Patents Assigned to State University
  • Device and method of partially separating gas
    Patent number: 7503325
    Abstract: The invention includes a partial gas separator, which may include a housing and a movable divider in the housing. A method according to the invention may provide a partial gas separator and gas may be moved to or from the housing. While moving gas to or from the housing, the movable divider may be allowed to move with the flow of gas.
    Type: Grant
    Filed: September 30, 2004
    Date of Patent: March 17, 2009
    Assignee: The Research Foundation of State University of New York
    Inventors: Bradley P. Fuhrman, Mark S. Dowhy
  • Animal model for identifying agents that inhibit or enhance CTLA4 signaling
    Patent number: 7504554
    Abstract: The present invention relates to a non-human transgenic animal, particularly a knock in mouse, whose genome comprises a heterologous, chimeric CTLA4 gene. The chimeric CTLA4 gene comprises exon 2 of the human CTLA4 gene, exon 1 and exon 4 of the non-human animal, and exon 3 of the CTLA4 gene of the non-human animal, or preferably, exon 3 of the human CTLA4 gene. The invention also relates to methods by which the transgenic mice are used to screen for monoclonal antibodies or other molecules that enhance immunity to tumors and infectious agents by interacting with the human CTLA4 receptor. The transgenic mice of the present invention are also useful for screening for monoclonal antibodies or other molecules that inhibit autoimmunity and transplant rejection.
    Type: Grant
    Filed: January 8, 2007
    Date of Patent: March 17, 2009
    Assignee: The Ohio State University Research Foundation
    Inventors: Yang Liu, Pan Zheng, Ping Lu, Bedrich Mosinger, Ken May
  • REFINED ROUTES TO CHLORIN BUILDING BLOCKS
    Publication number: 20090069558
    Abstract: A method of making chlorins comprises the steps of reacting (e.g. condensing) a dipyrrin western half intermediate with an eastern half intermediate to form a tetrahydrobilene, and then cyclizing the tetrahydrobilene to form a chlorin. Intermediates including tetrahydrobilenes useful in such reactions are also described.
    Type: Application
    Filed: November 14, 2008
    Publication date: March 12, 2009
    Applicant: North Carolina State University
    Inventors: Jonathan S. Lindsey, Masahiko Taniguchi, Doyoung Ra, Guoning Mo, Thiagarajan Balasubramanian
  • MESOPOROUS CALCIUM SILICATE COMPOSITIONS AND METHODS FOR SYNTHESIS OF MESOPOROUS CALCIUM SILICATE FOR CONTROLLED RELEASE OF BIOACTIVE AGENTS
    Publication number: 20090068272
    Abstract: Mesoporous calcium silicate compositions for controlled release of bioactive agents and methods for producing such compositions are disclosed herein. In one embodiment, mesoporous calcium silicate is synthesized by acid modification of wollastonite particles using hydrochloric acid. A hydrated silica gel layer having abundant Si—OH functional groups can be formed on the surface of wollastonite after acid modification. Bruhauer-Emmett-Teller (BET) surface area increased significantly due to acid modification and, in one arrangement, reached over 350 m2/g. Acid modified mesoporous calcium silicate compositions show a higher ability to adsorb protein compared to unmodified particles and demonstrate controlled release kinetics of these proteins.
    Type: Application
    Filed: September 15, 2008
    Publication date: March 12, 2009
    Applicant: Washington State University
    Inventors: Amit Bandyopadhyay, Susmita Bose, Weichang Xue
  • GDNF-DERIVED PEPTIDES
    Publication number: 20090069230
    Abstract: Compositions that include peptides derived from glial-derived neurotrophic factor (GDNF) (e.g., substantially pure polypeptides comprising a fragment of a GDNF precursor protein) and biologically active variants thereof are provided. The compositions can include one or more types of peptides and can include other substances (e.g., pharmaceutically acceptable carriers or diluents or liposomes). Also provided are methods for using the compositions for treatment of neurological disorders (e.g., motor system disorders and sensory system disorders).
