Patents Assigned to State University
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Patent number: 11285199Abstract: The present invention relates to a vaccine composition comprising a Staphylococcus aureus attenuated enterotoxin protein and cytotoxin protein, and more particularly to a Staphylococcus aureus enterotoxin protein, a Staphylococcus aureus cytotoxin protein, a vaccine composition for prevention of bovine mastitis, comprising the Staphylococcus aureus enterotoxin protein and Staphylococcus aureus cytotoxin protein and a method for preventing bovine mastitis comprising administering the vaccine composition to a bovine.Type: GrantFiled: December 13, 2018Date of Patent: March 29, 2022Assignees: Mississippi State UniversityInventors: Dong Chan Moon, Suk Kyung Lim, Keum Chan Jang, Suk Chan Jung, Hee Soo Lee, Bang Hun Hyun, Hyang Mi Nam, Heui Jin Kim, Keun Seok Seo
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Patent number: 11286340Abstract: The present invention provides efficient processes for preparing brush polymers. In general, the process comprises three distinct reaction steps utilizing two separate catalysts. In the first step, the initiating compound comprising norbornene is contacted with a silane in the presence of a catalyst, thereby forming a silated intermediate. This silated intermediate is then contacted with a monomer in the presence of a catalyst via Group Transfer Polymerization (GTP). The resulting compound from GTP is contacted with a ring opening metathesis polymerization (ROMP) catalyst to prepare the brush polymer. Surprisingly, the brush polymers obtained from the above process are accessed in an efficient and rapid GTP methodology as compared to prior methods.Type: GrantFiled: January 29, 2020Date of Patent: March 29, 2022Assignee: Colorado State University Research FoundationInventors: Garret Miyake, Ryan M. Pearson, Matthew D. Ryan
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Patent number: 11286494Abstract: Described herein are transgenic plants with increased oil content that exhibit enhanced expression of plastid-specific lipases (e.g., PLIP1). The manufacture of lipids can be enhanced by expression of FAD4.Type: GrantFiled: March 29, 2018Date of Patent: March 29, 2022Assignee: Board of Trustees of Michigan State UniversityInventors: Christoph Benning, Kun Wang
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Publication number: 20220090076Abstract: The present disclosure provides nucleic acid compositions that incorporate one or more halouracil molecules. More specifically, the present disclosure reveals that the replacement of uracil nucleotides within a microRNA nucleotide sequence with a 5-halouracil increases the ability of the micro-RNA to inhibit cancer progression and tumorigenesis. As such, the present disclosure provides various nucleic acid (e.g., microRNA) compositions having 5-halouracil molecules incorporated in their nucleic acid sequences and methods for using the same. The present disclosure further provides pharmaceutical compositions comprising the modified nucleic acid compositions, and methods for treating cancers using the same.Type: ApplicationFiled: November 24, 2021Publication date: March 24, 2022Applicant: The Research Foundation for The State University of New YorkInventors: Jingfang Ju, Andrew Fesler, Younghwa Song, Jun Chung
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Publication number: 20220088226Abstract: Fluorescent nucleobase surrogates capable of Watson-Crick hydrogen bonding are essential probes of nucleic acid structure and dynamics. Their limited brightness and short absorption and emission wavelengths have rendered them unsuitable for single-molecule detection. Herein, we synthesized a new tricyclic pyrimidine nucleoside analogue with a push-pull conjugated system. The resulting C-linked 8-(diethylamino)benzo[b][1,8] naphthyridin-2(1H)-one nucleoside (ABN), exhibits ?442=20,000 M?1 cm?1 and ?em,540=0.39 in water, increasing to ?em=0.50-0.53 when base paired with adenine in duplex DNA oligonucleotides. Single-molecule fluorescence measurements of ABN using both one-photon and two-photon excitation demonstrate its excellent photostability and indicate that the nucleoside is present to >95% in a bright state with count rates of at least 15 kHz per molecule.Type: ApplicationFiled: September 16, 2021Publication date: March 24, 2022Applicant: San Diego State University FoundationInventors: Byron W. PURSE, George SAMAAN, Mckenzie WYLLIE, Julian CIZMIC, Katrina NGO, Susan ANDERSEN
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Publication number: 20220088567Abstract: The invention is both a product and a method for the safe, harmless and effective remediation of oil spills on water and on land. The oil can then be successfully recovered from the product for use. The invention also allows for the reuse of two waste products—post consumer plastics and coal combustion product—into a material that is used for the clean-up of oil spills and for site remediation. Furthermore, the used product can be reprocessed post use into more usable product.Type: ApplicationFiled: December 6, 2021Publication date: March 24, 2022Applicant: Fayetteville State UniversityInventor: William T. Hall
