Abstract: A method of making dispersion-strengthened alloy particles involves melting an alloy having a corrosion and/or oxidation resistance-imparting alloying element, a dispersoid-forming element, and a matrix metal wherein the dispersoid-forming element exhibits a greater tendency to react with a reactive species acquired from an atomizing gas than does the alloying element. The melted alloy is atomized with the atomizing gas including the reactive species to form atomized particles so that the reactive species is (a) dissolved in solid solution to a depth below the surface of atomized particles and/or (b) reacted with the dispersoid-forming element to form dispersoids in the atomized particles to a depth below the surface of said atomized particles. The atomized alloy particles are solidified as solidified alloy particles or as a solidified deposit of alloy particles.

Abstract: Target and method for inhibition of bacterial RNA polymerase disclosed are targets and methods for specific binding and inhibition of RNAP from bacterial species.

Abstract: Isolated nucleic acid comprising a nucleotide sequence that codes for a mutant mammalian Nav1 protein are disclosed.

Abstract: Water permeable membranes and methods of forming water permeable membranes are provided. The water permeable membranes are comprised of a cross-linked polyamide containing at least one bifunctional additive that is hydrophilic and reactive. Additionally, in accordance with other embodiments of this invention, methods of forming water permeable membranes comprised of a cross-linked polyamide containing at least one bifunctional additive that is hydrophilic and reactive are provided. Specifically, the water permeable membranes may comprise a membrane formed from a cross-linked aromatic or aromatic/aliphatic polyamide interfacially polymerized on a porous support. The presence of the at least one hydrophilic and reactive additive improves the flux and salt retention properties of the membrane in comparison to a membrane formed without the at least one hydrophilic and reactive additive.

Abstract: Disclosed is a device and method for preventing seizures due to physiological system dysfunction. The method is based on a conjectural model of the brain wherein each brain site is modeled as a chaotic oscillator; a normal brain generates an internal feedback signal to prevent long-term entrainment among the oscillators; and a pathological brain fails to provide this feedback signal. The device of the present invention measures and characterizes the brain sites to determine if entrainment is occurring among the oscillators, derives an appropriate feedback signal to counteract the entrainment, and applies the feedback signal to the critical brain sites. The feedback signal generated by the device supplements or takes the place of the feedback signal that would otherwise be generated by the normal brain.

Abstract: The invention relates to compositions and methods useful in the labeling and identification of proteins. The invention provides for highly soluble zwitterionic dye molecules where the dyes and associated side groups are non-titratable and maintain their net zwitterionic character over a broad pH range, for example, between pH 3 and 12. These dye molecules find utility in a variety of applications, including use in the field of proteomics.

Abstract: An apparatus includes a single or dual output port, dual-drive Mach-Zehnder Interferometer configured to generate a first optical signal in one path, and to generate a second optical signal in a different path. The apparatus also includes an optical spectrum analyzer configured to receive output from at least one port of the dual-drive Mach-Zehnder Interferometer. A method includes causing radio frequency signals from two different antennae to modulate an optical carrier at a corresponding drive of a dual-drive Mach-Zehnder Interferometer, and causing output from at least one port of the Mach-Zehnder Interferometer to be directed to an optical spectrum analyzer. The method further comprises determining arrival angle at each of a plurality of frequencies in the radio frequency signals based on output from the optical spectrum analyzer.

Abstract: In various embodiments, the present invention can involve a method of synthesizing ?-amino-?-caprolactam. The method can comprise heating a salt of L-lysine in a solvent comprising an alcohol. In other embodiments, the present invention can involve methods for synthesizing ?-caprolactam. The methods can comprise heating a salt of L-lysine in a solvent comprising an alcohol and deaminating the reaction product. In various embodiments, the invention can include methods of converting biomass into nylon 6. The methods can comprise heating L-lysine in a solvent comprising an alcohol to produce ?-amino-?caprolactam, deaminating to produce ?-caprolactam and polymerizing into nylon 6, wherein the L-lysine is derived from the biomass. In other embodiments, the present invention can include methods of making nylon 6. The methods can comprise synthesizing ?-caprolactam and then polymerizing, wherein the ?-caprolactam is derived from L-lysine.

Abstract: An integrated circuit device that is secure from invasion and related methods are disclosed herein. Other embodiments are also disclosed herein.

Abstract: A number of compounds and use of the compounds in a method for treating or preventing cancer in a subject by administering to the subject a pharmaceutical composition including a compound of formula I or a pharmaceutically acceptable salt thereof are described. The compounds can also be used to inhibit integrin-linked kinase in a cell, which has an effect on the Akt signaling pathway.

Abstract: A composition, reactor apparatus, method, and control system for growing epitaxial layers of group III-nitride alloys. Super-atmospheric pressure is used as a process parameter to control the epitaxial layer growth where the identity of alloy layers differ within a heterostructure stack of two or more layers.

Abstract: The present invention provides for a hybrid dental implant having a screw body with at least one external thread, which comprises an upper portion with an open ceiling configured to receive an unhardened cement, a middle portion having an inner cavity and one or more side openings extending from the inner cavity, wherein the open ceiling is in communication with the inner cavity to form a hollow inner channel, which allows the unhardened cement to move through the side openings and to penetrate the surrounding bone; and a lower portion with a closed floor. It also provides for a method of installing a hybrid dental implant into a bone.

