Patents Assigned to State University
  • Endoscope for analyte consumption rate determination with single cell resolution for in vivo applications
    Patent number: 9597026
    Abstract: Novel methods and devices including modified endoscopes that employ fiber optic technology and multiple extrinsic optical sensors for enablement of simultaneous determination of change rates of biological analytes in vivo with single-cell resolution. The devices employ dynamic oscillatory actuation to determine the gradient of analytes of interest along one or multiple directions with respect to the cell. The change rate or flux of the analyte of interest can be easily determined by applying the first Fick's law that relates the flux with the concentration gradient. The dual operation mode of the device markedly increases measurement sensitivity and accuracy.
    Type: Grant
    Filed: November 11, 2014
    Date of Patent: March 21, 2017
    Assignee: Arizona Board of Regents on behalf of Arizona State University
    Inventors: Deirdre Meldrum, Laimonas Kelbauskas, Jeff Houkal, Roger Johnson, Yanqing Tian, Cody Youngbull
  • Photo-induced phase transfer of luminescent quantum dots
    Patent number: 9598635
    Abstract: A method for the photo-mediated phase transfer of inorganic nanocrystals, such as luminescent quantum dots, QDs, is provided. Irradiation, specifically UV excitation (?ex<400 nm), promotes the in-situ ligand exchange of hydrophobic quantum dots with hydrophilic ligands and their facile transfer to polar solvents and buffer media. The technique enables transfer of quantum dots and other nanocrystal materials from hydrophobic to polar and hydrophilic solutions.
    Type: Grant
    Filed: May 7, 2013
    Date of Patent: March 21, 2017
    Assignee: The Florida State University Research Foundation, Inc.
    Inventors: Hedi Mattoussi, Igor Alabugin, Goutam Palui, Tommaso Avellini
  • Recombinant bacterium to decrease tumor growth
    Patent number: 9598697
    Abstract: A recombinant bacterium capable of reducing tumor growth is provided, wherein said recombinant bacterium is capable of: a. increased expression of a nucleic acid encoding a chemoreceptor that directs chemotaxis towards tumors, b. accumulation in a quiescent tumor, c. hyper-invasion of a tumor, d. reduced fitness in normal tissue, e. enhanced stimulation of the host innate immune responses, f. delivering a tumor specific DNA vaccine vector to a tumor cell, and g. increased bacterium-induced host programmed cell death.
    Type: Grant
    Filed: May 31, 2011
    Date of Patent: March 21, 2017
    Assignee: The Arizona Board of Regents for and on Behalf of Arizona State University
    Inventors: Roy Curtiss, III, Wei Kong
  • Star polymer nanoshells and methods of preparation thereof
    Patent number: 9597405
    Abstract: A nanoshell is disclosed, comprising a star polymer occlusion complex comprising i) an amphiphilic unimolecular star polymer having a crosslinked core covalently linked to 6 or more independent polymer arms, and ii) a cargo material occluded in the star polymer; and a shell comprising an inorganic material in contact with a peripheral surface of the star polymer occlusion complex.
    Type: Grant
    Filed: January 2, 2015
    Date of Patent: March 21, 2017
    Assignees: International Business Machines Corporation, San Jose State University Research Foundation
    Inventors: Victor Yee-Way Lee, Robert D. Miller, Hector H. Nuno, Joseph Sly
  • Tobacco inbred and hybrid plants and tobacco products made thereof
    Patent number: 9596822
    Abstract: The present disclosure provides tobacco inbred plants NC174 SRC, CMS NC174 SRC, NC821-11 SRC, NC775 Bmr/Bmr SRC, CMS NC775 Bmr/Bmr SRC, NC645 Bmr/Bmr SRC, and hybrids NC 5 SRC and NC 8 SRC. The present disclosure also provides parts of such plants and cured tobacco and tobacco products made from those parts. The present disclosure also includes progenies of the provided plants including hybrids.
