Abstract: A dual side view display includes a waveguide with an inside transparent layer and an outside transparent layer spaced apart from and parallel to the inside transparent layer, and a plurality of inside view liquid crystal (LC) pixels and a plurality of outside view LC pixels disposed within the waveguide. The plurality of outside view LC pixels are disposed within the waveguide parallel to and in-plane with the plurality of inside view LC pixels. The plurality of inside LC pixels includes a plurality of outside blocking layers configured to block light scattered in the plurality of inside view LC pixels from propagating through the outside transparent layer. Also, the plurality of outside view LC pixels includes a plurality of inside blocking layers configured to block light scattered in the plurality of outside view LC pixels from propagating through the inside transparent layer.
Type:
Grant
Filed:
July 28, 2022
Date of Patent:
February 20, 2024
Assignees:
Toyota Motor Engineering & Manufacturing North America, Inc., MIRISE Technology Corporation, Kent State University
Inventors:
Deng-Ke Yang, Yunho Shin, Guangkui Qin, Sean P. Rodrigues
Abstract: Phenothiazine compounds of Formula (I) are described herein. These compounds are useful as highly reducing organic photoredox catalysts. Suitable substrates for use with the compounds of Formula (I) include acrylates, styrene, acrylamides, acrylonitrile, vinyl chloride, methylacrylonitrile, vinyl acetate, and acrylic acid.
Type:
Grant
Filed:
January 8, 2021
Date of Patent:
February 20, 2024
Assignees:
THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE, COLORADO STATE UNIVERSITY RESEARCH FOUNDATION
Inventors:
Steven Sartor, Niels Damrauer, Garet Miyake, Cameron Chrisman, Ryan Pearson
Abstract: A robotic coupling joint system and method are discussed herein, which may be utilized with a daylighting system or photovoltaic system to track sunlight. The system may provide a spherical joint allowing axial motion about two or more axes of the spherical joint. The joint comprises a first plate with four or more sockets, a second plate, a connector, and one or more spheres positioned between the first and second plates. The connector secures the sphere between the first and second plates. The system may also include a stand, an end effector coupled to the stand by the spherical joint, and a mobility system that is capable of actuating the end effector. The mobility system includes two or more linking elements coupled to the end effector, and a motor coupled to the linking elements to actuate the end effector to track sunlight.
Type:
Grant
Filed:
March 8, 2019
Date of Patent:
February 20, 2024
Assignee:
Texas State University
Inventors:
Ricardo Mateo Ramirez, III, Bahram Asiabanpour
Abstract: Embodiments of fiber substrate-based fluidic device and methods of manufacturing the same are described herein. In one example, a microfluidic diagnostic device for detecting a presence and/or concentration of an analyte includes a nitrocellulose substrate sandwiched between two bonded layers of a hydrophobic film. The nitrocellulose substrate includes a plurality of wells and/or fluidic channels formed in the nitrocellulose substrate such that boundaries of the wells and/or fluidic channels are defined by the nitrocellulose and at least one of the bonded layers of the hydrophobic film.
Abstract: A mammalian expression system comprising an attenuated, recombinant Ranavirus that has at least one foreign expression element using a unique combination of mammalian transcriptional and translational enhancement elements is disclosed. In other contemplated embodiments, a mammalian expression system comprising a virus, wherein the virus is engineered to express at least two vaccine antigens is disclosed. In addition, methods of delivering human antigens to a mammal are disclosed that include: providing a non-mammalian virus, engineering a recombinant virus that can express at least one foreign molecule by modifying the non-mammalian virus, and using the recombinant Ranavirus to express and deliver foreign antigens to a mammal.
Type:
Application
Filed:
October 17, 2023
Publication date:
February 15, 2024
Applicant:
The Trustees of the California State University
Abstract: Representative xanthohumol derivatives have been made and have been tested in vivo in mice. Such derivatives have a number of important medicinal benefits, including improving glucose tolerance and decreasing weight gain by increasing energy expenditure and locomotor activity in treated subjects. Disclosed derivatives also may function as mitochondrial uncouplers. Representative compounds include 4-(5-(4-hydroxyphenyl)-1-methyl-1H-pyrazol-3-yl)-5-methoxy-2-(3-methylbut-2-en-1-yl)benzene-1,3-diol and 4-(5-(4-hydroxyphenyl)isoxazole-3-yl)-5-methoxy-2-(3-methylbut-2-en-1-yl)benzene-1,3-diol.
