Abstract: A single molecule sensing or detecting device includes a first electrode and a second electrode separated from the first electrode by a gap. The first electrode and the second electrode have an opening formed therethrough. At least one of the first electrode and the second electrode is functionalized with a recognition molecule. The recognition molecule has an effective length LI and is configured to selectively bind to a target molecule having an effective length L2. The size of the gap is configured to be greater than L2, but less than or equal to the sum of LI and L2.

Abstract: The present disclosure relates to a continuous process for melt-coating active pharmaceutical ingredients, including introducing at least one active pharmaceutical ingredient (API) and at least one surfactant into a processor; and continuously and simultaneously heating and shearing the API and surfactant in the processor at a temperature close to the melting point of the surfactant so as to continuously form melt-coated API particles having at least a partial coating of surfactant. The disclosure also relates to melt-coated API particles prepared by the disclosed continuous melt-coating process, and pharmaceutical drug products prepared from such melt-coated API particles.

Abstract: Embodiments of the present disclosure pertain to methods of modulating a stress response in a eukaryotic organism against an environmental stress by introducing an RNA fragment (RF) or an antisense nucleotide to the eukaryotic organism. Thereafter, the RF or antisense nucleotide modulates the stress response against the environmental stress. Additional embodiments of the present disclosure pertain to the RFs and antisense nucleotides of the present disclosure. The RFs generally include: a sequence recognition site that contains a reverse complement sequence of a nucleotide sequence of the organism; and a stem loop structure with a paired region that includes paired RNA nucleotides, and an unpaired region that includes unpaired RNA nucleotides in the form of a loop. The antisense nucleotides may include a reverse complement sequence of the RFs.

Abstract: A method for detecting and recovery from a soft error in a computing device is provided. In examples discussed herein, the method can be performed to detect soft errors that may occur during execution of a predefined critical instruction(s) and/or has been propagated in the computing device prior to the execution of the predefined critical instruction(s). Specifically, a software compiler may be used to embed an error detector block(s) after the predefined critical instruction(s). In this regard, the error detector block(s) can be executed after the predefined critical instruction(s) to detect the soft error. Accordingly, it may be possible to invoke a diagnosis routine to determine severity of the detected soft error and take appropriate action against the detected soft error. As such, it may be possible to protect the execution of the predefined critical instruction(s) concurrent to eliminating vulnerable voting intervals and reducing soft error detection overhead.

Abstract: Detecting single molecules includes binding the single molecules to a surface of an optically transparent substrate, irradiating the surface of the substrate with light having an incident angle selected to achieve total reflection of the light, thereby scattering light from the surface and from the single molecules bound to the surface, and collecting light scatted by the surface and by the single molecules bound to the surface to form a series of images. Systems for detecting single molecules include an optically transparent substrate, a means for flowing a sample solution over a surface of the substrate, a light source configured to irradiate the surface, a camera, and a collection optical system configured to collect light scatted by the surface and by the target molecules on the surface to form a series of images on the camera.

Abstract: Compositions comprising RqSnOm(OH)x(HCO3)y(CO3)z are disclosed, where R is (i) C1—C10 hydrocarbyl or (ii) heteroaliphatic, heteroaryl, or heteroaryl-aliphatic including 1-10 carbon atoms and one or more heteroatoms; q = 0.1-1; x ? 4; y ? 4; z ? 2; m = 2 - q/2 - x/2 - y/2 - z; and (q/2 + x/2 + y/2 + z) ? 2 Methods of making a photoresist film comprising [(RSn)12O14(OH)6](OH)2 on a substrate also are disclosed. The photoresist film may be irradiated to form RqSnOm(OH)x(HCO3)y(CO3)z.

Abstract: A reinforced mixed-mode bending apparatus (RMMBA) is provided. The RMMBA is a new fixture design for testing fracture and characterizing delamination in layered materials under combined mode I (pulling/tension) and mode II (in-plane shear) loads. The purpose of this design is to provide a much less compliant fixture for conducting the Mixed Mode Bending (MMB) test. Embodiments described herein improve the accuracy of the MMB test and reduce the complexity of post-processing the collected data.

Abstract: The disclosure concerns biometeorological sensing devices including a processor communicatively coupled to a memory, and a plurality of sensors communicatively coupled to the processor. The plurality of sensors includes a humidity sensor, a UV sensor, an anemometer, an atmospheric thermometer, a globe thermometer, and a camera. The device also includes a network interface communicatively coupled to the processor. The processor is configured to estimate a mean radiant temperature (MRT) using data received from the plurality of sensors, identify a person in an image received from the camera, determine a bounding box that encloses the person in the image, generate a shadow map from the image, calculate an intersection over union (IOU) of the bounding box with the shadow map to determine if the person is in the shade, and transmit observed space usage and estimated MRT to a server communicatively coupled to the network interface.

Abstract: The present invention relates to solvothermal vapor synthesis methods for the crystallization of a phase from a mixture of selected inorganic or organic precursors in an unsaturated vapor-phase reaction medium.

Abstract: Fabricating a regrown GaN p-n junction includes depositing a n-GaN layer on a substrate including n+-GaN, etching a surface of the n-GaN layer to yield an etched surface, depositing a p-GaN layer on the etched surface, etching a portion of the n-GaN layer and a portion of the p-GaN layer to yield a mesa opposite the substrate, and passivating a portion of the p-GaN layer around an edge of the mesa. The regrown GaN p-n junction is defined at an interface between the n-GaN layer and the p-GaN layer. The regrown GaN p-n junction includes a substrate, a n-GaN layer on the substrate having an etched surface, a p-GaN layer on the etched surface, a mesa defined by an etched portion of the n-GaN layer and an etched portion of the p-GaN layer, and a passivated portion of the p-GaN layer around an edge of the mesa.