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Publication number: 20220091282Abstract: A method is provided to reduce the counting times in radiation detection systems using machine learning, wherein the method comprises: receiving output data from a detector which is to detect a target material from a target body; analyzing the output data; identifying a material of interest from the analyzed output data; and controlling a source of the target material to prevent the source from harming the target body. An apparatus is also provided which comprises: a detector to detect radiation and to provide an output data in real-time; and a processor coupled to the detector, wherein the processor is to: receive the output data; analyze the output data; identify a material of interest from the analyzed output data; and control a source of the target material.Type: ApplicationFiled: December 1, 2021Publication date: March 24, 2022Applicant: Oregon State UniversityInventors: Ophir Frieder, Steven Richard Reese, Jessica Ryan Curtis
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Publication number: 20220094070Abstract: A reflector apparatus is provided. A further aspect employs at least one antenna or radar operably emitting signals, and a moving object-mounted reflector which operably reflects at least some of the signals back to the at least one antenna or radar, the reflector including trihedral walls with metallic reflective surfaces. In another aspect, a programmable controller in an automotive vehicle determines a moving object-characteristic based on at least reflected signals received by a horn antenna using a Doppler or micro-Doppler effect. Still another aspect includes a trihedral reflector which moves with a movable object including handlebars, a straddled user seat and being one of: a bicycle, a motorcycle, or an all-terrain vehicle. A further aspect includes multiple spaced apart trihedral reflectors attached to a user-wearable, flexible and nonconductive substrate.Type: ApplicationFiled: September 21, 2021Publication date: March 24, 2022Applicant: Board of Trustees of Michigan State UniversityInventor: Lee HARLE
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Publication number: 20220092795Abstract: Methods, systems, and storage media are described for motion estimation in video frame interpolation. Disclosed embodiments use feature pyramids as image representations for motion estimation and seamlessly integrates them into a deep neural network for frame interpolation. A feature pyramid is extracted for each of two input frames. These feature pyramids are wrapped together with the input frames to the target temporal position according to the inter-frame motion estimated via optical flow. A frame synthesis network is used to predict interpolation results from the pre-warped feature pyramids and input frames. The feature pyramid extractor and the frame synthesis network are jointly trained for the task of frame interpolation. An extensive quantitative and qualitative evaluation demonstrates that the described embodiments utilizing feature pyramids enables robust, high-quality video frame interpolation. Other embodiments may be described and/or claimed.Type: ApplicationFiled: January 14, 2020Publication date: March 24, 2022Applicant: Portland State UniversityInventors: Feng LIU, Simon NIKLAUS
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Publication number: 20220088271Abstract: The present invention is a method for producing allograft tissue by applying an antimicrobial solution to allograft tissue. The antimicrobial solution exhibits antimicrobial activity to make allograft resistant to microbial organisms, such as a bacterium.Type: ApplicationFiled: December 2, 2021Publication date: March 24, 2022Applicant: Rutgers, The State University of New JerseyInventors: Sheldon S. Lin, Joseph Benevenia, Michael J. Vives, Pradeep Kumar, David Alland, James Patrick O'Connor
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Publication number: 20220088089Abstract: The present disclosure relates to compositions and methods for treating autism spectrum disorder (ASD) by restoring an ASD patient's gut microbiota. These methods can be used with ASD patient with or without ongoing gastrointestinal symptoms. Provided here is a method for ASD treatment in a subject in need thereof comprising or consisting essentially of administering a therapeutic composition comprising a fecal microbe or a fecal microbiota preparation to the subject. Also provided here is a method comprises administering an antibiotic to a human subject; subjecting the human subject to a bowel cleanse; and administering purified fecal microbiota to the human subject. Further provided are evaluation and quantitative characterization of patient symptom improvements upon treatment described here.Type: ApplicationFiled: December 1, 2021Publication date: March 24, 2022Applicants: Arizona Board Regents on behalf of Arizona State University, Regents of the University of Minnesota, Finch Therapeutics Holdings LLCInventors: James ADAMS, Rosa KRAJMALNIK-BROWN, Dae-Wook KANG, Michael J. SADOWSKY, Alexander KHORUTS, Thomas J. BORODY
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Publication number: 20220091128Abstract: Devices for ligand capture and methods of using the device are disclosed. The ligand may be captured from a sample, such as a plasma sample. Methods of identifying, quantifying, and/or characterizing captured ligands also are disclosed. Computer systems and methods for analyzing thermograms and determining the characteristics of ligands present in a sample are disclosed.Type: ApplicationFiled: January 21, 2020Publication date: March 24, 2022Applicant: Portland State UniversityInventors: Albert S. Benight, Matthew W. Eskew
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Patent number: 11278597Abstract: Compositions of insulin-secreting cells and stem cells and methods for their use as well as use of insulin and stem cell products in wound healing and/or reducing scar and/or scab formation are provided.Type: GrantFiled: March 16, 2018Date of Patent: March 22, 2022Assignee: Rutgers, The State University of New JerseyInventors: Ronke Olabisi, Ayesha Aijaz
