Patents Assigned to Sterling Winthrop
  • Collar and cartridge-needle unit assembly
    Patent number: 5447500
    Abstract: This invention relates to a collar adapted for use in combination with activatable prefilled cartridge-need units and disposable holders. The collar is adapted to fit over the hub of the cartridge-needle unit and comprises a solid circumferential neck; a circumferential foot interrupted in at least one point having inside and outside arcuate surfaces, the outside surface having thereon a circumferentially outwardly extending ring and the inside surface having thereon at least one radially inwardly extending shelf; and at least one leg connecting the neck to the foot. The collar provides improved safety reliability and thus reduces the susceptibility of health care workers to accidents, e.g., accidental needle strikes. In addition, the collar can be easily and economically manufactured, e.g., by conventional precision injection molding techniques.
    Type: Grant
    Filed: September 29, 1993
    Date of Patent: September 5, 1995
    Assignee: Sterling Winthrop, Inc.
    Inventors: William A. Bergstresser, Mark A. Stiehl, John J. Niedospial
  • X-ray contrast compositions containing iodophenoxyalkanes and cellulose derivatives
    Patent number: 5443814
    Abstract: Disclosed are x-ray contrast compositions for oral or retrograde examination of the gastrointestinal tract comprising a nonionic x-ray producing agent in combination with a cellulose derivative in a pharmaceutically acceptable carrier; and methods for their use in diagnostic radiology of the gastrointestinal tract.
    Type: Grant
    Filed: March 4, 1994
    Date of Patent: August 22, 1995
    Assignee: Sterling Winthrop, Inc.
    Inventors: Carl R. Illig, John L. Toner, Robert W. Lee, Edward J. Baker
  • 6,11-cyclyl-1,2,3,4,5,6,11,11a-octahydrobenzo[b]quinolines and compositions and method of use thereof
    Patent number: 5434159
    Abstract: 6,11'-Cyclyl-1,2,3,4,5,6,11,11a-octahydrobenzo[b]quinolizine derivatives, pharmaceutical compositions containing them and methods for the treatment or prevention of neurodegenerative disorders or neurotoxic injuries utilizing them.
    Type: Grant
    Filed: October 7, 1994
    Date of Patent: July 18, 1995
    Assignee: Sterling Winthrop Inc.
    Inventors: Diane L. DeHaven-Hudkins, William G. Earley, John P. Mallamo, Garry M. Pilling
  • 6,11-substituted-6,11-dihydrobenzo[b]quinolizinium salts and compositions and method of use thereof
    Patent number: 5430036
    Abstract: 6,11-Substituted-6,11-dihydrobenzo[b]quinolizinium salts, pharmaceutical compositions containing them and methods for the treatment or prevention of neurodegenerative disorders or neurotoxic injuries utilizing them.
    Type: Grant
    Filed: October 25, 1994
    Date of Patent: July 4, 1995
    Assignee: Sterling Winthrop Inc.
    Inventors: Diane L. DeHaven-Hudkins, William G. Earley, John P. Mallamo, Matthew S. Miller
  • Compositions of iodoaniline derivatives and cellulose derivatives for visualization of the gastrointestinal tract
    Patent number: 5422114
    Abstract: Disclosed are x-ray contrast compositions for oral or retrograde examination of the gastrointestinal tract comprising an x-ray producing agent of the formula or a pharmaceutically acceptable salt thereof ##STR1## and methods for their use in diagnostic radiology of the gastrointestinal tract, whereinZ is H, halo, C.sub.1 -C.sub.20 alkyl, cycloalkyl, lower alkoxy, cyano, where the alkyl and cycloalkyl groups can be substituted with halogen or halo-lower-alkyl groups;R.sub.1 and R.sub.2 are independently H, C.sub.1 -C.sub.25 alkyl, cycloalkyl, acetyl or halo-lower-alkyl, wherein said C.sub.1 -C.sub.
    Type: Grant
    Filed: February 25, 1994
    Date of Patent: June 6, 1995
    Assignee: Sterling Winthrop Inc.
