstract: Systems and methods for imaging object velocity are provided. In an embodiment, at least one Time-of-Flight camera is used to capture a signal representative of an object in motion over an exposure time. Illumination and modulation frequency of the captured motion are coded within the exposure time. A change of illumination frequency is mapped to measured pixel intensities of the captured motion within the exposure time, and information about a Doppler shift in the illumination frequency is extracted to obtain a measurement of instantaneous per pixel velocity of the object in motion. The radial velocity information of the object in motion can be simultaneously captured for each pixel captured within the exposure time. In one or more aspects, the illumination frequency can be coded orthogonal to the modulation frequency of the captured motion. The change of illumination frequency can correspond to radial object velocity.
    Type: Application
    Filed: August 5, 2016
    Publication date: May 23, 2019
    Applicants: KING ABDULLAH UNIVERSITY OF SCIENCE AND TECHNOLOGY, BONN UNIVERSITY, UNIVERSITY OF BRITISH COLUMBIA, STANFORD UNIVERSITY, BONN UNIVERSITY
    Inventors: Wolfgang HEIDRICH, Felix HEIDE, Gordon WETZSTEIN, Matthias HULLIN
  • Patent number: 10149860
    Abstract: Compounds, pharmaceutical compositions, and methods of using such compounds and compositions to treat or prevent Alzheimer's disease and related tauopathies through the inhibition of USP-9X and/or enhancement of SCF(?-TrCP).
    Type: Grant
    Filed: February 3, 2016
    Date of Patent: December 11, 2018
    Assignee: Board of Trustees of the Leland Stanford Junior University, Stanford University Office of Technology Licensing
    Inventors: Bingwei Lu, Seongsoo Lee
  • Patent number: 9944982
    Abstract: Surface chemistries for the visualization of labeled single molecules (analytes) with improved signal-to-noise properties are provided. To be observed, analyte molecules are bound to surface attachment features that are spaced apart on the surface such that when the analytes are labeled adjacent analytes are optically resolvable from each other. One way to express this concept is that binding elements should be spaced apart such that the Guassian point spread functions of adjacent labels do not overlap. Another way of expressing this concept is that the surface binding elements should be spaced apart by a distance equal to at least the diffraction limit for an optical label attached to the bound analytes.
    Type: Grant
    Filed: November 27, 2013
    Date of Patent: April 17, 2018
    Assignees: STANFORD UNIVERSITY, UNIVERSITY OF CHICAGO, CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Jerrod Schwartz, Stephen R. Quake, Milan Mrksich
  • Patent number: 9267174
    Abstract: The invention provides a non-invasive technique for the differential detection of multiple genotypes and/or mutations for a plurality of target genes in a biological sample containing genetic material from different genomic sources. Methods are conducted using multiplex amplification of a plurality of target sequences from the biological sample, and sequencing is used to detect and enumerate genetic mutations and chromosomal abnormalities at the single nucleotide level.
    Type: Grant
    Filed: October 26, 2011
    Date of Patent: February 23, 2016
    Assignee: Stanford University
    Inventors: Stephen R. Quake, Wei Gu, Hei-Mun Christina Fan
  • Patent number: 9157912
    Abstract: A method for the diagnosis and/or prognosis of inflammatory states, and the use of at least one soluble receptor-binding (RBD), for the identification and quantification of the expression of membrane receptors present on the surface of target granulocytes, said identification and quantification taking place at a given time or during a given time interval, and allowing the diagnosis and/or prognosis of inflammatory states in a mammal.
    Type: Grant
    Filed: September 19, 2011
    Date of Patent: October 13, 2015
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE MONTPELLIER 2 SCIENCES ET TECHNIQUES, STANFORD UNIVERSITY
    Inventors: Rabindra Tirouvanziam, Julie Laval, Jean-Luc Battini, Marc Sitbon
  • Publication number: 20150039289
    Abstract: Systems and methods for representing and diagnosing interaction sequences in accordance embodiments of the invention are disclosed.
    Type: Application
    Filed: July 31, 2013
    Publication date: February 5, 2015
    Applicant: Stanford University
    Inventors: Adegboyega Mabogunje, Neeraj Sonalkar, Larry J. Leifer, Shashikant Khandelwal
  • Patent number: 8849373
    Abstract: A method and system are disclosed for estimating internal position information of a target in real-time based on a single gantry-mounted x-ray imager and a respiratory signal. The x-ray imaging is done periodically to limit radiation dosage. Initial parameters for the estimation model are determined in a pre-treatment session using four dimensional computed tomography (4D CT) in combination with a respiratory signal acquired from the patient. The model parameters are updated during treatment based on the periodic x-ray image data and the respiratory signal.
