Patents Assigned to State University
  • Radiation Detector
    Publication number: 20170219720
    Abstract: A radiation detector is provided. In a further aspect, a detector employs a Parallel Plate Avalanche Counter (“OPPAC”) which includes an anode film, a parallel cathode film and multiple optical photo-detectors, such as photo-sensors and/or photo-multipliers. A method of using a radiation detector is also provided.
    Type: Application
    Filed: January 13, 2017
    Publication date: August 3, 2017
    Applicant: Board of Trustees of Michigan State University
    Inventors: Marco Cortesi, John E. Yurkon
  • ALPHA- AND GAMMA-TRUXILLIC ACID DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS THEREOF
    Publication number: 20170216241
    Abstract: The present invention provides a compound, and method of inhibiting the activity of a Fatty Acid Binding Protein (FABP) comprising contacting the FABP with a compound, having the structure:
    Type: Application
    Filed: February 10, 2017
    Publication date: August 3, 2017
    Applicant: The Research Foundation for The State University of New York
    Inventors: Iwao Ojima, Dale Deutsch, Martin Kaczocha, William T. Berger, Robert Rizzo, Trent E. Balius
  • Ceramide-Rubusoside Nanomicelles and Their Use in Cancer Therapy
    Publication number: 20170216329
    Abstract: Water-soluble, cell-permeable nanomicelles containing ceramides and a steviol glycoside, such as rubusoside, are disclosed. The ceramide-steviol glycoside complex has high water solubility, and can be used for treating cancers with p53 mutations. Preliminary results have shown that the Cer nanomicelles are effective in restoring p53 protein expression, and that they are functionally dominant over p53 mutants. The novel nanomicelles restore a wild-type phenotype, and have very low toxicity to noncancerous cells. The novel Cer nanomicelles may be used in treating p53-associated cancers.
    Type: Application
    Filed: May 6, 2015
    Publication date: August 3, 2017
    Applicants: Board of Supervisors of Louisiana State University and Agricultural and Mechanical College, University of Louisiana at Monroe
    Inventors: Zhijun Liur, Yong-Yu Liu
  • Method of providing a flexible semiconductor device and flexible semiconductor device thereof
    Patent number: 9721825
    Abstract: Some embodiments include a method. The method can include providing a carrier substrate having an edge. Further, the method can include providing a cross-linking adhesive, and providing a flexible substrate having an edge. Further still, the method can include coupling the flexible substrate to the carrier substrate using the cross-linking adhesive such that at least a portion of the edge of the flexible substrate is recessed from the edge of the carrier substrate and such that the cross-linking adhesive has an exposed portion of the cross-linking adhesive at an offset portion of the first surface of the carrier substrate between the at least the portion of the edge of the flexible substrate and the edge of the carrier substrate. Meanwhile, the method can include etching the exposed portion of the cross-linking adhesive. Other embodiments of related methods and devices are also disclosed.
    Type: Grant
    Filed: April 12, 2016
    Date of Patent: August 1, 2017
    Assignee: ARIZONA BOARD OF REGENTS, A BODY CORPORATE OF THE STATE OF ARIZONA, ACTING FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY
    Inventors: Michael A. Marrs, Emmett M. Howard, Douglas E. Loy, Nicholas Munizza
  • Gliding robotic fish navigation and propulsion
    Patent number: 9718523
    Abstract: A robotic submersible includes a housing having a body and a tail. In another aspect, a pump and a pump tank adjust the buoyancy of a submersible housing. In a further aspect, a first linear actuator controls the pump and/or a buoyancy, and/or a second linear actuator controls a position of a battery and/or adjusts a center of gravity. Another aspect includes a pump and at least one linear actuator that control gliding movements of the housing. In still a further aspect, a motor couples a tail with a body, such that the motor controls the movements of the tail to create a swimming movement. Moreover, an additional aspect provides a controller selectively operating the pump, first actuator, second actuator, and motor to control when swimming and gliding movements occur.
