Abstract: Aspects of the present disclosure include methods of producing modified polypeptides and modified polypeptide-ribosome or polypeptide-mRNA complexes, and methods of screening polynucleotide and polypeptide libraries. The present disclosure also provides polypeptide libraries useful in screening for single molecule phenotypes. Also provided are kits useful for producing polypeptides capable of being modified using methods disclosed herein.

Abstract: A method and system for enabling the determination of kinetic rates within a fluid of interest including directing fluid flow exiting a test bed to a multi-port switching valve. The multi-port switching valve to switches the fluid to a number of channels connected to in in-flow extraction cartridge. Analytes of interest from the fluid flow our concentrated and captured on an extraction medium. Rates are determined by (i) sequentially channeling the fluid through the each of the plurality of channels for a preselected time duration, (ii) analyzing the extraction cartridges, and computing the kinetic rate of interest.

Abstract: Methods, structures, and systems are disclosed for biosensing and drug delivery techniques. In one aspect, a device for detecting an analyte and/or releasing a biochemical into a biological fluid can include an array of hollowed needles, in which each needle includes a protruded needle structure including an exterior wall forming a hollow interior and an opening at a terminal end of the protruded needle structure that exposes the hollow interior, and a probe inside the exterior wall to interact with one or more chemical or biological substances that come in contact with the probe via the opening to produce a probe sensing signal, and an array of wires that are coupled to probes of the array of hollowed needles, respectively, each wire being electrically conductive to transmit the probe sensing signal produced by a respective probe.

Abstract: Printed active origami combines printed electronics with nanomaterial coated polymer based actuators to create active printed structures. The fabrication processes include the step of applying carbon nanomaterial coatings to polymeric films. Products produced by the processes include actuating materials, such as solid state actuators that can be used as active element(s) in a printable active origami robot.

Abstract: The invention describes a system for creating portable, porous structures for restoring coastline. The invention provides for a bag with multiple longitudinal pockets. The bag is made of porous natural or synthetic mesh material and the pockets are filled with lightweight, porous manufactured aggregate. In a preferred embodiment, the lightweight aggregate used in this invention is produced by thermal fusion of silicate clays in a rotary kiln. In another preferred embodiment, multiple bags are encased in a flexible grid material to form a mat. In another embodiment, the mat can be rolled into a log. The bags, mats, and logs can be placed on shorelines and other locations to restore coastline.

Abstract: The present invention provides novel aspirin derivatives useful for preventing and/or treating cancer. The novel compounds of this invention may be particularly useful for the prevention and/or treatment of cancers affecting the gastrointestinal system, such as colorectal cancer.

Abstract: The present invention provides compositions and methods for modification of rhizobacteria to reduce or eliminate gibberellin production. The modified rhizobacteria are used in methods and compositions that alter the physiology of nodulating plants. These methods and compositions involve combining the modified rhizobacteria with a nodulating plant, or a seed or part thereof, or providing the modified rhizobacteria to a nodulating plant, or seed or part thereof. In another aspect, the invention involves the nodulating plants produced by these methods, wherein the nodulating plants have altered physiology as a result of association with the modified rhizobacteria.

Abstract: Transgenic plants that have enhanced yield-related traits, such as increased seed oil production, are produced by genetically engineering the plants to down-regulate the expression of at least one BPM protein. Such transgenic plants can, for example, be cultivated and yield higher seed oil production than control plants which have not been genetically engineered for down regulation of a BPM protein.

Abstract: A system and method for automated polyp detection in optical colonoscopy images is provided. In one embodiment, the system and method for polyp detection is based on an observation that image appearance around polyp boundaries differs from that of other boundaries in colonoscopy images. To reduce vulnerability against misleading objects, the image processing method localizes polyps by detecting polyp boundaries, while filtering out irrelevant boundaries, with a generative-discriminative model. To filter out irrelevant boundaries, a boundary removal mechanism is provided that captures changes in image appearance across polyp boundaries. Thus, in this embodiment the boundary removal mechanism is minimally affected by texture visibility limitations. In addition, a vote accumulation scheme is applied that enables polyp localization from fragmented edge segmentation maps without identification of whole polyp boundaries.

Abstract: The cascaded multilevel inverter is considered to be a promising topology alternative for low-cost and high-efficiency photovoltaic (PV) systems. However, the leakage current issue, resulting from the stray capacitances between the PV panels and the earth, remains a challenge in the photovoltaic cascaded multilevel inverter application. The present invention presents leakage current suppression solutions for the PV cascaded multilevel inverter by introducing properly arranged and designed passive filters. The embodiments of the invention do not include an active semiconductor device, and as such, the leakage current suppression techniques of the present invention retain the simple structure of the cascaded inverter and do not complicate the associated control system.

Abstract: The genetic basis for severe combined immunodeficiency disease (SCID) in pigs is described. In addition, tests for detecting pigs that are carriers for SCID or pigs with SCID are also described. Further, methods for producing pigs or herds of pigs with SCID are also described. Further, methods and compositions for treating, ameilioraing, inhibiting or correcting SCID are provided.

