Patents Assigned to Stichting Dienst Landbouwkundig Onderzoek
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Patent number: 9745594Abstract: The present invention relates to non-mammalian ?-1,4-galactosyltransferases that can be used in their wild-type or in modified forms. The invention further relates to transformed plants and plant cells expressing non-mammalian ?-1,4-galactosyltransferases and methods to produce glycoproteins with altered and preferably mammalian-type glycosylation. The invention additionally provides nucleic acid molecules and expression vectors of non-mammalian ?-1,4-galactosyltransferases.Type: GrantFiled: July 25, 2014Date of Patent: August 29, 2017Assignee: Stichting Dienst Landbouwkundig OnderzoekInventors: Gerard Johan Adolph Rouwendal, Dionisius Elisabeth Antonius Florack, Hendrik Jan Bosch
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Patent number: 9657278Abstract: The invention relates to methods of producing infectious bunyavirus replicon particles. These bunyavirus replicon particles are safe and can be used outside a biosafety containment. The invention further relates to recombinant bunyavirus replicon particles and uses of these recombinant bunyavirus replicon particles.Type: GrantFiled: July 10, 2015Date of Patent: May 23, 2017Assignee: Stichting Dienst Landbouwkundig OnderzoekInventors: Jeroen Alexander Kortekaas, Robertus Jacobus Maria Moormann
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Publication number: 20170135259Abstract: A new and distinct cultivar of Apple tree named ‘WUR200’, characterized by its upright plant habit; moderately vigorous growth habit; numerous fruit produced per plant; fruits with red-colored skin spotted with lenticels; resistance to Apple Scab; and suitability for organic farming practices.Type: ApplicationFiled: November 11, 2015Publication date: May 11, 2017Applicant: STICHTING DIENST LANDBOUWKUNDIG ONDERZOEK - PPO/PRIInventor: Rene Smulders
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Patent number: 9636653Abstract: A stamp for making a microarray of biomolecules, wherein the stamp has a stamp body having a stamping surface for stamping the biomolecules onto a substrate, a plurality of reservoirs for liquids having the biomolecules, wherein each of the reservoirs has a bottom wall and a plurality of channels extending between each of the bottom wall and the stamping surface, wherein each of the reservoirs and the channels has a macroporous hydrogel and wherein the stamping surface is provided with a hydrophobic coating.Type: GrantFiled: September 24, 2013Date of Patent: May 2, 2017Assignees: TECHNISCHE UNIVERSITEIT TWENTE, STICHTING DIENST LANDBOUWKUNDIG ONDERZOEKInventors: Erhan Bat, Pascal Jonkheijm, Aart Van Amerongen, Jurriaan Hüskens
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Patent number: 9464024Abstract: Disclosed is a method of making methacrylic acid, or a carboxylic derivative thereof, from itaconic acid, isomers, or precursors thereof. A starting material comprising an acid selected from the group consisting of itaconic acid, citraconic acid, mesaconic acid, citric acid, aconitic acid, isocitric acid and mixtures thereof, is subjected to contact with 0.1 eq. to 3.0 eq. of a base, at a temperature of 150° C. to 350° C., under the influence of a transition metal-containing heterogeneous catalyst. A better yield at lower temperatures is achieved.Type: GrantFiled: August 26, 2014Date of Patent: October 11, 2016Assignee: Stichting Dienst Landbouwkundig OnderzoekInventors: Jerome Emile Lucien Le Notre, Elinor Lindsey Scott, Roeland Leo Croes, Jacobus Van Haveren
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Publication number: 20160271241Abstract: The invention relates to a bunyavirus, in which separated (NSm)Gn and Gc coding regions are functionally present on two different genome segments, preferably a bunyavirus that comprises a total of at least 4 genome segments. The invention further relates to methods for producing said bunyavirus, and to a composition comprising said bunyavirus and a suitable excipient.Type: ApplicationFiled: May 21, 2014Publication date: September 22, 2016Applicant: Stichting Dienst Landbouwkundig OnderzoekInventors: Jeroen Alexander Kortekaas, Paulus-Jozef Wichgers Schreur, Nadia Dimitrova Oreshkova, Robertus Jacobus Maria Moormann
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Patent number: 9399781Abstract: The expression vector includes: the nucleic acids coding for the polypeptides forming a polypeptide complex having an enzyme activity allowing acetoacetyl-CoA to be converted to acetoacetate; optionally, at least one nucleic acid coding for a polypeptide having an enzyme activity allowing acetoacetate to be converted to acetone; and at least one nucleic acid coding for a polypeptide having an enzyme activity allowing acetone to be converted to isopropanol; the expression of the nucleic acids being controlled by a single constitutive promoter located upstream of the abovementioned nucleic acids.Type: GrantFiled: October 3, 2012Date of Patent: July 26, 2016Assignees: IFP ENERGIES NOUVELLES, STICHTING DIENST LANDBOUWKUNDIG ONDERZOEKInventors: Florent Collas, Remy Marchal, Benjamin Clement, Ana Maria Lopez Contreras, Pieternel A.M Claassen
