Patents Assigned to Stichting Dienst Landbouwkundig Onderzoek
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Patent number: 8321147Abstract: This invention provides a novel means of predicting plant phenotypes that incorporates previously unusable dense marker data derived from historical pedigrees. The method operates by collecting information from a population pertaining to one or more loci, which is used to build one or more matrices by calculating, for the alleles present at the measured loci, the probability that the alleles are identical by descent. These matrices are then used to develop a second set of one or more matrices in which each value represents the probability that a certain individual in the population descended from a certain ancestral (founder) genotype. This set of second matrices can then be used as part of a breeding program for selecting and breeding individuals from the population or can be used to better classify the individuals in the population, leading to improved plant phenotypes.Type: GrantFiled: October 2, 2009Date of Patent: November 27, 2012Assignees: Pioneer Hi-Bred International, Inc, Wageningen University, Stichting Dienst Landbouwkundig OnderzoekInventors: Marinus C. A. M. Bink, Carl J. F. ter Braak, Oscar S. Smith, L. Radu Totir
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Publication number: 20120276139Abstract: The invention relates to methods of stimulating an immune response against an antigenic protein in a mammalian subject. More specifically, the invention relates to routes of administration of a hybrid Newcastle Disease Virus-vector (NDV-vector) for eliciting an immune response against an antigenic protein that is encoded by the hybrid NDV-vector.Type: ApplicationFiled: November 16, 2010Publication date: November 1, 2012Applicant: Stichting Dienst Landbouwkundig OnderzoekInventors: Robertus Jacobus Maria Moormann, Jeroen Alexander Kortekaas, Adrianus Franciscus Gerardus Antonis, Bernardus Petrus Hubertus Peeters, Aldo Dekker
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Publication number: 20120278949Abstract: The present invention relates to the field of transgenic plants with novel phenotypes, especially plants with enhanced drought tolerance. Provided are SHINE proteins and nucleic acid sequences encoding these, which are useful in conferring novel phenotypes to plants.Type: ApplicationFiled: July 6, 2012Publication date: November 1, 2012Applicant: Stichting Dienst Landbouwkundig OnderzoekInventors: Asaph AHARONI, Chital Dixit, Andy Pereira
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Publication number: 20120237972Abstract: The invention relates to the field of glycoprotein processing in transgenic plants used as cost efficient and contamination safe factories for the production of recombinant biopharmaceutical proteins or pharmaceutical compositions comprising these. The invention provides a plant comprising a functional mammalian enzyme providing N-glycan biosynthesis that is normally not present in plants, said plant additionally comprising at least a second mammalian protein or functional fragment thereof that is normally not present in plants.Type: ApplicationFiled: April 27, 2012Publication date: September 20, 2012Applicant: Stichting Dienst Landbouwkundig OnderzoekInventors: Hendrikus Antonius Cornelis Bakker, Hendrik Jan Bosch
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Patent number: 8252978Abstract: The present invention relates to the field of transgenic plants with given phenotypes, especially plants with enhanced drought tolerance. Provided are SHINE proteins and nucleic acid sequences encoding these, which are useful in conferring these phenotypes to plants.Type: GrantFiled: June 9, 2005Date of Patent: August 28, 2012Assignee: Stichting Dienst Landbouwkundig OnderzoekInventors: Asaph Aharoni, Chital Dixit, Andy Pereira
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Publication number: 20120192308Abstract: A method for providing a transgenic plant, including transforming a plant cell or plant material with a nucleotide sequence coding for a BBM protein, wherein activity of the BBM protein is induced during transformation and/or regeneration of the transformed plant cell or plant material, and wherein the plant cell or plant material originates from a recalcitrant plant is provided. In addition, a transgenic plant or material thereof having a BBM protein, wherein the transgenic plant is a recalcitrant plant is also provided.Type: ApplicationFiled: July 5, 2010Publication date: July 26, 2012Applicants: STICHTING DIENST LANDBOUWKUNDIG ONDERZOEK, ENZA ZADEN BEHEER B.V.Inventors: Iris Heidmann, Kimberly Anne Boutilier, Brenda Johanna Maria De Lange
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Publication number: 20120178961Abstract: Disclosed is a method for the combined synthesis of at least two vinylic monomers, at least one of which being an acrylic compound, comprising subjecting a monoconjugated alkene-1-carboxylic compound to reaction with a C2-C4 alkene under conditions of olefin cross-metathesis. The invention is particularly useful for extracting value from protein side streams. Upon protein hydrolysis, suitable amino acids (preferably phenylalanine or tyrosine) are subjected to reductive amination so as to form the corresponding alkene-1-carboxylic acid. Preferably after esterification and separation, this is used in cross-metathesis for the concomitant production of styrene resp. hydroxy styrene, and acrylates. The invention is applicable more widely, to the synthesis of olefins on the basis of carbohydrates, naturally occurring phenolic components, natural protein resources, or amino acids obtained from fermentations.Type: ApplicationFiled: May 14, 2010Publication date: July 12, 2012Applicants: WAGENINGEN UNIVERSITEIT, STICHTING DIENST LANDBOUWKUNDIG ONDERZOEKInventors: Johan Pieter Marinus Sanders, Jacobus Van Haveren, Elinor Scott, Daniël Stephan Van Es, Jérôme Le Nôtre, Jurjen Spekreijse