    Type: Grant
    Filed: October 23, 2014
    Date of Patent: August 1, 2017
    Assignee: Board of Trustees of Michigan State University
    Inventors: Xiaobo Tan, Feitian Zhang, Jianxun Wang, John Thon
  • Polymeric nanopillars and nanotubes, their manufacture and uses
    Patent number: 9718676
    Abstract: A method is disclosed for fabricating free-standing polymeric nanopillars or nanotubes with remarkably high aspect ratios. The nanopillars and nanotubes may be used, for example, in integrated microfluidic systems for rapid, automated, high-capacity analysis or separation of complex protein mixtures or their enzyme digest products. One embodiment, preferably fabricated entirely from polymer substrates, comprises a cell lysis unit; a solid-phase extraction unit with free-standing, polymeric nanostructures; a multi-dimensional electrophoretic separation unit with high peak capacity; a solid-phase nanoreactor for the proteolytic digestion of isolated proteins; and a chromatographic unit for the separation of peptide fragments from the digestion of proteins.
    Type: Grant
    Filed: September 12, 2007
    Date of Patent: August 1, 2017
    Assignee: Board of Supervisors of Louisiana State University And Agricultural and Mechanical College
    Inventors: Steven A. Soper, Robin L. McCarley, Guofang Chen, Hamed Shadpour
  • Small animal restraining harness or jacket
    Patent number: 9717217
    Abstract: An animal restraining harness or jacket and a method of use thereof, for protecting the shoulder and upper abdomen when experimental/surgical procedures are performed and when the experimental/surgical sites must be protected from biting, scratching, and other unwanted contact. The jacket generally includes a shoulder region and collar extensions, where the shoulder region is connected to the collar extensions. The collar extensions are wrapped and secured around the collar or neck area of the animal, and the shoulder region is wrapped and secured around the shoulder and torso area of the animal. Preferably, the collar extensions and shoulder region are secured on the dorsal side of the animal, thus providing a dorsal gap therebetween. This harnesses the animal effectively and prevents escape from the restraining jacket.
    Type: Grant
    Filed: October 29, 2015
    Date of Patent: August 1, 2017
    Assignee: The Florida State University Research Foundation, Inc.
    Inventors: Michael Blaber, Sachiko I. Blaber
  • Flight data tracker
    Patent number: 9718557
    Abstract: When flights meet disaster in the mid-air, the cause of the mishap is unknown immediately. Teams are dispatched in difficult conditions to retrieve the flight data recorder (FDR) also known as black box. Until the black box is found, the exact cause of the crash cannot be determined. Sometimes it may take years to find the black box. For example, Air France flight 447 crashed into the Atlantic Ocean on Jun. 1, 2009. The cause of the accident remained unknown mainly because the black box was missing. It was found after almost two years in May 2011. The delay in finding the flight data creates risks for future flights if the crash occurred due to a manufacturing defect in the model of the plane. The ability to reach the data without the burden and need for a physical black box has obvious benefits.
    Type: Grant
    Filed: January 17, 2014
    Date of Patent: August 1, 2017
    Assignee: The Research Foundation for The State University of New York
    Inventor: Junaid Ahmed Zubairi
  • Constructs for diagnosing and treating inflammatory bowel diseases and colon cancer
    Patent number: 9717695
    Abstract: The present invention features, inter alia, constructs for the delivery of therapeutic and diagnostic agents to a patient. The constructs can include a nanoparticle, a targeting agent that specifically binds a targeted tissue or cell, a therapeutic moiety, and a hydrogel. The constructs can be used in the treatment and diagnosis of bowel diseases, including inflammatory bowel disease (IBD) and colon cancer. In one embodiment, the therapeutic agent is a nucleic acid that mediates RNA inhibition (RNAi), and the invention is directed to treatments for IBD that combine the positive aspects of such agents {e.g., siRNAs) with the safety of a biodegradable polymeric delivery system to facilitate specific targeting of colonic tissues and cells. As the constructs can be formulated for oral administration, they are well tolerated and offer advantages with regard to patient compliance.
    Type: Grant
    Filed: May 18, 2013
    Date of Patent: August 1, 2017
    Assignee: Georgia State University Research Foundation, Inc.