    Type: Grant
    Filed: March 3, 2015
    Date of Patent: March 21, 2017
    Assignee: North Carolina State University
    Inventors: Ramsey S. Lewis, Ralph E. Dewey
  • Therapeutic and diagnostic method for ataxia-telangiectasia
    Patent number: 9599626
    Abstract: ATM kinase is shown to regulate proteasome-mediated protein turnover through suppression of the expression of the ubiquitin-like protein ISG15 (Interferon Stimulated Gene 15). Silencing of the ISG15 pathway restored both the ubiquitin and autophagy pathways, and the UV-mediated degradation of their substrates in A-T cells. The ATM kinase negatively regulates the ISG15 pathway, and the constitutively elevated ISG15 pathway induces proteinopathy in A-T cells, and in A-T patients. These findings indicate that proteasome-mediated protein degradation is impaired in A-T cells due to elevated expression of the ISG15 conjugation pathway, which contributes to progressive neurodegeneration in A-T patients. The ISG15 pathway is a new target for both detection and treatment of A-T Inhibitors if ISG15 expression can be used to inhibit or attenuate neurodegeneration in A-T patients.
    Type: Grant
    Filed: November 29, 2012
    Date of Patent: March 21, 2017
    Assignee: Board of Supervisors of Louisiana State University And Agricultural and Mechanical College
    Inventor: Shyamal D. Desai
  • METHODS OF DIFFERENTIATING PREADIPOCYTES AND USES THEREOF
    Publication number: 20170073639
    Abstract: Described herein are methods of transdifferentiating preadipocytes, populations of transdifferentiated preadipocytes, and methods of using the transdifferentiated preadipocytes.
    Type: Application
    Filed: September 15, 2016
    Publication date: March 16, 2017
    Applicant: Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
    Inventors: Kenneth James Eilertsen, Jong Rim
  • Control of ripening and senescence in pre-harvest and post-harvest plants and plant materials by manipulating alternative oxidase activity
    Patent number: 9591847
    Abstract: Methods of controlling the maturation of plants and/or plant products (e.g. fruit, vegetable, ornamentals, etc.) by manipulating Alternative Oxidize (AOX) activity. An increase in activity hastens the maturation process while a decrease in activity slows or stops maturation.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: March 14, 2017
    Assignee: Washington State University
    Inventors: Amit Dhingra, Christopher Hendrickson
  • Nitrile-containing enzyme inhibitors and ruthenium complexes thereof
    Patent number: 9593138
    Abstract: The invention provides nitrile-containing protease inhibitors caged to ruthenium compounds. The nitrile-caged ruthenium compounds provide inactivated inhibitors that can be delivered to surface or site for activation, for example, but exposure to light. The invention also provides methods for delivering protease inhibitors to subjects for the therapeutic treatment of conditions such as cancer.
    Type: Grant
    Filed: October 7, 2013
    Date of Patent: March 14, 2017
    Assignees: Wayne State University, Ohio State Innovation Foundation
    Inventors: Jeremy J. Kodanko, Claudia Turro
  • Method and system for minimally-invasive surgery training using tracking data
    Patent number: 9595207
    Abstract: A system and method for training a person in minimally-invasive surgery (“MIS”) utilizing a video of the MIS. The system comprises a processor, a display, and a first interaction device. The processor programmed to receive the video and to obtain tracking data. The tracking data may correspond to the motion of a tool controller. The tracking data may correspond to motion of a first surgical tool in the video. The processor programmed to calculate motion of the first interaction device corresponding to the tracking data, to display the video, and to cause the first interaction device to move according to the calculated motion. The method comprises receiving the video, obtaining the tracking data, calculating a motion of a first interaction device corresponding to the tracking data, displaying the video, and causing the first interaction device to move according to the calculated motion.
    Type: Grant
    Filed: May 26, 2011
    Date of Patent: March 14, 2017
    Assignees: Health Research, Inc., The Research Foundation for The State University of New York
    Inventors: Thenkurussi Kesavadas, Khurshid Guru
  • Antibacterial agents: aryl myxopyronin derivatives
    Patent number: 9592221
    Abstract: The invention provides compounds of formula Ia, Ib and Ic: and salts thereof, wherein variables are as described in the specification, as well as compositions comprising a compound of formula Ia-Ic, methods of making such compounds, and methods of using such compounds, e.g., as inhibitors of bacterial RNA polymerase and as antibacterial agents.
    Type: Grant
    Filed: March 8, 2016
    Date of Patent: March 14, 2017
    Assignees: Rutgers, The State University of New Jersey, Provid Pharmaceuticals Inc.
