Abstract: Bioadhesive films suitable for topical, local, and systemic drug delivery and methods for making the same. The films may incorporate one or more polymeric layers that enable delivery of a specific, desired dosage, to a specific, desired location over a specific, desired time period.

Abstract: Novel non-planar non-contiguous graphene structures and novel methods for forming the same. According to some embodiments the novel methods result in three-dimensional graphene structures. According to a further embodiment these three-dimensional graphene structures have a specific, controlled morphology. According to a still further method the novel method results in decoratable graphene sheets or three-dimensional graphene structures.

Abstract: An attenuated enterohemorrhagic E. coli-based vaccine vector is disclosed. Enterotoxigenic E. coli colonization factor antigen 1 and the B subunit of E. coli heat labile toxin have been expressed in the attenuated enterohemorrhagic E. coli vector strain. Immunized animals are further protected against lethal and non lethal challenges with the enterotoxigenic E. coli strain. Immunization of mice with the vaccine construct induces mucosal antibody against both antigens, establishing the attenuated E. coli vector strain as a generally useful vector for presenting one or more antigens to a subject in a vaccine.

Abstract: A method of treatment and/or prevention of cancer comprises administering agents which cause increased intracellular granularity in cancer cells, at least in an amount sufficient to inhibit proliferation of such cells and preferably in an amount sufficient to lead to cancer cell death. The method is particularly directed to refractory cancer, particularly hormone refractory prostate cancer. The agents identified cause increased intracellular granularity in the cancer cells, and also convert adherent cancer cells to non-adherent cancer cells, leading to cancer cell death. Using the present invention, cancer cells undergo increased intracellular granularity at relatively low agent concentrations, while also inhibiting cell proliferation. Increased concentrations lead to conversion of adherent cancer cells to non-adherent cancer cells, then to cell death.

Abstract: Apparatus, systems, and methods related to focal plane arrays can be used in a variety of applications. In various embodiments, focal plane arrays can be fabricated on a wafer integration level based on arrangement of a flexible conductive layer for photosensitive pixels of the focal plane arrays. Arrangement of a flexible conductive layer allows for a number of architectures of focal plane arrays. Additional apparatus, systems, and methods are disclosed.

Abstract: In one embodiment, the invention provides a method of inhibiting cAMP efflux and increasing intracellular cAMP in a subject who suffers from, or who is at risk of developing, a cancer by administering to the subject a therapeutically-effective amount of a cAMP efflux inhibitor. Novel compounds, pharmaceutical compositions, diagnostics and screening methods are also provided.

Abstract: The present invention provides novel methods and assays for high-throughput screening of combinatorial libraries to identify FPR1 and/or FPR2 ligands (e.g., agonists and/or antagonists), preferably FPR1 agonists and/or FPR2 antagonists, by positional scanning deconvolution. The invention also provides novel FPR1 and FPR2 ligands (e.g, agonists and antagonists), related pharmaceutical compositions and methods of treating FPR1 and FPR2-related disorders.

Abstract: Various embodiments provide methods of forming zero valent metal particles using an aerosol-reductive/expansion synthesis (A-RES) process. In one embodiment, an aerosol stream including metal precursor compound(s) and chemical agent(s) that produces reducing gases upon thermal decomposition can be introduced into a heated inert atmosphere of a RES reactor to form zero valent metal particles corresponding to metals used for the metal precursor compound(s).

Abstract: A photonically controlled microwave device having a photosensitive substrate having an interior region comprising a high radio frequency (“RF”) field for a resonant RF mode. An RF resonator is patterned on a surface of the substrate, the pattern includes an aperture in the resonator positioned to direct light received from a light source to the interior region. The light source may have a wavelength that enables illumination of the interior region to generate free carriers or other photo-induced changes in RF permittivity. An optical boundary may be provided that recirculates the unabsorbed optical power inside the high RF field region until it is fully absorbed.

Abstract: In various embodiments, systems and methods can be structured to provide efficient active bidirectional mode-locked lasers, which can be used as intracavity phase interferometer (IPI) sensors. Stable bidirectional mode-locking can be achieved by a combination of a passive mechanism, a passively driven active mechanism, and a beat note detection system. Such systems can be used in guidance, navigation, and control systems, where attitude control of a vehicle relies on accurate measurements of its position and motion. In various embodiments, a detection system can be based on an all fiber intracavity phase interferometer (IPI) active laser capable of delivering accurate simultaneous measurements of all three degrees of rotation and position in a single, compact, cost effective unit. A variation of the same system can include a linear cavity laser for accurate measurements of acceleration without the use of any inertial masses. Additional apparatus, systems, and methods are disclosed.

