Abstract: Nucleic acid amplification assays for mutations to two short sections of the fungal gene FKS1. Mutations in these target sequences have been shown to correlate with resistance to echinocandin-class drugs. Assays may include detection by sequencing or by labeled hybridization probes. Also, primers, probes and reagent kits for performing such assays.

Abstract: The present disclosure provides FGF1 mutant proteins having one or more mutations in the heparin binding domain. Such mutants may also have an N-terminal deletion, point mutation(s), or combinations thereof. In some examples, the mutant FGF1 proteins have reduced mitogenic activity. Also provided are nucleic acid molecules that encode such proteins, and vectors and cells that include such nucleic acids. The disclosed FGF1 mutants can reduce blood glucose in a mammal, and in some examples are used to treat a metabolic disorder.

Abstract: The disclosure provides methods of treating a condition of the retina by administering an inhibitor of connexin 36 and/or an inhibitor of connexin 45 to a subject with a retinal condition. This disclosure further provides compositions for the treatment of a retinal condition which include an inhibitor of connexin 36 and/or an inhibitor of connexin 45.

Abstract: A two-dimensional magneto-optical trap (2D GMOT) that is configured to produce a cold-atom beam exiting the 2D GMOT is disclosed. In embodiments, the 2D GMOT is configured to feed a three-dimensional GMOT with the cold atom beam. In embodiments, the 2D GMOT includes an input light beam having its direction along a first axis, its width along a second axis, normal to the first axis, and a substantially flat input light beam intensity profile. 2D GMOT may further includes a quadrupole magnetic field with its magnitude being zero along a third axis that is centered at the center of the input light beam's width. The 2D GMOT may also include a diffraction-grating surface positioned normal to the first axis, composed of closely adjacent parallel grooves spread across the width and run parallel to the third axis.

Abstract: A system and method of non-intrusive anemometry. The system comprises an acoustic transmitter disposed at a boundary of fluid flow and first and second acoustic receivers adapted to receive transmissions from the acoustic transmitter. A processor is coupled to the acoustic receivers to determine the time of arrival of the transmission at the acoustic receivers. The acoustic transmitter and acoustic receivers are arranged such that the acoustic transmitter is upstream from the first acoustic receiver which is in turn upstream from the second acoustic transmitter.

Abstract: The system and method of the invention utilizes computer software to determine an estimation of the age of an animal by measuring, analyzing, comparing, calculating, and presenting age features and the age of animals such as deer, moose, elk, bovids, pronghorns and the like from digital data and/or photographs of the animals.

Abstract: The present invention relates to a top-down symmetric deconstruction approach which provides a novel alternative means to successfully identify a useful polypeptide “building block” for subsequent “bottom-up” de novo design of target protein architecture. The present invention also pertains to a novel peptides isolated by top-down symmetric deconstruction which may be useful for design or directed evolution of novel proteins with novel functionalities.

Abstract: A method of forming electrical contacts on a diamond substrate comprises producing a plasma ball using a microwave plasma source in the presence of a mixture of gases. The mixture of gases include a source of a p-type or an n-type dopant. The plasma ball is disposed at a first distance from the diamond substrate. The diamond substrate is maintained at a first temperature. The plasma ball is maintained at the first distance from the diamond substrate for a first time, and a UNCD film, which is doped with at least one of a p-type dopant and an n-type dopant, is disposed on the diamond substrate. The doped UNCD film is patterned to define UNCD electrical contacts on the diamond substrate.

Abstract: For calculating statistical Markov model-like state transition probabilities, a method represents state transition probabilities between a plurality of statistical Markov model-like states and output probabilities associated with a plurality of previous statistical Markov model-like states. The state transition probabilities between the plurality of previous states depend on a sequence of previous states of the plurality of previous states. The output probabilities associated with each of the plurality of states depend on the sequence of previous states.

Abstract: Methods are provided for producing an intermittent liquid jet are provided that involve delivering a liquid through a gas dynamic nozzle, which includes an inner tube carrying the liquid, an outer tube carrying a focussing sheath gas, an exit channel and an exit aperture, injecting a stream of the liquid into the exit channel, wherein the liquid is enclosed by the focussing sheath gas in the exit channel, controlling emission of the liquid from the inner tube into the exit channel to produce a periodic, linear intermittent liquid jet including spurts of linear continuous jet sections separated by liquid-free gaps, and output of the intermittent liquid jet through the exit aperture. Furthermore, methods of scattering measurements on samples in a liquid using the method of producing an intermittent liquid jet and an injector device for producing an intermittent liquid jet are described.

