Abstract: Processing of genomic data is provided utilizing correlation analysis of first and second nucleotide loci employing a selected comparison type and value. The comparison type is either intersection or proximity type, and the comparison value is either a number (n) of nucleotide positions, wherein n?1, or a percent number (pn) of nucleotide positions, wherein pn?0, to be employed in comparing the loci. When intersection type is selected, correlation is defined by the loci overlapping with at least the number (n) of nucleotide positions in common, or by the loci overlapping with at least the percent number (pn) of nucleotide positions in common relative to a smaller one of the first and second loci, or when proximity type is selected, correlation is defined by the first and second loci being within at least the number (n) of nucleotide positions.

Abstract: Low resistivity graphite coated fibers having exfoliated and pulverized graphite platelets coated on an outer surface of electrically insulating fibers are provided. Various methods are also provided for surface coating of the graphite platelets onto the insulating fibers which are provided to increase the glass fiber surface conductivity. The graphite coated glass fibers can be used to produce reinforced composite materials. Reinforced composite materials incorporating the graphite coated fibers can be electrostatically painted without using a conductive primer.

Abstract: The present invention is directed toward oxidation-resistant, ligand-capped nanoparticles, each comprising one or more capping ligands on a copper-containing core. Methods of making and using these nanoparticles are also disclosed.

Abstract: Processing of genomic data is facilitated utilizing correlation analysis of mapped data sets, each data set including genomic data mapped and ordered relative to a genomic coordinate system. Correlation analysis identifies at a nucleotide level nucleotide positions wherein at least one nucleotide locus of each data set correlate. The analysis includes for each data set, selecting a nucleotide locus thereof closest to one end of the coordinate system, comparing the selected nucleotide loci for correlation, and if so, outputting results of the comparing, and updating the selected nucleotide loci by identifying the data set having a next nucleotide locus closest to the one end of the coordinate system, and inserting that next locus into the group of selected loci, and repeating the comparing for the newly selected loci. The process is repeated until nucleotide loci of the mapped data sets are compared and results of the comparison are output.

Abstract: The present invention relates to compositions and methods for producing a complex drug delivery system which specifically targets cancer cells, has an increase in cellular uptake, is cytotoxic, and suppresses antiapoptotic cellular defenses.

Abstract: The present invention provides substituted phenanthroline compounds with high two photon absorption cross sections, as well as substituted phenanthroline compounds which additionally have quenched fluorescence emission upon two photon absorption.

Abstract: A laser system using ultrashort laser pulses is provided. In another aspect of the present invention, the system includes a laser, pulse shaper and detection device. A further aspect of the present invention employs a femtosecond laser and a spectrometer. Still another aspect of the present invention uses a laser beam pulse, a pulse shaper and a SHG crystal. In yet another aspect of the present invention, a multiphoton intrapulse interference phase scan system and method characterize the spectral phase of femtosecond laser pulses. Fiber optic communication systems, photodynamic therapy and pulse characterization tests use the laser system with additional aspects of the present invention.

Abstract: The F. necrophorum gene expressing leukotoxin was sequenced and cloned. The leukotoxin open reading frame (lktA) is part of a multi-gene operon containing 9,726 bp, and encoding a protein containing 3,241 amino acids with an overall molecular weight of 335,956 daltons. The protein encoded by the gene was truncated into five polypeptides having overlapping regions by truncating the full length gene into five different sections and amplifying, expressing, and recovering the protein encoded by each of these sections. Additionally, a region upstream of the gene was sequenced and the polypeptide encoded by that nucleotide sequence was purified and isolated. These polypeptides along with the full length protein are then tested to determine their immunogenicity and protective immunity in comparison to the efficacy of immunization conferred by inactivated native leukotoxin in F. necrophorum culture supernatant.

Abstract: Nanolayered layered silicate materials of octahedrally arranged units with divalent metal ions at centers of the units covalently linked above and below to tetrahedrally arranged oxygen and hydroxyl units with silicon atoms. The silicate materials contain silanol groups which are reactive to form derivative compositions useful for water purification to remove heavy meal cations.

Abstract: Compounds exhibiting angiogenic properties incorporating the structure of Formula I: R3—NH—NH—C(?O)—R2—P—R1 ??(I) wherein P is a water-soluble, biodegradable polymer, R1 is hydrogen, lower alkyl, lower alkoxy or —R2—C(?O)—NH—NH—R3; each R2 is independently —CH2—, —NH— or O; and each R3 is independently hydrogen or a residue of a naturally occurring alpha-L-amino acid or dipeptide thereof. Polymer networks crosslinked with hydrazide compounds are also disclosed, together with implantable medical devices incorporating the compounds and crosslinked polymers, and angiogenesis-promoting treatment methods, including wound-treatment methods.

