Patents Assigned to State University
  • Patent number: 7514549
    Abstract: Methods are provided for identifying compounds that decrease the expression or activity of an overexpressed Sprouty protein in certain cancers. Such compounds can be useful for treating cancers in which a Sprouty protein is overexpressed. Also provided are therapeutic formulations and pharmaceutical formulations for treating cancers characterized by overexpression of a Sprouty protein.
    Type: Grant
    Filed: April 17, 2006
    Date of Patent: April 7, 2009
    Assignee: Michigan State University
    Inventors: J. Justin McCormick, Lito Piro
  • Patent number: 7514563
    Abstract: A process for producing cyano substituted arene boranes is described. The compounds are useful intermediates to pharmaceutical compounds using the cyano group as a reactant.
    Type: Grant
    Filed: June 8, 2006
    Date of Patent: April 7, 2009
    Assignee: Board of Trustees of Michigan State University
    Inventors: Milton R. Smith, III, Robert E. Maleczka, Ghayoor A. Chotana
  • Patent number: 7514587
    Abstract: The invention provides a method to prepare 1,3-propanediol from glycerol. The glycerol is contacted with porous silicon in the presence of an acid to provide the resulting 1,3-propanediol. The porous silicon can have at least one of three types of silicon hydride moieties of the formula Si—Hx, wherein x is 1, 2 or 3. The pores of the porous silicon can be about 1 nm in diameter to about 1 micrometer, and the surface area of the porous silicon can be about 200 to about 800 m2/g.
    Type: Grant
    Filed: May 14, 2008
    Date of Patent: April 7, 2009
    Assignee: Iowa State University Research Foundation, Inc.
    Inventors: Victor Shang-Yi Lin, Hung-Ting Chen
  • Publication number: 20090087910
    Abstract: Functional shRNA is produced from an expression vector prepared by selecting a two primer design in which the primers are less than about 50 nucleotides in length, annealing and extending the primers using primer extension, digesting the primer extension product and inserting the digestion product into a suitable vector. When the shRNA vectors are inserted into a cell, shRNA transcribed from the vectors modulates gene activity within the cell.
    Type: Application
    Filed: August 15, 2008
    Publication date: April 2, 2009
    Applicant: The Board of Regents for Oklahoma State University
    Inventors: Lin Liu, Deming Gou
  • Patent number: 7511624
    Abstract: The present invention provides systems and methods using a temporal-frequency sensitive receiver to detect laser light that is scattered by an oscillating object, thereby allowing remote monitoring of the object's position and movement.
    Type: Grant
    Filed: January 25, 2006
    Date of Patent: March 31, 2009
    Assignee: Montana State University
    Inventors: Joseph A. Shaw, Kevin S. Repasky, John L. Carlsten, Lee H. Spangler, David S. Hoffman
  • Patent number: 7510832
    Abstract: The present invention is directed to the use of human BC200 RNA in both the diagnosis and prognosis of carcinomas to determine the presence of a carcinoma and tumor grade, and also to predict the likelihood that a carcinoma will progress to an invasive carcinoma.
    Type: Grant
    Filed: February 21, 2003
    Date of Patent: March 31, 2009
    Assignee: The Research Foundation of State University of New York
    Inventor: Henri Tiedge
  • Patent number: 7510720
    Abstract: The present invention provides vaccines and methods for making the vaccines that actively or passively protect an equid or other animal against Sarcocystis neurona. In particular, the present invention provides vaccines that provide active immunity which comprise a polypeptide or DNA vaccine that contains or expresses at least one epitope of an antigen that has an amino acid sequence substantially similar to a unique 16 (±4) kDa antigen and/or 30 (±4) kDa antigen of Sarcocystis neurona. The present invention further provides a vaccine that provides passive immunity to Sarcocystis neurona comprising polyclonal or monoclonal antibodies against at least one epitope of an antigen substantially similar to a unique 16 (±4) kDa antigen and/or 30 (±4) kDa antigen of Sarcocystis neurona.