Abstract: A system and methods for optically detecting a target atmospheric gas are disclosed and described. An imaging system can include a narrow-band optical interference filter with a center wavelength that corresponds to a feature in an absorption spectrum of a target gas at a normal angle of incidence. An optical component can receive incoming light from the target gas that has passed through the narrow-band optical interference filter, wherein the narrow-band optical interference filter is tilted relative to the optical component, which tilt shifts the wavelength of light from each target point that is able to pass through the narrow-band optical interference filter. A camera can receive the incoming light that has been focused by the optical component. Multiple image frames are collected for different orientations of the system with respect to the target and analyzed to perform hyperspectral characterization of target gas absorption.

Abstract: A single-piece hybrid droplet generator and nozzle component for serial crystallography. The single-piece hybrid droplet generator component including an internally-formed droplet-generation channel, an internally-formed sample channel, a nozzle, and a pair of electrode chambers. The droplet-generation channel extends from a first fluid inlet opening to the nozzle. The sample channel extends from a second fluid inlet opening to the droplet-generation channel and joins the droplet-generation channel at a junction. The nozzle is configured to eject a stream of segmented aqueous droplets in a carrier fluid from the droplet-generation channel through a nozzle opening of the single-piece component. The pair of electrode chambers are positioned adjacent to the droplet-generation channel near the junction between the droplet-generation channel and the sample channel.

Abstract: Bulk assemblies are provided, which may have desirable photoluminescence quantum efficiencies. The bulk assemblies may include two or more metal halides, and a wide band gap organic network. The wide band gap organic network may include organic cations. The metal halides may be disposed in the wide band gap organic network. Light emitting composite materials also are provided.

Abstract: A system may perform speech enhancement of audio data in real-time by suppressing noise components that are present in the audio data while preserving speech components. The system may include an in-ear module and a separate signal processing module that is wirelessly communicatively coupled to the in-ear module. The system may include non-negative matrix factorization (NMF) dictionaries capable of identifying frequency band components associated with speech and frequency band components associated with noise. The NMF dictionaries may be trained using voice samples and noise samples. The NMF dictionaries may be applied to noisy speech data to produce an NMF representation of the speech data which may then be applied using a dynamic mask to the noisy speech data in order to suppress the noise components of the noisy speech data and produce speech enhanced data.

Abstract: The present disclosure relates to compositions and methods useful for the functionalization of surfaces in the absence of a metal catalyst. The compositions include compounds of formula (I), which react with strained alkene-containing compounds, before or after molecular assembly catalyzed by tyrosinase, to afford cycloadducts. The strained alkene-containing compound may further comprise any molecule of interest, including small molecules and macromolecules, thereby enabling surface functionalization. In certain embodiments, the strained alkene-containing molecule comprises a moiety selected from the group consisting of a trans-cyclooctene (TCO), cyclopropene, cyclobutene, and norbornene.

Abstract: A method for coating a multi-layered polymer film is disclosed including coating a first layer of polyimide onto a carrier, curing the first layer of polyimide by subjecting the first layer of polyimide to an elevated temperature, depositing a first layer of metal onto the cured first layer of polyimide, coating a second layer of polyimide onto the first layer of metal, and curing the second layer of polyimide by subjecting the second layer of polyimide to an elevated temperature. A flexible electronic device is also disclosed, including multiple interposed layers of polyimide and layers of metal, a dielectric barrier layer disposed on the top layer of polyimide, and a thin film transistor-based device disposed on the dielectric barrier layer. The flexible electronic device has little to no curl.

Abstract: Compounds and methods for use to treat a bacterial infection caused by, for example, gram positive bacteria, gram negative bacteria, and/or mycobacteria are provided herein. Also provided herein are compounds and methods for use in potentiating the effect of an antibiotic in the treatment of a bacterial infection. Pharmaceutical compositions including the compounds as described herein are also provided.

Abstract: A method is disclosed for making palatable methionine-restricted foods, to deliver a methionine-restricted diet to human or veterinary patients. A protein or a food product containing protein is partially oxidized, preferably with ozone, to oxidize nearly all of the methionine and cysteine. After oxidation, tryptophan and lysine are optionally added back since they tend to be oxidized also. Optionally, a small amount of methionine is also added back so that the final methionine is within a preferred range of about 0.85 to about 1.8 gram methionine per 100 gram total protein, preferably about 1.2 gram per 100 gram total protein.

Abstract: Provided is a method for inhibiting the growth of Gram-positive bacteria, including contacting said bacteria with a first compound and a second compound, wherein the first compound is a compound of Formula I: and the second compound is an antibiotic other than a compound of Formula I. Also provided is a composition including the first compound and the second compound.

Abstract: ‘NCORNSP-030ILPL’ is a moderately compact and loosely upright variety of Ipomoea batatas with a moderate growth rate and is well branched. It is distinguishable from other ornamental sweetpotato cultivars by its burgundy palmate, very deeply lobed leaves with 5-7 lobes, a moderately-compact habit and semi-erect mounding plant architecture. The burgundy leaves, very deep lobing, short internodes, and the plant architecture, which promotes good plant production in the greenhouse for wholesale distributors, distinguishes ‘NCORNSP-030ILPL’ amongst the current ornamental sweetpotatoes in the marketplace. ‘NCORNSP-030ILPL’ has been shown to be less vigorous than Ipomoea batatas ‘Margarita’ and ‘Mackie’ and is suitable for use as a landscape or containerized plant.