Abstract: Processes and systems for non-destructively storing, accessing, and editing information using nucleic acids are disclosed. Representative processes include a process for extracting a data file from a database, wherein the data file comprises information encoded into one or more polynucleotide strands and wherein the database comprises a plurality of polynucleotide strands; a process for expanding a number of unique data files in a database that can be addressed with a predetermined number of oligonucleotide primers, wherein the unique data files each comprise information encoded into one or more polynucleotide strands and wherein the database comprises a plurality of polynucleotide strands; a process for differentially reading information encoded into one or more polynucleotide strands; a process for manipulating files while in storage; and a process for extracting a data file from a database, wherein the data file comprises information encoded into a polynucleotide strand.
Type:
Application
Filed:
August 30, 2019
Publication date:
January 27, 2022
Applicant:
North Carolina State University
Inventors:
Albert Jun Qi Keung, James M. Tuck, III, Kevin Volkel, Kyle Tomek, Kevin Lin
Abstract: The disclosure provides for compositions and methods for the preservation of meat substitutes containing plant heme protein. In particular, small molecules that can fit in the unique heme pocket of plant heme proteins are provided to stabilize and preserve meat substitutes the products.
Type:
Application
Filed:
October 6, 2021
Publication date:
January 27, 2022
Applicants:
Wisconsin Alumni Research Foundation, Iowa State University Research Foundation, Inc.
Inventors:
Mark P. RICHARDS, Mark HARGROVE, Nantawat TATIYABORWORNTHAM, Jie YIN, Wenjing ZHANG
Abstract: Treatment systems, devices, articles, and associated methods of operation for treating open wounds are disclosed herein. In one embodiment, a method includes applying a first material and a second material to be in contact with a surface of the open wound having a water content at the surface and applying a voltage differential to the first and second materials, thereby producing hydrogen peroxide (H2O2) at the surface via an electrochemical reaction between oxygen (O2) in air and water (H2O) in the water content at the surface. The voltage differential is calibrated to correspond to a concentration of the produced hydrogen peroxide in the water content effective in reducing or preventing a bacterial infection at the surface of the open wound.
Abstract: The present disclosure provides a biosignature that distinguishes Lyme disease, including early Lyme disease, from STARI. The present disclosure also provides methods for detecting Lyme disease and STARI, as well as methods for treating subjects diagnosed with Lyme disease or STARI.
Type:
Grant
Filed:
December 4, 2019
Date of Patent:
January 25, 2022
Assignees:
Colorado State University Research Foundation, The United States of America, as represented by the Secretary, Department of Health and Human Services
Inventors:
John T. Belisle, Claudia R. Molins, Gary P. Wormser
Abstract: Disclosed are examples for printing a one-dimensional (1D) nanomaterial for use in stretchable electronic devices. An ink comprising a nanomaterial solution is dispersed from a pneumatic dispensing system of a printing device. The 1D nanomaterial is printed in a predefined pattern on an underlying substrate positioned on a ground electrode. A voltage is applied between the printing nozzle and the ground electrode to cause the ink to form into a cone during the printing. The substrate can be modified to increase the wettability of the substrate to enhance adhesion of the ink to the substrate.
Type:
Grant
Filed:
February 18, 2020
Date of Patent:
January 25, 2022
Assignee:
North Carolina State University
Inventors:
Yong Zhu, Jingyan Dong, Zheng Cui, Yiwei Han
Abstract: The present invention provides vaccines for treating or preventing a herpes simplex virus infection and methods of using and making the vaccine. Further provided are recombinant herpes simplex virus genomes, recombinant viruses, and immunogenic compositions.
Type:
Grant
Filed:
February 7, 2020
Date of Patent:
January 25, 2022
Assignee:
Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
Abstract: A pressure sensitive adhesive construct comprising: (A) a backing substrate; and (B) a pressure sensitive adhesive composition disposed on the backing substrate, wherein the pressure sensitive adhesive composition includes an ultraviolet radiation-cured polymer made from: (a) at least one epoxidized plant oil, at least one epoxidized animal fat, or a mixture thereof; (b) at least one dicarboxylic acid, at least one polycarboxylic acid, or a mixture thereof; and (c) at least one compound that contains both one carbon-carbon double bond (C?C) and at least one carboxylic acid group.
Abstract: Disclosed herein are libraries of reporter nucleic acids for functional regulatory elements as well as methods and kits for constructing and using such libraries. Exemplary libraries, methods, and kits can be used for high-throughput detection, identification, and/or quantitation of functional regulatory elements.
Type:
Application
Filed:
October 30, 2019
Publication date:
January 20, 2022
Applicant:
Rutgers, The State University of New Jersey
Abstract: The orthogonal space random walk (OSRW) algorithm is generalized to be the orthogonal space tempering (OST) method via the introduction of the orthogonal space sampling temperature. Moreover, a double-integration recursion method is developed to enable practically efficient and robust OST free energy calculations, and the algorithm is augmented by a novel ?-dynamics approach to realize both the uniform sampling of order parameter spaces and rigorous end point constraints. In the present work, the double-integration OST method is employed to perform alchemical free energy simulations, specifically to calculate the free energy difference between benzyl phosphonate and difluorobenzyl phosphonate in aqueous solution, to estimate the solvation free energy of the octanol molecule, and to predict the nontrivial Barnase-Barstar binding affinity change induced by the Barnase N58A mutation.
Type:
Grant
Filed:
May 16, 2018
Date of Patent:
January 18, 2022
Assignee:
The Florida State University Research Foundation, Inc.
Abstract: The disclosed methods are utilized for recovering a high percent of platinum group metals from spent catalytic converters. The methods use an aqua regia bath and ultrasonic agitation to liberate the metals from the carrier material of the washcoat, while leaving the metal supporting structure largely intact.
Type:
Grant
Filed:
March 14, 2019
Date of Patent:
January 18, 2022
Assignee:
The Board of Regents for Oklahoma State University
Abstract: Glycosaminoglycans, particularly hyaluronic acid, are extracted from alligator carcasses, feet, backstraps, and eyeballs. The alligator-derived glycosaminoglycans can be used in treatments for cystic fibrosis (CF), in treating other inflammatory conditions, and for other purposes.
Type:
Grant
Filed:
July 10, 2019
Date of Patent:
January 18, 2022
Assignee:
Board of Supervisors of Louisiana State University and Agricultural and Mechnical College
Inventors:
Jack N. Losso, Jose Daniel Estrada Andino
Abstract: Pennycress seed, seed lots, and seed meal having reduced fiber content and improved suitability for use in producing animal feed are provided.
Type:
Grant
Filed:
June 5, 2020
Date of Patent:
January 18, 2022
Assignees:
Covercress Inc., Board of Trustees of Illinois State University, Regents of the University of Minnesota
Inventors:
Tim Ulmasov, Cristine Handel, Gary Hartnell, John C. Sedbrook, Michael David Marks, Ratan Chopra, Maliheh Esfahanian
Abstract: A microfluidic solenoid point of use device for discrete quantitation of magnetized cells. The inventive device provides higher accuracy, lower cost, and less bulk than other counting devices.
Type:
Grant
Filed:
November 8, 2017
Date of Patent:
January 18, 2022
Assignee:
Kennesaw State University Research and Service Foundation, Inc.
Abstract: An optoelectronic light source includes a semiconductor laser configured to produce polarized primary radiation, a converter material configured to absorb at least part of the primary radiation and convert the primary radiation into a secondary radiation of an increased wavelength, a planar multi-layered mirror located between the semiconductor laser and the converter material, the multi-layered mirror configured to transmit the primary radiation and reflect the secondary radiation, and an optical element provided between the semiconductor laser and the multi-layered mirror, wherein the optical element is configured such that the primary radiation coming from the semiconductor laser impinges on the multi-layered mirror at a Brewster angle.