    Type: Grant
    Filed: September 26, 2000
    Date of Patent: March 31, 2009
    Assignee: Board of Trustees of Michigan State University
    Inventors: Linda S. Mansfield, Mary G. Rossano, Alice J. Murphy, Ruth A. Vrable
  • Patent number: 7510942
    Abstract: A method of increasing the work function of micro-electrodes includes providing a metal or silica surface functionalized with reactive groups and contacting the functionalized surface with a solution of at least one biochemical, having a permanent dipole moment and being capable of self assembly, for a sufficient time for the biochemical to self assemble molecularly (SAM) on the functionalized surface. The biochemical can be aminopropyl triethoxy silane, fatty acids, organosilicon derivatives, organosulfur compounds, alkyl chains, or diphosphates. Use in a wide variety of metals and metallic compounds is disclosed.
    Type: Grant
    Filed: November 24, 2004
    Date of Patent: March 31, 2009
    Assignee: Arizona Board of Regents, Acting for and on behalf of Arizona State University
    Inventors: Sandwip K. Dey, Diefeng Gu, Rizaldi Sistiabudi, Jaydeb Goswami
  • Patent number: 7510848
    Abstract: Prion protein binding materials and methods for using the binding materials to detect or remove a prion protein from a sample, such as a biological fluid or an environmental sample. The binding materials are capable of binding to one or more forms of prion protein including cellular prion protein (PrPc), infectious prion protein (PrPsc), recombinant prion protein (PrPr), and proteinase resistant prion protein (PrPres). Prions from various species, including humans and hamsters, are bound by the binding materials.
    Type: Grant
    Filed: October 13, 2004
    Date of Patent: March 31, 2009
    Assignees: North Carolina State University, Pathogen Removal and Diagnostic Technologies Inc.
    Inventors: David J. Hammond, Ruben G. Carbonell, Honglue Shen, Patrick V. Gurgel, Viterose Wiltshire-Lyerly, Steven J. Burton
  • Publication number: 20090082576
    Abstract: A method of making a metalloporphyrin is carried out by reacting (i) a linear tetrapyrrole, said linear tetrapyrrole having a 19-acyl group and a 1-protecting group, with (ii) a metal salt under basic conditions to produce the metalloporphyrin. Products produced by such methods and intermediates useful for carrying out such methods are also described.
    Type: Application
    Filed: February 11, 2008
    Publication date: March 26, 2009
    Applicant: North Carolina State University
    Inventors: Jonathan S. Lindsey, Dilek Dogutan Kiper
  • Patent number: 7508858
    Abstract: A detuned duo-cavity laser-modulator device and method are provided which include lower, middle and upper reflectors, a gain region and an absorber region integrated into a semiconductor die. The middle reflector is disposed between the lower and upper reflectors. Together, the lower and middle reflectors define a first resonant cavity, while the upper and middle reflectors define a second resonant cavity. A gain region is disposed within a laser cavity of the resonant cavities to generate an optical carrier wave, while an absorber region is disposed within a modulator cavity of the resonant cavities to modulate a signal on the optical carrier wave. The laser and modulator cavities are detuned resonant cavities, with the detuning of the laser and modulator cavities being selected to minimized change in reflection from the modulator cavity to the laser cavity when the absorber region modulates the signal on the optical carrier wave.
    Type: Grant
    Filed: April 30, 2007
    Date of Patent: March 24, 2009
    Assignee: The Research Foundation of State University of New York
    Inventors: Serge Oktyabrsky, Vadim Tokranov, Michael Yakimov, Jobert VanEisden, Edris M. Mohammed, Ian Young
  • Patent number: 7507749
    Abstract: The invention provides compounds of formula I: wherein Y is F, Cl, Br, methyl or methoxy; and pharmaceutically acceptable salts thereof. The compounds are effective antitumor agent. The invention also provides pharmaceutical compositions comprising a compound of formula I or a salt thereof, intermediates useful for preparing a compound of formula I, and therapeutic methods comprising administering a compound of formula I or a salt thereof to a mammal in need thereof.
