Abstract: A method for processing a stream of cellulosic fines containing inorganic particles, to increase a hydrolysis yield of polysaccharide degradation enzymes, such fines in a waste stream from a recycled packaging paper mill to produce a stream of fermentable sugars, comprising treating the fines with a surfactant which selectively binds to the inorganic particles and which reduces binding to the inorganic particles by the polysaccharide degradation enzymes, and degrading polysaccharides in the waste stream with the polysaccharide degradation enzymes.

Abstract: A method and apparatus includes an optical source for a single order single-sideband suppressed-carrier optical signal with a bandwidth that scales from over 4 gigaHertz or is at least 8 GHz from an optical carrier frequency. In an example embodiment, an apparatus includes a stable laser source configured to output an optical carrier signal at a carrier frequency. The apparatus includes a radio frequency electrical source configured to output an electrical radio frequency signal with a radio frequency bandwidth less than one octave. The apparatus also includes an optical modulator configured to output an optical signal with the optical carrier signal modulated by the radio frequency signal in a plurality of orders (harmonics) of optical frequency sidebands. The apparatus further includes an optical filter configured to pass one single order optical frequency sideband of the optical signal, which sideband does not overlap the sideband of any other harmonic.

Abstract: The wear status of a micro-endmill tool may be inferred by monitoring the chip production rate of the tool in operation. Chips may be extracted from a work area, captured on an adhesive surface, imaged, and counted to determine the chip production rate. When the rate of chip production falls, the feed rate of the micro-endmill may be increased to a level suitable for the current state of tool wear. In this manner, costly and inconvenient work stoppages to evaluate the wear status of a tool are eliminated.

Abstract: An electrochemical method for measuring the activity of enzymes using nanoelectrode arrays fabricated with vertically aligned carbon nanofibers. Short peptide substrates specific to disease-related enzymes are covalently attached to the exposed nanofiber tips. A redox moiety, such as ferrocene, can be linked at the distal end of the nanofibers. Contact of the arrays with a biological sample containing one or more target enzymes results in cleavage of the peptides and changes the redox signal of the redox moiety indicating the presence of the target enzymes.

Abstract: The present invention provides novel aspirin derivatives useful for preventing and/or treating cancer. The novel compounds of this invention may be particularly useful for the prevention and/or treatment of cancers affecting the gastrointestinal system, such as colorectal cancer.

Abstract: A device with a pouch having a pouch wall with an inner side and an outer side, the pouch wall defining an interior of the pouch. A plurality of electrodes embedded in the pouch wall with at least one electrode partially exposed within the interior of the pouch. The plurality of electrodes generate plasma within the interior of the pouch in response to application of an voltage to the plurality of electrodes.

Abstract: The present disclosure provides compositions and methods for preparing engineered porous protein crystals comprising at least one guest molecule.

Abstract: A method includes sensing one or more pattern elements on a patterned contact lens on the eye of a person. Movement or direction of the person's eye is assessed based on the sensing of the one or more pattern elements. The pattern elements may be sensed using a single-pixel sensor. The pattern may include, for example, a pattern of elements having different colors.

Abstract: A method of making a synthetic foldable having a tertiary structure emulating the tertiary structure of a reference foldable protein is described. The method includes determining a folding nucleus peptide sequence associated with folding the reference foldable protein. The synthetic foldable protein is synthesized by including the determined folding nucleus peptide sequence and at least one repeat thereof in the peptide sequence of the synthetic foldable protein.

Abstract: A method and system for treating cardiac arrhythmias which includes inserting one or more electrodes into a patient's neck, and connecting the electrodes to the vagus nerve in the patient's neck. A cardiac monitoring device detects a cardiac arrhythmia. A controller connected to an electrical power source provides electrical power to the electrodes to apply electrical stimulation to the vagus nerve when a cardiac arrhythmia is detected.

Abstract: A system and method for collecting a core sample. The system includes an outer cylindrical tube, a drive head, a drive shoe, a cooling chamber housed inside the outer cylindrical tube, insulation, a core sample liner, an inlet tube, and outlet tube. The drive shoe further comprises a first, second, and third step, the first step configured to receive the insulation, the second step configured to receive the cooling chamber, the third step configured to receive the core sample liner, wherein the first step has a diameter larger than the second step and the second step has a diameter larger than the third step. The method includes drilling a hole in the ground with a drilling tool, enclosing a core sample by a core sample liner, freezing the core sample via a cooling liquid, retrieving the drilling tool at a surface of the ground, and removing the core sample encased in the core sample liner from the cooling chamber.