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Patent number: 11280642Abstract: A reflection mode sensor system may include an optical fiber core and an optical fiber cladding. A first long period grating (LPG) may be positioned along the optical fiber core having a first grating period, a second LPG may be positioned along the optical fiber core having a second grating period, and a third LPG may be positioned along the optical fiber core having a third grating period. The grating periods may enable sensing of multiple parameters simultaneously. A metal coating may be applied to an end facet of the combined optical fiber core and optical fiber cladding. The metal coating may also cover a side surface of the optical fiber cladding along a length from the end facet. The metal coating may include a paste applied to the optical fiber core and the optical fiber cladding, where the paste has been cured, and includes a metal.Type: GrantFiled: June 11, 2020Date of Patent: March 22, 2022Assignee: Boise State UniversityInventors: Harish Subbaraman, Sohel Rana, Nirmala Kandadai
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Patent number: 11278442Abstract: A fiber-reinforced composite article useful in supporting or immobilizing an injured body part is disclosed. The composite is a multi-layer, flexible precursor including fiber reinforcement plies, which can be rapidly cured into a rigid body using a thermosetting resin. Methods of making and using the same are also disclosed, along with kits containing such composite articles.Type: GrantFiled: May 13, 2019Date of Patent: March 22, 2022Assignees: Wichita State University, Commercial Chemistries, LLCInventors: John S. Tomblin, Thomas Aldag, William T. McCarvill, Kimberly M. Reuter, Joel D. White, Andrea C. Meyer
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Patent number: 11279945Abstract: Isolated cDNA sequences encoding for highly conserved domains of plant viral pathogen genomes. The cDNA sequences are selected from the group consisting of those listed in Table I (SEQ ID NOs: 1-68). cDNA fusion constructs or chimeric transgene constructs comprising at least two different cDNA sequences selected from the list in Table I, and more specifically cDNA corresponding to at least two different viruses is described, along with methods of creating transgenic plants with broad-spectrum, durable resistance to multiple viral pathogens using these cDNA sequences.Type: GrantFiled: May 4, 2017Date of Patent: March 22, 2022Assignees: Kansas State University Research Foundation, Heartland Plant Innovations, Inc.Inventors: Dorith Rotenberg, Anna E. Whitfield, William W. Bockus, Forrest G. Chumley, Rodolfo Acosta-Leal
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Patent number: 11279129Abstract: An amorphous thin metal film can comprise a combination of three metals or metalloids including: 5 at % to 90 at % of a metalloid selected from the group of carbon, silicon, and boron; 5 at % to 90 at % of a first metal selected from the group of titanium, vanadium, chromium, iron, cobalt, nickel, zirconium, niobium, molybdenum, ruthenium, rhodium, palladium, hafnium, tantalum, tungsten, osmium, iridium, and platinum; and 1 at % to 90 at % of cerium. The three elements may account for at least 50 at % of the amorphous thin metal film.Type: GrantFiled: June 24, 2016Date of Patent: March 22, 2022Assignees: Hewlett-Packard Development Company, L.P., Oregon State UniversityInventors: James Elmer Abbott, Jr., John M McGlone, Kristopher Olsen, Douglas A Keszler, John Wager, Roberto A Pugliese, William F Stickle, Greg Scott Long
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Patent number: 11279626Abstract: Provided is a method of extracting a metal ion, which comprises contacting a compound of formula (R2SiO)n with a source of the metal ion, whereby the compound and the metal ion form a complex, wherein each R is independently C1-10alkyl, and n is 3-10.Type: GrantFiled: June 11, 2019Date of Patent: March 22, 2022Assignee: Board of Trustees of the California State UniversityInventors: Robert E. Pellenbarg, Kimberley R. Cousins
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Patent number: 11276208Abstract: An exemplary system, method, and computer-accessible medium for generating computed tomography (“CT”) image(s) of a subject(s) can be provided which can include receiving low dose CT imaging information for the subject(s), where the low dose CT imaging information can be based on a radiation dose of less than about 50 mAs, receiving a priori CT image data, and generating the CT image(s) based on the low dose CT imaging information and the a priori CT image data. A further CT images(s) can be generated based on the CT image(s) and the a priori CT image data. The a priori CT image data can include a set of Markov Random Field (MRF) coefficients derived from high dose or full dose CT image data.Type: GrantFiled: June 12, 2018Date of Patent: March 15, 2022Assignee: The Research Foundation for the State University of New YorkInventors: Jerome Zhengrong Liang, Yongfeng Gao, Yuxiang Xing, Hongbing Lu
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Patent number: 11274088Abstract: Disclosed herein is a method for making oleofuran compounds according to formula 3 from a furan aldehyde or ketone and a fatty alcohol. The method comprises combining the furan compound and the fatty alcohol in the presence of a first catalyst to form an intermediate compound, and exposing the intermediate compound to hydrogen in the presence of a second catalyst to form the oleofuran compound. The hydrogen may be either hydrogen gas or hydrogen provided by a hydrogen donor.Type: GrantFiled: March 23, 2021Date of Patent: March 15, 2022Assignee: Oregon State UniversityInventors: Konstantinos Goulas, Nicholas L. Gadinas, Kyle B. Reem