Abstract: Assemblies incorporating cells, biologically active molecules, or combinations thereof. Three dimensional tissue scaffolds are used in the assemblies. The three dimensional tissue scaffolds include a plurality of scaffold layers seeded with cells, biologically active molecules, or combinations thereof, the plurality of cell scaffold layers stacked one on top of another and bonded together in the absence of a solvent or an adhesive. Methods of making the assemblies are also disclosed.
Type:
Application
Filed:
June 1, 2007
Publication date:
February 14, 2008
Applicant:
The Ohio State University
Inventors:
Ly Lee, Yong Yang, Yubing Xie, Douglas Kniss
Abstract: The invention provides profilin-related immunomodulatory polypeptides and toll-like receptor agonists, as well as related pharmaceutical compositions and methods of treatment, useful for treating cancer and infectious disease.
Abstract: Nucleic acids encoding Thermotoga maritima mannitol dehydrogenase and the Thermotoga maritima mannitol dehydrogenase polypeptide are disclosed. Further provided are an electrochemical bioreactor system and a bioreactor electrode that can be used to convert glucose or fructose to mannitol.
Type:
Application
Filed:
August 10, 2007
Publication date:
February 14, 2008
Applicant:
Board of Trustees of Michigan State University
Abstract: An alloy including a Pt-group metal, Ni and Al in relative concentration to provide a ?-Ni+??-Ni3Al phase constitution, and a coating including the alloy.
Type:
Application
Filed:
August 16, 2007
Publication date:
February 14, 2008
Applicant:
Iowa State University Research Foundation, Inc.
Inventors:
Brian Gleeson, Daniel Sordelet, Wen Wang
Abstract: Methods and systems for selectively connecting and disconnecting conductors in a fabric are disclosed. First and second conductors are integrated into a fabric such that the conductors intersect at a crossover point. The conductors are bonded to each other at the crossover point to improve AC and DC characteristics. Disconnect areas may be provided near the crossover point to allow selective disconnection of the conductors from the crossover point.
Type:
Grant
Filed:
November 19, 2004
Date of Patent:
February 12, 2008
Assignee:
North Carolina State University
Inventors:
Anuj Dhawan, Tushar Kanti Ghosh, John Muth, Abdelfattah Seyam
Abstract: The present invention relates to compositions and an apparatuses for determining protease activity. The compositions of the invention contain a reporter protein fused to at least one protease cleavage sequence, and a linker for attaching the protease cleavage sequence to a solid support. Methods for determining protease activity and characterizing proteases are also provided.
Abstract: A process for producing a ring-substituted arene borane which comprises reacting a ring-substituted arene with an HB organic compound in the presence of a catalytically effective amount of an iridium or rhodium complex with three or more substituents, excluding hydrogen, bonded to the iridium or rhodium and a phosphorus organic ligand, which is at least in part bonded to the iridium or rhodium, to form the ring-substituted arene borane. Also provided are catalytic compounds for catalyzing the process comprising an iridium or rhodium complex with three or substituents, excluding hydrogen, bonded to the iridium or rhodium and optionally, a phosphorus organic ligand, which is at least in part bonded to the iridium or rhodium.
Type:
Grant
Filed:
March 29, 2005
Date of Patent:
February 12, 2008
Assignee:
Board of Trustees of Michigan State University
Abstract: An algorithm diagnoses the noise source strength distribution on an arbitrarily shaped object based on acoustic pressures measured in the far field, known as FANS. FANS enable one to acquire a quick estimate of the acoustic pressure at locations that are off limit to traditional measurement microphones. Generally, in the method of the present invention, the noise source is modeled in terms a plurality of virtual spherical wave sources distributed on an auxiliary surface conformal to a source boundary from the inside, but not on the source boundary itself. Sound is then measured at a plurality of measurement points external to the source boundary. The sound field is reconstructed on the source boundary surface itself.
Abstract: A method for forming a fluoropolymer comprises providing a reaction mixture comprising carbon dioxide, at least one fluoromonomer, and an initiator; and reacting the at least one fluoromonomer in the reaction mixture to form a fluoropolymer. The fluoropolymer has a multimodal molecular weight distribution.
Type:
Application
Filed:
October 9, 2007
Publication date:
February 7, 2008
Applicants:
University of North Carolina at Chapel Hill, North Carolina State University
Inventors:
Joseph DeSimone, George Roberts, Paul Charpentier
Abstract: Improved methods for production of stilbenoids including resveratrol, pinosylvin and their respective derivatives are provided, including producing hairy roots from plant cells and eliciting production of the stilbenes. The plant cells in an embodiment are infected by Agrobacterium to produce hairy roots, and contacted with substances which elicit production of the stilbenoid compounds.
Type:
Application
Filed:
July 3, 2007
Publication date:
February 7, 2008
Applicant:
Arkansas State University Research and Development Institute
Inventors:
Luis Medina-Bolivar, Maureen Dolan, Selester Bennett, Jose Condori, John Hubstenberger
Abstract: The present inventions relate to compositions and methods for providing stress tolerant transgenic plants comprising a RING domain zinc-finger motif transcription factor protein. More particularly, the invention relates to compositions and methods comprising a RING-H2 domain transcription factor protein for providing drought and salt tolerant plants, in particular comprising a recombinant XERICO gene and protein.
