Abstract: Methods of screening for compounds which are, for example, capable of modulating amino acid-DNA interaction, modulating DNA replication, modulating cell proliferation, and for identifying compounds which inhibit cellular proliferation caused by cancer, are provided.

Abstract: The invention includes RNA complexes comprising at least three monomeric units of an RNA molecule, each monomeric unit comprising an RNA polymer having first and second helical domains that have respective first and second binding sites, wherein the first binding sites are adapted to binding to one another and are not adapted to bind to the second binding sites, and the second binding sites are adapted to binding to one another and are not adapted to bind to the first binding sites; such that the at least three monomeric units are adapted to self-assemble by forming pairs of cognate interactions and so as to form the RNA complex in a circular closed complex. The invention also includes derivatives of these complexes including aptamers, and analytical methods and devices using same.

Abstract: In various embodiments, electronic apparatus, systems, and methods include a unified compact spatiotemporal method that provides a process for machines to deal with space and time and to deal with sensors and effectors. Additional apparatus, systems, and methods are disclosed.

Abstract: A process for producing bulk thermoelectric compositions containing nanoscale inclusions is described. The thermoelectric compositions have a higher figure of merit (ZT) than without the inclusions. The compositions are useful for power generation and in heat pumps for instance.

Abstract: A wind harnessing system comprises a substantially grooved shell disposed about a rigid frame. The grooved shell can be constructed of lightweight shell panels connected to one another and to the frame. Alternatively, the grooved shell can be constructed of inflatable shell sections.

Abstract: Monodisperse macromolecular conjugate compositions of a peptidic carrier irreversibly or reversibly conjugated with one or more effectors and one or more therapeutic agents, wherein at least one effector or therapeutic agent is attached to a pendant reactive group on said peptidic carrier via a water-soluble polymer. Monodispersity is obtained through the use of orthogonal and separate conjugation reactions.

Abstract: A method and vaccine for treatment of pythiosis in humans and animals is described. In particular a vaccine comprising a mixture of extracellular and intracellular proteins is described. The vaccine enables cures of chronic pythiosis in some patients.

Abstract: Embodiments of the present system and method are useful for chemical deposition, particularly continuous deposition of thin films. Disclosed systems typically comprise a micromixer and a microchannel applicator. A deposition material or materials is applied to a substrate, such as an oxidized silicon substrate, a flexible substrate useful for forming flexible devices, such as flexible transistors, and combinations of different substrates. Uniform and highly oriented surface morphologies of films deposited using disclosed embodiments are clearly improved compared to films deposited by a conventional batch process. The process can be used to tailor the composition and morphology of the material deposited on a substrate. The present process can be used at low temperatures as a post-deposition, high-temperature annealing step is obviated.

Abstract: A compound having the formula Y-A-Z, wherein: A is a phenyl group which is unsubstituted or substituted; Y and Z are substituents at adjacent positions on ring A; Y represents: Z represents: and wherein the remaining variables are as defined in the specification.

Abstract: An efficient computational method and system for predicting the folding regions and associated secondary and tertiary structures of a protein is disclosed. Methods and systems for sorting amino acid sequences based on predicted structures, as well as methods and systems for determining the presence or absence of genes in nucleic acid sequences or structural mutations in amino acid sequences are also disclosed. A method and system for the design of a protein is also disclosed.

Abstract: The present invention encompasses a recombinant Edwardsiella bacterium, and compositions and methods of use thereof.

Abstract: The device and method for remotely monitoring animal behavior consists of a sensor unit mounted on an animal. The sensor unit utilizes motion sensors to monitor the specific behavioral patterns of the animal. Power management is controlled to turn the system on when specific types of motion are detected. Motion data is wirelessly transmitted to a base station for analysis. Data analysis functions are used to detect and identify the occurrence of characteristic motions. Network decision algorithms analyze the characteristic motions and compute weighted indicators and weighted counter-indicators which are combined into a final diagnostic score. When the final diagnostic score exceeds a threshold value, a specific behavioral pattern is confirmed which may indicate the animal is in a distress situation or experiencing another type of behavior that requires intervention. If distress is detected, the system sends a communication to notify the appropriate personnel that a distress condition exists.

