Patents Assigned to State University
  • Microfluidic device and methods
    Patent number: 11213824
    Abstract: This disclosure provides devices and methods for the isolation of single cells or particles of interest from a solution comprising a plurality of cells or a solution composed of a homogenous population of particles. Specifically, the present disclosure is directed to microfluidic devices and methods for analyzing cells in a sample. More specifically, the present disclosure provides droplet microfluidic devices and methods for using the same to obtain (trap), encapsulate, and retrieve (isolate) single cells or particles from a sample with improved efficiency.
    Type: Grant
    Filed: March 29, 2018
    Date of Patent: January 4, 2022
    Assignee: The Research Foundation for The State University of New York
    Inventors: Eric Brouzes, Martin Sauzade
  • Antibacterial and protective bacteriophage formulations and methods for making and using them
    Patent number: 11214773
    Abstract: In alternative embodiments, provided are compositions comprising chemically or structurally modified bacteriophages of the genus Caudovirales having an exterior or outer surface comprising at least one heterologous carbohydrate binding domain (CBD) comprising a lectin or a plurality of additional homologous CBDs, or more CBDs than found on a comparable wild type (WT) bacteriophage.
    Type: Grant
    Filed: September 20, 2016
    Date of Patent: January 4, 2022
    Assignee: San Diego State University (SDSU) Foundation
    Inventors: Forest Rohwer, Jeremy J. Barr
  • CELL PENETRATING PEPTIDES THAT INHIBIT IRF5 NUCLEAR LOCALIZATION
    Publication number: 20210403520
    Abstract: Inhibitors of interferon regulatory factor 5 (IRF5) nuclear localization and methods of using the inhibitors to treat autoimmune diseases such as systemic lupus erythematosus (SLE) are described.
    Type: Application
    Filed: September 13, 2021
    Publication date: December 30, 2021
    Applicant: Rutgers, The State University of New Jersey
    Inventor: Betsy J. Barnes
  • PEROVSKITES FOR PHOTOCATALYTIC ORGANIC SYNTHESIS
    Publication number: 20210402380
    Abstract: Nature is capable of storing solar energy in chemical bonds via photosynthesis through a series of C—C, C—O and C—N bond-forming reactions starting from CO2 and light. Direct capture of solar energy for organic synthesis is a promising approach. Lead (Pb)-halide perovskite solar cells reach 24.2% power conversion efficiency, rendering perovskite a unique type material for solar energy capture. We show that photophysical properties of perovskites is useful in photoredox organic synthesis. Because the key aspects of these two applications are both relying on charge separation and transfer. Here we demonstrated that perovskites nanocrystals are exceptional candidates as photocatalysts for fundamental organic reactions, i.e. C—C, C—N and C—O bond-formations. Stability of CsPbBr3 in organic solvents and ease-of-tuning their bandedges garner perovskite a wider scope of organic substrate activations.
    Type: Application
    Filed: June 17, 2021
    Publication date: December 30, 2021
    Applicant: San Diego State University Foundation
    Inventor: Yong YAN
  • NANO-GRAPHITIC SPONGES AND METHODS FOR FABRICATING THE SAME
    Publication number: 20210403326
    Abstract: This disclosure provides a nano-graphitic sponge (NGS) and methods for preparing the nano-graphitic sponge. The disclosed nano-graphitic sponge possesses many excellent properties, including large surface areas and pore volumes, low-mass densities, good electrical conductivities and mechanical properties. These excellent properties make the nano-graphitic sponge an ideal material for many applications, such as electrodes for batteries and supercapacitors, fuel cells and solar cells, catalysts and catalyst supports, and sensors.