    Type: Application
    Filed: February 12, 2008
    Publication date: March 12, 2009
    Applicant: The Research Foundation of State University of New York
    Inventors: Srinivas N. Pentyala, John D. Glass
  • Cationic polymerization of biological oils with superacid catalysts
    Patent number: 7501479
    Abstract: A method for the cationic polymerization of unsaturated biological oils (e.g., vegetable oils and animal oils) based on the cationic reaction of double bonds initiated by superacids is provided. The process occurs under very mild reaction conditions (about 70-110° C. and atmospheric pressure) and with short reaction times. The polymerized oils have a viscosity about 10 to 200 times higher than the initial oil and relatively high unsaturation (only about 10-30% lower than that of initial oils).
    Type: Grant
    Filed: May 7, 2007
    Date of Patent: March 10, 2009
    Assignee: Pittsburg State University
    Inventors: Mihail Ionescu, Zoran S. Petrovic
  • Route to formyl-porphyrins
    Patent number: 7501507
    Abstract: A method of making a 5-formylporphyrin, comprises the steps of: condensing a 5-acetaldipyrromethane with a dipyrromethane-1,9-dicarbinol to produce a porphyrin having an acetal group substituted thereon at the 5 position; and then hydrolyzing said porphyrin to produce said 5-formylporphyrin. Products and intermediates useful in such methods, along with methods of making such intermediates, are also described.
    Type: Grant
    Filed: June 14, 2004
    Date of Patent: March 10, 2009
    Assignee: North Carolina State University
    Inventors: Arumugham Balakumar, Kannan Muthukumaran, Jonathan S. Lindsey
  • Cyclopropanes with central nervous system activity
    Patent number: 7501453
    Abstract: Disclosed are aromatic cyclopropane compounds with CNS activity. These compounds can be used for alleviating symptoms of CNS disorders.
    Type: Grant
    Filed: March 12, 2007
    Date of Patent: March 10, 2009
    Assignee: The Research Foundation of State University of New York
    Inventors: Huw M. L. Davies, Timothy Gregg
  • Methods and intermediates for the synthesis of porphyrins
    Patent number: 7501508
    Abstract: A method of making a porphyrin is carried out by: (a) condensing (i) a 1,9-bis(N,N-)dialkylaminomethyl)dipyrromethane of Formula II: with (ii) a dipyrromethane to produce a reaction product; then (b) oxidizing the reaction product; and then (c) optionally demetallating said reaction product to produce the porphyrin. The reaction is particularly useful for making substituted porphyrins with a wide range of substituents at the A and/or B (the 5 and/or 15) positions.
    Type: Grant
    Filed: July 29, 2005
    Date of Patent: March 10, 2009
    Assignee: North Caroline State University
    Inventors: Jonathan S. Lindsey, Masahiko Taniguchi, Dazhong Fan
  • Evanescent microwave microscopy probe and methodology
    Patent number: 7501833
    Abstract: The present invention generally relates to an evanescent microwave spectroscopy probe and methods for making and using the same. Some embodiments relate to a probe in electrical communication with sapphire tuning capacitors that are arranged in parallel. Some embodiments relate to using capacitors arranged in this manner to achieve higher Q values. Furthermore, probe can be used in microwave microscopy applications, and for imaging samples thereby.
    Type: Grant
    Filed: July 11, 2006
    Date of Patent: March 10, 2009
    Assignee: Wright State University
    Inventors: Richard A. Kleismit, Gregory Kozlowski
  • Gas assisted bonding of polymers and polymer composites
    Patent number: 7501039
    Abstract: A method of bonding materials. The method comprises providing a polymer; providing a second material; contacting the polymer and the second material at a low contact pressure in the absence of a solvent or an adhesive; maintaining the polymer at a temperature less than a bulk Tg of the polymer; introducing a gas at low pressure; and bonding the polymer and the second material.
