Abstract: A method for making a hydrophilic polydimethylsiloxane elastomer, the method including: mixing a polydimethylsiloxane elastomer base with a polydimethylsiloxane elastomer curing agent to form a mixture; placing the mixture in a mold coated or permeated with a surfactant; and curing the mixture in the mold.
Abstract: The present invention provides novel methods and compositions for the diagnosis and treatment of colon cancers. In particular, the present invention provides diagnostics and prognostics for colon (including colon adenocarcinoma) cancer patients, wherein the methods related to measuring miR levels can predict poor survival. The invention also provides methods of identifying inhibitors of tumorigenesis.
Type:
Application
Filed:
November 14, 2011
Publication date:
March 15, 2012
Applicants:
DEPARTMENT OF HEALTH AND HUMAN SERVICES, THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION
Inventors:
Carlo M. Croce, Curtis C. Harris, Aaron J. Schetter
Abstract: Embodiments of content addressable memories for internet protocol devices and operations are described herein. Other examples and related methods are also disclosed herein.
Type:
Application
Filed:
May 26, 2010
Publication date:
March 15, 2012
Applicant:
Arizona Board of Regents for and on Behalf of Arizona State University
Inventors:
Satendra Kumar Maurya, Lawrence T. Clark
Abstract: Nitroxide free radicals attached to antineoplastic agents can synergize their potencies to cancer cells. This invention relates to any antineoplastic agents and their derivatives chemically attached with nitroxide free radicals, such as TEMPO and its radical derivatives. This invention also relates to precursors of such compounds, as well as the products formed from the adducts after administration.
Type:
Application
Filed:
March 21, 2011
Publication date:
March 15, 2012
Applicant:
The Trustees of California State University
Abstract: The present invention provides devices and methods for testing the electrical performance of thin-film transistor backplane arrays and protecting thin-films during testing and handling.
Type:
Application
Filed:
February 23, 2010
Publication date:
March 15, 2012
Applicant:
Arizona Board of Regents, a body Corporate acting for and on behalf of Arizona State University
Inventors:
Edward J. Bawolek, Curtis D. Moyer, Sameer M. Venugopal
Abstract: The present invention provides selenium derivatives of nucleosides, nucleoside phosphoramidites, nucleotides, nucleotide triphosphates, oligonucleotides, polynucleotides, and larger nucleic acids and methods for their synthesis. Selenium derivatives of both ribonucleic acids and deoxyribonucleic acids, as well as methods for their synthesis, crystallization and uses in structural determinations, particularly by X-ray crystallographic techniques are disclosed. The selenium derivatives of the present invention are also useful as food supplements.
Type:
Application
Filed:
June 29, 2011
Publication date:
March 15, 2012
Applicant:
GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.
Abstract: Glass-ceramic compositions exhibiting high reliability and tensile strength are described. The compositions can include crystal phases including roedderite and/or potassium fluorrichterite. The glass-ceramic compositions are bioactive, and can be used as components of a wide variety of biomedical devices such as dental restorations.
Type:
Grant
Filed:
May 13, 2009
Date of Patent:
March 13, 2012
Assignee:
The Ohio State University Research Foundation
Abstract: A mechanical property testing device and method for reliably measuring strain and fatigue characteristics of material specimens is described. An input electrical signal is applied to create an electric field around a first piezoelectric member. The resultant deformation of the first piezoelectric member transfers a force to the specimen being tested which transfers a force to a second piezoelectric member causing deformation. The deformation of the second piezoelectric member generates an output electrical field which is measured. The stress state of the specimen is calculated from fundamental material constants and the measured output electrical field.
Abstract: A dynamic device for reducing functional mitral regurgitation is described. The device is disposed externally to the heart and effectively acts as a splint for reducing further dilation of the heart in patients diagnosed with cardiomyopathy, and for reducing tethering of the papillary muscle on the mitral valve. The device does not require cardiopulmonary bypass for its installation since it is attached to the outside of the left ventricle, thereby reducing surgical risk, and is not exposed to the patient's blood once installed, thereby reducing the risk of thromboembolic disease.
Type:
Grant
Filed:
September 1, 2006
Date of Patent:
March 13, 2012
Assignee:
Colorado State University Research Foundation
Inventors:
Eric Monnet, E. Christopher Orton, Susan P. James, Kyle Garrett Ordway, John Ordway, legal representative
Abstract: A transgenic animal such as a transgenic snake or other reptile that expresses a heterologous expression product is described, along with methods of making the same. In general, the animal comprises cells containing a sequence encoding the heterologous expression product. The sequence encoding the heterologous expression product is integrated into the genome of the animal (e.g., in some or all cells thereof, and in some embodiments into germ cells thereof). The sequence encoding the heterologous expression product is, in general, operatively associated with an expression sequence or promoter. The animals are useful for, among other things, testing of repellents, testing of toxicological compounds, as teaching aids, for venom production, etc.
Abstract: The present invention provides novel methods and compositions for the diagnosis and treatment of colon cancers. In particular, the present invention provides diagnostics and prognostics for colon (including colon adenocarcinoma) cancer patients, wherein the methods related to measuring miR levels can predict poor survival. The invention also provides methods of identifying inhibitors of tumorigenesis.
