Patents Assigned to State University
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Publication number: 20090140603Abstract: The present invention provides for a static charge generating assembly. The static charge generating assembly is comprised of: (a) a support structure built from a plurality of friction fit building elements; (b) positive and negative static charge generating wheels; (c) a belt wrapped around the static charge generating wheels; (d) a power source electrically coupled to a driving means for rotating at least one of the static charge generating wheels and the belt at a preselected rotational speed; and (e) positive and negative electrodes secured to the support structure adjacent to the belt. Each of the electrodes is mounted on at least one of the friction fit building elements positioned adjacent to a static charge generating wheel operable to collect static charge. Separate positive and negative static charge collectors are used for storing the negative and positive static charges from the electrodes.Type: ApplicationFiled: November 25, 2008Publication date: June 4, 2009Applicant: Board of Trustees of Michigan State UniversityInventor: Dean Aslam
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Patent number: 7541346Abstract: Selective phosphorylation of phenpanstatin (3a) with tetrabutylammonium dihydrogen phosphate and dicyclohexylcarbodiimide in pyridine followed by cation exchange chromatographic procedures was found to provide an efficient route to a new series (3b-3d) of promising 3,4-O-cyclic phosphate prodrugs designated phenpanstatin phosphates. Application of analogous reaction conditions to pancratistatin (1a) led to a mixture of monophosphate derivatives where sodium pancratistatin 4-O-phosphate (4a) was isolated and the structure confirmed by x-ray crystallography. Modification of the reaction conditions allowed direct phosphorylation of pancratistatin followed by cation exchange chromatography to afford sodium pancratistatin 3,4-O-cyclic phosphate (5b) which was selected for preclinical development.Type: GrantFiled: February 4, 2008Date of Patent: June 2, 2009Assignee: Arizona Board of Regents, a body corporate of the State of Arizona, Acting for and on Behalf of the Arizona State UniversityInventors: George R. Pettit, Noeleen Melody
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Patent number: 7541462Abstract: Methods and compounds are provided for the formation of carbon-nitrogen or carbon-carbon bonds comprising reacting an amine or an aryl boronic acid with an aryl halide in the presence of a palladium catalyst, a base, and a compound of formula II:Type: GrantFiled: January 24, 2008Date of Patent: June 2, 2009Assignee: Iowa State University Research Foundation, Inc.Inventors: John G. Verkade, Sameer Urgaonkar, JuHua Xu
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Patent number: 7540961Abstract: A method for manufacturing a biomass enriched with hydrogen-producing bacteria or spores includes providing a biomass comprising a hydrogen-producing bacteria and a competing bacteria and treating the biomass with a sufficient amount of a chemical agent for a period of time such that the treatment (i) kills, inhibits or injures substantially all of the competing bacteria and (ii) does not kill or inhibit the hydrogen-producing bacteria or causes the hydrogen-producing bacteria to form spores that are not destroyed during the chemical treatment. The method also includes digesting an enriched biomass with a non-sterile organic substrate. The enriched biomass includes hydrogen-producing bacteria or spores that are mixed in sufficient quantities with the organic substrate such that the hydrogen-producing bacteria can overcome the competing bacteria to consume the organic substrate and produce hydrogen.Type: GrantFiled: June 23, 2006Date of Patent: June 2, 2009Assignee: Utah State UniversityInventors: Conly L. Hansen, Dae-Yeol Cheong
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Patent number: 7540706Abstract: A wind harnessing system comprises a substantially helical structure including at least a portion of a spiraling groove and at least one energy converter positioned at least partially within the portion of the spiraling groove. In other embodiments, wind grooves formed by adjacent bands which are fixed with respect to one another, carry energy converters which are moveable with respect to these fixed bands.Type: GrantFiled: June 2, 2006Date of Patent: June 2, 2009Assignee: Cleveland State UniversityInventor: Majid Rashidi
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Patent number: 7541832Abstract: The present invention provides a PLA architecture where the AND plane is implemented with NAND logic. The OR plane may be implemented with various logic, but in one embodiment, the OR plane is implemented with NOR logic. The AND plane may have multiple sequential stages providing hierarchical NAND logic. The NAND logic may be broken into a hierarchy of NAND logic blocks. Each NAND logic block may include one or more series-connected NAND transistor stacks. Each transistor in the transistor stack may receive an input signal representing the product of a PLA clock signal and either a direct PLA input or the complement thereof. As such, the PLA clock is inherently integrated with the input signals that drive the various transistors of the NAND transistor stacks.Type: GrantFiled: April 30, 2007Date of Patent: June 2, 2009Assignee: Arizona Board of Regents for and on behalf of Arizona State UniversityInventors: Lawrence T. Clark, Giby Samson
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Patent number: 7541458Abstract: The present invention is directed to a process for the preparation of ?-lactams. Generally, an imine is cyclocondensed with a ketene acetal or enolate to form the ?-lactam product in a “one pot” synthesis, this process is generally performed at a higher temperature than conventional processes.Type: GrantFiled: June 8, 2006Date of Patent: June 2, 2009Assignee: Florida State University Research Foundation, Inc.Inventors: Phong Vu, Robert A. Holton
