Abstract: The present invention relates to SHIP inhibitor compounds and methods for using these compounds. In particular, the present invention discloses the following methods: (i) a method of treating graft versus host disease in a subject; (ii) a method of inhibiting a SHIP1 protein in a cell; (iii) a method of selectively inhibiting a SHIP1 protein in a cell; (iv) a method for treating or preventing graft-versus-host disease (GVHD) in a recipient of an organ or tissue transplant; (v) a method of modulating SHIP activity in a cell expressing SHIP1 or SHIP2; (vi) a method of ex vivo or in vitro treatment of transplants; (vii) a method of inhibiting tumor growth and metastasis in a subject; (viii) a method of treating a hematologic malignancy in a subject; (ix) a method of inducing apoptosis of multiple myeloma cells; (x) a method of treating multiple myeloma in a subject; (xi) a method of inhibiting the proliferation of a human breast cancer cell; and (xii) a method of treating breast cancer in a subject.

Abstract: We constructed S. Gallinarum strains deleted for the global regulatory gene fur (FIG. 1) and evaluated their virulence and protective efficacy in Rhode Island Red chicks and Brown Leghorn layers. The fur deletion mutant was a virulent and, when delivered orally to chicks, elicited excellent protection against lethal S. Gallinarum challenge. We also examined the effect of a pmi mutant and a combination of fur deletions with mutations in the pmi and rfaH genes, which affect O-antigen synthesis, and ansB, whose product inhibits host T cell responses. The ?Afur ?pmi and ?fur ?ansB double mutants were attenuated, but not protective when delivered orally to chicks. However, a ?pmi ?fur strain was substantially immunogenic when administrated intramuscularly. Altogether our results show that the fur gene is essential for virulence of S. Gallinarum and the fur mutant is effective as a live recombinant vaccine against fowl typhoid.

Abstract: A novel method for real-time small-signal stability analysis for power electronic-based components in a power system. The method may be used to monitor a power system in real-time by perturbing the source side of an electronic-based component of the power system by injecting a current of about 0.5 to 1 percent of a nominal current of the power system at the source side and perturbing the load side of the power electronic-based component by injecting a voltage of about 0.5 to about 1 percent of a nominal voltage of the power system at the load side and varying the voltage at the load side. Time-domain results of the perturbations may be transferred to frequency-domain results and the stability of the power system may be monitored by obtaining a Nyquist contour and employing Generalized Nyquist Criterion or unit circle criterion.

Abstract: Systems and methods for a content-adaptive photo-enhancement recommender that produces multiple enhanced images based on content and color layout parameters derived from related high-quality images are disclosed. In some embodiments, a user-uploaded image is enhanced based on parameters learned from high-quality images similar in content to the user-uploaded image and obtained using content-based image retrieval techniques.

Abstract: The invention provides compounds of formulae (I), (II), (III), and (IV): and salts thereof, as well as pharmaceutical compositions comprising such compounds. The compounds are useful for treating cancers and Alzheimer's disease.

Abstract: We disclose novel metallic nanoparticles coated with a thin protective carbon shell, and three-dimensional nano-metallic sponges; methods of preparation of the nanoparticles; and uses for these novel materials, including wood preservation, strengthening of polymer and fiber/polymer building materials, and catalysis.

Abstract: A novel method for real-time small-signal stability analysis for power electronic-based components in a power system. The method may be used to monitor a power system in real-time by perturbing the source side of an electronic-based component of the power system by injecting a current of about 0.5 to 1 percent of a nominal current of the power system at the source side, while simultaneously perturbing the load side of the power electronic-based component by varying the voltage at the load side. Time-domain results of the simultaneous perturbations may be transferred to frequency-domain results and the stability of the power system may be monitored by obtaining a Nyquist contour and employing Generalized Nyquist Criterion or unit circle criterion.

Abstract: Compressive sensing based video rate imaging techniques are presented. Rather than scan the entire image, the imaging system only scans part of the topography of the sample as a compressed scan. After the data has been collected, an algorithm for image reconstruction is applied for recovering the image. Because compressive sensing is used, the imaging rate is increased from several minutes per frame to seconds per frame. Non-vector space control techniques are also presented. No-vector space control use image or compressive data as the input and feedback to generate a closed-loop motion control. Compressive sensing technique provides an efficient data reduction method to retain the essential information in the original image. The non-vector space control method can be used as motion control method with compressive feedback without or with noise.

Abstract: A novel Rh(I)-catalyzed approach to synthesizing functionalized (E,Z) dienal compounds has been developed via tandem transformation where a stereoselective hydrogen transfer follows a propargyl Claisen rearrangement. Z-Stereochemistry of the first double bond suggests the involvement of a six-membered cyclic intermediate whereas the E-stereochemistry of the second double bond stems from the subsequent protodemetallation step giving an (E,Z)-dienal. The reaction may be represented by the following sequence.

Abstract: Described herein are methods and compositions for the diagnosis, prognosis and treatment of ovarian cancer. Also described are methods of identifying anti-cancer agents.

