Abstract: Cardiac Output (CO) has traditionally been difficult, dangerous, and expensive to obtain. Surrogate measures such as pulse rate and blood pressure have therefore been used to permit an estimate of CO. MEMS technology, evolutionary computation, and time-frequency signal analysis techniques provide a technology to non-invasively estimate CO, based on precordial (chest wall) motions. The technology detects a ventricular contraction time point, and stroke volume, from chest wall motion measurements. As CO is the product of heart rate and stroke volume, these algorithms permit continuous, beat to beat CO assessment. Nontraditional Wavelet analysis can be used to extract features from chest acceleration. A learning tool is preferable to define the packets which best correlate to contraction time and stroke volume.

Abstract: Printed poly(ethylene oxide) (PEO) organometallic halide Perovskite (Pero) optoelectronic devices, including light emitting diodes (LEDs) fabricated on both rigid indium tin oxide (ITO)/glass and flexible carbon nanotube (CNTs)/polymer substrates using a composite thin film of PEO and Br-Pero as the light-emitting layer. Method of manufacturing Printed poly(ethylene oxide) (PEO) organometallic halide Perovskite (Pero) optoelectronic devices performed in an environment at a temperature of about 25° C. and a relative humidity between about 70% and 80%.

Abstract: A stereoscopic display device is provided for displaying a three-dimensional (3D) image as viewed by eyes consisting of a left eye and a right eye. In the display device, a single display screen, or separate left and right display screens, present a left image to the left eye but not the right eye, and present a right image to the right eye but not the left eye. A gaze distance tracker is configured to track gaze distance of the eyes. Variable-power lenses include a left variable-power lens arranged to provide eye accommodation for the left eye, and a right variable-power lens arranged to provide eye accommodation for the right eye. An electronic eye accommodation controller is configured to control the power of the variable power lenses to allow the image from the display to be focused on the retina, while the biological eye lens is accommodated to the gaze distance.

Abstract: The present disclosure provides methods of treating a human having a disease or disorder that would benefit from increasing platelet counts. The method involves inhibiting the enzyme activity of biliverdin IX? reductase (BLVRB) activity or inhibiting the expression of BLVRB gene.

Abstract: A sensor including a layer of amorphous selenium (a-Se) and at least one charge blocking layer is formed by depositing the charge blocking layer over a substrate prior to depositing the amorphous selenium, enabling the charge blocking layer to be formed at elevated temperatures. Such a process is not limited by the crystallization temperature of a-Se, resulting in the formation of an efficient charge blocking layer, which enables improved signal amplification of the resulting device. The sensor can be fabricated by forming first and second amorphous selenium layers over separate substrates, and then fusing the a-Se layers at a relatively low temperature.

Abstract: The present disclosure relates to wheat plants having grain with high ?-glucan content, methods for constructing said wheat plants, grain therefrom and uses thereof. Wheat lines homozygous for the HvCslF6 gene from barley having five times the fiber content and an increased ?-glucan content of TA5790, TA5792, and TA5795 are disclosed.

Abstract: A system and method of determining blood pressure includes measuring heart sounds, separating the measured heart sounds into a first heart sound (S1) and a second heart sound (S2), mathematically characterizing S1 and S2, and determining a blood pressure based on the characterization.

Abstract: Compositions and methods for reducing the level of nornicotine and N?-nitrosonornicotine (NNN) in Nicotiana plants and plant parts thereof are provided. The compositions comprise isolated polynucleotides and polypeptides for cytochrome P450s that are involved in the metabolic conversion of nicotine to nornicotine in these plants. Expression cassettes, vectors, plants, and plant parts thereof comprising inhibitory sequences that target expression or function of the disclosed cytochrome P450 polypeptides are also provided. Methods for the use of these novel sequences to inhibit expression or function of cytochrome P450 polypeptides involved in this metabolic conversion are also provided. The methods find use in the production of tobacco products that have reduced levels of nornicotine and its carcinogenic metabolite, NNN, and thus reduced carcinogenic potential for individuals consuming these tobacco products or exposed to secondary smoke derived from these products.

Abstract: A device for non-contact measurement of blood oxygen saturation (SpO2) in a mammalian subject including a camera and one or more arrays of LEDs each having a first set of LEDs emitting near infrared (NIR), and the second set of LEDs emitting orange light located in an optical path adapted to transmit reflected light from a subject to the camera. A controller transmits a camera trigger to the camera, and is further coupled to transmit control signals to the one or more arrays of LEDs. A processor receives photoplethysmography (PPG) data signal values from the camera. The PPG data signal values are present in the reflected light and include pulsatile and non-pulsatile components. The processor determines SpO2 values from the PPG data signal values from the measured ratios of pulsatile to non-pulsatile components of the PPG signals.

