Abstract: A system and method for preparing a crystal delivery medium comprising agarose for serial femtosecond crystallography and uses thereof.

Abstract: Disclosed herein are inhibitors of PU.1. The inhibitors are useful for treating disorders associated with abnormal PU.1 levels and function.

Abstract: Treatments and diagnostics for treatment efficacy against solid and liquid cancers are described. The treatments utilize a combination therapy of Galeterone and a proteasome inhibitor. The diagnostics can measure androgen receptor (AR) cleavage products including AR-variant 7 (AR-V7) cleavage products, Poly (ADP-ribose) polymerase (PARP) cleavage products, and/or Spectrin ?2 cleavage products or inhibition of DUB activities from a blood sample to monitor treatment efficacy for castration-resistant prostate cancer (CRPC) or multiple myeloma (MM).

Abstract: The present invention generally relates to carbon monoxide releasing compounds and compositions, and their use as carbon monoxide prodrugs.

Abstract: Provided are antisense oligomers targeted against bacterial mRNAs and other macromolecules associated with a biochemical pathway and/or cellular process, and related compositions and methods of using the oligomers and compositions to treat an infected mammalian subject, for example, as primary antimicrobials or as adjunctive therapies with classic antimicrobials.

Abstract: Methods of detecting immunogenic endogenous retroviruses and treating cancer are disclosed herein. In some embodiments, the methods include detecting increased expression of endogenous retroviruses in a tumor sample.

Abstract: A system for fluidizing particles includes a fluidization reactor having a base, a gas injection surface positioned at the base configured to inject a first gas into the fluidization reactor, and a gas outlet, a secondary gas injector comprising a nozzle, positioned in the fluidization reactor and configured to deliver a secondary flow of a second gas into the fluidization reactor, a vibration inducing device rigidly attached to the fluidization reactor and configured to induce a vibrational acceleration on the fluidization reactor, and a vibration isolating device rigidly attached to the fluidization reactor and a mounting surface, configured to isolate vibrational forces from the vibration inducing device from the mounting surface. A method of fluidizing particles is also described.

Abstract: A white organic light emitting diode (OLED) having a substrate, a first electrode, a hole transporting layer proximate the first electrode, a second electrode, an electron transporting layer proximate the second electrode, an emissive layer between the hole transporting layer and the electron transporting layer, and a red-shifting layer optically coupled to the emissive layer. The red-shifting layer includes a red-shifting down-conversion emitter, and can be a scattering layer between the first electrode and the substrate, an C extraction layer optically coupled to the white OLED, or a microlens layer optically coupled to the white OLED.

Abstract: A new solvent-based method is presented for making low-cost composite graphite electrodes containing a thermoplastic binder. The electrodes, termed thermoplastic electrodes (TPEs), are easy to fabricate and pattern, give excellent electrochemical performance, and have high conductivity (1500 S m?1). The thermoplastic binder enables the electrodes to be hot embossed, molded, templated, and/or cut with a CO2 laser into a variety of intricate patterns. These electrodes show a marked improvement in peak current, peak separation, and resistance to charge transfer over traditional carbon electrodes. The impact of electrode composition, surface treatment (sanding, polishing, plasma treatment), and graphite source were found to impact fabrication, patterning, conductivity, and electrochemical performance. Under optimized conditions, electrodes generated responses similar to more expensive and difficult to fabricate graphene and highly oriented pyrolytic graphite electrodes.

Abstract: The present disclosure relates to synthetic oncolytic viruses comprising a lipid nanoparticle comprising one or more types of lipid and a self-amplifying replicon RNA comprising a sequence that encodes an immunomodulatory molecule.

Abstract: Disclosed herein are antibacterial compounds, pharmaceutical compositions including the antibacterial compounds, and methods of treating bacterial infections using the compounds and compositions.

Abstract: Various embodiments of an infrastructure modeling system that simulates vulnerability of critical interdependent infrastructures are disclosed herein.

Abstract: A magnetizable concrete wireless power transfer pad can include a base, an inductive coil and a pillar. The base can comprise a magnetizable base concrete including concrete and first magnetizable particles, the first magnetizable particles having a magnetic permeability and a magnetic saturation. The inductive coil can be positioned directly adjacent and centered over the base, the inductive coil forming an inductive coil gap at its center inner perimeter between a conductive wire that form the inductive coil, the inductive coil having an outer perimeter, a lateral width, and a longitudinal length.