    Type: Grant
    Filed: May 24, 2007
    Date of Patent: March 24, 2009
    Assignee: Wayne State University
    Inventors: Jerome P. Horwitz, Stuart T. Hazeldine, Thomas H. Corbett, Lisa Polin
  • Patent number: 7507380
    Abstract: Embodiments of an apparatus, system, and method for chemical synthesis and/or analysis are disclosed. One embodiment of a disclosed apparatus comprises a laminated, microfluidic structure defining a reactor and a separator. Such apparatuses, or portions thereof, generally have dimensions ranging from about 1 micrometer to about 100 micrometers. To implement synthetic processes, disclosed embodiments of the apparatus generally include at least one valve, and often plural, selectively actuatable valves. Detectors, including optical detectors, also can be used to detect product and other materials as they flow by, or are otherwise presented to, the detector. Individual apparatuses may be coupled both in series and in parallel to form a system for making chemical compounds. The apparatus is particularly useful for making compounds requiring iterative reaction schemes, and further can be used to make compounds having morphological structures that resemble the morphology of the apparatus itself, such as dendrimers.
    Type: Grant
    Filed: March 21, 2005
    Date of Patent: March 24, 2009
    Assignee: State of Oregon Acting By and Through the State Board of Higher Education on behalf of Oregon State University
    Inventors: Chih-Hung Chang, Brian Kevin Paul, Vincent Thomas Remcho
  • Patent number: 7508039
    Abstract: Carbon nanotube (CNT) based devices include an actuator/switch that includes one or more fixed CNTs and a moveable CNT that can be urged toward or into contact with a selected fixed CNT with a magnetic field produced by a current in a control conductor. The control conductor can be formed of one or more CNTs, and the fixed and moveable CNTs can be retained by a support, and motion of the moveable CNT limited by a cavity defined in the support. In other examples, CNT FETS are used to form CNT transmission gates that are arranged to define circuits configured as multiplexers or to realize logical functions, addition, multiplication, or other operations such as Galois field arithmetic.
    Type: Grant
    Filed: May 4, 2005
    Date of Patent: March 24, 2009
    Assignee: State of Oregon Acting By and Through The State Board of Higher Education On Behalf of Portland State University
    Inventor: Anas N. Al-Rabadi
  • Patent number: 7507851
    Abstract: The invention relates to novel compounds denominated halocombstatins. The halocombstatins are derivatives of combretastatin A-3, and include compounds that exhibit cancer growth cell inhibition against a panel of human cancer cell lines and the murine P388 leukemia, as well as activity as inhibitors of tubulin polymerization and inhibitors of the binding of colchicine to tubulin.
    Type: Grant
    Filed: January 28, 2008
    Date of Patent: March 24, 2009
    Assignee: Arizona Board of Regents, a state corporate of the State of Arizona, acting for and on behalf of Arizona State University
    Inventors: George R. Pettit, Mathew D. Minardi, Heidi J. Rosenberg
  • Publication number: 20090075368
    Abstract: Diagnostic tools for serodiagnosing ehrlichiosis in mammals, particularly in members of the Canidae family and in humans are provided. The diagnostic tools are a group of outer membrane proteins of E. chaffeensis and variants thereof, referred to hereinafter as the “OMP proteins”, a group of outer membrane proteins of E. canis and variants thereof referred to hereinafter as the “P30F proteins”, and antibodies to the ONP proteins and the P30F proteins. The OMP proteins of E. chaffeensis encompass OMP-1, OMP-1A, OMP1-B, OMP-1C, OMP1-D, OMP1-E, OMP1-F, OMP1-H, OMP-1R, OMP-1S, OMP-1T, OMP-1U, OMP-1V, OMP-1W, OMP-1X, OMP-1Y and OMP-1Z. The P30F proteins of E. canis encompass P30, P30a, P30-1, P30-2, P30-3; P30-4, P30-5, P30-6, P30-7, P30-8, P30-9, P30-10, P30-11, and P30-12. Isolated polynucleotides that encode the E. chaffeensis OMP proteins and isolated polynucleotides that encode the E. canis P30F protein are also provided.
