Abstract: Disclosed are compositions and methods for reducing the proliferation of ALL cancer cells through targeted interactions with ALL1 fusion proteins.

Abstract: The present invention is directed to methods and substrates for promoting the differentiation of neural stem cells to neurons.

Abstract: Disclosed are compositions and methods for reducing the proliferation of ALL cancer cells through targeted interactions with ALL1 fusion proteins.

Abstract: Semiconductor materials suitable for being used in radiation detectors are disclosed. A particular example of the semiconductor materials includes tellurium, cadmium, and zinc. Tellurium is in molar excess of cadmium and zinc. The example also includes aluminum having a concentration of about 10 to about 20,000 atomic parts per billion and erbium having a concentration of at least 10,000 atomic parts per billion.

Abstract: A biosensor for use in detecting the presence of diseases, the biosensor comprising a detector for detecting a presence of at least one marker indicative of a specific disease. A method of determining efficacy of a pharmaceutical for treating a disease or staging disease by administering a pharmaceutical to a sample containing markers for a disease, detecting the amount of at least one marker of the disease in the sample, and analyzing the amount of the marker in the sample, whereby the amount of marker correlates to pharmaceutical efficacy or disease stage. Markers for gynecological disease selected from the list in Table 8. An immuno-imaging agent comprising labeled antibodies, whereby the labeled antibodies are isolated and reactive to proteins overexpressed in vivo. Informatics software for analyzing the arrays of claim 17, the software including analyzing means for analyzing the arrays.

Abstract: A method for detecting a haptoglobin-matrix metalloproteinase 9 (Hp-MMP9) complex in a biological sample. The sample includes incubating the biological sample with a capture reagent immobilized on a solid support to bind Hp-MMP9 to the capture reagent. The capture reagent includes a monoclonal antibody that binds MMP9. The method detects Hp-MMP9 bound to the immobilized capture reagent by contacting the bound Hp-MMP9 with a detectable antibody that binds to Hp.

Abstract: Mutants of human FGF-1 are disclosed having increased stability and mitogenic potency. In the FGF-1 polypeptide, primarily residue 12 is substituted with valine and residue 134 is substituted cysteine or threonine to render the polypeptide more stable and/or to increase its mitogenecity.

Abstract: The present invention is directed to a two-dimensional parity technique for data to be stored in one or more memory arrays, each of which has various rows and columns of cells. A row of bits in a super bundle is referred to as a row bundle. A super bundle includes numerous rows of row bundles, and corresponding bits in each of the row bundles in the super bundle are aligned in columns. A row check bit is provided for each row bundle in each super bundle. Each row check bit provides a parity bit that is derived from the k bits of the corresponding row bundle. A column check bit is provided for each column in each super bundle. Each column check bit provides a parity bit that is derived from each of the bits in the corresponding column in the super bundle.

Abstract: The present invention provides a system for stabilizing gas and particularly gas hydrates at low pressures and for safe storage and transportation of the gas. The invention also provides minimization of the decomposition of the gas in hydrate form.

Abstract: A turbocharged engine includes an internal combustion engine and a variable geometry turbocharger. The turbocharger is adjustable to operate efficiently under various engine operating and environmental conditions. The turbocharger includes a turbine and compressor, with the compressor including a compressor housing, an impeller rotatably mounted in the housing, and an adjustable diffuser vane assembly. The diffuser vane assembly includes a plurality of pivotal diffuser vanes spaced about the impeller and a vane rotation drive that interconnects the vanes and permits simultaneous adjustment of the diffuser vanes to improve the efficiency and operating range of the turbocharger. The diffuser vane assembly also includes a vane locking drive operable to engage the pivotal vanes and prevent vane movement during turbocharger operation.

Abstract: Disclosed are compositions that include anti-CD74 immunoconjugates and optionally a therapeutic and/or diagnostic agent. In preferred embodiments, the immunoconjugates comprise one or more anti-CD74 antibodies or antigen-binding fragments thereof, conjugated to a liposome or micelle. Also disclosed are methods for preparing the immunoconjugates and using the immunoconjugates in diagnostic and therapeutic procedures. In certain preferred embodiments, the therapeutic methods comprise administering to a subject with a CD74-expressing disease an anti-CD74 immunoconjugate and thereby inducing apoptosis of CD74-expressing cells. In more preferred embodiments, the CD74 immunoconjugate is capable of inducing cell death in the absence of any other therapeutic agent, although such agents may be optionally administered prior to, together with or subsequent to administration of the anti-CD74 immunoconjugate. The compositions may be part of a kit for administering the anti-CD74 immunoconjugates or compositions.