    Type: Grant
    Filed: May 12, 2008
    Date of Patent: September 30, 2014
    Assignee: Stanford University
    Inventors: Paul J. Keall, Amit Sawant, Peter Maxim, Yelin Suh, Lei Xing, Billy W. Loo, Jr., Byung Chul Cho
  • Publication number: 20140280224
    Abstract: Systems and methods for relationship recommendations systems in accordance with embodiments of the invention are illustrated. In one embodiment, a relationship recommendation server system includes a processor wherein a relationship recommendation program configures the processor to obtain a graph database including a set of nodes including node attribute data and a set of edges including edge attribute data and describing relationships between nodes in the set of nodes, determine a set of motif data, where the motif data describes at least one subgraph including a subset of the nodes and a subset of the edges within the graph database, obtain a search node, generate additional edges between the search node and a subset of the nodes within the graph database, where the additional edges form subgraphs including the search node that are isomorphic to a subset of the motif data, and recommend relationships based on the generated additional edges.
    Type: Application
    Filed: March 14, 2014
    Publication date: September 18, 2014
    Applicant: STANFORD UNIVERSITY
    Inventors: Evan Feinberg, Julien Clancy
  • Publication number: 20140277666
    Abstract: Systems and methods for generating scheduling options in consideration of space and resource constraints in accordance with embodiments of the invention are disclosed. One embodiment of the invention includes a scheduling application that configures the processor to generate a project schedule from a TODO list comprising a plurality of construction operations, where the construction operations comprise at least one specific space requirements within a construction site, resource requirements, and a duration time.
    Type: Application
    Filed: March 15, 2013
    Publication date: September 18, 2014
    Applicant: Stanford University
    Inventor: Rene Morkos
  • Patent number: 8687891
    Abstract: Various methods for tracking and recognition with rotation invariant feature descriptors are provided. One example method includes generating an image pyramid of an image frame, detecting a plurality of interest points within the image pyramid, and extracting feature descriptors for each respective interest point. According to some example embodiments, the feature descriptors are rotation invariant. Further, the example method may also include tracking movement by matching the feature descriptors to feature descriptors of a previous frame and performing recognition of an object within the image frame based on the feature descriptors. Related example methods and example apparatuses are also provided.
    Type: Grant
    Filed: November 18, 2010
    Date of Patent: April 1, 2014
    Assignees: Stanford University, Nokia Corporation
    Inventors: Gabriel Takacs, Radek Grzeszczuk, Vijay Chandrasekhar, Bernd Girod
  • Publication number: 20130252251
    Abstract: A method for the diagnosis and/or prognosis of inflammatory states, and the use of at least one soluble receptor-binding (RBD), for the identification and quantication of the expression of membrane receptors present on the surface of target granulocytes, said identification and quantification taking place at a given time or during a given time interval, and allowing the diagnosis and/or prognosis of inflammatory states in a mammal.
    Type: Application
    Filed: September 19, 2011
    Publication date: September 26, 2013
    Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, STANFORD UNIVERSITY, UNIVERSITE MONTPELLIER 2 SCIENCES ET TECHNIQUES
    Inventors: Rabindra Tirouvanziam, Julie Laval, Jean-Luc Battini, Marc Sitbon
  • Patent number: 8457717
    Abstract: Motion artifacts and patient dose during 4D CT imaging are reduced by adaptive control of data acquisition. The respiration signal (310) and CT data acquisition (340) are linked, such that ‘bad’ data from erratic breathing cycles that cause artifacts is not acquired by pausing CT data acquisition (360) when erratic breathing is detected, and not resuming CT data acquisition until steady-state respiration is resumed. Training data is used to develop a tolerance envelope for a respiratory signal such that for erratic breathing cycles the respiratory signal is not within the tolerance envelope (330).