Abstract: Human pluripotent stem cells (hPSCs) are promising cell source to produce therapeutic endocrine cells for diabetes treatment. A gel solution made by decellularized tissue-specific extracellular matrix (dpECM) significantly promotes three-dimensional (3D) islet-like organogenesis during induced hPSC differentiation into endocrine lineages. Islet organoids are self-organized even in a two-dimensional (2D) culture mode. Cells derived from hPSCs differentiated on such ECM coated substrates exhibit similar cellular composition to native pancreatic islets. These cells express islet signature markers insulin, PDX-1, C-peptide, MafA, glucagon, somatostatin, and pancreatic polypeptide, and secrete more insulin in response to glucose level compared to a traditional matrix substrate (Matrigel). The dpECM facilitates generating more C-peptide+/glucagon? cells rather than C-peptide+/glucagon+ cells. Remarkably, dpECM also facilitated intra-organoid vascularity by generating endothelial cells and pericytes.

Abstract: A power supply includes an active bridge section with input terminals that receive power from a constant current source where the active bridge section operates at a fixed switching frequency. The power supply includes a resonant section with a resonant inductor and a resonant capacitor. The resonant section is connected to an output of the active bridge section. The power supply includes an output rectifier that receives power from the resonant section and includes output terminals for connection to a load and a controller that regulates output current to the load where the controller regulates output current to the load by controlling switching of the active bridge section. The fixed switching frequency of the active bridge section matches a resonant frequency of the resonant section.

Abstract: Methods of and systems for adaptive cruise control (ACC) of a vehicle include a controller for the vehicle that is configured to execute a computer-implemented model predictive control and a safe spacing policy that reduces collision risk between the vehicle and both a leading vehicle and a following vehicle. The methods include sensing a speed of a leader vehicle in front of the ego vehicle and a distance of the leader vehicle from the ego vehicle, sensing a speed of a follower vehicle behind the ego vehicle and a distance of the follower vehicle from the ego vehicle, and controlling the speed of the ego vehicle to avoid collision with the leader vehicle while reducing risk of the ego vehicle being hit by the follower vehicle.

Abstract: A method for gas atomization of oxygen-reactive reactive metals and alloys wherein the atomized particles are exposed as they solidify and cool in a very short time to multiple gaseous reactive agents for the in-situ formation of a protective reaction film on the atomized particles. The present invention is especially useful for making highly pyrophoric reactive metal or alloy atomized powders, such as atomized magnesium and magnesium alloy powders. The gaseous reactive species (agents) are introduced into the atomization spray chamber at locations downstream of a gas atomizing nozzle as determined by the desired powder or particle temperature for the reactions and the desired thickness of the reaction film.

Abstract: Electrolytes for use in electric double-layer capacitors (EDLCs; often referred as supercapacitors or ultracapacitors) are disclosed. In one example, the electrolyte comprises viologen in both the anolyte and the catholyte (with bromide). In another example, the electrolyte comprises viologen (in the anolyte) and tetraalkylammonium with bromide (in the catholyte), wherein the tetraalkylammonium is used to achieve solid complexation of bromine in the activated carbon of the cathode. In a third example, a zinc bromine/tetraalkylammonium supercapacitor/battery hybrid is disclosed. Also disclosed is a corrosion resistant bipolar pouch cell that can be used with the electrolyte embodiments described herein.

Abstract: Systems and methods for self-cleaning a surface of an object where an electrodynamic shield is mounted to a surface of the object. The electrodynamic shield includes one or more sets of electrodes atop a substrate, at least one or more sets of electrodes being covered in a protective film. A coating is applied to the top surface of the protection film. A signal pulse generator is connected to the one or more sets of electrodes. The signal pulse generator generates a pulse signal that causes the one or more sets of electrodes to generate an electric field. The pulse signal comprises a plurality of different pulse signals which have phase differences between consecutive signals, and the electric field causes a particle atop the coating to experience an electrostatic force and be repelled away from the coating. These pulse signals (including shapes, amplitudes, shifts, and frequencies) can be tuned to increase efficiency of removal depending on dust type and relative humidity.

Abstract: An apparatus for measuring normal and shear stress at a surface. The apparatus includes a substrate; and a plurality of sensing units on the substrate. Each sensing unit includes a mechanical transducer having a receiving surface and a sensing surface; and a plurality of normal force sensors between the sensing surface and the substrate.