    Type: Application
    Filed: October 15, 2019
    Publication date: December 30, 2021
    Applicant: Rutgers, The State University of New Jersey
    Inventors: Thomas J. Nosker, Bernard H. Kear, Nofel Z. Whieb, Jennifer K. Lynch-Branzoi, Arya S. Tewatia
  • Resurrection Of Antibiotics That MRSA Resists By Silver-Doped Bioactive Glass-Ceramic Particles
    Publication number: 20210402062
    Abstract: A bioactive scaffold is provided. The bioactive scaffold includes an interconnected web of struts composed of a glass-ceramic material, the web of struts being printed as a three-dimensional structure from a filament composition having a bimodal distribution of glass-ceramic microparticles, wherein the bioactive scaffold has a porosity defined by spaces between struts of greater than or equal to about 40% to less than or equal to about 80% and an average pore size of greater than or equal to about 200 ?m to less than or equal to about 400 ?m. Methods of making the bioactive scaffold and treating bone defects using the bioactive scaffolds are also provided.
    Type: Application
    Filed: July 7, 2021
    Publication date: December 30, 2021
    Applicant: Board of Trustees of Michigan State University
    Inventors: Xanthippi CHATZISTAVROU, Neal D. HAMMER, Aljoscha ROCH
  • ELECTRONIC DEVICES AND RELATED METHODS
    Publication number: 20210405217
    Abstract: Some embodiments include an electronic device. The electronic device includes a first scintillator layer, a transistor, and one or more device elements over the transistor, and the one or more device elements include a photodetector. Meanwhile, the first scintillator layer is monolithically integrated with at least one of the transistor or the one or more device elements. Other embodiments of related systems, devices, and methods are also disclosed.
    Type: Application
    Filed: April 19, 2021
    Publication date: December 30, 2021
    Applicant: Arizona Board of Regents on behalf of Arizona State University
    Inventors: Xan Henderson, Michael Marrs
  • USE OF IMMORTALIZED PLACENTAL STEM CELLS IPSC/EXTRACELLULAR VESICLES TO ENHANCE THERAPEUTIC RECOVERY FROM TISSUE DAMAGE AND ISCHEMIA-REPERFUSION INJURY AND DELAYED ORGAN FUNCTION
    Publication number: 20210401898
    Abstract: Therapeutics and methods for treating a stroke in a human comprising administering a therapeutic to the patient, wherein the therapeutic comprises one of immortalized human placenta mesenchymal stem cells (hPMSCs) and a product from the immortalized hPMSCs. Methods and therapeutic products comprising extracellular vesicles (EVs) isolated from of immortalized hPMSCs. Therapeutics and methods of treating COVID-19 disease vascular injury comprising administering a therapeutic to the patient, wherein the therapeutic comprises one of hPMSCs and a product from the hPMSCs.
    Type: Application
    Filed: April 12, 2021
    Publication date: December 30, 2021
    Applicant: Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
    Inventors: Johnathan Steven ALEXANDER, Mansoureh BARZEGAR, Yuping WANG, Anthony Wayne ORR, Mabruka ALFAIDI
  • Microbial syringol utilization
    Patent number: 11208642
    Abstract: Disclosed herein are compositions of non-naturally occurring enzymes to enable microbial syringol utilization with GcoAB.
    Type: Grant
    Filed: November 14, 2019
    Date of Patent: December 28, 2021
    Assignees: Alliance for Sustainable Energy, LLC, Montana State University, University of Portsmouth
    Inventors: Gregg Tyler Beckham, Jennifer DuBois, Melodie M. Machovina, Simon James Bradshaw Mallinson, John E. McGeehan, Christopher W. Johnson, Alexander William Meyers
  • Modulating human Cas9-specific host immune response
    Patent number: 11208640
    Abstract: Provided herein are methods and compositions for reducing an undesirable T cell immune response in human patients prior to and/or during gene therapy using CRISPR/Cas9-based genetic modulation.
    Type: Grant
    Filed: April 27, 2018
    Date of Patent: December 28, 2021
    Assignee: Arizona Board of Regents on behalf of Arizona State University
    Inventors: Radwa Ewaisha, Samira Kiani, Shayesteh Roshdi Ferdosi, Karen Anderson, Farzaneh Moghadam, Sri Krishna, Mo Reza Ebrahimkhani
  • Amylase-degraded organic acid anhydride substituted starches and methods of preparing the same
    Patent number: 11208499
    Abstract: Water soluble, lipophilic starches are provided, which comprise a mixture of functionalized high and low molecular weight maltodextrin molecules. The starches may be formed by dispersing a granular starch in a liquid medium to form a slurry that is simultaneously cooked and subjected to enzyme hydrolysis. Following hydrolysis, the starch is functionalized with an organic acid anhydride reagent, such as octenylsuccinic anhydride. The organic acid anhydride substitution occurs randomly and at various locations within the maltodextrin molecules.