Abstract: A fiber measurement system for precision measurement of individual fiber properties, including length and fiber length distribution is provided. The fiber measurement system includes a fiber introduction system configured to introduce a plurality of individualized fibers. A fiber guidance enclosure is configured to receive the fibers from the fiber introduction system. The fiber guidance enclosure has an enclosed pathway and a viewing area. The viewing area has a height that limits mobility of the fibers in a Z-direction and the viewing area has a width that is wider than the enclosed pathway. A sensing system is provided for detecting the presence of the fibers within the fiber guidance enclosure. An imaging system is positioned proximal the viewing area of the fiber guidance enclosure to capture an image of the individualized fiber as the fibers pass through the viewing area. A controller is provided for analyzing the image data to determine at least one property of the fibers.

Abstract: A system and method for tracking features, e.g., facial features, is provided, which allows for the tracking of features which move in a series of images and whose shape changes nonlinearly due to perspective projection and complex 3D movements. A training set of images is processed to produce clustered shape subspaces corresponding to the set of images, such that non-linear shape manifolds in the images are represented as piecewise, overlapping linear surfaces that are clustered according to similarities in perspectives. A landmark-based training algorithm (e.g., ASM) is applied to the clustered shape subspaces to train a model of the clustered shape subspaces and to create training data.

Abstract: The present invention generally relates to methods and systems for analysis of real-time user-generated text messages. The methods and systems allow analysis to be performed using term associations and geographical and temporal constraints.

Abstract: Disclosed are specific mutants of L3 and transgenic plants that produce them. The plants exhibit increased resistance to fungal toxins that target ribosomal L3 protein. Also disclosed are transgenic plants that co-produce L3 mutant and an RIP protein, and exhibit increased resistance to various fungal toxins and viruses, while reducing toxicity normally associated with production of the RIP. Uses of the L3 mutants in animals are further disclosed.

Abstract: Methods and devices for treatment of biomass comprised of crystalline structures are described that provide a combined mechanical, chemical and thermal effect (i.e., nano-hybrid pretreatment) to synergistically break down the crystalline structures. Such nano-hybrid mixing provides efficient, and cost-effective breakdown which enhances enzymatic accessibility to lignocellulosic materials. Methods and devices shown can be used to produce products such as pulp, chemicals, or biofuels.

Abstract: The present embodiments provide an apparatus, system, and method for ultrasound powered neurotelemetry. In one embodiment, the apparatus includes a piezoelectric element configured to receive an ultrasonic pulse and convert the electronic pulse into an electric potential. A diode may be coupled to the piezoelectric element, the diode configured to cause an electric current to flow in response to the electric potential. The apparatus may additionally include a reference electrode and a stimulating electrode coupled to the diode. The reference electrode may sense bioelectric activity in a region of body tissue located in proximity to the reference diode. The stimulating electrode may emit a carrier signal, wherein the carrier signal is modulated in response to the bioelectric activity sensed by the reference electrode.

Abstract: Amorphous semiconductor films with enhanced charged carrier transport are disclosed. Also disclosed is a method for fabricating and treating the film to produce the enhanced transport. Also disclosed are semiconductor p-n junctions fabricated with the films which demonstrate the enhanced transport. The films are amorphous and include boron, carbon, and hydrogen.

Abstract: A detection system and methods are described for determining whether a target contains a selected substance or device such as an explosive device, illegal drugs, dangerous chemicals, or the like. According to some embodiments, a detection system is comprising a radiation source and one or more detectors. The detection system in this directs radiation from a distance and towards a target suspected to contain a dangerous device or substance. A response is detected from the target. The response is compared to one or more templates that represent known explosives, drugs, dangerous chemicals, or the like. A score may be generated that corresponds to a similarity between the targeted and known substances. When the score indicates that the target substance is likely to be dangerous or contraband, then an alarm or other indication may be generated in some embodiments.

Abstract: An enzyme-linked immunosorbent assay (ELISA) is based on the non-structural protein 7 (nsp7) of porcine reproductive and respiratory syndrome virus (PRRSV) and provides for the simultaneous detection and differentiation of serum antibodies directed against Type 1 (European) and Type 2 (North American) PRRSV. The invention provides a serological assay for the detection and/or differentiation of serum antibodies directed against Type 1 and/or Type 2 PRRSV utilizing PRRSV nsp7 as an antigen, and provides a diagnostic method for the detection of PRRSV infection, epidemiological surveys, and outbreak investigations. The invention may be used either alone or as a follow-up assay to determine the true status of unexpected positive results that may occur using other assays, such as the IDEXX HERDCHEK PRRS ELISA.