Abstract: This invention relates to nucleic acid aptamers that recognize and bind the complement protein C3 or its biologically active proteolytic products and methods of their use. Particularly preferred are bi-functional aptamer construct that binding specifically with C3b or iC3b, and another target protein. Use of these molecular constructs for commandeering the opsonization process is also described herein.

Abstract: An apparatus for transferring cryogenic refrigeration includes a cryocooler interface, a housing, a working fluid, a heat exchanger, a flexible thermal link, and a remote cartridge cold head. The cryocooler interface is thermally connected to a cryocooler providing a source of refrigeration. The refrigeration is passed from the crycooler into the heat exchanger via the cryocooler interface. The remote cartridge cold head is attached to a remote location. Heat is drawn from the remote location through the remote cartridge cold head and into the heat exchanger via the working fluid within the flexible thermal link and housing. Within the heat exchanger, heat is transferred from the working fluid to the refrigeration source, such as a cryocooler; accordingly, the remote location is cooled.

Abstract: An apparatus and method for treating morbid obesity in mammals using a gastric reduction assembly that reduces the gastric volume of a stomach and induces early satiety. The gastric reduction assembly comprises at least two or more expandable devices, each able to be adjustably inflated with a fluid (e.g., a liquid or a gas) using a filling tube. In a preferred embodiment, the gastric reduction assembly is inserted through the abdominal wall and placed at a location exterior to the stomach body, avoiding an abdominal incision. Once positioned near the stomach body, the gastric reduction assembly allows for the external compression of the stomach body to limit food intake. The gastric reduction assembly also minimizes the potential for shifting of the expandable devices after insertion to the stomach body to revert to its pre-compressed state.

Abstract: The present invention is directed to methods, reagents, kits and compositions for detecting microRNA (miRNA) precursors in a biological sample. The methods uses gene-specific primers and reverse transciptase to convert the primary miRNA precursors (pri-miRNA) and pre-miRNA precursors (pre-miRNAs) to cDNA. The method also uses amplification reactions using gene specific forward and reverse primers that are targeted to the hairpin sequence of pri- and pre-microRNA precursors to detect the expression levels of both the pri- and the pre-microRNAs.

Abstract: A nanoscale motion detector attaches a gold nanorod (30) to the rotating arm (26) of a molecular structure (10) to cause the nanoparticle to rotate. The molecular structure is an F1-ATPase enzyme. The gold nanorod is exposed to a light source. The long axis of the gold nanorod scatters red light when the nanorod is in a first position. The short axis of the gold nanorod scatters green light when the nanorod is in a second position. A polarizing filter filters the red and green light to detect the rotational motion by observing alternating red and green lights. A detection DNA stand (50) is coupled between the gold nanorod and the molecular structure. The detection DNA strand hybridizes with a target DNA strand (58) if the target DNA strand matches the detection DNA strand to form a structural link between the molecular structure and gold nanorod.

Abstract: Combining multiple clusterings arises in various important data mining scenarios. However, finding a consensus clustering from multiple clusterings is a challenging task because there is no explicit correspondence between the classes from different clusterings. Provided is a framework based on soft correspondence to directly address the correspondence problem in combining multiple clusterings. Under this framework, an algorithm iteratively computes the consensus clustering and correspondence matrices using multiplicative updating rules. This algorithm provides a final consensus clustering as well as correspondence matrices that gives intuitive interpretation of the relations between the consensus clustering and each clustering from clustering ensembles. Extensive experimental evaluations demonstrate the effectiveness and potential of this framework as well as the algorithm for discovering a consensus clustering from multiple clusterings.

Abstract: The invention encompasses micelle assemblies, compositions having micelle assemblies, and methods for preparing micelle assemblies and compositions thereof. Also, the invention encompasses compounds of the formula: A-X—Y—Z—R1 wherein A is a carboxy group or is absent; X is a polyol, Y is —C(?O)—, —C(?S)—, or is absent; Z is O, S, or NH; and R1 is a polyether, wherein one or more hydroxy groups of the polyol are acylated with a fatty acid residue, wherein the compounds form micelle assemblies. The invention encompasses methods of encapsulating molecules using the compounds of the invention.

Abstract: (?)-EGCG, the most abundant catechin, was found to be chemopreventive and anticancer agent. However, (?)-EGCG has at least one limitation: it gives poor bioavailability. This invention provides compounds of generally formulae below, wherein R11, R12, R13, R21, R22, R2, R3, and R4 are each independently selected from the group consisting of —H, and C1 to C10 acyloxyl group; and R5 is selected from the group consisting of —H, C1-C10-alkyl, C2-C10-alkenyl, C2-C10-alkynyl, C3-C7-cycloalkyl, phenyl, benzyl and C3-C7-cycloalkenyl, whereas each of the last mentioned 7 groups can be substituted with any combination of one to six halogen atoms; at least one of R11, R12, R13, R21, R22, R2, R3 and R4 is —H, which were found to be more potent than their non-protected counterparts, which can be used as proteasome inhibitors to reduce tumor cell growth.