    Type: Application
    Filed: June 14, 2006
    Publication date: March 19, 2009
    Applicant: The Ohio State university Research Foundation
    Inventors: Yasuko Rikihisa, Norio Ohashi
  • Publication number: 20090075291
    Abstract: The present invention relates to proteins and polypeptides that (i) have the formula A-[Wm-A]n where each A is independently a peptide of formula XXXXRXPXXXX where each X is independently any amino acid, R is arginine, and P is proline; each W is independently a linker; m is 1 or 2; and n is any number from 1 through 5; (ii) consist essentially of the formula XnRXPXm where each X is independently any amino acid, R is arginine, P is proline, n is any number from zero to fifteen, m is any number from zero to fifteen, and the sum of n and m is any number from eight to fifteen; (iii) have the formula A-An where each A is independently a peptide of formula XXXXRXPXXXX where each X is independently any amino acid, R is arginine, and P is proline; and n is any number from 1 through 5; or (iv) consist essentially of the formula XnRXPXm where each X is independently any amino acid, R is arginine, P is proline, n is any number from zero to seven, m is any number from zero to seven, and the sum of n and m is any number
    Type: Application
    Filed: July 14, 2008
    Publication date: March 19, 2009
    Applicants: The Research Foundation of State University of New York, Zealand Pharma A/S
    Inventors: Mario DELMAR, Steven M. TAFFET, Bjarne Due LARSEN
  • Patent number: 7505853
    Abstract: Since ultrasonic velocities in anisotropic media can change by a factor of 3 or more depending on the direction of propagation, accounting for these changes is extremely important. Also many anisotropic materials are made up of multiple layers of varying orientation, hence the need to account for refraction at ply boundaries. In the present invention, an algorithm is used to calculate these velocities and travel times and properly account for refraction phenomena. Specifically a multilayer SAFT algorithm has been developed that will calculate the time shift, shift and sum A-scan waveforms in layered anisotropic media at any given depth, ply orientation, and number of plies. The algorithm showed an improvement in signal to noise ratio with synthetic data as was expected. This algorithm can be used as a replacement for homogenizing material properties in layered media and will calculate time shifts with increased accuracy since exact material properties are used.
    Type: Grant
    Filed: July 27, 2006
    Date of Patent: March 17, 2009
    Assignee: San Diego State University Research Foundation
    Inventors: Cody Royce Engstrand, Ronald Alan Kline
  • Patent number: 7504555
    Abstract: DNA constructs containing translational control elements are provided. These 5? regulatory segments facilitate high level expression of transgenes introduced into the plastids of higher plants.
    Type: Grant
    Filed: January 11, 2006
    Date of Patent: March 17, 2009
    Assignee: Rutgers, The State University of New Jersey
    Inventors: Pal Maliga, Hiroshi Kuroda, Muhammad Sarwar Khan
  • Patent number: 7504473
    Abstract: Novel chain polymers comprising weakly basic anionic moieties chemically bound into a polyether backbone at controllable anionic separations are presented. Preferred polymers comprise orthoborate anions capped with dibasic acid residues, preferably oxalato or malonato acid residues. The conductivity of these polymers is found to be high relative to that of most conventional salt-in-polymer electrolytes. The conductivity at high temperatures and wide electrochemical window make these materials especially suitable as electrolytes for rechargeable lithium batteries.
    Type: Grant
    Filed: June 16, 2001
    Date of Patent: March 17, 2009
    Assignee: Arizona Board of Regents for and on behalf of Arizona State University
    Inventors: Charles A. Angell, Wu Xu