    Inventors: Didier Merlin, Bo Xiao, Hamed Laroui
  • Methods for identifying ligands that target nucleic acid molecules and nucleic acid structural motifs
    Patent number: 9719191
    Abstract: Disclosed are methods for identifying a nucleic acid (e.g., RNA, DNA, etc.) motif which interacts with a ligand. The method includes providing a plurality of ligands immobilized on a support, wherein each particular ligand is immobilized at a discrete location on the support; contacting the plurality of immobilized ligands with a nucleic acid motif library under conditions effective for one or more members of the nucleic acid motif library to bind with the immobilized ligands; and identifying members of the nucleic acid motif library that are bound to a particular immobilized ligand. Also disclosed are methods for selecting, from a plurality of candidate ligands, one or more ligands that have increased likelihood of binding to a nucleic acid molecule comprising a particular nucleic acid motif, as well as methods for identifying a nucleic acid which interacts with a ligand.
    Type: Grant
    Filed: November 29, 2007
    Date of Patent: August 1, 2017
    Assignee: The Research Foundation for The State University of New York
    Inventors: Matthew D. Disney, Jessica L. Childs-Disney
  • Scaling and parameterizing a controller
    Patent number: 9720387
    Abstract: Controller scaling and parameterization are described. Techniques that can be improved by employing the scaling and parameterization include, but are not limited to, controller design, tuning and optimization. The scaling and parameterization methods described here apply to transfer function based controllers, including PID controllers. The parameterization methods also applies to state feedback and state observer based controllers, as well as linear active disturbance rejection controllers. It is emphasized that this abstract is provided to comply with the rules requiring an abstract that will allow a searcher or other reader to quickly ascertain the subject matter of the application. It is submitted with the understanding that it will not be used to interpret or limit the scope or meaning of the claims.
    Type: Grant
    Filed: May 28, 2015
    Date of Patent: August 1, 2017
    Assignee: CLEVELAND STATE UNIVERSITY
    Inventor: Zhiqiang Gao
  • Method and apparatus for segmentation and registration of longitudinal images
    Patent number: 9721338
    Abstract: The described invention provides systems and methods for detecting and segmenting a lesion from longitudinal, time series, or multi-parametric imaging by utilizing spectral embedding-based active contour (SEAC). In addition, the described invention further provides systems and methods for registering time series data by utilizing reduced-dimension eigenvectors derived from spectral embedding (SE) of feature scenes (SERg).
    Type: Grant
    Filed: January 9, 2012
    Date of Patent: August 1, 2017
    Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Anant Madabhushi, Shannon C. Agner
  • Vanadyl phosphates as high energy density cathode materials for rechargeable sodium battery
    Patent number: 9722247
    Abstract: A positive electrode comprising ?-VOPO4 and/or Nax(?-VOPO4) wherein x is a value from 0.1 to 1.0 as an active ingredient, wherein the electrode is capable of insertion and release of sodium ions and a reversible sodium battery containing the positive electrode are provided.
    Type: Grant
    Filed: June 10, 2015
    Date of Patent: August 1, 2017
    Assignees: Toyota Motor Engineering & Manufacturing North America, Inc., The Research Foundation for The State University of New York
    Inventors: Ruigang Zhang, Fuminori Mizuno, Chen Ling, M. Stanley Whittingham, Ruibo Zhang, Zehua Chen
  • Metal-air flow batteries using oxygen enriched electrolyte
    Patent number: 9722289
    Abstract: A metal air flow battery includes an electrochemical reaction unit and an oxygen exchange unit. The electrochemical reaction unit includes an anode electrode, a cathode electrode, and an ionic conductive membrane between the anode and the cathode, an anode electrolyte, and a cathode electrolyte. The oxygen exchange unit contacts the cathode electrolyte with oxygen separate from the electrochemical reaction unit. At least one pump is provided for pumping cathode electrolyte between the electrochemical reaction unit and the oxygen exchange unit. A method for producing an electrical current is also disclosed.
    Type: Grant
    Filed: April 30, 2013
    Date of Patent: August 1, 2017
    Assignee: Florida State University Research Foundation
    Inventors: Jian-ping Zheng, Petru Andrei, Annadanesh Shellikeri, Xujie Chen
  • SYSTEMS AND METHODS FOR HIGH THROUGHPUT SOLVENT ASSISTED IONIZATION INLET FOR MASS SPECTROMETRY
    Publication number: 20170213714
    Abstract: A multiplex system and method for achieving high throughput analysis of samples using solvent assisted ionization inlet includes an ionizing system with a heated inlet channel and a pressure differential across the inlet channel, pipet tips serially aligned with the inlet to a mass spectrometer, and a system of mapping data generated by mass spectrometry.