Abstract: An optical resonator made from an elongated fiber having a proximal and distal end. A sphere is created on the distal end by locating the distal end in cylindrically symmetrical heating zone along a centerline. For some embodiments, the distal end is rapidly cooled by allowing it to retract away from the heating zone along the centerline during the formation and solidification of the molten microsphere. The resulting optical resonator has an intrinsic quality factor greater than 106 over the 2.0 to 3.2 ?m MIR wavelength range.

Abstract: The present invention is directed to the use of silicic acid to transform biological materials, including cellular architecture into inorganic materials to provide biocomposites (nanomaterials) with stabilized structure and function. In the present invention, there has been discovered a means to stabilize the structure and function of biological materials, including cells, biomolecules, peptides, proteins (especially including enzymes), lipids, lipid vesicles, polysaccharides, cytoskeletal filaments, tissue and organs with silicic acid such that these materials may be used as biocomposites. In many instances, these materials retain their original biological activity and may be used in harsh conditions which would otherwise destroy the integrity of the biological material. In certain instances, these biomaterials may be storage stable for long periods of time and reconstituted after storage to return the biological material back to its original form.

Abstract: Various embodiments provide non-planar nanowires, nanowire arrays, and nanowire networks as well as methods of their formation and applications. The non-planar nanowires and their arrays can be formed in a controlled manner on surfaces having a non-planar orientation. In embodiments, two or more adjacent nanowires from different surfaces can grow to merge together forming one or more nanowire branches and thus forming a nanowire network. In embodiments, the non-planar nanowires and nanowire networks can be used for cantilever oscillation, switching and transistor actions.

Abstract: An affordable flow cytometry system with a significantly increased analytical rate, volumetric sample delivery and usable particle size including a light beam that interrogates multiple flow streams so as to provide excitation across all of the streams, and an optical objective configured to collect light from the sample streams and image the light onto an array detector.

Abstract: Apparatus, systems, and methods using multi-shelled nanostructures can be used in a variety of applications. In various embodiments, a multi-shelled nanostructure can include one or more light-absorbing and light-emitting cores enclosed by a number of nanoshells. For a multi-shelled nanostructure having multiple conductive nanoshells, the nanoshells are separated from each other by a dielectric. Additional apparatus, systems, and methods are disclosed.

Abstract: Lattice-mismatched semiconductor devices having a substrate, a first epitaxial film disposed thereon, a dielectric material, and a second epitaxial film. The first epitaxial film contains etch pits that extend from the outer surface of the first epitaxial film into the first epitaxial film. The dielectric material is disposed within the etch pits and blocks at least some of the threading dislocations in the first epitaxial film from propagating into the second epitaxial film. Semiconductor devices containing a silicon (Si) substrate or a silicon germanium (SiGe) substrate, a germanium (Ge) film disposed over the substrate, and a dielectric material. Methods for producing such semiconductor devices.

Abstract: The present invention, provides a flow cytometry apparatus for the detection of particles from a plurality of samples comprising: means for moving a plurality of samples comprising particles from a plurality of respective source wells into a fluid flow stream; means for introducing a separation gas between each of the plurality of samples in the fluid flow stream; and means for selectively analyzing each of the plurality of samples for the particles. The present invention also provides a flow cytometry method employing such an apparatus.

Abstract: A system and methods for transferring information between two or more incompatible security domains or levels of classification by embedding policy-centric content management components into an information-centric network. Specifically, overlay architectures enable cloud computing for multi-level security environments.

Abstract: An embodiment of the present disclosure is directed to a semiconductor device. The semiconductor devise comprises a substrate. An epitaxially grown semiconductor material is disposed over at least a portion of the substrate. A nanotemplate structure is disposed at least partially within the semiconductor material. The nanotemplate structure comprises a plurality of dielectric nanoscale features defining a plurality of nanoscale windows. An air gap is disposed between at least a portion of one or more of the nanoscale features and the semiconductor material.

Abstract: The present disclosure relates to molecules which function as selective modulators (i.e., inhibitors and agonists) of the Ras-homologous (Rho) family of small GTPases and, in particular, CDC42 GTPase, and their use to treat bacterial infection including systemic infection from sources such as Staphylococcus aureus.