Abstract: Controller scaling and parameterization are described. Techniques that can be improved by employing the scaling and parameterization include, but are not limited to, controller design, tuning and optimization. The scaling and parameterization methods described here apply to transfer function based controllers, including PID controllers. The parameterization methods also applies to state feedback and state observer based controllers, as well as linear active disturbance rejection controllers. It is emphasized that this abstract is provided to comply with the rules requiring an abstract that will allow a searcher or other reader to quickly ascertain the subject matter of the application. It is submitted with the understanding that it will not be used to interpret or limit the scope or meaning of the claims.

Abstract: The present invention provides novel methods and compositions for the diagnosis and treatment of solid cancers. The invention also provides methods of identifying inhibitors of tumorigenesis.

Abstract: A method is provided for determining specifications that meet electronic system or integrated circuit product requirements at all stages of the product lifecycle. Early in the product lifecycle design features must be specified. Later in the lifecycle datasheet specifications must be determined and published to customers, and test specifications in manufacturing must be determined. The method includes acquiring data from a test vehicle, fitting the data to a copula-based statistical model using an appropriately programmed computer, and using the statistical model to compute producer- and customer-oriented figures of merit of a product, different from the test vehicle, using the appropriately programmed computer. Different size, fault tolerance schemes, test coverage, end-use (datasheet), and test condition specifications of the product may be modeled. The statistical model is a copula-based and so can take into account dependency among attributes of the product.

Abstract: The present invention relates to an alternative strategy for expressing the antisense sequence of a miRNA. This system allows for continuous production of the antisense sequence and subsequently complete knockdown of the targeted miRNA.

Abstract: A method of electrophoretic movement of particles through a liquid crystal utilizes a direct (DC) or alternating (AC) electric field that is applied along the liquid crystal director (for liquid crystals with a positive dielectric anisotropy) or perpendicular to the director (for liquid crystals with a negative dielectric anisotropy). A perpendicular or tilted orientation of the liquid crystal molecules at the surface of the particle causes distortions, such that the fore-aft (or left-right) symmetry of the particle is broken. The asymmetric orientation of the liquid crystal around the particle allows both charged and neutral particles to be transported, even when the particles themselves are perfectly symmetric (spherical).

Abstract: The present invention provides electrochemical energy storage systems comprising metallolyte composites, iron fluoride composites and iron oxyfluoride composites. The present invention further provides methods for fabricating metallolyte composites.

Abstract: Systems and methods for forecasting wind farm power generation are disclosed. Via use of a support vector machine (SVM) enhanced Markov model, short-term wind power generation forecasts may be generated. Exemplary approaches accurately account for wind ramp-up and ramp-down, as well as diurnal non-stationarity and seasonality of wind power generation. Via use of the disclosed forecasting approaches, utilities and grid managers can make improved decisions relating to electrical power generation and transmission, thus reducing costs and reducing pollution.

Abstract: The invention relates to an oral nanoparticle drug delivery system, including methods for preparing such a system using a hydrophobic water insoluble protein, which nanoparticles may include prolamine to generate said oral drug delivery system.

Abstract: A ZnO based display pixel structure that includes system-on-glass (SOG) substrates with embedded non-volatile resistive random access memory iNV-RRAM) is provided. Such pixels feature high frame rates and low power consumption. The entire SOG is based on ZnO devices. Different devices including TFT, TCO, RRAM, inverters, and shift registers are obtained through doping of different elements into selected ZnO active regions. This reduces the cost to package control circuitry onto a backplane of a display system, resulting in a low cost, light weight and uUra-thin display.

Abstract: A hearing assistive device is provided having a microphone, at least one audio signal processing mechanism, a vibration signal processing mechanism, and a vibrator. The audio signal processing mechanism receives an input audio signal from the microphone and generates a first output signal according to the received input audio signal wherein the first output signal coupled to a transducer that generates auditory perception in an ear of a user. The vibration signal processing mechanism receives the input audio signal and generates a second output signal according to the input audio signal. The vibrator is configured to be placed adjacent to the skin of the user, and configured to generate a vibration stimulation signal on the skin of the user according to the second output signal.

Abstract: The present invention comprises a method for selecting lactic acid bacterial strains effective for preventing bone loss in humans and strains that have been selected according to the presented method. The selection method is based on the strain's capability of reestablishing an altered microbial community to normal and/or harboring at least one of four specific SNPs.

Abstract: A facile method to produce covalently bonded graphene coating on various solid substrates is disclosed in the present invention. According to one embodiment, a combination of graphite, graphene oxide or graphene and silicon compound with or without a metal containing compound in an air free environment is processed at high temperatures to produce covalent carbide bonding among graphene layers and between graphene and substrate surface.

Abstract: The present invention provides a method of inhibiting the growth of or promoting differentiation and destruction of cancer stem cells (CSCs) comprising contacting the cancer stem cells with a compound having the structure: or a pharmaceutically acceptable salt thereof.

Abstract: Oral compositions and methods of use thereof are provided herein. The oral compositions comprise a first component comprising at least one Eh-raising compound and a pharmaceutically acceptable carrier, and a second component comprising at least one zinc compound, an anti-microbial agent and a pharmaceutically acceptable carrier.

Abstract: Methods and compositions for reducing the incidence of C. jejuni bacteria infections in poultry and in humans and other animals are formulated to include C. jejuni antigens, and particularly CadF, FlpA and FlaA. The antigens may be provided in the form of polypeptides or by hosts that produce the antigens. Fibronectin binding proteins of C. jejuni may also be used to deliver substances of interest to humans and other animals.

Abstract: A method of determining change in a state of an object using images of the object, the method including providing a first image and a second image of the object, the first image and the second image being spaced apart in time, performing a plurality of pixel-based change detection algorithms to obtain a plurality of output difference products/images containing change information and pseudo change information, combining the plurality of output difference products to form a hybrid output difference product, and thresholding the output difference product to detect changes in the object.

Abstract: The present invention relates to new auristatin compounds and prodrugs thereof, compositions comprising them and uses thereof.

Abstract: The present invention provides the amino acid and polynucleotide sequences of the transcobalamin receptor, as well as modulators of the transcobalamin receptor. Accordingly, the present invention provides compositions and methods for the treatment and prevention of diseases and disorders associated with cobalamin deficiency, including compositions and methods that promote cobalamin uptake. In addition, the present invention provides compositions and methods for the detection, treatment, and prevention of diseases associated with deregulated cell growth, including, e.g., cancer and autoimmune disorders, including compositions and methods that inhibit cobalamin uptake.

Abstract: In various embodiments, provided are implantable devices for replacing all or a portion of a metatarsophalangeal joint, comprising (i) a metatarsal component comprising a substantially convex bearing surface; or (ii) a phalanx component comprising a substantially concave bearing surface; or (iii) both. In various embodiments, also provided are methods of treating hallux valgus by replacing all or a portion of a metatarsophalangeal joint with one or more of the provided implantable devices.

Abstract: This disclosure describes a distributed, fault-tolerant security system that enables the secure storage and distribution of private keys. In one implementation, the security system includes a plurality of computing resources that independently store private keys provided by publishers and encrypted using a single security system public key. To protect against malicious activity, the security system private key necessary to decrypt the publication private keys is not stored at any of the computing resources. Rather portions, or shares of the security system private key are stored at each of the computing resources within the security system and multiple security systems must communicate and share partial decryptions in order to decrypt the stored private key.