    Inventors: Richard H. Ebright, Yon W. Ebright, Juan Shen, James Bacci, Anne-Cecile Hiebel, William Solvibile, Christopher Self, Gary Olson
  • Estimating the location of a wireless terminal based on radio-frequency pattern matching and cooperative measurements
    Patent number: 9596571
    Abstract: A method for estimating the location of a wireless terminal is disclosed that is based on using: the known location of one or more devices, empirical data that indicates the relative position of the wireless terminal to the devices, and empirical data that indicates the relative position of the wireless terminal (which is at an unknown location) relative to other wireless terminals that are also at unknown locations.
    Type: Grant
    Filed: December 16, 2014
    Date of Patent: March 14, 2017
    Assignees: Polaris Wireless, Inc., Virginia Polytechnic Institute & State University
    Inventors: Scot Douglas Gordon, Sayed Reza Monir Vaghefi, R. Michael Buehrer
  • Methods for quantitative analysis of metabolic mixtures by 2D C-constant-time TOCSY NMR spectroscopy
    Patent number: 9594880
    Abstract: This disclosure provides for new methods for quantification of metabolite concentrations in metabolomics studies, which addresses the difficulties in quantification through 1D peak integrals due to significant peak overlaps in metabolomics samples. For samples from uniformly 13C-labeled organisms the 2D NMR 13C-13C constant-time (CT) TOCSY experiment provides high-resolution information about individual metabolites that allows their identification via database searching or, in the case of novel compounds, through the reconstruction of their backbone-carbon topology. This disclosure further demonstrates using CT-TOCSY spectra for quantification purposes.
    Type: Grant
    Filed: May 15, 2014
    Date of Patent: March 14, 2017
    Assignee: Florida State University Research Foundation, Inc.
    Inventors: Rafael Brüschweiler, Kerem Bingol
  • Linear-Motion Stage
    Publication number: 20170067731
    Abstract: A linear-motion stage that is angularly or radially symmetric or asymmetric, or monolithic may be used as the moving mechanism in a Fourier transform spectrometer. In embodiments, a linear-motion stage includes a base; a first multiple-arm linkage extending from the base to a first carriage attachment end; a second multiple-arm linkage extending from the first carriage attachment end to the base; a third multiple-arm linkage extending from the base to a second carriage attachment end; a carriage extending from the first carriage end to the second carriage end. Also in embodiments, the first, second, and third multiple-arm linkages comprise a first arm rotateably connected to a second arm through a flexure, the angular travel of the first arm is configured to be different than an angular travel of the second arm as the carriage moves along the carriage motion line.
    Type: Application
    Filed: November 1, 2016
    Publication date: March 9, 2017
    Applicant: Utah State University Research Foundation
    Inventors: Kendall B. Johnson, Gregory R. Hopkins
  • LIVE ATTENUATED EDWARDSIELLA ICTALURI VACCINE AND METHOD OF USING THE SAME
    Publication number: 20170065695
    Abstract: A live attenuated Edwardsiella ictaluri bacterium lacking a viable gene encoding a functional evpB protein and a method of using the same to protect fish against infection from virulent Edwardsiella ictaluri. The methods and compositions for protecting fish against infection from virulent Edwardsiella ictaluri comprising administering to a fish a therapeutically effective amount of an attenuated Edwardsiella ictaluri bacterium lacking a viable gene encoding a functional EvpB protein. The bacterium may include an insertion and/or deletion mutation in the evpB gene. The fish include catfish, preferably catfish fingerling or a catfish fry. The composition may be delivered via immersion delivery, an injection delivery, an oral delivery, or combinations thereof.
    Type: Application
    Filed: September 6, 2016
    Publication date: March 9, 2017
    Applicant: Mississippi State University
    Inventors: Attila Karsi, Mark L. Lawrence, Hossam Abdelhamed
  • GENE EXPRESSION BASED BIOMARKER SYSTEM FOR IRRITABLE BOWEL SYNDROME (IBS) DIAGNOSIS
    Publication number: 20170067107
    Abstract: We have identified a suite of genes in a limited number of human colonic tissue samples with expression patterns that correlate with whether an individual is experiencing symptoms of Irritable Bowel Syndrome (IBS) (FIG. 2). Interestingly, in the efforts to screen for genes that might be used as biomarkers for IBS, it was found that no single gene could be used for this purpose. Instead, when examining the entire dataset, there exist signature gene expression patterns (e.g., fingerprints or biosignatures) of IBS that have use as a diagnostic tool for IBS.