    Inventors: Carl R. Illig, Thomas J. Caulfield, Robert W. Lee, Edward J. Baker
  • Interleukin 1.beta. protease and interleukin 1.beta. protease inhibitors
    Patent number: 5416013
    Abstract: There is disclosed an isolated polypeptide and derivatives thereof having protease biological activity for human precursor IL-1.beta. and for a substrate comprising:R.sub.1 - Asp - R .sub.2 - R.sub.3wherein R.sub.1 and R.sub.3 are independently any D or L isomer amino acid, R.sub.2 is Ala or Gly, and wherein the specific protease cleavage site is between Asp and R.sub.2. Inhibitor compounds, compositions and methods for inhibiting Interleukin 1.beta. protease activity are also disclosed. The inhibitor compounds comprise an amino acid sequence of from 1 to about 5 amino acids having an N-terminal blocking group and a C-terminal Asp residue connected to an electronegative leaving group, wherein the amino acid sequence corresponds to the sequence Ala-Tyr-Val-His-Asp.
    Type: Grant
    Filed: February 28, 1994
    Date of Patent: May 16, 1995
    Assignee: Sterling Winthrop Inc.
    Inventors: Roy A. Black, Paul R. Sleath, Shirley R. Kronheim
  • Vinyl sulfone coupling of polyoxyalkylenes to proteins
    Patent number: 5414135
    Abstract: A new class of polyalkylene oxide vinyl sulfone reagents is described. Also described are a method by which these reagents can be prepared as well as a method for using them in hydrated media for the modification of proteins. The novel polymer-to-protein conjugates made by reacting these reagents with proteins have advantages over similar conjugates prepared with prior art reagents in that they are more stable against hydrolysis and retain the positive charge carrying capacity at amine sites at which the modifying reagents are attached.
    Type: Grant
    Filed: November 16, 1993
    Date of Patent: May 9, 1995
    Assignee: Sterling Winthrop Inc.
    Inventors: Robert A. Snow, David L. Ladd
  • Pre-filled syringe having a plunger, plunger insert and plunger rod
    Patent number: 5413563
    Abstract: Disclosed are pre-filled syringes equipped with an improved plunger having a plunge insert and a plunger rod, characterized by a leak-proof seal and easy sliding property.
    Type: Grant
    Filed: May 6, 1994
    Date of Patent: May 9, 1995
    Assignee: Sterling Winthrop Inc.
    Inventors: Peter A. Basile, Scott C. Brown, Fred E. Snyder, Joseph V. Tirrell
  • Pre-filled syringe and pre-filled cartridge having actuating cylinder/plunger rod combination for reducing syringing force
    Patent number: 5411489
    Abstract: Disclosed are pre-filled syringes equipped with an improved plunger, a plunger actuating cylinder and a plunger rod, characterized by a leak-proof seal and easy sliding property.
    Type: Grant
    Filed: May 6, 1994
    Date of Patent: May 2, 1995
    Assignee: Sterling Winthrop Inc.
    Inventors: Shrikant N. Pagay, Robert J. Bachorik, II, Richard T. Liebert
  • Pre-filled syringe and pre-filled cartridge having an improved plunger and plunger rod for reducing syringing force
    Patent number: 5411488
    Abstract: Disclosed are pre-filled syringes equipped with an improved plunger and a plunger rod, characterized by a leak-proof seal and easy sliding property.
    Type: Grant
    Filed: May 6, 1994
    Date of Patent: May 2, 1995
    Assignee: Sterling Winthrop Inc.
    Inventors: Shrikant N. Pagay, Robert J. Bachorik, II, Richard T. Liebert
  • X-ray contrast compositions containing film-forming materials
    Patent number: 5405600
    Abstract: Disclosed are x-ray contrast compositions for oral or retrograde examination of the gastrointestinal tract comprising a polymeric material capable of forming a coating on the gastrointestinal tract and a nonionic x-ray producing agent in a pharmaceutically acceptable carrier; and methods for their use in diagnostic radiology of the gastrointestinal tract.
    Type: Grant
    Filed: August 11, 1993
    Date of Patent: April 11, 1995
    Assignee: Sterling Winthrop Inc.