Abstract: Methods of identifying malignant thyroid tissue comprising testing a thyroid tissue sample for the expression of at least two genes chosen from CCND2, PCSK2, and PLAB. Kits for use in the disclosed methods are also provided.

Abstract: The present invention provides a method for diagnosing a subject suffering a pathological condition characterized by parvovirus infection by detecting the presence of IgE anti-Parvovirus B 19 antibodies.

Abstract: Extruded composite compositions of PVC and wood particles containing chitosan or chitin as a coupling agent are described. The composite compositions have improved physical and mechanical properties.

Abstract: An article of manufacture useful for adding creamer base to hot beverages such as coffee or tea-based beverages comprises (a) a center core comprising a creamer base (for example, the creamer base preferably comprising a high-intensity sweetener and a humectant), and (b) an outer coating at least partially encapsulating the center core, the outer coating comprising chocolate. In a preferred embodiment the chocolate comprises not more than 10 percent by weight of cocoa butter and at least 20 percent by weight of vegetable oil, and with the chocolate coating preferably having a softening point of at least about 100° F. In a preferred embodiment, the article further comprises (c) an elongate stirring member having a distal end portion, with the distal end portion connected to the outer coating.

Abstract: Multi-precision multiplication methods over GF(2m) include representing a first polynomial and a second polynomial as an array of n words. A recursive algorithm may be used to iteratively decompose the multiplication into a weighted sum of smaller subproducts. When the size of the smaller subproducts is less than or equal to a predetermined size, a nonrecursive algorithm may be used to complete the multiplication. The nonrecursive algorithm may be optimized to efficiently perform the bottom-end multiplication. For example, pairs of redundant subproducts can be identified and excluded from the nonrecursive algorithm. Moreover, subproducts having weights in a special form may be efficiently calculated by a process that involves storing and reusing intermediate calculations.

Abstract: Use of a new class of phosphoinositide-dependent kinase-1 (PDK-1) inhibitors of formula I for inducing apoptosis in unwanted rapidly proliferating cells, for treating, inhibiting, or delaying the onset of cancer, and for preventing restenosis in a subject that has undergone an angioplasty or stent: wherein X is selected from the group consisting of alkyl and haloalkyl; Ar is an aryl radical selected from the group consisting of phenyl, biphenyl, naphthyl, anthryl, phenanthryl, and fluorenyl; and wherein Ar is optionally substituted with one or more radicals selected from the group consisting of halo, C1-C4 alkyl, C1-C4 haloalkyl, azido, C1-C4 azidoalkyl, aryl, akylaryl, haloaryl, haloalkylaryl, and combinations thereof; and R is selected from the group consisting of nitrile, acetonitrile, ethylnitrile, propylnitrile, carboxamide, amidine, tetrazole, oxime, hydrazone, acetamidine, aminoacetamide, guanidine, and urea.

Abstract: A method of making a phosphono-substituted dipyrromethane comprises reacting an aldehyde or acetal having at least one phosphono group substituted thereon with pyrrole to produce a phosphono-substituted dipyrromethane; and wherein the phosphono is selected from the group consisting of dialkyl phosphono, diaryl phosphono, and dialkylaryl phosphono. Additional methods, intermediates and products are also described.

Abstract: Compositions including composites of polyvinyl chloride (PVC) and nanoparticles are disclosed. A wood-polymer composite using the PVC-nanoparticle composite as a matrix also is disclosed. The nanoparticle filler is dispersed throughout the PVC matrix by blending the nanoparticles with a mixture of PVC particles that have been pre-heated to a temperature at or above a fusion point of the PVC, thereby fusing the PVC particles prior to the addition of the nanoparticles to the matrix. Also disclosed are methods of forming the composite compositions. The composite compositions can be used to replace wood boards.

Abstract: An augmented reality user interaction system includes a wearable computer equipped with at least one camera to detect one or more fiducial markers worn by a user. A user-mounted visual display worn by the user is employed to display visual 3D information. The computer detects in an image a fiducial marker worn by the user, extracts a position and orientation of the fiducial marker in the image, and superimposes on the image a visual representation of a user interface component directly on or near the user based on the position and orientation.

Abstract: A new cranberry variety distinguished by significantly higher yields, higher anthocyanin content (red pigment), higher stolon vigor, and earlier flowering phenology.