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Patent number: 9376414Abstract: Disclosed is a method of making 5-formyl-2-furoic acid and furan-2,5-dicarboxylic acid. The method involves the use of 5-keto-aldonic acids as intermediates, as these can be subjected to ring formation by a cyclodehydration reaction under mild conditions. The 5-formyl-2-furoic acid or carboxylic derivative thereof is subjected to oxidation so as to form furan-2,5-dicarboxylic acid. The 5-keto-aldonic acid intermediates can be obtained by isomerization of uronic acids which can be obtained from sugar beet pulp, chicory pulp, fruit peals including orange peels, or non-terrestrial sources like seaweeds. A preferred source is sugar beet pulp.Type: GrantFiled: May 8, 2014Date of Patent: June 28, 2016Assignee: Stichting Dienst Landbouwkundig OnderzoekInventors: Jacobus van Haveren, Daniël Stephan van Es, Frits van der Klis, Henricus Wilhelmus Carolina Raaijmakers
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Patent number: 9340841Abstract: The invention relates to control of pathogen caused diseases on leaves, fruits and ears in plants, such as apple scab (Venturia inaequalis by treatment of plant with an isolate of Cladosporium cladosporioides. The treatment is effective in both prevention and treatment of the fungal infection.Type: GrantFiled: February 21, 2013Date of Patent: May 17, 2016Assignee: STICHTING DIENST LANDBOUWKUNDIG ONDERZOEKInventor: Jurgen Anton Kohl
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Publication number: 20160107967Abstract: A catalytic method is disclosed for the valorization of lignin. The method comprises subjecting lignin to a catalyzed hydrothermal conversion reaction, said reaction being conducted in the presence of water at an alkaline pH>8 and a temperature of 200° C.-300° C., under the influence of a noble metal catalyst comprising a carbon support. The same reaction can also be applied to subsequently defunctionalize one or more phenolic compounds, notably guaiacol, so as to produce six-membered cyclic hydrocarbons, such as phenol.Type: ApplicationFiled: April 7, 2014Publication date: April 21, 2016Applicant: Stichting Dienst Landbouwkundig OnderzoekInventors: Daniël Stephan VAN ES, Frits VAN DER KLIS, Jacobus VAN HAVEREN, Richard Johannes Antonius GOSSELINK
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Patent number: 9255277Abstract: The invention relates to the field of glycoprotein processing in transgenic plants used as cost efficient and contamination safe factories for the production of recombinant biopharmaceutical proteins or pharmaceutical compositions comprising these glycoproteins. The invention provides a plant comprising a functional mammalian enzyme providing mammalian GnTIII that is normally not present in plants, said plant additionally comprising at least a second mammalian protein or functional fragment thereof that is normally not present in plants.Type: GrantFiled: June 19, 2013Date of Patent: February 9, 2016Assignee: Stichting Dienst Landbouwkundig OnderzoekInventors: Hendrikus Antonius Cornelis Bakker, Dionisius Elisabeth Antonius Florack, Hendrik Jan Bosch
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Patent number: 9212369Abstract: A method for providing a transgenic plant, including transforming a plant cell or plant material with a nucleotide sequence coding for a BBM protein, wherein activity of the BBM protein is induced during transformation and/or regeneration of the transformed plant cell or plant material, and wherein the plant cell or plant material originates from a recalcitrant plant is provided. In addition, a transgenic plant or material thereof having a BBM protein, wherein the transgenic plant is a recalcitrant plant is also provided.Type: GrantFiled: July 5, 2010Date of Patent: December 15, 2015Assignees: Enza Zaden Beheer B.V., Stichting Dienst Landbouwkundig OnderzoekInventors: Iris Heidmann, Kimberly Anne Boutilier, Brenda Johanna Maria De Lange
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Publication number: 20150296779Abstract: Cyclopentyl 2,7,7-trimethyl-5-oxo-4-(4-pyridinyl)-1,4,5,6,7,8-hexahydro-3-quinolinecarboxylate and similar compounds are potentiators of auxin-induced somatic embryogenesis in plants. In particular, the inventors have discovered certain of these compounds induce somatic embryogenesis in Arabidopsis in the presence of 2,4-D. Also tested is BAY K 8644. Methods of inducing somatic embryogenesis comprise exposing selected plant tissues, e.g. seed embryos, to auxins, e.g. 2.4-D and the compounds.Type: ApplicationFiled: November 28, 2012Publication date: October 22, 2015Applicant: STICHTING DIENST LANDBOUWKUNDIG ONDERZOEKInventors: Martijn FIERS, Kimberly BOUTILIER