Type:
Application
Filed:
July 19, 2023
Publication date:
February 15, 2024
Applicant:
Oregon State University
Inventors:
Ines L. Paraiso, Jan Frederik Stevens, Paul R. Blakemore, Luce M. Mattio
Abstract: In one aspect, the present disclosure relates to tumor associated macrophage (TAM) targeting peptide. In another aspect, the present disclosure relates to a method of targeting a TAM in a subject, the method comprising administering to the subject a TAM targeting peptide attached to and/or displayed on the surface of a solid particle. In yet another aspect, the present disclosure relates to a method of treating a tumor infiltrated with a TAM in a subject, the method comprising administering to the subject a TAM targeting peptide attached to and/or displayed on the surface of a solid particle.
Type:
Application
Filed:
December 20, 2021
Publication date:
February 15, 2024
Applicants:
Rutgers, The State University of New Jersey, Board of Regents, The University of Texas System
Abstract: A system includes a Bayesian Spatiotemporal Graph Transformer (B-STAR) architecture that models spatial and temporal relationship of multiple agents under uncertainties. The system enables Multi-Agent Trajectory Prediction for safety-critical engineering applications, (e.g., autonomous driving and flight systems) and considers the impact of various sources, such as environmental conditions, pilot/controller behaviors, and potential conflicts with nearby aircraft. It is shown that B-STAR achieves state-of-the-art performance on the ETH/UCY pedestrian dataset with UQ competence.
Type:
Application
Filed:
August 15, 2023
Publication date:
February 15, 2024
Applicant:
Arizona Board of Regents on behalf of Arizona State University
Abstract: The present disclosure describes probiotic compositions comprising Emergencia timonensis and methods for using probiotic compositions comprising Emergencia timonensis to reducing TMA and/or TMAO levels in subjects in need thereof.
Type:
Application
Filed:
August 15, 2023
Publication date:
February 15, 2024
Applicant:
Oregon State University
Inventors:
Veronika Kivenson, Stephen J. Giovannoni
Abstract: A nanocarrier containing a combination of bioactive agents is provided. The nanocarrier allows for targeted delivery of the agents to cancer cells with minimized side effect.
Type:
Grant
Filed:
October 22, 2021
Date of Patent:
February 13, 2024
Assignee:
Rutgers, The State University of New Jersey
Abstract: Disclosed herein is a glucose-responsive insulin delivery system based on the interaction between the glucose-modified insulin and glucose transporters (GLUTs) on erythrocytes (or red blood cells, RBCs). After being conjugated with glucose, insulin can efficiently bind to RBC membranes. The binding is reversible in the setting of hyperglycemia, resulting in fast release of insulin and subsequent drop of blood glucose (BG) level in vivo. In some embodiments, the delivery vehicle can include: 1) intravenously injectable polymeric nanoparticles (˜100 nm in diameter) coated with RBC membrane and loaded with glucose-modified insulin and/or 2) painless microneedle (MN) patches loaded with the complex of GLUT and glucose-modified insulin.
Abstract: A wound dressing includes: a structural material formed into a dressing; at least one immunomodulatory agent associated with the dressing; and a growth factor associated with the dressing. A wound dressing kit includes: a structural material formed into a wound dressing; an immunomodulatory agent; and a growth factor composition, wherein the structural material contains the immunomodulatory agent and/or the immunomodulatory agent in a separate composition. A method of treating a wound in a tissue includes: applying an immunomodulatory agent to the wound; applying a wound dressing to the wound; and allowing the wound to heal with the immunomodulatory agent and wound dressing. The application of a growth factor can be before, during and/or after applying the wound dressing to the wound.
Type:
Grant
Filed:
October 7, 2020
Date of Patent:
February 13, 2024
Assignee:
Arizona Board of Regents on behalf of Arizona State University
Abstract: A method of treating a bacterial infection including bacteria that have become resistant to an antibiotic in a subject in need thereof is provided. The method includes administering to the subject a safe and therapeutically effective amount of the antibiotic and a reviving agent selected from the group consisting of glass-ceramic particles, silver ions, and combinations thereof. The reviving agent restores antibiotic activity to the antibiotic against the bacteria.