    Inventors: Carl R. Illig, John L. Toner
  • Water insoluble non-magnetic manganese particles as magnetic resonance contract enhancement agents
    Patent number: 5401492
    Abstract: This invention is directed to a magnetic resonance imaging composition for imaging of an organ rich in mitochondria comprising particles of a substantially insoluble manganese compound. In a preferred embodiment, the organ rich in mitochondria is the liver. In a further preferred embodiment, the particles are substantially nonmagnetic. In another preferred embodiment, the particles have a particle size of less than about 10 microns.In a still further preferred embodiment, the insoluble manganese compound is a manganese salt. The manganese compound is preferably selected from the group consisting of manganese phosphate, manganese carbonate and manganese 8-hydroxy quinolate.In another preferred embodiment, the composition of the present invention further comprises a surfactant.
    Type: Grant
    Filed: December 17, 1992
    Date of Patent: March 28, 1995
    Assignee: Sterling Winthrop, Inc.
    Inventors: Kenneth E. Kellar, Piotr H. Karpinski, Elaine Liversidge, Wolfgang H. H. Gunther, Gregory L. McIntire, Barbara Van Orman
  • Lyophilized polyethylene oxide modified protein and polypeptide complexes with cyclodextrin
    Patent number: 5389381
    Abstract: Disclosed are lyophilized biologically active proteinaceous compositions containing low diol polyalkylene oxide, such as polyethylene glycol, covalently attached to a biologically active proteinaceous substance and combined with the cryoprotectant cyclodextrin.
    Type: Grant
    Filed: January 5, 1994
    Date of Patent: February 14, 1995
    Assignee: Sterling Winthrop Inc.
    Inventors: Christopher P. Phillips, Robert A. Snow
  • Safety cannula
    Patent number: 5389086
    Abstract: A coupling system for transferring fluids from a medicament-containing cartridge to an injection site comprises a fluid flow channel, a blunt cannula defining the distal end of the fluid flow channel, a needle cannula defining the proximal end of the fluid flow channel, and means for fixedly connecting the needle cannula to the blunt cannula.
    Type: Grant
    Filed: July 6, 1992
    Date of Patent: February 14, 1995
    Assignee: Sterling Winthrop Inc.
    Inventors: Kurt Attermeier, Thomas E. Dudar, Mark A. Stiehl, Joseph M. Tartaglia
  • 2-saccharinylmethyl aryl and aryloxy acetates useful as proteolytic enzyme inhibitors
    Patent number: 5385923
    Abstract: 4-R.sup.4 --R.sup.5 -2-Saccharinylmethyl aryl and aryloxy acetates, useful in the treatment of degenerative diseases, are prepared by reacting a 4-R.sup.4 --R.sup.5 -2-halomethylsaccharin with an aryl or aryloxyacetic acid in the presence of an acid-acceptor.
    Type: Grant
    Filed: August 20, 1993
    Date of Patent: January 31, 1995
    Assignee: Sterling Winthrop Inc.
    Inventors: Lee H. Latimer, Richard P. Dunlap
  • Compositions of iodobenzoic acid derivatives and cellulose derivatives for visualization of the gastrointestinal tract
    Patent number: 5385720
    Abstract: Disclosed are x-ray contrast compositions for oral or retrograde examination of the gastrointestinal tract comprising an x-ray producing agent of the formula or a pharmaceutically acceptable salt thereof ##STR1## wherein Z is H, halo, C.sub.1 -C.sub.20 alkyl, cycloalkyl, lower alkoxy, cyano, where the alkyl and cycloalkyl groups can be substituted with halogen or halo-lower-alkyl groups;R is C.sub.1 -C.sub.25 alkyl, cycloalkyl, or halo-lower-alkyl, each of which may be optionally substituted with halo, fluoro-lower-alkyl, aryl, lower-alkoxy, hydroxy, carboxy, lower-alkoxy carbonyl or lower-alkoxy-carbonyloxy;(CR.sub.1 R.sub.2).sub.p -- (CR.sub.3 =CR.sub.4).sub.m Q, or (CR.sub.1 R.sub.2).sub.p -- C.dbd.C--Q;R.sub.1, R.sub.2, R.sub.3 and R.sub.
    Type: Grant
    Filed: March 23, 1994
    Date of Patent: January 31, 1995
    Assignee: Sterling Winthrop Inc.