Abstract: The invention provides compounds of formula (I): and salts and prodrugs thereof wherein R4, X1 and X2 have any of the meanings defined in the specification, as well as pharmaceutical compositions comprising the compounds or salts and methods for their use in therapy. The compounds have useful antiviral properties.

Abstract: A diagnostic device for and method of detecting the presence of head and neck squamous cell carcinoma (HNSCC) in a patient including a detector device for detecting a presence of at least one marker indicative of HNSCC, the detector device including a panel of markers for HNSCC. A diagnostic device for and method of staging HNSCC in a patient including a detector device for detecting a presence of at least one marker indicative of stages of HNSCC, the detector device including a panel of markers for HNSCC. Markers for head and neck squamous cell carcinoma selected from the markers listed in Table 5. Methods of personalized immunotherapy, making a personalized anti-cancer vaccine, and predicting a clinical outcome in a HNSCC patient. A method of making a panel of HNSCC markers.

Abstract: An optical zoom lens device for use with a portable electronic device comprising an encasement including a lens and a light sensor and a pivot for connecting the encasement to the portable electronic device.

Abstract: The American Cancer Society estimated that in 2009, 1,479,350 new cancer cases would be diagnosed in the United States of which 219,440 would be lung and bronchus related. The standard treatments for NSCLC include surgery, chemotherapy, radiation, laser and photodynamic therapy, all with various success rates depending on the stage of the cancer. National Cancer Institute assesses, however, that results of standard treatment are generally poor with only a 15 percent 5-year survival rate for combined cancer stages. Challenges facing the current chemotherapy drugs include excessive toxicity to healthy tissues and limited ability to prevent metastases. A dual drug delivery system described herein selectively targets the lung to deliver anti-cancer drugs and inhibit the formation of metastases.

Abstract: Implementations described and claimed herein provide systems and methods for palpation training. In one implementation, a system for medical procedure simulation includes an examination model, a sensor network, and a computing device. The examination model has a plurality of anatomical structure models, and the sensor network has a plurality of sensors. Each of the sensors is associated with one of the plurality of anatomical structure models and configured to capture examination data. The computing device is in communication with the sensor network and configured to generate feedback for an accuracy of a medical examination using the examination data.

Abstract: A method of forming electrical contacts on a diamond substrate comprises producing a plasma ball using a microwave plasma source in the presence of a mixture of gases. The mixture of gases include a source of a p-type or an n-type dopant. The plasma ball is disposed at a first distance from the diamond substrate. The diamond substrate is maintained at a first temperature. The plasma ball is maintained at the first distance from the diamond substrate for a first time, and a UNCD film, which is doped with at least one of a p-type dopant and an n-type dopant, is disposed on the diamond substrate. The doped UNCD film is patterned to define UNCD electrical contacts on the diamond substrate.

Abstract: A rapid antibiotic susceptibility test (AST) based on the detection and quantification of the movement of single bacterial cells with a plasmonic imaging and tracking (PIT) technology. The PIT-based AST detects changes in the metabolic activity of the bacterial cells long before cell replication, and allows rapid AST for both cultivable and non-cultivable strains. PIT tracks 3D movement with sub-nanometer resolution and millisecond temporal resolution. PIT also allows simultaneous measurement of the binding kinetic constants of antibiotics and bacterial metabolic state after the introduction of antibiotics.

Abstract: Sensory information can be delivered to a subject mammal, for example, for restoring a sense of cutaneous touch and limb motion to the subject mammal. A biomimetic electrical signal is generated based on (a) a stimulation reference signal applied to a somatosensory region of a nervous system of a reference mammal, (b) a stimulated-response signal acquired from a sensory cortex of the reference mammal in response to application of the stimulation reference signal to the thalamic nucleus, and (c) a natural-response signal acquired from the sensory cortex in response to peripheral touch stimuli and/or peripheral nerve stimulation of the reference mammal. The biomimetic electrical signal is applied to a somatosensory region of a nervous system of the subject mammal to induce an activation response, in a sensory cortex of the subject mammal.

Abstract: The present invention is directed to reagents useful for generating immune responses to Mycobacterium tuberculosis and for diagnosing infection and disease in a subject that has been exposed to M. tuberculosis.

Abstract: A turbo-compression cooling system includes a power cycle and a cooling cycle coupled one to the other. The power cycle implements a waste heat waste heat exchanger configured to evaporate a first working fluid and a turbine configured to receive the evaporated working fluid. The turbine is configured to rotate as the first working fluid expands to a lower pressure. A condenser condenses the first working fluid to a saturated liquid and a pump pumps the saturated liquid to the waste heat waste heat exchanger. The cooling cycle implements a compressor increasing the pressure of a second working fluid, a condenser condensing the second working fluid to a saturated liquid upon exiting the compressor, an expansion valve expanding the second working fluid to a lower pressure, and an evaporator rejecting heat from a circulating fluid to the second working fluid, thereby cooling the circulating fluid.