Type:
Grant
Filed:
March 27, 2020
Date of Patent:
February 13, 2024
Assignee:
Board of Trustees of Michigan State University
Inventors:
Xanthippi Chatzistavrou, Neal D. Hammer, Aljoscha Roch
Abstract: In accordance with the purpose(s) of the present disclosure, as embodied and broadly described herein, the disclosure, in one aspect, relates to compound Bi-poor perovskite crystals, methods for making the same, and ionizing and other electromagnetic radiation detectors constructed using the Bi-poor perovskite crystals. The Bi-poor perovskite crystals can be synthesized using melt-based growth methods and solution-based growth methods and contain no toxic heavy metals such as lead, cadmium, thallium, or mercury. Devices fabricated from the crystals maintain acceptable levels of performance over time. In some aspects, post-growth annealing can be used to improve the properties, including, but not limited to, room temperature resistivity and response to radiation.
Abstract: Disclosed herein are self-degradable microneedle devices for the controlled-release of an immunotherapeutic agent. Also disclosed are methods for treating a disease (for example, cancer) using a self-degradable microneedle patch for the sustained delivery of an immunotherapeutic agent (for example, a PD1 antibody).
Abstract: Recombinant, live, attenuated viruses of the Pneumoviridae family are disclosed that include a baculovirus GP64 envelope glycoprotein or variant or fragment thereof and a respiratory syncytial virus (RSV) F protein variant or fragment thereof. Also disclosed are polynucleotides encoding the virus as well as pharmaceutical compositions and vaccines containing the virus. In addition, methods of producing and using each of the above compositions are also disclosed.
Type:
Grant
Filed:
June 24, 2022
Date of Patent:
February 13, 2024
Assignee:
Board of Regents for Oklahoma State University
Abstract: Provided herein are synthetic nucleic acid molecules and methods of using such synthetic nucleic acid molecules for strong repression of target gene expression. In particular, provided herein are methods for altering expression of a protein in a cell, where the method comprises introducing into a cell a protein coding sequence operably linked to a near-threshold translational repressor having first and second trigger recognition sequences that are fully or partially complementary to a repressing trigger RNA; and introducing into a cell the repressing trigger RNA.
Type:
Grant
Filed:
January 22, 2021
Date of Patent:
February 13, 2024
Assignee:
ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY
Abstract: Methods of forming metal multipod nanostructures. The methods may include providing a mixture that includes a metal acetylacetonate, a reducing agent, and a carboxylic acid. The mixture may be contacted with microwaves to form the metal multipod nanostructures. The methods may offer control over the structure and/or morphology of the metal multipod nanostructures.
Type:
Grant
Filed:
October 3, 2022
Date of Patent:
February 13, 2024
Assignee:
The Florida State University Research Foundation, Inc.
Abstract: A polishing apparatus is provided. Another aspect pertains to a self-leveling polishing apparatus for smoothing diamonds. Yet another aspect of the present system uses a ball and swivel joint in a diamond polishing machine. A further aspect employs a polishing apparatus including a diamond-holder, an elongated arm using gravity to apply downward polishing pressure of the diamond workpiece against a polishing wheel, and a sweeping transmission to cause the holder to radially move across the rotating polishing wheel.
Type:
Grant
Filed:
March 9, 2022
Date of Patent:
February 13, 2024
Assignees:
Board of Trustees of Michigan State University, Fraunhofer USA
Inventors:
Aaron Hardy, Timothy A. Grotjohn, Edward K. Drown, Michael Becker
Abstract: The present invention describes a bio-based process to produce high quality protein concentrate (HQPC) by converting plant derived celluloses into bioavailable protein via aerobic incubation, including the use of such HQPC so produced as a nutrient, including use as a fish meal replacement in aquaculture diets.
Type:
Grant
Filed:
January 21, 2022
Date of Patent:
February 13, 2024
Assignee:
The South Dakota Board of Regent, as Governing Board for South Dakota State University