Abstract: Embodiments of the present invention are directed to various devices, systems and methods of providing a restartable, hybrid-rocket system that uses Acylonitrile Butadiene Styrene (ABS) and compressed air containing oxygen levels up to 40% as a propellant. Alternatively, embodiments of the present invention includes restartable hybrid rocket system that uses a heterogeneous matrix of ABS and a solid oxidizing agent in addition to compressed air as a propellant. When the ABS is exposed to an electrical potential field, the electrical field's effect on the ABS produces localized arcing between multiple layers of the ABS resulting in joule heating and pyrolysis of the ABS. The pyrolysis produces spontaneous combustion of the ABS once the oxidizer flow provides a local oxygen partial pressure greater than two atmospheres at the surface of the ABS.

Abstract: Compositions and methods for treating hypertension in a subject are provided, including administering an antisense oligomer effective to reduce expression of cytochrome P450 3A5 (CYP3A5) enzyme. The antisense oligomer includes phosphorodiamidate morpholino oligonucleotide (PMO), phosphorothioate 2?-O-methyl oligoribonucleotides (PSO), locked nucleic acid nucleotide, locked nucleic acid analog nucleotide, or another modified oligonucleotide backbone or nuclease-resistant backbone. The antisense oligomer is administered transdermally, subcutaneously, or orally, and optionally with a pharmaceutically acceptable carrier. In one embodiment, the antisense oligomer is an oligomer that is antisense to mRNAs that encode CYP3A5, for instance targeted at the AUG start site of the mRNAs that encode CYP3A5 or at a G4 structure within CYP3A5.

Abstract: Simple ?-hairpin peptides in linear and cyclic form that specifically bind to HIV-1 Trans-Activation Response element (HIV-1 TAR), as well as compositions and use thereof are described.

Abstract: A dynamic-zoom analog to digital converter (ADC) having a coarse flash ADC and a fine passive single-bit modulator is disclosed. Radio frequency (RF) devices incorporating aspects of the present disclosure may support multiple wireless modes operating at different frequencies. Therefore, the RF devices have need for an ADC which is flexible and optimizable in terms of resolution, bandwidth, and power consumption. In this regard, the RF devices incorporate circuits, such as ADC circuits, which incorporate a discrete-time passive delta-sigma modulator. In order to improve the resolution of the delta-sigma modulator, a coarse ADC is deployed as a zooming unit to a single-bit passive delta-sigma modulator to provide a coarse digital conversion. Coarse conversion is used to dynamically update reference voltages at an input of the delta-sigma modulator using a multi-bit feedback digital to analog converter (DAC). The dynamic-zoom ADC supports multiple modes with improved power and quantization noise.

Abstract: Analogs of largazole are described herein. Methods of treating cancer, blood disorders, autoimmune disease, and Alzheimer's Disease using largazole analogs and pharmaceutical compositions comprising the same are additionally described herein. Methods for preparing largazole analogs are likewise described.

Abstract: A medical device comprising a structure formed of polyvinyl alcohol.

Abstract: The invention provides a compound of formula (I): (I) wherein R1-R4 have any of the values defined in the specification, as well as compositions comprising a compound of formula (I) and methods for treating diseases (e.g. cancer).

Abstract: Embodiments for systems and methods of sequential event prediction with noise-contrastive estimation for marked temporal point process are disclosed.

Abstract: The invention is both a product and a method for the safe, harmless and effective remediation of oil spills on water and on land. The oil can then be successfully recovered from the product for use. The invention also allows for the reuse of two waste products—post consumer plastics and coal combustion product—into a material that is used for the clean-up of oil spills and for site remediation. Furthermore, the used product can be reprocessed post use into more usable product.

Abstract: A pressure sensor system is provided. In another aspect, a wireless intraocular pressure sensor includes a deformable or stretchable inductor. A further aspect of an intraocular pressure sensing system includes a deformable inductor sized to contact an eye. Another aspect provides an organ pressure sending system including a passive inductor with a wavy, serpentine or undulating shape.

Abstract: Structures and methods are provided for adjusting a size of a slide ring aperture for a musical instrument. Embodiments include a trumpet slide ring spacer adapted to be mounted on an instrument and retained within a valve slide ring.