    Type: Grant
    Filed: December 27, 2019
    Date of Patent: December 28, 2021
    Assignee: Kansas State University Research Foundation
    Inventors: Yong-Cheng Shi, Yanjie Bai, Zhenhua Sun
  • Central executive training platform
    Patent number: 11210967
    Abstract: Various embodiments are directed to a central executive training (CET) platform that targets central executive processes, rather than short term memory. Central executive deficits have been linked experimentally and developmentally with Attention Deficit Hyperactivity Disorder (ADHD) symptoms and impairments. Unfortunately, substantial evidence indicates that conventional working memory training programs fail to improve these symptoms and impairments. This discrepancy may reflect insufficient targeting, as extant protocols focus on short term memory and do not adequately engage the specific central executive components linked with the disorder's behavioral and functional impairments.
    Type: Grant
    Filed: March 28, 2018
    Date of Patent: December 28, 2021
    Assignee: Florida State University Research Foundation, INC.
    Inventor: Michael J. Kofler
  • Nanostructures comprising cobalt porphyrin-phospholipid conjugates and polyhistidine-tags
    Patent number: 11207421
    Abstract: The present disclosure provides nanostructures (e.g., monolayer or bilayer nanostructures) comprising porphyrins with cobalt chelated thereto such that the cobalt metal resides within monolayer or bilayer in the porphyrin macrocycle. The nanostructures can have presentation molecules comprising epitopes from microorganisms with a histidine tag attached thereto, such that at least a part of the his-tag is within the monolayer or bilayer and coordinated to the cobalt metal core and the presentation molecules are exposed to the outside of the nanostructures. The nanostructures can further comprise a cargo. The nanostructures can be used to deliver the cargo to an individual.
    Type: Grant
    Filed: April 30, 2019
    Date of Patent: December 28, 2021
    Assignees: The Research Foundation for The State University of New York, PATH
    Inventors: Jonathan Lovell, Shuai Shao, Jumin Geng, Wei-Chiao Huang, Shwu-Maan Lee, Charles Richter King
  • Model-driven technique for virtual network function rehoming for service chains
    Patent number: 11212173
    Abstract: A system that determines whether a trigger has occurred within a cloud infrastructure. The system, in response to determining that a trigger has occurred, extracts characteristics from one or more virtual network functions (VNFs) of a service chain. The system, in response to extracting characteristics from the one or more VNFs, determines rehoming actions for each of the one or more VNFs. The system, in response to determining rehoming actions, predicts a rehoming delay or a chain downtime for each of the rehoming actions for each of the one or more VNFs. The system determines an optimal rehoming action from the rehoming actions for at least one of the one or more VNFs using the rehoming delay or the chain downtime for each rehoming action of the rehoming actions. The system performs the optimal rehoming action for the at least one of one or more VNFs.
    Type: Grant
    Filed: December 12, 2019
    Date of Patent: December 28, 2021
    Assignees: AT&T Intellectual Property I, L.P., The Research Foundation for the State University of New York
    Inventors: Shankaranarayanan Puzhavakath Narayanan, Bharath Balasubramanian, Gueyoung Jung, Muhammad Wajahat, Anshul Gandhi
  • Emetine compounds for treatment and prevention of flavivirus infection
    Patent number: 11207315
    Abstract: The present invention concerns the use of emetine compounds for the treatment or prevention of Flavivirus infections, such as dengue virus infections. Aspects of the invention include methods for treating or preventing Flavivirus virus infection, such as dengue virus infection, by administering an emetine compound such as emetine or cephaeline, or a combination of two or more emetine compounds, to a subject in need thereof; methods for inhibiting Flavivirus infections such as dengue virus infections in a cell in vitro or in vivo; pharmaceutical compositions; packaged dosage formulations; and kits for treating or preventing Flavivirus infections, such dengue virus infections.