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Patent number: 7541514Abstract: Methods are provided for producing apomictic plants from sexual plants divergent with respect to responses to different photoperiods and schedules of megaspore and gametophyte development. A preferred system is to identify divergent lines from within a species or closely related group of species, accentuate the divergence by breeding where necessary, and produce artificial amphiploids that contain genomes from the apposing divergent lines. Apomixis results from the asynchronous expression of female developmental programs induced by combining the reproductively divergent lines. The procedures for manipulating the expression of apomixis described herein permit the development of true-breeding hybrids of various cultivated crops.Type: GrantFiled: February 25, 2004Date of Patent: June 2, 2009Assignee: Utah State UniversityInventor: John G. Carman
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Publication number: 20090134334Abstract: The invention provides methods and apparatus for detecting radiation including x-ray, gamma ray, and particle radiation for nuclear medicine, radiopaphic imaging, material composition analysis, high energy physics, container inspection, mine detection and astronomy. The invention provides detection systems employing one or more detector modules (102) comprising edge-on scintillator detectors (101) with sub-aperture resolution (SAR) capability employed, e.g., in nuclear medicine, such as radiation therapy portal imaging, nuclear remediation, mine detection, container inspection, and high energy physics and astronomy. The invention also provides edge-on imaging probe detectors for use in nuclear medicine, such as radiation therapy portal imaging, or for use in nuclear remediation, mine detection, container inspection, and high energy physics and astronomy.Type: ApplicationFiled: March 31, 2006Publication date: May 28, 2009Applicant: San Diego State University Research FoundationInventor: Robert Sigurd Nelson
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Publication number: 20090137679Abstract: Zn2+-chelating motif-tethered fatty acids as histone deacetylase (HDAC) inhibitors. Compounds performed well in in vitro and in vivo tests.Type: ApplicationFiled: January 29, 2009Publication date: May 28, 2009Applicant: The Ohio State University Research FoundationInventors: Ching-Shih Chen, Qiang Lu
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Publication number: 20090137795Abstract: A method of making a 5-formylporphyrin, comprises the steps of: condensing a 5-acetaldipyrromethane with a dipyrromethane-1,9-dicarbinol to produce a porphyrin having an acetal group substituted thereon at the 5 position; and then hydrolyzing said porphyrin to produce said 5-formylporphyrin. Products and intermediates useful in such methods, along with methods of making such intermediates, are also described.Type: ApplicationFiled: January 30, 2009Publication date: May 28, 2009Applicant: North Carolina State UniversityInventors: Arumugham Balakumar, Kannan Muthukumaran, Jonathan S. Lindsey
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Publication number: 20090136999Abstract: The present invention provides compositions and methods for the prevention and treatment of primary and metastatic neoplastic diseases and infectious diseases, for stimulating an immune response in a subject, and for use as an alternative to interleukin-12 (IL-12) treatment. In particular, the present invention provides Apicomplexa-related proteins (ARPs) that have immune stimulatory activity and thus have uses in the treatment and prevention of cancer and infectious diseases and in immune modulation. Compositions comprising an ARP are provided. Methods of use of an ARP for the prevention and/or treatment of cancer and/or infectious diseases, for use as an alternative to interleukin-12 (IL-12) treatment, and for eliciting an immune response in a subject, are also provided.Type: ApplicationFiled: April 14, 2008Publication date: May 28, 2009Applicants: Michigan State University, Barros Research InstituteInventors: Charles Aylsworth, Siu-Cheong Ho, David Juckett, John W. Judge, Barnett Rosenberg, Igor V. Zlatkin, Tatiana Zlatkin
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Patent number: 7538085Abstract: A macrocyclic peptide deformylase (PDF) inhibitor comprising a peptide or peptide mimetic having three residues, P1?, P2?, and P3?, wherein P2? connects P1? and P3?, wherein P1? and P3? each have a side chain, and wherein the side chains on P1? and P3? are crosslinked to form the macrocyclic PDF inhibitor. The side chains of P1? and P3? interact with the PDF active site, and preferably, P2? has a side chain that interacts with a solvent. Also provided are methods of inhibiting the growth of a bacterium, the methods comprising contacting the bacterium with an anti-bacterial effective amount of the inventive macrocyclic PDF inhibitor. Additionally, a method of treating a bacterial infection in a subject comprising administering an effective amount of a macrocyclic PDF inhibitor to a subject in need of treatment.Type: GrantFiled: April 23, 2007Date of Patent: May 26, 2009Assignee: The Ohio State University Research FoundationInventor: Dehua Pei