Type:
Application
Filed:
July 12, 2006
Publication date:
February 7, 2008
Applicant:
The Board of Trustees Operating Michigan State University
Abstract: Magnetostrictive material based on cobalt ferrite is described. The cobalt ferrite is substituted with transition metals (such manganese (Mn), chromium (Cr), zinc (Zn) and copper (Cu) or mixtures thereof) by substituting the transition metals for iron or cobalt to form substituted cobalt ferrite that provides mechanical properties that make the substituted cobalt ferrite material effective for use as sensors and actuators. The substitution of transition metals lowers the Curie temperature of the material (as compared to cobalt ferrite) while maintaining a suitable magnetostriction for stress sensing applications.
Type:
Grant
Filed:
July 23, 2004
Date of Patent:
February 5, 2008
Assignee:
Iowa State University Research Foundation, Inc.
Inventors:
David C. Jiles, Jason A. Paulsen, John E. Snyder, Chester C. H. Lo, Andrew P. Ring, Keith A. Bormann
Abstract: Plants and crops subject to attack by fungal related diseases are protected or treated by the application of Pseudomycin compositions which were originally isolated from Pseudomonas syringae.
Type:
Grant
Filed:
August 17, 2001
Date of Patent:
February 5, 2008
Assignees:
Eli Lilly and Company, Montana State University
Abstract: A thermoelectrically active p- or n-conductive semiconductor material is constituted by a ternary compound of the general formula (I) (Pb1-xGex)Te??(I) with x value from 0.16 to 0.5, wherein 0 to 10% by weight of the ternary compound may be replaced by other metals or metal compounds, wherein the semiconductor material has a Seebeck coefficient of at least ±200 ?V/K at a temperature of 25° C.
Type:
Grant
Filed:
April 11, 2003
Date of Patent:
February 5, 2008
Assignees:
BASF Aktiengesellschaft, Michigan State University
Inventors:
Hans-Josef Sterzel, Klaus Kühling, Mercouri G. Kanatzidis, Duck-Young Chung
Abstract: An anisotropically conductive layer ‘ACL’ for mechanical and electrical bonding of two circuit containing structures, such as a flip chip and carrier is disclosed. The ACL is formed of a rigid insulating substrate or membrane with a top and bottom planar surfaces formed with a plurality of pins therein. The pins extend beyond the top and bottom surfaces so that a portion of each pin is exposed. The pins provide electrical connection between contact terminals or pads of the flip chip and carrier and additionally provide mechanical support between the flip chip and carrier so that the flip chip can undergo post-bonding processing without substantial deformation or breaking. A method of electrically and mechanically bonding the flip chip and carrier and a method of making a semiconductor device using the ACL is also disclosed.
Type:
Grant
Filed:
January 23, 2006
Date of Patent:
February 5, 2008
Assignee:
Research Foundation of State University of New York
Inventors:
Sangmin Lee, Michael Gurvitch, Serge Luryi
Abstract: A formulation containing a biologically active compound having a structure with hydrogen bonding sites blended with a first polymer having a structure with complementary hydrogen bonding sites and a second polymer that degrades to form degradation products that promote the release of the active compound from the first polymer.
Abstract: The present invention relates to a coating composition including a sol-gel matrix and a dendrimeric organochalcogeno derivative and a system including the coating composition and a substrate. The present invention also relates to a method of preventing fouling of surfaces subjected to a marine environment.
Type:
Application
Filed:
July 6, 2007
Publication date:
January 31, 2008
Applicant:
The Research Foundation of State University of New York
Inventors:
Michael Detty, Michael Drake, Ying Tang, Frank Bright
Abstract: A method is provided for improving error recovery of corrupt data packets in a wireless communication system. The method includes: receiving a plurality of incoming data packets over a wireless medium at a receiver; capturing an indicator of bit errors for each of the data packets at a layer of the receiver below an application layer; passing the bit error indicator for each of the data packets to the application layer of the receiver; and performing an error recovery operation in relation to a given data packet at the application layer using the bit error indicator associated with the given data packet.
Type:
Application
Filed:
March 16, 2007
Publication date:
January 31, 2008
Applicant:
Board of Trustees of Michigan State University
Abstract: The present invention relates to solid phase or solution phase combinatorial libraries of autoinducer analogs. The present invention also relates to autoinducer agonists and antagonists. In addition, the present invention relates to methods for identifying autoinducer agonists and antagonists, as well as methods for regulating the activity of an autoinducer receptor, regulating biofilm formation, regulating growth or virulence of an organism in a subject, inhibiting the quorum sensing mechanism of an organism, and treating an infection in a subject caused by an organism possessing a quorum sensing mechanism which use the autoinducer analogs of the present invention.
Type:
Application
Filed:
August 6, 2007
Publication date:
January 31, 2008
Applicant:
The Research Foundation of State University of New York
Abstract: Methods for generating a centerline or skeleton structure within a 3D virtual object are provided. A first method defines a centerline based on distance from boundary values along points of the defined centerline. A second method uses a distance from boundary field to assign costs to voxels in the virtual object and defines a minimum cost spanning tree based on assigned costs. The centerline is defined along the minimum cost spanning tree. Branches along the centerline are identified and added to the centerline to define a skeleton.
Type:
Grant
Filed:
September 16, 2002
Date of Patent:
January 29, 2008
Assignee:
The Research Foundation of State University of New York
Inventors:
Ingmar Bitter, Arie E. Kaufman, Ming Wan, Jerome Liang, Mark R. Wax