Abstract: Compositions and methods for reducing the level of nornicotine and N?-nitrosonornicotine (NNN) in tobacco plants and plant parts thereof are provided. The compositions comprise isolated polynucleotides and polypeptides for a root-specific nicotine demethylases, CYP82E10, and variants thereof, that are involved in the metabolic conversion of nicotine to nornicotine in these plants. Compositions of the invention also include tobacco plants, or plant parts thereof, comprising a mutation in a gene encoding a CYP82E10 nicotine demethylase, wherein the mutation results in reduced expression or function of the CYP82E10 nicotine demethylase. Seed of these tobacco plants, or progeny thereof, and tobacco products prepared from the tobacco plants of the invention, or from plant parts or progeny thereof, are also provided. Methods for reducing the level of nornicotine, or reducing the rate of conversion of nicotine to nornicotine, in a tobacco plant, or plant part thereof are also provided.

Abstract: A fiber grating device of low cost and arbitrary length is formed on a portion of a portion or the entirety of a highly elastic fiber optic core having a low Young's modulus of elasticity by causing elongation of the fiber optic core and forming or depositing a hard skin or cladding on the elongated fiber optic core. When the stress is then released, the hard skin or cladding buckles (including elastic or plastic deformation or both) to form wrinkles at the interface of the fiber optic core and the hard skin or cladding which are oriented circumferentially and highly uniform in height and spacing which can be varied at will by choice of materials, stretching, and thickness and composition of the cladding. Since the elastic elongation of the fiber optic core portion may be 200% or greater, an unprecedented measurement range is provided.

Abstract: Systems and methods for modeling memory access behavior and memory traffic timing behavior are disclosed. According to an aspect, a method includes receiving data indicative of memory access behavior resulting from instructions executed on a processor. The method also includes determining a statistical profile of the memory access behavior, the profile including tuple statistics of memory access behavior. Further, the method includes generating a clone of the executed instructions based on the statistical profile for use in simulating the memory access behavior.

Abstract: The present invention is directed to reagents useful for generating immune responses to Mycobacterium tuberculosis and for diagnosing infection and disease in a subject that has been exposed to M. tuberculosis.

Abstract: A micronozzle device can include at least one layer having a plurality of nozzle exits for delivering a mixture of a first fluid and a second fluid, at least one first-fluid header layer having a plurality of first microchannels for receiving the first fluid, at least one first-fluid via layer adjacent the at least one first-fluid header layer to receive the first fluid and direct it to respective ones of the plurality of nozzle exits, at least one second-fluid header layer having a plurality of second microchannels for receiving the second fluid, at least one second-fluid via layer adjacent the at least one second-fluid header layer to receive the second fluid and direct it respective ones of the plurality of nozzle exits, and a plurality of first curtain-gas nozzles located at a first side of the micronozzle device and a plurality of second curtain-gas nozzles located at a second side of the micronozzle device.

Abstract: The present invention relates to novel 2,5,6-benzimidazole derivatives and pharmaceutically acceptable salts thereof. Another aspect of the invention relates to methods of treating a patient infected by Mycobacterium tuberculosis by administering to the patient a 2,5,6-benzimidazole derivative or a pharmaceutically acceptable salt thereof.

Abstract: The invention provides promoter sequences that regulate specific expression of operably linked sequences in developing xylem cells and/or in developing xylem tissue. The developing xylem-specific sequences are exemplified by the DX5, DX8, DX11, and DX15 promoters, portions thereof, and homologs thereof. The invention further provides expression vectors, cells, tissues and plants that contain the invention's sequences. The compositions of the invention and methods of using them are useful in, for example, improving the quantity (biomass) and/or the quality (wood density, lignin content, sugar content etc.) of expressed biomass feedstock products that may be used for bioenergy, biorefinary, and generating wood products such as pulp, paper, and solid wood.

Abstract: An apparatus and device for repetitive use in automotive testing is provided. The apparatus includes a frame dimensioned in the same shape as a bicycle frame. The frame includes a first support beam and a plurality of second support beams. The apparatus further includes an elastic member elastically coupling each of the plurality of second support beams to the first support beam so as to allow the frame to separate when impacted and be easily reassembled for further testing. The device includes a disk having a first radar transparent layer opposite a second radar transparent layer and a reflective film disposed between the first radar transparent layer and the second radar transparent layer. The reflective film has a radar cross section pattern similar to that of an actual bicycle wheel when seen by automotive radar.

Abstract: The invention provides compounds of formula I: wherein A, B, X, and Y have any of the values defined in the specification, as well as pharmaceutical compositions comprising such compounds, processes for preparing such compounds, and therapeutic methods for treating cancer and other topoisomerase mediated conditions.