    Type: Grant
    Filed: June 17, 2005
    Date of Patent: March 10, 2009
    Assignee: The Ohio State University
    Inventors: L. James Lee, David Lane Tomasko, Yong Yang, Changchun Zeng
  • Regioselective halogenation of nicotine and substituted nicotines
    Patent number: 7501520
    Abstract: A first aspect of the present invention is a method for of making a compound of Formula Ia or Formula Ib: wherein X is halo, by (a) metalating a precursor compound to form an organometallic intermediate, and then reacting the organometallic intermediate with a halogenating agent to produce the compound of Formula Ia or Formula Ib.
    Type: Grant
    Filed: January 16, 2007
    Date of Patent: March 10, 2009
    Assignee: North Carlina State University
    Inventors: Daniel L. Comins, Florence Fevrier, Emilie Despagnet Smith
  • Groups Of Borrelia Burgdorferi And Borrelia Afzelii That Cause Lyme Disease In Humans
    Publication number: 20090060932
    Abstract: The present invention is drawn to an immunogenic composition comprising OspC polypeptides from Lyme Disease causing Borrelia. In one embodiment, the immunogenic composition of the present invention comprises at least one OspC polypeptide or immunogenic fragment thereof from each of Borrelia burgdorferi OspC families A, B, I and K. In another embodiment, the immunogenic composition of the present invention comprises at least one OspC polypeptide or immunogenic fragment thereof from each of Borrelia afzelii OspC families A and B.
    Type: Application
    Filed: March 9, 2006
    Publication date: March 5, 2009
    Applicants: Research Foundation of the State University of New York, Brook Biotechnologies, Inc.
    Inventors: Raymond Dattwyler, Gerald Seinost, Daniel Dykhuizen, Benjamin Luft, Maria Gomes-Solecki
  • Reconstitution Medium For Protein and Peptide Formulations
    Publication number: 20090062205
    Abstract: Compositions useful for reconstitution of concentrated formulations containing protein/peptide pharmaceuticals are provided. The composition generally includes one or more lipids, as well as one or more alcohols that promote and stabilize the formation of (a) lipid molecular assemblies with greater protein encapsulation; (b) protein-lipid complexes and (c) protein and lipid solutions. The reconstitution medium improves the protein-lipid association that in turn alters the pharmaceutical properties.
    Type: Application
    Filed: September 5, 2008
    Publication date: March 5, 2009
    Applicant: The Research Foundation of State University of New York
    Inventor: Sathyamangalam V. Balasubramanian
  • Polyazacrown-based materials for mercury capture and synthesis of those materials
    Publication number: 20090057233
    Abstract: Polyazacrown polymers based on the azacrown monomer 1,4,7,10,13,16,21,24-octaazabicyclo[8.8.8]hexacosane (“H6Aza222”) are disclosed. Azacrown monomer units are preferably linked with a suitable linking agent, and the resulting polymers are can absorb mercury from a water stream and form a stable complex therewith. Methods of making and using the polyazacrown polymers are also disclosed. The polymers have a high absorption capacity for and selectivity towards mercury, which properties are useful for the remediation of mercury-contaminated water. The polymers can be regenerated by the efficient removal of the absorbed mercury. Further, the absorbed mercury that is liberated from the polyazacrown polymers can be effectively concentrated and captured to prevent its re-release into the environment.
    Type: Application
    Filed: February 19, 2008
    Publication date: March 5, 2009
    Applicant: Board of Trustees of Michigan State University
    Inventors: Mikhail Y. Redko, James E. Jackson, Volodymyr Tarabara, Julian Taurozzi
  • Use of visible light at wavelengths of 500 to 550 nm to reduce the number of pathogens in blood and blood components
    Patent number: 7498156
    Abstract: This invention is directed towards a method of using visible light at wavelengths of at least 500 nm and above in combination with a sensitizer having a flavin moiety to reduce any pathogens that may be contained in blood and blood components. By exposing the blood and blood components to light of 500 nm and higher, only the sensitizer that is bound to nucleic acids of the pathogens will be activated, thus destroying the sensitizer-pathogenic nucleic acid complex. Because unbound sensitizer is not activated at this wavelength, damage to blood and blood components caused by photolysis of unbound sensitizer may be avoided.
