Abstract: Methods of preventing or decreasing PEDv and/or Salmonella bacteria in animal feed, feed ingredients, and pet food are provided. The methods utilize generally safe chemical mitigants, such as medium chain fatty acids, essential oils, and sodium bisulfate. The chemical mitigants are introduced to the feed or feed ingredients at inclusion rates selected so as to prevent or decrease PEDv and/or Salmonella bacteria in the animal feed, feed ingredients, or pet rood. The methods are particularly suitable for use in post-processing treatment of animal feed, feed ingredients, or pet food that will be transported and stored for multiple days or weeks.

Abstract: In accordance with the purpose(s) of the present disclosure, as embodied and broadly described herein, the disclosure, in one aspect, relates to compound Bi-poor perovskite crystals, methods for making the same, and ionizing and other electromagnetic radiation detectors constructed using the Bi-poor perovskite crystals. The Bi-poor perovskite crystals can be synthesized using melt-based growth methods and solution-based growth methods and contain no toxic heavy metals such as lead, cadmium, thallium, or mercury. Devices fabricated from the crystals maintain acceptable levels of performance over time. In some aspects, post-growth annealing can be used to improve the properties, including, but not limited to, room temperature resistivity and response to radiation.

Abstract: The present invention describes a bio-based process to produce high quality protein concentrate (HQPC) by converting plant derived celluloses into bioavailable protein via aerobic incubation, including the use of such HQPC so produced as a nutrient, including use as a fish meal replacement in aquaculture diets.

Abstract: A permeable pavement system including a permeable pavement composition and a related method are provided. The permeable pavement system includes a first layer of a permeable pavement composition including a quantity of a first permeable pavement material and a quantity of cured carbon fiber composite material (CCFCM) incorporated therewith, the first layer defining a first surface; and a second layer of a second permeable pavement material deposited over a substantial entirety of and covering the first surface of the first layer of the permeable pavement composition, wherein the first layer interfaces with the second layer to at least strengthen the permeable pavement system.

Abstract: A voltage converter, method for operating a voltage converter, and a controller for a voltage converter is provided. An input stage, comprising a first pair of switches is configured to receive electrical power and generate therefrom an oscillating waveform in a transformer circuit comprising an inductor, the oscillating waveform being associated with an inductor current in the inductor. A synchronous rectifier stage, comprising a second pair of switches, is configured to produce a rectified output voltage from power transferred through the transformer circuit. A controller, producing switch control signals, is configured to operate the first pair of switches in a soft switching mode to produce the oscillating waveform having a switching rate dependent on the rectified output voltage and a switching duty cycle dependent on the inductor current; and synchronously operate the second pair of switches to produce the rectified output voltage.

Abstract: An assembly that includes a first substrate formed of aluminum or an aluminum alloy; and a second substrate formed of a polymer composite that includes a plurality of carbon fibers. The second substrate is joined to the first substrate in a manner where a surface of exposed carbon fibers contacts the aluminum or aluminum alloy of the first substrate; and an is adlayer formed on the surface of the exposed carbon fibers that is configured to inhibit galvanic corrosion of the first substrate, corrosion of the carbon fibers, and debonding of the polymer of the composite from the carbon fibers upon formation of a galvanic couple between the first substrate and the second substrate.

Abstract: The invention provides inhibitors of interferon regulatory factor 5 FIG. 5 (IRF5) nuclear localization and methods of using the inhibitors to treat autoimmune diseases such as systemic lupus erythematosus (SLE).

Abstract: A method of treating or preventing methamphetamine related endothelial dysfunction in a patient comprising administering to the patient an effective dose of a pharmacologic composition; the composition comprising a therapeutic, the therapeutic including a hydrogen sulfide (H2S) donor, or a salt, solvate, ester, amide, clathrate, stereoisomer, enantiomer, prodrug or analogs thereof. The H2S donor may be one of sodium sulfide, diallyl trisulfide, diallyl disulfide, acillin, sugammadex, sulfanilamide, disulfram, sulfonamide, sulfinates, sulfoxides, persulfides, polysulfides, and sulfones. The H2S donor may be sugammadex. The H2S donor may be administered in a dosage of between 0.5 mg/kg and 10.0 mg/kg.

Abstract: Disclosed is a method of treating a tumor in a patient, comprising (a) administering riluzole in an amount effective to sensitize the tumor cells to ionizing radiation, and (b) irradiating the tumor cells with ionizing radiation in a dose effective to reduce tumor cell growth. The method can further comprise administering an effective amount of one or more additional therapeutic agents.

Abstract: The present invention is directed to novel polynucleotides, polypeptides, and polyproteins of Mycoplasma surface proteins, all of which are useful in detecting infection and for the preparation of vaccines for treating and preventing diseases in swine and other animals. Vaccines provided according to the practice of the invention are effective against Mycoplasma infections. Detection and therapeutic polyclonal and monoclonal antibodies are also a feature of the present invention. Assays, kits, systems, and nanoparticle encapsulated compositions related to the polynucleotides, polypeptides, polyproteins, antibodies or fragments, derivatives, and variants thereof are also disclosed.