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Patent number: 7538203Abstract: Disclosed are major allergenic proteins in cashew nut, which are legumin-like proteins and 2S albumins. Also disclosed is a polypeptide allergen in the 7S superfamily, which includes vicilin-like and sucrose binding proteins. Several linear epitopes of the cashew nut are identified and characterized. The invention further discloses the sequence of cDNA encoding the allergenic polypeptide, the allergen being designated Ana o 1, and also describes the characterization of the expressed recombinant polypeptide and associated methods employing the polypeptide.Type: GrantFiled: April 1, 2005Date of Patent: May 26, 2009Assignee: Florida State University Research Foundation, Inc.Inventors: Kenneth H. Roux, Shridhar K. Sathe, Suzanne S. Teuber
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Patent number: 7537914Abstract: The invention describes an isolated nucleic acid sequence comprising the nucleotide sequence of SEQ ID NO:1 or a degenerate variant of SEQ ID NO:1. The nucleic acid sequence encodes an Ig-E binding immunogenic polypeptide the amino acid sequence of which comprises at least one sequence selected from SEQ ID NOS:4-25. The invention additionally provides an in vitro diagnostic test for detecting anti-cashew IgE in a patient. The test comprises reacting the patient's serum with a purified polypeptide the amino acid sequence of which comprises at least one sequence selected from SEQ ID NOS:3-25; separating the polypeptide from unreacted patient serum; reacting the polypeptide with a labeled human IgE-reactive agent after separating from unreacted patient serum; separating the polypeptide from unreacted labeled human IgE-reactive agent; and detecting labeled human IgE-reactive agent bound to the polypeptide after separating from unreacted agent to thereby indicate presence in the patient's serum of anti-cashew IgE.Type: GrantFiled: November 4, 2003Date of Patent: May 26, 2009Assignee: Florida State University Research Foundation, Inc.Inventors: Kenneth Roux, Shridhar K. Sathe, Jason M. Robotham, Suzanne S. Teuber
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Patent number: 7537889Abstract: An assay for determining presence of human DNA in a sample in which non-human DNA may also be present and for quantitating such human DNA. One embodiment uses intra-Alu based PCR and another uses inter-Alu based PCR. The assays are performed without unique, expensive equipment. The assays are based on detection of multiple-copy Alu elements recently integrated into the human genome that are largely absent from non-human primates and other mammals.Type: GrantFiled: September 30, 2003Date of Patent: May 26, 2009Assignees: Life Genetics Lab, LLC., Board of Supervisors of Louisiana State University and Agricultural and Mechanical CollegeInventors: Sudhir K. Sinha, Jerilyn A. Walker, Mark A. Batzer
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Patent number: 7538209Abstract: Cell wall, cell surface and secreted protein nucleic acid molecules and polypeptides and fragments and variants thereof are disclosed in the current invention. In addition, cell wall, cell surface and secreted fusion proteins, antigenic peptides, and anti-cell wall, cell surface and secreted antibodies are encompassed. The invention also provides recombinant expression vectors containing a nucleic acid molecule of the invention and host cells into which the expression vectors have been introduced. Methods for producing the polypeptides of the invention and methods for their use are further disclosed.Type: GrantFiled: February 1, 2007Date of Patent: May 26, 2009Assignee: North Carolina State UniversityInventors: Todd R. Klaenhammer, W. Michael Russell, Eric Altermann, B. Logan Buck
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Patent number: 7537415Abstract: A fluid injection and removal system to inject or remove fluids from a landfill or contaminated area. The system allows for treatment of waste in the landfill or the contaminated area. The fluid injection and removal system includes a permeable layer and at least one perforated pipe. The permeable layer enables essentially uniform distribution of the fluid into the underlying waste or contaminated area. The fluid injection and removal system can be combined with a leachate collection system to create a leachate recirculation system for use in a landfill. The leachate collection system includes at least one perforated collection pipe embedded in a drainage layer. Sensors can be provided in the permeable layer to enable the change in the physical characteristics of the waste adjacent the permeable layer to be monitored.Type: GrantFiled: October 29, 2007Date of Patent: May 26, 2009Assignee: Board of Trustees of Michigan State UniversityInventor: Milind V. Khire
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Publication number: 20090126262Abstract: A process for producing mixed esters of fatty acids as biofuel or additive to a petroleum fuel for use in a compression ignition (CI) engine. The process preferably provides a partial transesterification of a mixture of fatty acid methyl esters with at least one alkyl alcohol containing 2 to 8 carbon atoms in the presence of a heterogeneous solid acid catalyst to produce a mixture of the fatty acid methyl esters and alkyl alcohol esters of the fatty acids.Type: ApplicationFiled: November 19, 2008Publication date: May 21, 2009Applicant: Board of Trustees of Michigan State UniversityInventors: Navinchandra S. Asthana, Dennis J. Miller, Carl T. Lira, Evan Bittner
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Publication number: 20090133123Abstract: A worm propagation modeling system for use with a mobile ad-hoc network (MANET) includes an infection detection module receiving temporal dynamics information relating to temporal dynamics of worm spread in the MANET and spatial dynamics information relating to spatiality of nodes in the MANET. The infection detection module detects infection in a network segment of the MANET based on the temporal dynamics information and the spatial dynamics information.Type: ApplicationFiled: June 2, 2006Publication date: May 21, 2009Applicant: Board of Trustees of Michigan State UniversityInventors: Hayder Radha, Syed Ali Khayam