Abstract: The invention administers an objective clinical test to an eye that measures the visual sensitivity of the superior retina and the inferior retina, by alternately presenting a stimulus pair comprising a shaped superior light stimulus and a shaped inferior light stimulus that are horizontal mirror images of one another and have shapes encompassing visual field defects. The shaped superior and inferior light stimuli stimulate pupillary responses whose amplitudes are measured. A cycle-averaged pupillary response balance and a luminance ratio are computed for each presentation of a stimulus pair. A stimulus pair response curve is computed by fitting cycle-averaged pupillary response balances to a sigmoid function of the luminance ratios. A balanced luminance ratio at which the cycle-averaged pupillary response balance is equal to about zero is computed from the sigmoid function. The balanced luminance ratio is indicative of the presence and location of retinal nerve damage.

Abstract: Magnetic nanoparticle compositions are provided which provide an inherent temperature regulator for use in magnetic heating, particularly for use in magnetic hyperthermia medical treatments. The composition includes magnetic nanoparticles having a Curie temperature of between 40 and 46° C., preferably about 42° C., and may further include a polymeric material and optionally a drug or radiosensitizing agent. Methods of hyperthermia treatment of a patient in need thereof are provided which include the steps of administering to the patient a composition comprising magnetic nanoparticles having a Curie temperature of between 40 and 46° C.; and exposing the magnetic nanoparticles in the patient to an alternating magnetic field effective to generate hysteresis heat in the nanoparticles.

Abstract: The present invention relates to the a new protecting group, 4-(O-nitrophthalimido)butyric acid (NPB) that may be attached to a monomer unit during oligosaccharide synthesis such that upon cleavage of this molecule, the solution turns orange. The orange color allows the simple colorimetric monitoring of the completion of the cleavage reaction and, upon collection of the colored fraction, quantification of the amount of the monomer unit that was successfully coupled to the solid phase.

Abstract: A handheld sensor device is provided for measuring an ion concentration in a solution. The solution is in an electrochemical cell that includes a counter electrode, a working electrode, and a reference electrode. The sensor includes a control amplifier configured to provide a current through the counter electrode and the working electrode so as to maintain a predetermined voltage between the working electrode and the reference electrode. The sensor also includes a current amplifier configured to measure the current provided through the counter electrode and the working electrode. In one embodiment, the sensor also includes a direct digital frequency synthesizer (DDFS) including a phase accumulator. The DDFS is configured to selectively generate a waveform specified by an electrochemical technique such as square wave voltammetry, cyclic voltammetry, linear sweep voltammetry, differential-pulse polarography, normal-pulse polarography, or other known electrochemical techniques.

Abstract: The present invention provides an isolated canine influenza virus of subtype H3N8 comprising an HA having SEQ ID NO: 4 or an amino acid sequence that is greater than 99% identical to SEQ ID NO: 4, with the proviso that the amino acids at positions 94 and 233 are identical to SEQ ID NO: 4; a composition comprising attenuated or inactivated virus; isolated or purified HA, NM, NP, M1, NS1, PA, PB1, and PB2 proteins and fragments thereof and compositions comprising same or nucleic acids, optionally as part of a vector, encoding same; and a method of inducing an immune response to canine influenza virus in an animal comprising administering to the animal an aforementioned composition.

Abstract: Methods and systems for estimating atmospheric conditions are disclosed according to embodiments of the invention. In one embodiment, a method may include receiving reflective atmospheric data and solving a flow equation for motion coefficients using the reflective atmospheric data. Future atmospheric conditions can be estimated using the motion coefficients and the reflective atmospheric data. In another embodiment of the invention, the flow equation is solved in the frequency domain. Various linear regression tools may be used to solve for the coefficients. In another embodiment of the system, a radar system is disclosed that predicts future atmospheric conditions by solving the spectral flow equation.

Abstract: A new and distinct variety of Lagerstroemia crapemyrtle plant named ‘Chocolate Mocha’, characterized by its combination of deep dark brown/red-purple leaf color and brilliant bubble gum pink flower color. ‘Chocolate Mocha’ is also distinguished by its resistance to leaf scorch, upright non-spreading growth, and medium growth size.

Abstract: ‘Crystalina’ is a new variety of Clethra alnifolia with a low, compact, rounded habit, with long flower racemes and numerous fragrant flowers, is disclosed.