Abstract: The present invention relates to a new source of high quality plant protein, termed, “quinoa protein concentrate (QPC)”, which contains at least about 50 wt % protein which is food-grade and/or pharmaceutical-grade and methods of preparing such protein concentrates as well as starch, oil, and fiber from quinoa grain. The quinoa protein concentrate of the invention is useful as food ingredients, infant formula ingredients, cosmetic ingredients, pet food ingredients, and animal feed supplements.

Abstract: A method for assisting multi-tasking computer users includes receiving from a user a specification of a task being performed by the user or an indication of completion of a task, collecting state changes in multiple executing programs, predicting a current task being performed by the user based on a recent state change event, a past specification of a task being performed by the user, and past events and associated tasks. Based on the predicted current task, user interface elements in multiple executing programs are adapted to facilitate performance of the task. The method may also allow a user to specify a new task based on a task template derived from a completed task to facilitate completion of the new task. The task templates also may be shared among users, and active tasks may also be team tasks shared among users.

Abstract: The invention provides an article comprising, a mesoporous silicate matrix, such as a particle, having one or more pores; and one or more releasable caps obstructing one or more of the pores. The articles are useful as delivery vehicles for encapsulated agents such as therapeutic agents, polynucleotides, polypeptides and the like.

Abstract: A carbohydrate-gypsum composite for use as a bonding agent in manufacturing gypsum construction materials is disclosed. The composite includes a carbohydrate substituted with sulfate moieties such as cellulose sulfate and a crystalline calcium sulfate dihydrate. The composite may be used in bonding paper cover sheets to a gypsum core to form a gypsum wallboard. Also disclosed are methods of making the composite and methods of making gypsum wallboard with the composite.

Abstract: A multi-color cavity ringdown based spectrometer is housed in a light tight enclosure to detect the presence of trace quantities of gas phase molecules emanating from explosives, drugs, or hazardous materials being transported through the enclosure or compounds contained in a patient's breath. A method is also disclosed for detecting gas phase molecules emanating from explosives, drugs, hazardous materials, or a patient's breath.

Abstract: The disclosure relates to porous silicon/conductive polymer composites that can be used in biosensor applications (e.g., in a binding assay that captures a target analyte). The composite material generally includes (a) a p-doped silicon substrate that has a porous surface; (b) a lawn of a conductive polymer bound to the porous surface; and (c) a binding pair member bound to the conductive polymer. The porous silicon surface provides excellent adhesion between the substrate and the conductive polymer, thereby eliminating the need for an intervening metallic layer. Processes according to the disclosure for forming the composite material generally include electropolymerizing and electrodepositing the conductive polymer onto the porous surface of the silicon substrate and then binding the binding pair member to the conductive polymer. Methods and kits employing the composite materials are also disclosed.

Abstract: The present invention provides novel HDAC inhibitors and methods of treating diseases using the same.

Abstract: Methods and systems for predicting the significance of a biological pathway in a disease state, the method and system comprising: (a) providing data on the expression levels of a plurality of biomolecules differentially expressed in a disease state as compared with the same biomolecules expressed in a non-diseased state within the pathway: (b) determining the probability of the presence of the plurality of biomolecules in said diseased state; (c) determining the effect of each biomolecule from the plurality of biomolecules on the expression of different downstream biomolecules within the pathway thereby providing a perturbation factor for each biomolecule in the pathway; (d) combining the statistical significance of the differentially expressed biomolecule within the pathway present in the disease state with a sum of perturbation factors for all of the biomolecules in the pathway to generate an impact factor for the pathway relevant to the disease state; (e) calculating the statistical significance of the imp

Abstract: Rubus idaeus Linnaeus ‘Nantahala’ is a new and distinct variety of raspberry that has the following unique combination of desirable features that are outstanding in a new variety. 1. Late season ripening to follow ‘Heritage’. 2. Fruit is medium size, 3.5 g. 3. Fruit is firm, very attractive, uniform and conical to ovate. 4. Consistent and moderate yields.

Abstract: A thermoelectric material and a method of fabricating a thermoelectric material are provided. The thermoelectric material includes a doped compound of at least one Group IV element and at least one Group VI element. The compound is doped with at least one dopant selected from the group consisting of: at least one Group Ia element, at least one Group IIb element, at least one Group IIIa element, at least one Group IIIb element, at least one lanthanide element, and chromium. The at least one Group IV element is on a first sublattice of sites and the at least one Group VI element is on a second sublattice of sites, and the at least one Group IV element includes at least 95% of the first sublattice sites. The compound has a peak thermoelectric figure of merit ZT value greater than 0.7 at temperatures greater than 500 K.

Abstract: There is provided a system and methods for segmenting datapath resources such as reorder buffers, physical registers, instruction queues and load-store queues, etc. in a microprocessor so that their size may be dynamically expanded and contracted. This is accomplished by allocating and deallocating individual resource units to each resource based on sampled estimates of the instantaneous resource needs of the program running on the microprocessor. By keeping unused datapath resources to a minimum, power and energy savings are achieved by shutting off resource units that are not needed for sustaining the performance requirements of the running program. Leakage energy and switching energy and power are reduced using the described methods.

Abstract: An antenna made up of addressable conductive segments, or pixel elements, affixed to the top of each piston in a piston array is presented. The pixel elements can be activated in less than a millisecond to form an antenna array and transmission line pattern using movable pistons and a two-dimensional actuator. Each piston comprises a handle, a bottom conductive segment affixed to the top of the handle, a dielectric segment affixed to the uppermost surface of the bottom conductive segment, and a top conductive segment affixed to the uppermost surface of the dielectric segment. When the piston is not actuated, the top conductive segment forms part of a ground plane. The top conductive segment form part of the transmission line and antenna array patterns, the dielectric segment becomes a dielectric space and the bottom conductive segment forms part of the ground plane when the piston is actuated.

Abstract: Particular aspects provide novel methods for analysis of ion populations, the methods comprising filtering and selecting an ion population using a low-field dual-gate ion mobility spectrometer comprising a drift tube, the spectrometer operating at a pressure of at least 100 Torr, to provide mobility-selected ions. Certain aspects comprise: (i) subsequently accumulating the low-field selected ions in an ion trap (e.g., an MS ion trap) and mass spectrometry analysis; (ii) introducing the low-field selected ions into a high-field ion mobility spectrometer for separating thereby (optionally followed by mass spectrometry); and (iii) introducing the low-field selected ions into an ion trap mass spectrometer, and subsequently into a second low-field ion mobility spectrometer (e.g., a non-dual gate spectrometer operating at less than about 100 Torr). Additional aspects provide novel apparatus and combination thereof for performing the disclosed methods.

Abstract: The invention encompasses micelle assemblies, compositions having micelle assemblies, and methods for preparing micelle assemblies and compositions thereof. Also, the invention encompasses compounds of the formula: A-X-Y-Z-R1 wherein A is a carboxy group or is absent; X is a polyol, Y is —C(?O)—, —C(?S)—, or is absent; Z is O, S, or NH; and R1 is a polyether, wherein one or more hydroxy groups of the polyol are acylated with a fatty acid residue, wherein the compounds form micelle assemblies. The invention encompasses methods of encapsulating molecules using the compounds of the invention.

Abstract: Delivery of bioactive molecules (BAMs) to organelles, cells, tissues, or animals with high efficiency is desirable. Novel compositions for highly efficient delivery of bioactive molecules by biolistic methods are described. The novel compositions include novel microparticle cores, microparticle core/BAM complexes, microparticle core/nanoparticle complexes and multilayer-microparticle core/BAM complexes. Any one of these may be further modified to include targeting agents.

Abstract: A wave rotor apparatus is provided. In another aspect of the present invention, a radial wave rotor includes fluid passageways oriented in a direction offset from its rotational axis. A further aspect of the present invention employs stacked layers of generally radial channels in a wave rotor. Moreover, turbomachinery is located internal to a wave rotor in yet another aspect of the present invention. In yet another aspect of the present invention, a radial wave rotor has an igniter and fuel injector. Correctional passages are employed in still another aspect of the present invention wave rotor.

Abstract: Disclosed herein are novel probes, which can be used to detect and identify target molecules of interest in a sample. The disclosed probes can be used to monitor conformational changes induced by molecular recognition events in addition to providing signaling the presence and/or identity of a target molecule. Methods, including solid phase synthesis techniques, for making probe molecules that exhibit changes in their optical properties upon target molecule binding are described in the disclosure. Also disclosed herein are novel chromophore moieties, which have tailored fluorescent emission spectra.

Abstract: Combretastatin A-4 has been previously selected for pre-clinical development as antineoplastic agent. However, it is essentially insoluble in water. New water soluble derivatives of combretastatin A-4 and its qualified analogs have been discovered and synthesized through a multistage process using other derivatives of combretastatin A-4 as intermediates. These water soluble derivatives are herein denominated as “Combretastatin A-4 Prodrugs”.

Abstract: A mass air flow sensor for an internal combustion engine is provided. The sensor has a pair of opposed nozzles. A converging nozzle has a first conical throughbore having a first throughbore axis, the first throughbore has first and second apertures, the first aperture has a diameter greater than the second aperture. The diverging nozzle has a second conical throughbore having a second through axis. The throughbore has third and fourth apertures, with the third aperture having a diameter greater than the fourth aperture. A first hotwire sensor positioned within the first aperture. A second hotwire sensor positioned within the second aperture.

Abstract: The present invention relates to a method for identifying a target nucleotide sequence. This method involves forming a ligation product on a target nucleotide sequence in a ligase detection reaction mixture, amplifying the ligation product to form an amplified ligation product in a polymerase chain reaction (PCR) mixture, detecting the amplified ligation product, and identifying the target nucleotide sequence. Such coupling of the ligase detection reaction and the polymerase chain reaction permits multiplex detection of nucleic acid sequence differences.