Type:
Application
Filed:
November 14, 2011
Publication date:
March 8, 2012
Applicants:
DEPARTMENT OF HEALTH AND HUMAN SERVICES, THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION
Inventors:
Carlo M. Croce, Curtis C. Harris, Aaron J. Schetter
Abstract: A feedback control module for stabilizing a carrier-envelope phase of an output of a laser oscillator system comprises a first photodetector, a second photodetector, a phase stabilizer, an optical modulator, and a thermal control element. The first photodetector may generate a first feedback signal corresponding to a first portion of a laser beam from an oscillator. The second photodetector may generate a second feedback signal corresponding to a second portion of the laser beam filtered by a low-pass filter. The phase stabilizer may divide the frequency of the first feedback signal by a factor and generate an error signal corresponding to the difference between the frequency-divided first feedback signal and the second feedback signal. The optical modulator may modulate the laser beam within the oscillator corresponding to the error signal. The thermal control unit may change the temperature of the oscillator corresponding to a signal operable to control the optical modulator.
Type:
Application
Filed:
May 27, 2010
Publication date:
March 8, 2012
Applicant:
KANSAS STATE UNIVERSITY RESEARCH FOUNDATION
Inventors:
Zenghu Chang, Chenxia Yun, Shouyuan Chen, He Wang, Michael Chini
Abstract: Methods are provided for administering a phospholipid composition to a subject, comprising coating a medical device with at least one layer of a phospholipid composition, wherein the coating is achieved by electrospraying the device with the composition, and wherein the composition is carrying or can carry at least one therapeutic agent.
Type:
Application
Filed:
March 7, 2011
Publication date:
March 8, 2012
Applicant:
COLORADO STATE UNIVERSITY RESEARCH FOUNDATION
Inventors:
David A. Prawel, Susan P. James, Ketul C. Popat
Abstract: The invention provides compounds that are A-type procyanidins. The compounds can be prepared by reacting flavylium salts with catechins or analogs thereof, for example, under anhydrous conditions in alcohol.
Type:
Application
Filed:
November 9, 2011
Publication date:
March 8, 2012
Applicant:
Iowa State University Research Foundation, Inc.
Abstract: The present invention provides novel methods and compositions for the diagnosis and treatment of colon cancers. In particular, the present invention provides diagnostics and prognostics for colon (including colon adenocarcinoma) cancer patients, wherein the methods related to measuring miR levels can predict poor survival. The invention also provides methods of identifying inhibitors of tumorigenesis.
Type:
Application
Filed:
November 15, 2011
Publication date:
March 8, 2012
Applicants:
DEPARTMENT OF HEALTH AND HUMAN SERVICES, THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION
Inventors:
Carlo M. Croce, Curtis C. Harris, Aaron J. Schetter
Abstract: A precursor for the deposition of a thin film by atomic layer deposition is provided. The compound has the formula MxLy where M is a metal and L is an amidrazone-derived ligand or an amidate-derived ligand. A process of forming a thin film using the precursors is also provided.
Type:
Application
Filed:
May 17, 2010
Publication date:
March 8, 2012
Applicant:
WAYNE STATE UNIVERSITY
Inventors:
Charles H. Winter, Thomas Joseph Knisley, Panditha Koralalage Don Mahesh Chinthaka Karunarathne
Abstract: An optical scanning apparatus and method confocally image comparatively small features such as particles or bubbles in a relatively large volume. The main components of the apparatus include an illumination source and focusing optics, whose light is scattered to an optical sensor, typically an imager such as a camera, focal plane array, or the like. The illumination beam is focused such that its height is much less than its width, thus creating an almost planar or rectangular parallelepiped illuminated object space. The optical imager is positioned with its object-space focal plane parallel to the illumination beam such that the illumination beam passes through the in-focus object space of the imager. Images are collected while a fluid stream containing features of interest passes through imaging volume defined by the intersection of the in-focus object space and the illuminated object space.
Abstract: The present invention provides novel methods and compositions for the diagnosis and treatment of colon cancers. In particular, the present invention provides diagnostics and prognostics for colon (including colon adenocarcinoma) cancer patients, wherein the methods related to measuring miR levels can predict poor survival. The invention also provides methods of identifying inhibitors of tumorigenesis.
Type:
Application
Filed:
November 14, 2011
Publication date:
March 8, 2012
Applicants:
DEPARTMENT OF HEALTH AND HUMAN SERVICES, THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION
Inventors:
Carlo M. Croce, Curtis C. Harris, Aaron J. Schetter
Abstract: The present invention relates to immunoassays for serologically differentiating animals naturally infected with PRRS virus from animals vaccinated against PRRS. The immunoassays provide detection of at least a portion of the N terminal region of the 2b portion of PRRSV. The immunoassay is preferably an enzyme-linked immunosorbent assay (ELISA).
Type:
Application
Filed:
November 17, 2011
Publication date:
March 8, 2012
Applicant:
IOWA STATE UNIVERSITY RESEARCH FOUNDATION, INC.
Abstract: Disclosed are compositions and methods for reducing the proliferation of ALL cancer cells through targeted interactions with ALL1 fusion proteins.
Type:
Application
Filed:
October 17, 2011
Publication date:
March 8, 2012
Applicant:
THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION