Abstract: Various embodiments of a framework for user authentication based on finger motion signal and hand geometry matching are disclosed herein.

Abstract: Aptamers having a G-quadruplex structure that bind specifically to the most commonly used azole-class antifungal drugs, biosensors that comprise those aptamers, and invitro methods for determining the level of one of those drugs utilizing those aptamers or biosensors.

Abstract: A protection system capable of safely quenching a high temperature superconductor (HTS) magnet coil. The protection circuit provides for a frequency loss induced quench design that advances the protection technology for HTS magnet coils and provides a protection system that is capable of quickly distributing the heat energy uniformly in all the coil sections when a localized hot-spot is created.

Abstract: A cluster of nodes, comprising: a plurality of nodes, each having a security policy, and being associated task processing resources; a registration agent configured to register a node and issue a node certificate to the respective node; a communication network configured to communicate certificates to authorize access to computing resources, in accordance with the respective security policy; and a processor configured to automatically dynamically partition the plurality of nodes into subnets, based on at least a distance function of at least one node characteristic, each subnet designating a communication node for communicating control information and task data with other communication nodes, and to communicate control information between each node within the subnet and the communication node of the other subnets.

Abstract: Tunable filters, cancellers, and duplexers based on passive mixers. A tunable delay cell includes passive mixers electrically coupled together for receiving an input signal and outputting a delayed signal, each passive mixer comprising a plurality of mixer switches. The tunable delay includes a control circuit for providing, to each passive mixer, a respective plurality of local oscillator (LO) signals, one to each mixer switch of each passive mixer. The control circuit is configured to vary the LO signals to cause a target frequency band of the input signal to be delayed by a target delay time in propagating through the passive mixers.

Abstract: Amino, amido, and heterocyclic compounds are disclosed. The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, diabetes complications, inflammation, and neurodegeneration, obesity, cancer, ischemia/reperfusion injury, cardiovascular disease and other diseases related to RAGE activity.

Abstract: Various examples are provided related to fault-tolerant controller architectures for multi-level converters. In one example, a multi-level converter includes an array of power modules. The power modules can include a controller communicatively coupled to controllers of adjacent power modules in the array of power modules. Circuitry of the controllers can receive operational data from the adjacent power modules; identify a fault condition in an adjacent power module using the operational data; and initiate reconfiguration of the array of power modules in response to an indication of the fault condition, where the reconfiguration bypasses the adjacent power module. In another example, a method includes identifying a fault condition in an adjacent power module in an array of power modules based upon operational data from one or more adjacent power modules of the array; and initiating reconfiguration of the array of power modules in response to an indication of the fault condition.

Abstract: The invention provides complexes of Zn2+ of formulae (la) and (IIa) that are useful for treating cancer, as well as compositions and kits comprising such complexes.

Abstract: Various embodiments disclosed herein relate to systems and methods for an intelligent autonomous decision making module that maximizes the return of the most scientifically relevant dataset over the low bandwidth for experts to analyze further. A rule based knowledge extraction methodology is disclosed, guided by expert knowledge for all scientifically relevant geological landforms with respect to expert selected attributes. The datasets are subsequently prioritized based on how novel the instances are with respect to its rule and is used to update the rules. The effectiveness of the proposed approach is then determined by evaluating how acceptable the prioritization order is to experts and explaining the decisions to increase the interpretability of the assigned priority.

Abstract: This disclosure is directed to the discovery of an improved method to diagnose malignant melanoma of the oral cavity in the dog.

Abstract: A novel technique for label-free, rapid detection of ultra-low concentrations of virus specific antibodies is described. We have developed a simple, robust capacitive biosensor using microwires coated with Zika or Chikungunya virus envelope antigen. With little discernable nonspecific binding, the sensor can detect as few as 10 antibody molecules in a small volume (10 molecules/30 ?L) within minutes. It can also be used to rapidly, specifically, and accurately determine the isotype of antigen-specific antibodies. Finally, we demonstrate that anti-Zika virus antibody can be sensitively and specifically detected in dilute mouse serum and can be isotyped using the sensor. Overall, our findings indicate that our microwire sensor platform can be used as a reliable, sensitive, and inexpensive diagnostic tool to detect immune responses at the point of care.

Abstract: A method and system for generating inverted electrical signals includes a first string of batteries connected in series, each battery having a half-bridge circuit connected in parallel and each having upper switch and lower switches. A first H-bridge circuit is connected in parallel with the first string of batteries, and a triangle wave generator generates a plurality of triangle wave signals at a given amplitude and carrier frequency. The plurality of triangle wave signals have individual triangle wave signals phase-shifted from one another. A modulation wave generator generates a modulation signal at a modulation amplitude and at twice a fundamental frequency that is less than the carrier frequency. A controller compares an instantaneous magnitude of the individual triangle wave signals to an instantaneous magnitude of the modulation signal, and outputs commands to the upper switch of a respective half-bridge circuit based on the comparison.

Abstract: The present invention provides efficient processes for preparing brush polymers. In general, the process comprises three distinct reaction steps utilizing two separate catalysts. In the first step, the initiating compound comprising norbornene is contacted with a silane in the presence of a catalyst, thereby forming a silated intermediate. This silated intermediate is then contacted with a monomer in the presence of a catalyst via Group Transfer Polymerization (GTP). The resulting compound from GTP is contacted with a ring opening metathesis polymerization (ROMP) catalyst to prepare the brush polymer. Surprisingly, the brush polymers obtained from the above process are accessed in an efficient and rapid GTP methodology as compared to prior methods.

Abstract: A sensor including a layer of amorphous selenium (a-Se) and at least one charge blocking layer is formed by depositing the charge blocking layer over a substrate prior to depositing the amorphous selenium, enabling the charge blocking layer to be formed at elevated temperatures. Such a process is not limited by the crystallization temperature of a-Se, resulting in the formation of an efficient charge blocking layer, which enables improved signal amplification of the resulting device. The sensor can be fabricated by forming first and second amorphous selenium layers over separate substrates, and then fusing the a-Se layers at a relatively low temperature.

Abstract: The disclosure relates to PRMT5 inhibitors, including optionally substituted N-alkyl-9H-carbazole analogs, derivatives thereof, and related compounds; synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating disorders of uncontrolled cellular proliferation and benign hematologic diseases using the compounds and compositions.

Abstract: The present invention provides methods for mineral precipitation of porous particulate starting materials using isolated urease.

Abstract: Disclosed are yeast-based immunotherapeutic compositions and fusion proteins for the treatment and/or prevention of TB infection and symptoms thereof, as well as methods of using the yeast-based immunotherapeutic compositions and fusion proteins for the prophylactic and/or therapeutic treatment of TB and/or symptoms thereof.

Abstract: Provided herein are systems and devices capable of detecting an event, such as the fall of a human. The devices may include a motion sensor, a heat sensor, and a vibration sensor. The devices and systems also may include an alarm and/or communication device configured to function when the event occurs.

Abstract: System, method, and accelerator to process a convolutional neural network. In accordance therewith, a tile structure having input data values is loaded for a convolution layer. Each tile of the tile structure corresponds to a respective feature map in a set of input feature maps. The tile structure of each iteration represents a different subset of data values in the input feature maps. Intermediate data values associated with a subset of the data values of the input feature maps in the current intermediate tile structure are reused, when the intermediate data values of a previous tile structure overlap values to be computed in the current tile structure. Intermediate non-overlapping data values that are associated with the subset of the data values in the current tile structure are computed using associated filters having weight data values. Available reused intermediate data values and computed intermediate data values are buffered as intermediate data.

Abstract: Proteins that are differentially expressed or elevated in tissue and biofluids after central nervous system injuries are described. Elevated or reduced levels of the proteins, alone or in various combinations or ratios, can be used to assess severity of central nervous system injury (CNS injury) including traumatic brain injury (TBI), traumatic spinal cord injury (SCI) and chronic traumatic encephalopathy (CTE). Time course measurements post CNS-injury of these proteins can be used to monitor progress or recovery over periods up to several months. Differentiation of acute, subacute and chronic injury can be diagnosed by comparing the protein levels in CNS-injury patients at days 1-3, day 4-10 with levels at day 30-180 in comparison with normal controls.