Abstract: A method of (a) treating a lymphoproliferative disease in a subject in need thereof; (b) slowing the progression of lymphoproliferative disease in a subject who has been diagnosed with a lymphoproliferative disease; or (c) preventing or delaying development of a lymphoproliferative disease in a subject who is at risk of developing a lymphoproliferative disease. The method generally comprises administering to the individual an effective amount of a combination therapy comprising: i) at least one autophagy modulating agent, or a derivative, pharmaceutically acceptable salt thereof, or prodrug thereof; and ii) at least one CDK inhibitor agent, or a derivative, pharmaceutically acceptable salt thereof, or prodrug thereof, wherein the i) agent and the ii) agents are administered in amounts sufficient to enhance the cytotoxicity of the combination relative to the CDK inhibitor agent treatment alone.

Abstract: A soft tissue fixation device for use in ACL or CrCL reconstruction has a base member provided with a passageway extending perpendicularly from its top surface through its bottom surface. The passageway is sized to allow soft tissue to be inserted through the passageway. The fixation device also includes an affixing member attachable to the base member. The base member has a notched section in the top surface extending from the passageway to a first perimeter section of the base member sized to accommodate at least a portion of the graft. Either surgical grade tissue glue or at least one perpendicularly extending spike is used to secure the base member to the bone. The base member is also provided with a sleeve whose interior wall surfaces form a part of the passageway and is sized to be inserted into the bone opening. The affixing member is provided with a series of teeth members extending downward from its lower surface.

Abstract: The present invention encompasses a recombinant Edwardsiella bacterium, and compositions and methods of use thereof.

Abstract: An arrangement that converts mechanical energy into electrical energy employs a base member and a cantilever member coupled thereto. The cantilever member has two piezoelectric layers with an air space therebetween. A proof mass is coupled to the cantilever member distal from the base member. The first and second piezoelectric layers are formed of lead zirconate titanate (PZT), and the output voltage of the cantilever member is proportional to the height of the air gap. A piezoresistive accelerometer that is useful for measuring mechanical vibration has a suspension beam and a piezoresistive layer be separated from the suspension beam. A method of monitoring an acoustic vibration utilizes a piezoresistive element having an air-spaced cantilever formed of a piezoelectric material in the vicinity of the system to be monitored and obtains an alternating voltage form the air-spaced cantilever of the piezoresistive element.

Abstract: A laser apparatus includes a fiber oscillator. In another aspect, an Ytterbium (Yb) doped fiber is employed. Another aspect provides an unamplified laser pulse emitted from an Yb fiber oscillator having a repetition rate less than 5 MHz and a pulse energy greater than 100 nJ. In still an additional aspect, a flexible Yb fiber has a length greater than 1 m which is capable of being looped with an outside loop diameter less than 150 mm. Another aspect provides for a fiber oscillator with passive optical fiber lengths of at least 10 meters, and more preferably more than 100 meters while having repetition rates less than 4 MHz.

Abstract: The described invention provides self-forming compositions as positive electrode materials. The described invention further provides electrode compositions related to an electrochemical energy storage cell comprising a metal, a glass former and lithium fluoride.

Abstract: Compositions and methods for modulating flowering, sugar metabolism and stress response in plants are provided.

Abstract: An opto-mechanical deployable telescope includes a hub, at least one deployable multiple petal primary mirror mounted to the hub, a deployment assembly, a secondary optic assembly, and a deployment engine assembly. The deployment assembly is operable to move the at least one primary mirror between a stowed position and a deployed position. The deployment engine assembly is operable to power the deployment assembly using stored mechanical energy. The deployment assembly includes a kinematic or semi-kinematic interface between the hub and the at least one primary mirror to hold petals of the at least one primary mirror in alignment relative to each other in the deployed position. The secondary optic assembly comprising a secondary optical member and is operable to axially position the secondary optical member relative to the primary mirror.

Abstract: A method for ultrasound modulation of the brain for treatment of stroke, brain injury, and other neurological disorders or the improvement of cognitive functioning in patients. The method may include identifying a stimulation site of a brain, where the stimulation site is associated with a brain disorder, applying ultrasound to the stimulation site, and initiating physical therapy. Alternately, ultrasound may be applied to the brain to enhance aspects of cognitive functioning by the combination of exercising the functionality of the brain and applying ultrasound to the region(s) or structures of the brain known to be associated with that function.

Abstract: Embodiments of the present disclosure are directed to recognition tunneling methods, systems and devices for the detection of carbohydrates by measuring tunneling currents of sugars which give distinct electronic signals in a tunnel gap functionalized respectively with, for example, in some embodiments, 4(5)-(2-mercaptoethyl)-1H imideazole-2-carboxamide and 4-mercaptophenylboronic acid molecules on at least one, and preferably each electrode.