    Inventors: Edward J. Baker, Robert W. Lee, Carl R. Illig, Brent D. Douty, John L. Toner
  • Compositions of iodophenyl esters and iodophenyl sulfonates and cellulose derivatives for visualization of the gastrointestinal tract
    Patent number: 5385722
    Abstract: Disclosed are contrast agents of the formula ##STR1## wherein ##STR2## Z is H, halo, C.sub.5 -C.sub.20 alkyl, cycloalkyl, lower alkoxy, cyano, where the alkyl and cycloalkyl groups can be substituted with halogen or halo-lower-alkyl groups;R is C.sub.1 -C.sub.25 alkyl, cycloalkyl, aryl or halo-lower-alkyl, each of which may be optionally substituted with lower-alkoxy, hydroxy, carboxy or lower-alkoxy carbonyl, lower-alkenyl, lower-alkynyl, lower-alkylene or lower-alkoxy-carbonyloxy;n is 1-5;y is 0-4; andw is 1-4;in a pharmaceutically acceptable carrier comprising a cellulose derivative.
    Type: Grant
    Filed: April 18, 1994
    Date of Patent: January 31, 1995
    Assignee: Sterling Winthrop Inc.
    Inventors: Edward J. Baker, Robert W. Lee, Edward R. Bacon, Sol J. Daum, Kimberly G. Estep, Kurt A. Josef, Brent D. Douty, Carl R. Illig, John L. Toner
  • Compositions of alkylbenzenes and cellulose derivatives for visualization of the gastrointestinal tract
    Patent number: 5385721
    Abstract: Disclosed are x-ray contrast compositions for oral or retrograde examination of the gastrointestinal tract comprising an x-ray producing agent of the formula or a pharmaceutically acceptable salt thereof ##STR1## wherein R is methyl, ethyl, n-propyl, C.sub.4 -C.sub.25 alkyl, cycloalkyl, unsaturated allyl or halo-lower-alkyl, each of which may be optionally substituted with halo, fluoro-lower-alkyl, aryl, lower-alkoxy, hydroxy, carboxy or lower-alkoxy carbonyl; (CR.sub.1 R.sub.2).sub.p --(CR.sub.3 .dbd.CR.sub.4).sub.m Q, or (CR.sub.1 R.sub.2).sub.p --C.tbd.C--Q;R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are independently H, lower-alkyl, optionally substituted with halo;n is 2-5;m is 2-5;p is 1-10; andQ is H, lower-alkyl, lower-alkenyl, lower-alkynyl, lower-alkylene, aryl, or aryl-lower alkyl;in a pharmaceutically acceptable carrier comprising a cellulose derivative.
    Type: Grant
    Filed: March 22, 1994
    Date of Patent: January 31, 1995
    Assignee: Sterling Winthrop Inc.
    Inventors: Edward J. Baker, Kurt A. Josef, Edward R. Bacon, Kimberly G. Estep, Carl R. Illig, Brent D. Douty, John L. Toner, Robert W. Lee
  • Iodinated aromatic compounds
    Patent number: 5384107
    Abstract: Compounds having the structure ##STR1## wherein (Z--COO is the residue of an iodinated aromatic acid; n is an integer from 0 to 6;R.sup.1 and R.sup.2 are independently H, alkyl, fluoroalkyl, cycloalkyl, aryl, aralkyl, alkoxy or aryloxy;R.sup.3 and R.sup.4 are independently H, alkyl, fluoroalkyl, cycloalkyl, aryl, aralkyl, alkoxy, aryloxy, halogen, hydroxy or acylamino;Q represents the atoms necessary to complete a carbocyclic or heterocyclic unsaturated mono- or bicyclic aromatic ring; andR.sup.5 is H, alkyl, cycloalkyl, aryl, aralkyl, alkoxy, aryloxy, halogen, hydroxy, amino, acylamino, alkoxyalkyl, fluoroalkyl, acetamidoalkyl, COO-alkyl, cyano, carboxamido, sulfonate, sulfonamido, ureido, or carbamyl are useful as contrast agents in x-ray imaging compositions and methods.
    Type: Grant
    Filed: August 3, 1994
    Date of Patent: January 24, 1995
    Assignee: Sterling Winthrop Inc.
    Inventors: Baldev Singh, Edward R. Bacon, Carl R. Illig
  • Hand-held power syringe
    Patent number: D360462
    Type: Grant
    Filed: September 22, 1993
    Date of Patent: July 18, 1995
    Assignee: Sterling Winthrop Inc.
    Inventors: Randy Armbruster, Bruce J. Semmler