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Patent number: 9109199Abstract: The invention relates to methods of producing infectious bunyavirus replicon particles. These bunyavirus replicon particles are safe and can be used outside a biosafety containment. The invention further relates to recombinant bunyavirus replicon particles and uses of these recombinant bunyavirus replicon particles.Type: GrantFiled: September 20, 2011Date of Patent: August 18, 2015Assignee: STICHTING DIENST LANDBOUWKUNDIG ONDERZOEKInventors: Jeroen Alexander Kortekaas, Robertus Jacobus Maria Moormann
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Patent number: 9079844Abstract: Disclosed is the oxidation of uronic acids, such as galacturonic acid, to the corresponding aldaric acids (characterized by the formula HOOC—(CHOH)n-COOH, with n being an integer of from 1 to 5) such as galactaric acids. The starting material comprising the uronic acid is subjected to oxygen under the influence of a supported gold catalyst and in the presence of a base. The oxidation occurs in good selectivity and yield, under unexpectedly mild conditions. A source of galacturonic acids is pectin, such as that derived from sugar beet pulp.Type: GrantFiled: March 28, 2013Date of Patent: July 14, 2015Assignee: STICHTING DIENST LANDBOUWKUNDIG ONDERZOEKInventors: Daniël Stephan Van Es, Jacobus van Haveren, Henricus Wilhelmus Carolina Raaijmakers, Frits van der Klis, Gerardus Petrus Franciscus Maria van Engelen, Augustinus Emmanuël Frissen
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Publication number: 20150192575Abstract: The invention relates to an elongate membrane assembly having a length, a width and a height, the assembly comprising a microporous membrane layer supported on a liquid-impermeable support layer and the assembly being suitable for lateral flow of a liquid through the membrane layer under the action of capillary forces, wherein the assembly has a constant height and at least part of the membrane layer has a first thickness in the range of from 20 to 80 ?m over the entire width of the assembly. The invention further relates to a lateral flow immunoassay device comprising such membrane assembly.Type: ApplicationFiled: July 23, 2013Publication date: July 9, 2015Applicant: Stichting Dienst Landbouwkundig OnderzoekInventors: Aart Van Amerongen, Jan Herman Wichers
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Publication number: 20150183954Abstract: Plasticized, unpigmented and pigmented PVC films are described which utilize a biobased, phthalate ester alternative primary plasticizer. The films show comparable color performance to the phthalate ester-plasticized unpigmented or pigmented PVC films, even where the neat biobased plasticizer has a much higher Pt—Co color as measured according to DIN-6271 (ASTM D 1209) compared to the neat phthalate ester plasticizer. Biobased primary plasticizers in the form of diesters of furan-2,5-dicarboxylic acid are especially contemplated, and provide increased thermal stability to the PVC films as an added benefit.Type: ApplicationFiled: June 4, 2013Publication date: July 2, 2015Applicants: STICHTING DIENST LANDBOUWKUNDIG ONDERZOEK, ARCHER DANIELS MIDLAND COMPANYInventors: Daniel Stephen VanEs, Jacobus VanHaveren, Augustinus Emmanuel Frissen, Johannes Cornelis VandeKolk
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Publication number: 20150176020Abstract: The present invention relates to non-mammalian ?-1,4-galactosyltransferases that can be used in their wild-type or in modified forms. The invention further relates to transformed plants and plant cells expressing non-mammalian ?-1,4-galactosyltransferases and methods to produce glycoproteins with altered and preferably mammalian-type glycosylation. The invention additionally provides nucleic acid molecules and expression vectors of non-mammalian ?-1,4-galactosyltransferases.Type: ApplicationFiled: July 25, 2014Publication date: June 25, 2015Applicant: Stichting Dienst Landbouwkundig OnderzoekInventors: Gerard Johan Adolph Rouwendal, Dionisius Elisabeth Antonius Florack, Hendrik Jan Bosch
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Patent number: PP27953Abstract: A new and distinct cultivar of Apple tree named ‘WUR200’, characterized by its upright plant habit; moderately vigorous growth habit; numerous fruit produced per plant; fruits with red-colored skin spotted with lenticels; resistance to Apple Scab; and suitability for organic farming practices.Type: GrantFiled: November 11, 2015Date of Patent: May 2, 2017Assignee: Stichting Dienst Landbouwkundig Onderzoek-PPO/PRIInventor: Rene Smulders
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Patent number: PP28397Abstract: A new and distinct cultivar of Apple tree named ‘WUR37’, characterized by its upright plant habit; vigorous growth habit; numerous fruit produced per plant; fruits with red-colored skin spotted with lenticels; resistance to Apple Scab; and suitability for organic farming practices.Type: GrantFiled: February 9, 2016Date of Patent: September 19, 2017Assignee: Stichting Dienst Landbouwkundig Onderzoek-PPO/PRIInventor: Rene Smulders