Abstract: Methods for producing biliverdin in a microorganism, methods for producing biliverdin from a non-animal source, cells for producing biliverdin and methods for producing cells for producing biliverdin are disclosed.

Abstract: Disclosed herein, in certain instances, is a novel photovoltaic cell that uses unique micro-architectural and multi-layer functional designs. Further disclosed herein, in certain instances, is a 3-dimensional electrode. Disclosed herein, in certain instances, is a novel electroluminescent cell that uses unique micro-architectural and multi-layer functional designs. Further disclosed herein, in certain instances, is a 3-dimensional diode.

Abstract: The disclosure relates generally to sequential state elements (SSEs), triple-mode redundant state machines (TMRSMs), and methods and systems for testing triple-mode redundant pipeline stages (TMRPSs) within the TMRSMs using triple-mode redundant SSEs (TMRSSEs). The SSEs, TMRSMs, TMRPSs, and TMRSSEs may be formed as integrated circuits on a semiconductor substrate. Of particular focus in this disclosure are SSEs used to sample and hold bit states. Embodiments of the SSEs have a self-correcting mechanism to protect against radiation-induced soft errors. The SSE may be provided in a pipeline circuit of a TMRSM to receive and store a bit state of a bit signal generated by combinational circuits within the pipeline circuit. More specifically, the SSEs may be provided in a TMRSSE configured to perform self-correction. Also disclosed are methods for using the TMRSSE to test redundant pipeline stages of the TMRSM.

Abstract: Methods and compositions for targeted delivery of biotherapeutics are provided. The compositions comprise bile-sensitive St. thermophilus bacteria modified to release a biotherapeutic agent following bile exposure. Biotherapeutic agents released by the St. thermophilus bacteria disclosed herein include AQ and AQR rich peptides. Methods of the invention comprise administering to a subject a St. thermophilus bacterium modified to release a biotherapeutic agent following bile exposure. Administration of the St. thermophilus bacterium promotes a desired therapeutic response. The bacterium may be modified to express and release AQ or AQR rich peptides which subsequently inhibit cellular apoptosis or reduce mucosal damage. Thus, methods of the invention find use in treating or preventing a variety of gastrointestinal disorders including C. difficile infection and antibiotic-associated diarrhea.

Abstract: A method of tilting liquid crystal molecules is presented. The method entails providing a substrate including a photoalignment layer on top of a layer of liquid crystal molecules. The photoalignment layer is exposed to patterned light that is incident on the substrate at a substantially normal angle. The patterned light is polarized in a polarization direction that is non-parallel to an incident surface of the substrate.

Abstract: The present invention encompasses recombinant bacteria and immunogenic compositions comprising the bacteria. The immunogenic composition may be used to induce an immune response against C. perfringens.

Abstract: Methods of treatment using D-serine to target brain cells expressing GluN3 subunit-containing triheteromeric NMDARs are disclosed. The methods include inhibiting calcium ion uptake by brain cells, treating epilepsy, and treating seizures by artificially administering D-serine.

Abstract: A process is provided comprising subjecting a quantity of plant biomass fibers to a pretreatment to cause at least a portion of lignin contained within each fiber to move to an outer surface of said fiber, wherein a quantity of pretreated tacky plant biomass fibers is produced; and densifying the quantity of pretreated tacky plant biomass fibers to produce one or more densified biomass particulates, wherein said biomass fibers are densified without using added binder.

Abstract: A fluid cooled cold plate can comprise a fluid output port connected near a thermally conductive base plate having a coupled heat source device, a fluid input port connected to a top surface of the cold plate, and multiple extended surface areas connected to the base plate and extending normal to the base plate. The cold plate can be configured for generally uniform fluid flow across the multiple extended surface areas. Furthermore, the multiple extended surface areas can create more resistance near a top surface of the multiple extended surface areas and less resistance near the base plate. For example, the plurality of extended surface areas can be wires that are wound near the base plate and fanned out near the top surface. An advantage of the disclosed cold plate design is the increase in heat transfer area and efficiency.

Abstract: The present invention encompasses a phototrophic microorganism with altered and controlled adhesive properties. One aspect of the present invention encompasses a genetically modified phototrophic microorganism capable of controlled adhesion. The microorganism comprises a recombinant nucleic acid construct, wherein the nucleic acid construct comprises an inducible promoter operably-linked to a nucleic acid encoding an adhesion protein.