Abstract: A counter-swarm firework includes a shell casing, multiple streamers positioned in the shell casing, a burst charge positioned in the shell casing and configured to disperse the multiple streamers from the shell casing when discharged, a pusher plate positioned in the shell casing between the burst charge and the multiple streamers, a fire suppressant layer positioned between the burst charge and the pusher plate, and a kick charge configured to launch the shell casing and its contents prior to discharging the burst charge. The fire suppression layer may be configured to suppress heat generated by the discharge of the burst charge.

Abstract: The present invention relates to compositions and methods for enhancing T cell metabolism and activity for more effective adoptive T cell therapy. By expressing an chimeric antigen receptor and bispecific antibodies in T cells, the T cells are metabolically enhanced with improved cytotoxicity and resistance to immunosuppression imposed by tumor microenvironments. Certain aspects include modified T cells and pharmaceutical compositions comprising the modified cells for adoptive cell therapy and treating a disease or condition associated with enhanced immunity.

Abstract: Methods for producing engineered exosomes and other vesicle-like biological targets, including allowing a target vesicle-like structure to react and bind with immunomagnetic particles; capturing the immunomagnetic particle/vesicle complex by applying a magnetic field; further engineering the captured vesicles by surface modifying with additional active moieties or internally loading with active agents; and releasing the engineered vesicle-like structures, such as by photolytically cleaving a linkage between the particle and engineered vesicle-like structures, thereby releasing intact vesicle-like structures which can act as delivery vehicles for therapeutic treatments.

Abstract: A power converter includes a primary H-bridge with switches and an LCL-Transformer section with a first inductor with a first end connected to a first terminal of the primary H-bridge, a capacitor connected between a second end of the first inductor and a second terminal of the primary H-bridge, and a second inductor with a first end connected to the second end of the first inductor. The converter includes a transformer with a primary connected between a second end of the second inductor and the second terminal of the primary H-bridge, a secondary H-bridge with switches with an input connected to a secondary side of the transformer, and an output capacitor connected across output terminals of the secondary H-bridge. The primary H-bridge is fed by a DC constant current source and the output terminals of the secondary H-bridge have a regulated DC output voltage are connected to a load.

Abstract: An electrode comprising a space group Pna21 VOPO4 lattice, capable of electrochemical insertion and release of alkali metal ions, e.g., sodium ions. The VOPO4 lattice may be formed by solid phase synthesis of KVOPO4, milled with carbon particles to increase conductivity. A method of forming an electrode is provided, comprising milling a mixture of ammonium metavanadate, ammonium phosphate monobasic, and potassium carbonate; heating the milled mixture to a reaction temperature, and holding the reaction temperature until a solid phase synthesis of KVOPO4 occurs; milling the KVOPO4 together with conductive particles to form a conductive mixture of fine particles; and adding binder material to form a conductive cathode. A sodium ion battery is provided having a conductive NaVOPO4 cathode derived by replacement of potassium in KVOPO4, a sodium ion donor anode, and a sodium ion transport electrolyte. The VOPO4, preferably has a volume greater than 90 ?3 per VOPO4.

Abstract: Fabricating a nanopore sensor includes depositing a first and second oxide layers on first and second sides of a sapphire substrate. The second oxide layer is patterned to form an etch mask having a mask opening in the second oxide layer. A crystalline orientation dependent wet anisotropic etch is performed on the second side of the sapphire substrate using the etch mask to form a cavity having sloped side walls through the sapphire substrate to yield an exposed portion of the first oxide layer, each of the sloped side walls being a crystalline facet aligned with a respective crystalline plane of the sapphire substrate. A silicon nitride layer is deposited on the first oxide layer. The exposed portion of the first oxide layer in the cavity is removed, thereby defining a silicon nitride membrane in the cavity. An opening is formed through the silicon nitride membrane.

Abstract: Various embodiments for predicting which software vulnerabilities will be exploited by malicious hackers and hence prioritized by patching are disclosed.

Abstract: Described herein are polyhedral, three-dimensional tunable nanocages assembled with a multimeric protein covalently linked to a polynucleotide handle and a DNA origami base assembly including sequences complementary to the polynucleotide handles, wherein the polynucleotide handle and the complementary sequences hybridize to for double-stranded DNA helices.

Abstract: The present invention provides rolled scaffold devices and cell culture systems that can provide a large surface-area-to-volume ratio for expanded cell culture. The rolled scaffolds minimize shear stress on cultured cells and support sufficient and uniform mass transfer rates of gases and nutrients. The rolled scaffolds can be connected to a media source via holders to support large-scale expansion and maintenance of cell cultures.

Abstract: A new and distinct variety of Cercis plant, referred to by its cultivar name ‘NC2017-9’, is disclosed. The new variety is characterized by its purple-colored flowers, small and green colored foliage which exhibits an attractive moderate reddish orange color on newly emerging leaves, and moderately slow growing, profuse branching, weeping, and compact growth habit.