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Publication number: 20120036596Abstract: The present invention relates to non-mammalian ?-1,4-galactosyltransferases that can be used in their wild-type or in modified forms. The invention further relates to transformed plants and plant cells expressing non-mammalian ?-1,4-galacto-syltransferase and methods to produce glycoproteins with altered and preferably mammalian-type glycosylation. The invention additionally provides nucleic acid molecules and expression vectors of non-mammalian ?-1,4-galactosyltransferases.Type: ApplicationFiled: April 17, 2008Publication date: February 9, 2012Applicant: Stichting Dienst Landbouwkundig OnderzoekInventors: Gerard Johan Adolph Rouwendal, Dionisius Elisabeth Antonius Florack, Hendrik Jan Bosch
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Publication number: 20120021930Abstract: The present invention relates to a novel multiplex detection of nucleic acid targets in a sample. This is accomplished by using novel padlock probes which contain a unique cleavage site for linearization and a first member of a binding pair for isolation of the padlock probe from the sample. Three different designs of the padlock probes are described and examples are shown for ligation, amplification and qualitative and quantitative detection.Type: ApplicationFiled: November 22, 2005Publication date: January 26, 2012Applicant: Stichting Dienst Landbouwkundig OnderzoekInventors: Cornelis Dirk Schoen, Marianna Szemes, Petrus Johannes Maria Bonants
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Publication number: 20120011600Abstract: The invention is directed to methods for optimizing glycan processing in organisms (and in particular, plants) so that a glycoprotein having complex type bi-antennary glycans and thus containing galactose residues on both arms and which are devoid of (or reduce in) xylose and fucose can be obtained. The invention is further directed to said glycoprotein obtained and host system comprising said protein.Type: ApplicationFiled: September 22, 2011Publication date: January 12, 2012Applicant: Stichting Dienst Landbouwkundig OnderzoekInventors: Hendrikus Antonius Cornelis Bakker, Hendrik Jan Bosch, Dionisius Elisabeth Antonius Florack, Gerard Johan Adolph Rouwendal
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Patent number: 8088909Abstract: The invention relates to an ex vivo animal or challenge model as a method to identify protective (recombinant) proteins and rapidly measure protective immunity in intestinal segments directed against parasites and vaccines directed against parasitic infections. The invention further relates to vaccines directed against infection with parasites, such as Fasciola hepatica, which vaccines contain protective (recombinant) proteins identified and shown to be protective in studies using the ex vivo model. The invention further relates to protective (recombinant) proteins obtained from newly excysted juveniles (NEJ) of Fasciola hepatica. The protective (recombinant) protein corresponding to an NEJ protein has an apparent molecular weight of 32 kD and an N-terminal amino acid sequence comprising the sequence XXDVSWPFWDRMYNY (SEQ ID NO:1).Type: GrantFiled: May 10, 2010Date of Patent: January 3, 2012Assignee: Stichting Dienst Landbouwkundig OnderzoekInventors: Florine Johanna van Milligen, Johannes Bernardus Wilhelmus Joseph Cornelissen, Bernard Adri Bokhout
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Publication number: 20110302823Abstract: The present invention relates to formulations of volatile organic compounds having effects on Otiorhynchus weevils e.g., Otiorhynchus sulcatus. In some embodiments, volatile organic compounds selected from (E)-2-hexenol, (Z)-2-pentenol, methyl eugenol and a combination thereof are effective for attracting Otiorhynchus weevils. The invention also relates to traps and particularly to a “weevil trap” combined with any one or more of the disclosed volatile organic compounds selected from (E)-2-hexenol, (Z)-2-pentenol, methyl eugenol, and light which are effective for monitoring and controlling Otiorhynchus weevils.Type: ApplicationFiled: June 10, 2011Publication date: December 15, 2011Applicants: Stichting Dienst Landbouwkundig Onderzoek, The United States of America, as represented by the Secretary of AgricultureInventors: Denny J. Bruck, Robert W.H.M van Tol, Frans C. Griepink
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Patent number: 8071111Abstract: The invention relates to the field of diagnosis of and vaccination against Streptococcal infections and to the detection of virulence markers of Streptococci. The invention discloses a method for modulating virulence of a Streptococcus, the method comprising modifying a genomic fragment of Streptococcus wherein the genomic fragment comprises at least a functional part of a fragment identifiable by hybridization in Streptococcus suis to a nucleic acid or fragment thereof as shown in FIG. 5.Type: GrantFiled: December 3, 2009Date of Patent: December 6, 2011Assignee: Stichting Dienst Landbouwkundig OnderzoekInventor: Hilda Elizabeth Smith