    Type: Application
    Filed: June 13, 2016
    Publication date: July 27, 2017
    Applicant: WAYNE STATE UNIVERSITY
    Inventor: Sarah Trimpin
  • METHODS FOR GENERATING INDUCED PLURIPOTENT STEM CELLS
    Publication number: 20170211091
    Abstract: Provided herein are methods and compositions for inducing a somatic cell to acquire a less differentiated phenotype and for generating induced pluripotent stem cells (i PS cells) by inducing expression of ASF1A in the cell and/or by contacting the cell with GDF9. Also provided herein are compositions and methods for treating and/or diagnosing cancer and for identifying agents useful in the treatment and/or diagnosis of cancer.
    Type: Application
    Filed: July 16, 2015
    Publication date: July 27, 2017
    Applicants: FUNDACIÓN PÚBLICA ANDALUZA PROGRESO Y SALUD, MICHIGAN STATE UNIVERSITY, INSTITUTO DE SALUD CARLOS III
    Inventors: Jose B. Cibelli, María Elena Gonzalez-Muñoz
  • MICROPULSE DIFFERENTIAL ABSORPTION LIDAR
    Publication number: 20170212219
    Abstract: A shared optics and telescope, a filter, and a micropulse differential absorption LIDAR are provided, with methods to use the same. The shared optics and telescope includes a pair of axicon lenses, a secondary mirror, a primary mirror including an inner mirror portion and an outer mirror portion, the inner mirror portion operable to expand the deflected annular transmission beam, and the outer mirror portion operable to collect the return signal. The filter includes an etalon and a first filter. The micropulse differential absorption LIDAR includes first and second laser signals, a laser transmission beam selection switch, a first laser return signal switch, and a toggle timer.
    Type: Application
    Filed: April 27, 2016
    Publication date: July 27, 2017
    Applicants: University Corporation for Atmospheric Research, Montana State University, NASA Langley Research Center
    Inventors: Scott M. SPULER, Kevin S. Repasky, Amin R. Nehrir
  • Methods and Compositions for the Treatment of Prostate Related Disorders using miR-106b
    Publication number: 20170211066
    Abstract: Methods and compositions for the treatment of prostate associated disorders are disclosed.
    Type: Application
    Filed: April 6, 2017
    Publication date: July 27, 2017
    Applicants: The Ohio State University Research Foundation, The Government of the United States of America, as represented by the Secretary of the Department of
    Inventors: Carlo M. Croce, Stefan Ambs
  • CONTROL OF RIPENING AND SENESCENCE IN PRE-HARVEST AND POST-HARVEST PLANTS AND PLANT MATERIALS BY MANIPULATING ALTERNATIVE OXIDASE ACTIVITY
    Publication number: 20170208813
    Abstract: Methods of controlling the maturation of plants and/or plant products (e.g. fruit, vegetable, ornamentals, etc.) by manipulating Alternative Oxidase (AOX) activity. An increase in activity hastens the maturation process while a decrease in activity slows or stops maturation.
    Type: Application
    Filed: March 10, 2017
    Publication date: July 27, 2017
    Applicant: Washington State University
    Inventors: Amit Dhingra, Christopher Hendrickson, Seanna Hewitt
  • IRIDIUM PINCER COMPLEX FOR ALKANE DEHYDROGENATION PROCESS
    Publication number: 20170210771
    Abstract: Disclosed herein are processes for dehydrogenation of an alkane to an alkene using an iridium pincer complex and iridium pincer complexes. In the dehydrogenation reactions, hydrogen that is co-formed during the process must be removed for the chemical reaction to proceed and to prevent the excess hydrogen from poisoning the catalyst. In one embodiment the process comprises providing an alkane feedstock comprising at least one alkane and contacting the alkane with an iridium pincer complex in the presence of a hydrogen acceptor selected from the group consisting of ethylene, propene, or mixtures to form an alkene product.
    Type: Application
    Filed: April 7, 2017
    Publication date: July 27, 2017
    Applicants: Chevron U.S.A. Inc., Rutgers, The State University of New Jersey
    Inventors: Akshai KUMAR, Oleg MIRONOV, Robert J. SAXTON, Alan S. GOLDMAN