Abstract: The present invention describes methods and formulations for protecting plants against various pathogens, involving the use of Prunus maackii materials. In some embodiments the biopesticide formulation comprises of at least one flavonoid such as 3,5,7-trihydroxy-6-methoxyflavone, 3,5,7-trihydroxy-6-methoxyflavanone or 5,7-dihydroxy-8-methoxyflavanone. The invention further provides a method of making the biopesticide by extracting a Prunus species with a solvent and formulating the composition using adjuvants, and kits for application of the biopesticide.

Abstract: Biomarkers associated with neuroimmunological disease are described. The disclosed biomarkers are secreted proteins identified in cerebral spinal fluid (CSF) samples of patients with neurological disease. The disclosed biomarkers identify patients with intrathecal inflammation, distinguish multiple sclerosis (MS) patients from patients with other types of inflammatory neurological diseases and from subjects without MS, distinguish progressive MS patients from patients with relapsing-remitting MS, identify subjects with non-MS inflammatory neurological diseases, differentiate healthy subjects from patients with any type of neurological disease, and/or identify subjects with increased disability, CNS tissue damage and/or neurodegeneration. Process-specific biomarkers that can be used in place of a brain biopsy to identify immune cell infiltration and/or activation in the CNS are also described.

Abstract: A system and method is provided for automated polyp detection in optical colonoscopy images. The system includes an input configured to acquire a series of optical images, and a processor configured to process the optical images. Processing steps include performing a boundary classification with steps comprising locating a series of edge pixels using at least one acquired optical image, selecting an image patch around each said edge pixel, performing a classification threshold analysis on each image patch of said edge pixels using a set of determined boundary classifiers, and identifying, based on the classification threshold analysis, polyp edge pixels consistent with a polyp edge. Processing steps for the processor also include performing a vote accumulation, using the identified polyp edge pixels, to determine a polyp location. The system also includes an output configured to indicate potential polyps using the determined polyp location.

Abstract: The invention is a method of increasing hydrocarbon recovery through the biomineralization sealing of fractured geological formations followed by refracturing, including preparing a composition with biochemical components that is delivered into a geological subsurface through a cased well bore. Nutrient solutions are delivered into the geological subsurface through the well bore, thereby metabolizing the nutrient solutions with the biochemical components to create a mineralizing byproduct. Mineralizing solutions are delivered into the geological subsurface, delivering the composition, nutrient solutions and mineralizing solutions to targeted geological formations having existing formation fractures, through casing openings. Mineralizing solutions react with the mineralizing byproduct to produce minerals, which crystallize in the existing formation fractures, sealing and strengthening the existing formation fractures and resulting in sealed fractures.

Abstract: Some embodiments include a method of providing an electronic device. The method includes: (i) providing a carrier substrate, (ii) providing a device substrate comprising a first side and a second side opposite the first side, the device substrate having a flexible substrate, (iii) coupling the first side of the device substrate to the carrier substrate; and (iv) after coupling the first side of the device substrate to the carrier substrate, providing two or more active sections over the second side of the device substrate, each active section of the two or more active sections being spatially separate from each other and having at least one semiconductor device. Other embodiments of related methods and devices are also disclosed.

Abstract: Instruction issue circuits are disclosed that are configured to issue multiple instructions within a superscalar pipeline of a microprocessor. The instruction issue circuit includes an instruction queue that stores instructions. A ready generation circuit is operably associated with the instruction queue and generates ready signals that indicate which instructions in the instruction queue are ready for execution. To simplify the instruction issue circuit, the instruction issue circuit has group blocks. Each group block receives a different group of the ready signals corresponding to a different group of the instructions. Each group block generates a group output indicating a group set within the corresponding group of the instructions that has a highest instruction execution priority and are ready for execution. By splitting the ready signals into groups, the groups of ready signals can be processed in parallel thereby reducing both the resulting delay and complexity of the instruction issue circuit.

Abstract: A chip-scale, reusable sensor can detect aromatic hydrocarbons, such as benzene, toluene, ethylbenzene, and xylenes (BTEX), rapidly in water without sample preparation. The device is capable of real-time, continuous monitoring for BTEX solutes, which diffuse into a film, such as a polymer, on the sensors surface. In operation, BTEX analytes concentrate in the film, causing an increase in refractive index, which modulates evanescent coupling into the chips integrated photodetector array. Integration of the photodetector array simplifies system instrumentation and permits incorporation of an on-chip photocurrent reference region in the immediate vicinity of the sensing region, reducing drift due to temperature fluctuations. In some examples, the chip responds linearly for BTEX concentrations between 1 ppm and 30 ppm, with a limit of detection of 359 ppb, 249 ppb, and 103 ppb for benzene, toluene, and xylene in water, respectively.

Abstract: Methods, structures, and systems are disclosed for biosensing and drug delivery techniques. In one aspect, a^ device for detecting an analyte and/or releasing a biochemical into a biological fluid can include an array of hollowed needles, in which each needle includes a protruded needle structure including an exterior wall forming a hollow interior and an opening at a terminal end of the protruded needle structure that exposes the hollow interior, and a probe inside the exterior wall to interact with one or more chemical or biological substances that come in contact with the probe via the opening to produce a probe sensing signal, and an array of wires that are coupled to probes of the array of hollowed needles, respectively, each wire being electrically conductive to transmit the probe sensing signal produced by a respective probe.

Abstract: ‘NCDX2’ is a new cultivar of hybrid Deutzia with a compact, low-growing, arching/spreading growth habit with a profusion of showy pink-striped petals.