Abstract: The present disclosure relates to carbon monoxide releasing molecules (“CORMs”), and methods of synthesizing and applying the molecules. More specifically, this disclosure relates to structurally tunable CORMS, compounds containing CORMS (and salts thereof).

Abstract: It has been determined that co-administration of a rifamycin and a switch-region inhibitor 1) results in synergistic antibacterial effects, enabling efficacy at low, subtoxic doses, and/or 2) results in a low spontaneous resistance frequency, enabling treatment of high-titer infections without treatment failure due to spontaneous resistance. Accordingly, certain embodiments provide a composition comprising a rifamycin and a switch region inhibitor, as well as methods of use thereof.

Abstract: For low complexity error correction, a decoder modifies each reliability metric of an input data stream with a random perturbation value. The reliability metric comprises a weighted sum of a channel measurement for the input data stream and parity check results for the input data stream. In addition, the decoder may generate an output data stream as a function of the reliability metrics.

Abstract: The present disclosure provides, among other things, novel cyclic-GMP-AMP (cGAMP) analogs, mimics, mimetics and variants, and compositions and kits thereof; methods of using the compounds as described herein for treating cancer, and immune disease, disorders, or conditions; methods of using the compounds as described herein for modulating cGAS and STING; and methods of designing or characterizing a cGAS modulator.

Abstract: Described herein are compounds for use in vaccine compositions which contain natural or synthetic carbohydrate antigens. Such vaccines may be highly immunologically active due to the conjugation with an immune-stimulating protein or with a monophosphorylated lipid A derivative, and may be self-adjuvanting due to the presence of a monophosphorylated lipid A derivative. Treatments for cancer and fungal and bacterial infections are described herein.

Abstract: Methods, structures, and systems are disclosed for biosensing and drug delivery techniques. In one aspect, a device for detecting an analyte and/or releasing a biochemical into a biological fluid can include an array of hollowed needles, in which each needle includes a protruded needle structure including an exterior wall forming a hollow interior and an opening at a terminal end of the protruded needle structure that exposes the hollow interior, and a probe inside the exterior wall to interact with one or more chemical or biological substances that come in contact with the probe via the opening to produce a probe sensing signal, and an array of wires that are coupled to probes of the array of hollowed needles, respectively, each wire being electrically conductive to transmit the probe sensing signal produced by a respective probe.

Abstract: A system and method for imaging gamma- and x-ray, and charged particles sources employing a three dimensional array of scintillation elements arranged surrounding an emission source. According to a preferred embodiment, each element of the array comprises a scintillator element, a solid-state photon detector, and processing electronics to output an electronic signal. The elements may be efficiently packed in both the X-Y plane and stacked in the Z-axis, to provide depth of interaction information. The elements of the array are preferably hierarchically arranged with control electronics provided together for subarray modules (e.g., an n×m×1 module), and synchronization electronics provided at a larger scale. The modules preferably communicate with a control system through a shared addressable packet switched digital communication network with a control and imaging system, and receive control information from that system through the network.

Abstract: Methods and compositions for replication of threose nucleic acids (TNAs) are described. The described methods include a method for transcribing a DNA template into a TNA, and a method for reverse transcribing a threose nucleic acid into a cDNA.

Abstract: A system and method for the efficient compression of the Channel State Information (CSI) in a wireless network with very low complexity and implementation cost. In accordance with the present invention, the CSI can be approximated as the summation of very few sinusoids on constant frequencies and the parameters of the sinusoids can be found efficiently by very simple calculations such as dot products of vectors which are implementable in hardware at very low cost.

Abstract: An encapsulated polymer stabilized cholesteric texture (EPSCT) light shutter is formed from a cholesteric liquid crystal and monomer that is encapsulated into micron sized, polymer-coated droplets by either an emulsification or phase separation process. The polymer-coated droplets are disposed between transparent electrodes, where they are irradiated by ultra-violet (UV) light to polymerize the monomer.