    Type: Application
    Filed: February 24, 2015
    Publication date: March 9, 2017
    Applicant: Arizona Board of Regents on behalf of Arizona State University
    Inventors: Todd Sandrin, Peter Jurutka
  • SEPARATION SAMPLING MODULES FOR USE WITHIN A BUCKET OF A CENTRIFUGE
    Publication number: 20170067812
    Abstract: A separation sampling module for use within a bucket of a centrifuge for monitoring separation of a sample in a container includes a housing operable for supporting the container for containing the sample and removably positionable within the bucket of the centrifuge, at least one light source for illuminating the sample, at least one light detector for detecting light from the sample, an accelerometer for measuring acceleration of the housing, and at least one of a power source and a connector operably connectable to a power source for use in powering the at least one light source. Light from the at least one light source passing through the sample defines a light path disposed in a direction across the direction of a centrifugal force when the separation sampling module is disposed in the bucket and rotated in the centrifuge.
    Type: Application
    Filed: November 18, 2016
    Publication date: March 9, 2017
    Applicant: The Research Foundation for the State University of New York
    Inventors: Tony P. HOANG, Kenneth A. HALVORSEN
  • ADAPTERS AND INSTRUMENT MODULES FOR USE IN A CENTRIFUGE BUCKET
    Publication number: 20170065985
    Abstract: An adapter is connectable to any one of a plurality of different instrument modules so that the connected adapter and any one of the plurality of different instrument modules is positionable within a centrifuge bucket. The adapter includes, for example, a support positionable in a first portion of the centrifuge bucket so that the any one of the plurality of different instrument modules is positionable in a second portion of the centrifuge bucket, a processor attachable to the support, a power source or a connector to a power source operably electrically connected to the processor, an interface operably connected to the processor for receiving data from the any one of the plurality of different instrument modules, and a transmitter for wirelessly transmitting data from the processor to a remote location.
    Type: Application
    Filed: November 18, 2016
    Publication date: March 9, 2017
    Applicant: The Research Foundation for the State University of New York
    Inventor: Tony P. HOANG
  • Methods for wafer bonding and for nucleating bonding nanophases using wet and steam pressurization
    Patent number: 9589801
    Abstract: Substrates may be bonded according to a method comprising contacting a first bonding surface of a first substrate with a second bonding surface of a second substrate to form an assembly in the presence of an steam atmosphere under suitable conditions to form a bonding layer between the first and second surfaces, wherein the first bonding surface comprises a polarized surface layer; the second bonding surface comprises a hydrophilic surface layer; the first and second bonding surfaces are different.
    Type: Grant
    Filed: October 31, 2012
    Date of Patent: March 7, 2017
    Assignee: Arizona Board Of Regents, A Body Corporated Of The State Of Arizona, Acting For And On Behalf Of Arizona State University
    Inventors: Nicole Herbots, Shawn Whaley, Robert Culbertson, Ross Bennett-Kennett, Ashlee Murphy, Matthew Bade, Sam Farmer, Brance Hudzietz
  • Sequestration of carbon dioxide with hydrogen to useful products
    Patent number: 9587256
    Abstract: Provided herein are genetically engineered microbes that include at least a portion of a carbon fixation pathway, and in one embodiment, use molecular hydrogen to drive carbon dioxide fixation. In one embodiment, the genetically engineered microbe is modified to convert acetyl CoA, molecular hydrogen, and carbon dioxide to 3-hydroxypropionate, 4-hydroxybutyrate, acetyl CoA, or the combination thereof at levels greater than a control microbe. Other products may also be produced. Also provided herein are cell free compositions that convert acetyl CoA, molecular hydrogen, and carbon dioxide to 3-hydroxypropionate, 4-hydroxybutyrate, acetyl CoA, or the combination thereof. Also provided herein are methods of using the genetically engineered microbes and the cell free compositions.
    Type: Grant
    Filed: September 6, 2013
    Date of Patent: March 7, 2017
    Assignees: University of Georgia Research Foundation, Inc., North Carolina State University
    Inventors: Michael W. W. Adams, Robert M. Kelly, Aaron B. Hawkins, Angeli Lal Menon, Gina Lynette Pries Lipscomb, Gerrit Jan Schut