    Type: Grant
    Filed: December 18, 2019
    Date of Patent: December 28, 2021
    Assignees: Florida State University Research Foundation, Inc., The Johns Hopkins University, The United States of America, as Represented by the Secretary, Department of Health and Human Services
    Inventors: Hengli Tang, Emily M. Lee, Anil Mathew Tharappel, Hongjun Song, Guo-Li Ming, Wei Zheng, Miao Xu, Shu Yang, Ruili Huang, Wenwei Huang, Khalida Shamim, Hao Li
  • High throughput oil-emulsion synthesis of bowtie barcodes for paired mRNA capture and sequencing from individual cells
    Patent number: 11208681
    Abstract: Methods for incorporation of unique bowtie-barcodes into a nucleic acid origami nanostructure (FIG. 1). In particular, provided herein are methods that facilitate pairing and analysis of nucleic acids from individual cells using, for example, high-throughput next-generation sequencing.
    Type: Grant
    Filed: August 14, 2017
    Date of Patent: December 28, 2021
    Assignee: Arizona Board of Regents on behalf of Arizona State University
    Inventors: Joseph Blattman, Louis Schoettle
  • Membrane device for blood separation and methods of making and using the same
    Patent number: 11207455
    Abstract: Disclosed herein are membrane device embodiments that can be used for separating blood plasma and/or blood serum from blood samples. The membrane device embodiments comprise built-in features that facilitate blood plasma and/or blood serum separation and also provide the ability to detect, quantify, and qualify analytes present in a blood sample. The membrane device embodiments are portable and just a single membrane can be used for a plethora of detection and analysis techniques. Also disclosed herein are embodiments of methods for making and using the membrane device.
    Type: Grant
    Filed: March 4, 2020
    Date of Patent: December 28, 2021
    Assignee: Oregon State University
    Inventors: Vincent T. Remcho, Gayan C. Bandara, Linus Jacob Unitan, Matthew H. Kremer
  • Application of electrical stimulation via nanoelectrodes to modulate stem cells
    Patent number: 11208647
    Abstract: The presently disclosed subject matter relates generally to the delivery of electrical stimuli via cell-penetrating nanoelectrodes. Such electrical stimuli leads to differentiation of cells, including but not limited to adipose derived stem cells, to neural lineage, specifically to neural cells.
    Type: Grant
    Filed: May 28, 2019
    Date of Patent: December 28, 2021
    Assignee: North Carolina Agricultural and Technical State University
    Inventors: Shyam Aravamudhan, Komal Garde
  • Preparation of metal chalcogenides
    Patent number: 11208334
    Abstract: A method embodiment involves preparing single metal or mixed transition metal chalcogenide using exfoliation of two or more different bulk transition metal dichalcogenides in a manner to form an intermediate hetero-layered transition metal chalcogenide structure, which can be treated to provide a single-phase transition metal chalcogenide.
    Type: Grant
    Filed: July 26, 2018
    Date of Patent: December 28, 2021
    Assignee: Iowa State University Research Foundation, Inc.
    Inventors: Viktor Balema, Ihor Hlova, Vitalij K. Pecharsky
  • SYSTEMS AND METHODS FOR DIFFERENTIABLE PROGRAMMING FOR HYPERSPECTRAL UNMIXING
    Publication number: 20210396580
    Abstract: Various embodiments of a system for linear unmixing of spectral images using a dispersion model are disclosed herein.
    Type: Application
    Filed: June 21, 2021
    Publication date: December 23, 2021
    Applicants: Arizona Board of Regents on Behalf of Arizona State University, Arizona Board Of Regents For And On Behalf Of Northern Arizona University
    Inventors: John Janiczek, Suren Jayasuriya, Gautam Dasarathy, Christopher Edwards, Philip Christensen