Type:
Grant
Filed:
August 13, 2020
Date of Patent:
January 18, 2022
Assignees:
OSRAM Opto Semiconductors GmbH, The Research Foundation for State University of New York
Abstract: Embodiments described herein are directed to wireless power transfer systems, which can include a vertical pair of an inner and an outer coupling capacitors. According to certain embodiments, one plate from each of the outer coupling capacitor at least in part overlaps one plate of the inner coupling capacitor on a primary side and another plate from the outer coupling capacitor at least partially overlaps another plate of the inner coupling capacitor on a secondary side. Each plate of the outer coupling capacitor has a larger area than each plate of the inner coupling capacitor. Further, a power transfer unit is included and configured to transfer power capacitively through the vertical pair of coupling capacitors, where the power transfer unit can include first and second inductors coupled to each plate of the outer coupling capacitor, respectively.
Type:
Grant
Filed:
March 22, 2017
Date of Patent:
January 18, 2022
Assignee:
San Diego State University Research Foundation
Abstract: Provided are compositions and methods for determining an imprinting status of a gene subject to parent-of-origin, monoalleleic expression in a subject, and for using the information derived therefrom to detect a presence of and/or a susceptibility to a medical condition associated with monoallelic expression in a subject, predict a susceptibility to future development of a medical condition prior to the onset of any symptoms, monitor the development of such a medical condition and/or the effectiveness of a treatment, and for treating such a medical condition. In some embodiments, a composition for use in the disclosed methods is nucleic acid array, which in some embodiments can include one or more interrogatable nucleotide molecules, wherein the interrogatable nucleotide molecules are designed to allow identification of the DNA methylation status of one or more imprint control regions (ICRs) that regulate one or more genes subject to monoalleleic expression in subjects.
Type:
Application
Filed:
July 9, 2021
Publication date:
January 13, 2022
Applicant:
North Carolina State University
Inventors:
Cathrine Hoyo, David Skaar, Dereje Jima, Randy L. Jirtle
Abstract: The present invention provides a longitudinally split immature tiller separated from a rhizome (LSITR), a cluster of multiple in vitro shoots (CMIT), a cluster of stem segments containing shoot primordia (CSSSP) and an in vitro tiller of Miscanthus x giganteus (Giant Miscanthus), and their uses in propagating Miscanthus x giganteus (Giant Miscanthus).
Type:
Application
Filed:
September 23, 2021
Publication date:
January 13, 2022
Applicant:
Delaware State University
Inventors:
Bertrand B. Hankoua, Ayalew Ligaba Osena
Abstract: A new and distinct cultivar of Viburnum plant named ‘NCVP1’ with a compact habit, and white flowers in spring that rebloom in summer. ‘NCVP1’ is a new cultivar of doublefile Viburnum, suitable for ornamental garden purposes.
Type:
Grant
Filed:
June 9, 2021
Date of Patent:
January 25, 2022
Assignee:
North Carolina State University
Inventors:
Thomas Green Ranney, Darren Touchell, Irene Palmer, Andra Nus, Nathan P. Lynch
Abstract: A new and distinct cultivar of Rhododendron plant named ‘NCRX5’ having a profusion of large, double white flowers with a yellow-green blotch, cold-hardiness in USDA Zone 6b, consistent reblooming in Fall, dense habit, and a tetraploid cytotype. The new cultivar is a Rhododendron, suitable for ornamental garden purposes.
Type:
Grant
Filed:
June 9, 2021
Date of Patent:
January 25, 2022
Assignee:
North Carolina State University
Inventors:
Thomas Green Ranney, Darren Touchell, Irene Palmer, Andra Nus, Nathan P. Lynch
Abstract: A new and distinct cultivar of Rhododendron plant named ‘NCRX8’ having prolific, bright cherry-red single flowers, cold hardy to USDA Zone 6b, consistent Fall reblooming, and a dense, compact habit. The new cultivar is a Rhododendron, suitable for ornamental garden purposes.
Type:
Grant
Filed:
June 9, 2021
Date of Patent:
February 1, 2022
Assignee:
North Carolina State University
Inventors:
Thomas Green Ranney, Darren Touchell, Irene Palmer, Andra Nus, Nathan P. Lynch