    Type: Grant
    Filed: June 15, 2005
    Date of Patent: March 3, 2009
    Assignees: CaridianBCT Biotechnologies, LLC, Ohio State University Research Foundation
    Inventors: Raymond P. Goodrich, Matthew S. Platz, Christopher B. Martin
  • Method of synthesis of 1, 4, 7, 10, 13, 16, 21, 24-octaazabicyclo [8.8.8] hexacosane (1) and 1, 4, 7, 10, 13, 16, 21, 24-octaazabicyclo [8.8.8] hexacosa, 4, 6, 13, 15, 21, 23-hexaene (2)
    Patent number: 7498432
    Abstract: A process for producing compound 1,4,7,10,13,16,21,24-octaazabicyclo[8.8.8]hexacosa, 4,6,13,15,21,23-hexaene (2) and then compound 1,4,7,10,13,16,21,24-octaazabicyclo[8.8.8]hexacosane (1) from compound (2) is described. The process uses a reaction between triaminoethylamine and glyoxal in the presence of water, alcohol and tertiary amine at low temperature to produce compound 2. Then compound 1 is produced from compound 2 by reduction with an alkali metal containing ammonia as the reductant. The compounds are aza cryptands which are used to bind metals and the like for electrides, and in alkalides, medicine and water treatment, for instance.
    Type: Grant
    Filed: June 14, 2004
    Date of Patent: March 3, 2009
    Assignee: Board of Trustees of Michigan State University
    Inventors: Mikhail Redko, James E. Jackson
  • Method of fabricating electro-optical devices with polymer-stabilized liquid crystal molecules
    Patent number: 7499125
    Abstract: In a preparation method, a chiral or cholesteric liquid crystal, a photoreactive monomer, and a photoinitiator are disposed in a liquid crystal cell. A principal surface of the liquid crystal cell is illuminated with ultraviolet light selected to have a non-uniform ultraviolet light intensity profile in the liquid crystal cell. The illuminating cooperates with the photoinitiator to polymerize at least a portion of the photoreactive monomer near the principal surface to generate a polymer network having a density corresponding to the non-uniform ultraviolet light intensity profile. The polymer network biases the liquid crystal toward a selected helical alignment direction. In some embodiments, the illuminating includes illuminating with first and second ultraviolet light intensity profiles to produce surface and volume polymer network components.
    Type: Grant
    Filed: March 1, 2006
    Date of Patent: March 3, 2009
    Assignees: Kent State University, Lachezar Komitov
    Inventors: Lachezar Komitov, Liang-Chy Chien, Sang Hwa Kim
  • Combinatorial libraries of autoinducer analogs, autoinducer agonists and antagonists, and methods of use thereof
    Patent number: 7498292
    Abstract: The present invention relates to solid phase or solution phase combinatorial libraries of autoinducer analogs. The present invention also relates to autoinducer agonists and antagonists. In addition, the present invention relates to methods for identifying autoinducer agonists and antagonists, as well as methods for regulating the activity of an autoinducer receptor, regulating biofilm formation, regulating growth or virulence of an organism in a subject, inhibiting the quorum sensing mechanism of an organism, and treating an infection in a subject caused by an organism possessing a quorum sensing mechanism which use the autoinducer analogs of the present invention.
    Type: Grant
    Filed: August 8, 2003
    Date of Patent: March 3, 2009
    Assignee: The Research Foundation of State University of New York
    Inventors: Hiroaki Suga, Yigong Bu
  • Process for the preparation and separation of arabinose and xylose from a mixture of saccharides
    Patent number: 7498430
    Abstract: A process for the preparation and separation of the pentoses, xylose and arabinose from mixtures of saccharides by forming acetals is described. D-xylose is a precursor to xylitol, a sweetener, and L-arabinose is a precursor to the drug intermediate (R)-3,4-dihydroxybutyric acid, carnitine and agrichemicals.
    Type: Grant
    Filed: November 9, 2004
    Date of Patent: March 3, 2009
    Assignee: Board of Trustees of Michigan State University
    Inventor: Rawle I. Hollingsworth