    Type: Grant
    Filed: April 7, 2005
    Date of Patent: June 4, 2013
    Assignee: Stanford University
    Inventors: Paul J. Keall, Jeffrey F. Williamson
  • Publication number: 20130114900
    Abstract: Methods, apparatuses, and computer program products are herein provided for providing a REVV system that is configured to provide an MVS that is operable on a mobile terminal. One example method may include causing a plurality of vector word residuals to be aggregated for at least one visual word using local feature descriptors extracted from an image. The method may further include causing the dimensionality of the aggregated at least one vector word residual for each visual word to be reduced by using a classification aware linear discriminant analysis. The method may further include computing, using a processor, a weighted correlation for at least one compact image signature that is binarized from the aggregated at least one vector word residual when compared to a list of candidates. The method may further include determining a ranked list of candidates based on the computed weighted correlation.
    Type: Application
    Filed: November 7, 2011
    Publication date: May 9, 2013
    Applicants: Stanford University, Nokia Corporation
    Inventors: Ramakrishna Vedantham, Radek Grzeszczuk, David Mo Chen, Shang-Hsuan Tsai, Bernd Griod
  • Patent number: 8367796
    Abstract: The disclosure relates to methods and materials useful for polymerizing a monomer. In one embodiment, for example, the disclosure provides a method for polymerizing a monomer containing a plurality of electrophilic groups, wherein the method comprises contacting the monomer with a nucleophilic reagent in the presence of a guanidine-containing catalyst. The methods and materials of the disclosure find utility, for example, in the field of materials science.
    Type: Grant
    Filed: July 1, 2009
    Date of Patent: February 5, 2013
    Assignees: International Business Machines Corporation, Stanford University
    Inventors: James Lupton Hedrick, Russell Clayton Pratt, Robert M. Waymouth
  • Patent number: 8340247
    Abstract: A deliverable four dimensional (4D) intensity modulated radiation therapy (IMRT) planning method is disclosed, for delivery using a linear accelerator with a dynamic multi-leaf collimator (DMLC). A 4D computed tomography (CT) scan is used for segmenting tumor anatomy on a reference phase of periodic motion of the tumor. Deformable registration of the 4D CT data is used to generate corresponding anatomical structures on other phases. Preferably, the collimator for each beam position is aligned using the gross tumor volume (GTV) centroid motion corresponding to the periodic motion of the tumor, as determined from the two dimensional (2D) projection of a given beam position. A deliverable IMRT plan is created on the 4D CT image set in which the MLC leaf positions and beam on/off status can vary as a function of respiratory phase by solving a four dimensional optimization problem. The mechanical constraints of the MLC leaves are included in the optimization.
    Type: Grant
    Filed: November 16, 2010
    Date of Patent: December 25, 2012
    Assignee: Stanford University
    Inventors: Paul J. Keall, Yelin Suh, Elisabeth Weiss
  • Patent number: 8309618
    Abstract: The disclosure relates to methods and materials useful for depolymerizing a polymer. In one embodiment, for example, the disclosure provides a method for depolymerizing a polymer containing electrophilic linkages, wherein the method comprises contacting the polymer with a nucleophilic reagent in the presence of a guanidine-containing compound. The methods and materials of the disclosure find utility, for example, in the field of waste reclamation and recycling.
    Type: Grant
    Filed: July 1, 2009
    Date of Patent: November 13, 2012
    Assignees: International Business Machines Corporation, Stanford University
    Inventors: James Lupton Hedrick, Russell Clayton Pratt, Robert M. Waymouth
  • Patent number: 8289519
    Abstract: Surface plasmon resonance (SPR) microscopy systems, methods of making SPR microscopy systems, methods of measuring and detecting the presence of one or more compounds present in a sample using the SPR microscopy system, and the like, are disclosed. In an embodiment, a surface plasmon resonance (SPR) microscopy system can include an integrated microfluidic chip that includes a plurality of layers, an SPR imaging system, and a pressure manifold to actuate flow control components in the integrated microfluidic chip.
    Type: Grant
    Filed: March 21, 2008
    Date of Patent: October 16, 2012
    Assignee: Stanford University
    Inventors: Richard Neil Zare, Yiqi Luo, Fang Yu
  • Publication number: 20120255046
    Abstract: Recombinant adeno-associated viral (AAV) capsid proteins are provided. Methods for generating a library of recombinant adeno-associated viral capsid proteins are also provided.
    Type: Application
    Filed: May 15, 2012
    Publication date: October 4, 2012
    Applicant: The Board of Trustees of The Leland Stanford University
    Inventors: MARK KAY, Dirk Grimm