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Patent number: 8058508Abstract: The invention is directed to methods for optimizing glycan processing in organisms (and in particular, plants) so that a glycoprotein having complex type bi-antennary glycans and thus containing galactose residues on both arms and which are devoid of (or reduce in) xylose and fucose can be obtained. The invention is further directed to said glycoprotein obtained and host system comprising said protein.Type: GrantFiled: September 2, 2009Date of Patent: November 15, 2011Assignee: Stichting Dienst Landbouwkundig OnderzoekInventors: Hendrikus Antonius Cornelis Bakker, Hendrik Jan Bosch, Dionisius Elisabeth Antonius Florack, Gerard Johan Adolph Rouwendal
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Publication number: 20110159559Abstract: The invention relates to a process for the combined production of butanol and hydrogen from biomass, comprising the steps of fermenting biomass to obtain butanol in a first reaction mixture; removing the butanol and hydrogen from the first reaction mixture to obtain effluent; and using the effluent as a substrate in a second reaction mixture in a process using low substrate concentrations, in particular a hydrogen production process. Preferably, the process using low substrate concentrations is a hydrogen production process and at least part of the end products of the hydrogen production process is removed from the second reaction mixture for obtaining an effluent that comprises organic acid, which effluent is returned to the first reaction mixture.Type: ApplicationFiled: June 23, 2009Publication date: June 30, 2011Applicant: Stichting Dienst Landbouwkundig OnderzoekInventors: Pieternel Claassen, Miriam Budde, Geertruida De Vrije, Astrid Mars
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Patent number: 7927605Abstract: The invention relates to the field of the diagnosis of and vaccination against Streptococcal infections, and to the detection of virulence markers of Streptococci. The invention discloses a method for modulating virulence of a Streptococcus comprising modifying a genomic fragment of the Streptococcus, wherein the genomic fragment comprises at least a functional part of a fragment identifiable by hybridization in Streptococcus suis to a nucleic acid or fragment thereof.Type: GrantFiled: July 31, 2003Date of Patent: April 19, 2011Assignee: Stichting Dienst Landbouwkundig OnderzoekInventor: Hilda Elizabeth Smith
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Patent number: 7897842Abstract: The invention relates to the field of glycoprotein processing in transgenic plants used as cost efficient and contamination safe factories for the production of recombinant biopharmaceutical proteins or pharmaceutical compositions comprising these glycoproteins. The invention provides a plant comprising a functional mammalian enzyme providing mammalian GnTIII that is normally not present in plants, said plant additionally comprising at least a second mammalian protein or functional fragment thereof that is normally not present in plants.Type: GrantFiled: March 18, 2003Date of Patent: March 1, 2011Assignees: Stichting Dienst Landbouwkundig OnderzoekInventors: Hendrikus Antonius Cornelis Bakker, Dionisius Elisabeth Antonius Florack, Hendrik Jan Bosch
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Publication number: 20110030108Abstract: The invention relates to the field of glycoprotein processing in transgenic plants used as cost efficient and contamination safe factories for the production of recombinant biopharmaceutical proteins or pharmaceutical compositions comprising these. The invention provides a plant comprising a functional mammalian enzyme providing N-glycan biosynthesis that is normally not present in plants, said plant additionally comprising at least a second mammalian protein or functional fragment thereof that is normally not present in plants.Type: ApplicationFiled: July 16, 2010Publication date: February 3, 2011Applicant: Stichting Dienst Landbouwkundig OnderzoekInventors: Hendrikus Antonius Cornelis Bakker, Hendrik Jan Bosch
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Patent number: 7781647Abstract: The invention relates to the field of glycoprotein processing in transgenic plants used as cost efficient and contamination safe factories for the production of recombinant biopharmaceutical proteins or pharmaceutical compositions comprising these. The invention provides plants and plant cells comprising of functional mammalian enzyme providing N-glycan biosynthesis that is normally not present in plants, for example mammalian ? 1,4-galactosyltransferase, said plants or plant cells additionally comprising at least a second mammalian protein or functional fragment thereof, for example a mammalian antibody, that is normally not present in plants.Type: GrantFiled: February 8, 2007Date of Patent: August 24, 2010Assignee: Stichting Dienst Landbouwkundig OnderzoekInventors: Hendrikus Antonius Cornelis Bakker, Hendrik Jan Bosch
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Patent number: 7776323Abstract: The invention relates to Streptococcus suis infection in pigs, vaccines directed against those infections and tests for diagnosing Streptococcus suis infections. The invention provides an isolated or recombinant nucleic acid encoding a capsular gene cluster of Streptococcus suis or a gene or gene fragment derived thereof. The invention further provides a nucleic acid probe or primer allowing species or serotype-specific detection of Streptococcus suis. The invention also provides a Streptococcus suis antigen and vaccine derived thereof.Type: GrantFiled: September 5, 2006Date of Patent: August 17, 2010Assignee: Stichting Dienst Landbouwkundig OnderzoekInventor: Hilda Elizabeth Smith