Abstract: Novel compositions of matter comprising a foamable delivery system are provided. Novel methods for treating a disease, disorder, or condition using the novel compositions are further provided. Novel methods for making and delivering a foamable pharmaceutical composition are also provided. While the novel compositions and foamable drug delivery system may be utilized for administration of a wide variety of drugs to epithelial tissues, to treat a wide variety of diseases, disorders, or conditions, the inventive compositions and foamable drug delivery systems are particularly useful for the dermatological administration of corticosteroids and antifungal agents.

Abstract: Topical compositions and methods of using same for treating various skin disorders or conditions. In a particular aspect, these compositions comprise a storage-stable mixture of a benzoyl peroxide-containing composition, an antibiotic or a pharmaceutically acceptable salt or ester thereof, and a retinoid or a pharmaceutically acceptable salt thereof. In an alternative embodiment, these compositions comprise a storage-stable mixture of a retinoid or a pharmaceutically acceptable salt thereof and either a benzoyl peroxide-containing composition or an antibiotic or a pharmaceutically acceptable salt or ester thereof.

Abstract: Topical dermatological compositions comprising urea as an active ingredient, a vegetable oil or a derivative thereof, water, and conventional excipients. These compositions are used for topical medical applications, particularly to treat various skin disorders.

Abstract: The present invention provides improved sulfacetamide and sulfur formulations including sunscreens for the treatment of rosacea.

Abstract: A composition for treatment of hyperpigmentation having a SPF value of at least 15 includes hydroquinone, sunscreens, antioxidants and emulsifiers and emollients. The composition can be made into an emulsion having physical and chemical stability for a prolonged period of time over a wide range of temperatures.

Abstract: A dietary supplement composition for promoting healthy skin comprised of lycopene and other carotenoids, selenium, chromium and biotin.

Abstract: The in vivo catalytic dismutation of hydrogen peroxide by pseudocatalase such as a transition metal bicarbonate complex is increased by the addition of a chelating agent, preferably ethylenediaminetetraacetic acid (EDTA), citic acid, 2,6-pyridinedicarboxylic acid, or a salt thereof Further, the stability of a topical composition comprising a transition metal bicarbonate complex is improved by storing the composition under carbon dioxide, preferably under pressure in aerosol form.

Abstract: Dermatological conditions are treated by topically applying to the affected area an effective amount of a combination benzoyl peroxide and clindamycin composition.

Abstract: Dermal microbial infections in animals are treated with a topical cream composition comprising about 3 to 4% erythromycin in an emulsion.

Abstract: The present invention relates to the enhancement of suntanning following exposure to sunlight or other source of UV light by topically applying pseudocatalase compounds.

Abstract: Vitiligo and other tyrosinase-positive depigmentation disorders are treated by topical application of a pseudocatalase and subsequent exposure to a sub-minimal erythema dose of UVB light. After a course of treatment, pigmentation of the affected areas can be maintained by treatment with the pseudocatalases without UVB light treatment. The preferred pseudocatalases are transition metal co-ordination complexes, especially manganese (II) bicarbonate.

Abstract: Esters of silybin with dicarboxylic acids, and the salts thereof, are antiinflammatory agents. A typical example is the disodium salt of the bis-(hemisuccinate).

Abstract: Topical compositions of biotin or a pharmaceutically acceptable salt thereof are used in the treatment of ungual pathologies and to harden ungues in humans.

Abstract: An ointment-like base comprises a blend of at least one topically acceptable alkyl ester of an aromatic carboxylic acid and at least one topically acceptable dialkyl ester of a hydroxyalkanedicarboxylic acid, the ratio of the two esters being from about 1:3 to 4:1. This blend is combined with from about 10 to about 30% of a polysiloxane and from about 5 to about 20% of a topically acceptable alkanol having 10 to 20 carbon atoms.

Abstract: A topical pharmaceutical composition comprising a mixture of (i) at least one topically acceptable UV absorber in a concentration sufficient to block a substantial quantity of sun-generated UV radiation and (ii) an antibacterially effective amount of erythromycin in (iii) an pharmaceutically acceptable topical carrier. A typical formulation contains about 2.2% of erythromycin, about 8% of octyl p-dimethylaminobenzoate, and about 6% of 2-hydroxy-4-methoxybenzophenone in a mixture of about 3.8% hydroxypropylcellulose in ethanol.

Abstract: The firmness and tone of aged skin is improved by repeatedly applying a fluid topical composition containing a suspension of fine particles of a non-absorbable aluminum oxide abrasive in a topically acceptable aqueous base of sodium cocoisethionate, at least one emollient, and a suspending agent.

Abstract: Inflammatory acne is treated topically with a non-aqueous gel of 13-cis retinoic acid.

Abstract: The drying time of fluid collodion topical compositions can be decreased without significant increase in overall viscosity through the incorporation of D,L-lactic acid.

Abstract: The sponge has a flat washing surface and a round back. It is shaped so as to minimize the bending of the fingers when gripping it, thus facilitating its use by people with arthritic or crippled hands. The sponge also has a notch for a finger to fit into. This makes the sponge easier to grip and control, and allows the application of greater scrubbing pressure to a small area by applying finger pressure against a thin section of sponge material at the end of the notch. This facilitates washing crevices of the body and other difficult-to-reach surfaces. Although the sponge can be used for a wide variety of washing jobs, it is especially useful as a bath sponge. Preferably, the sponge is made of fully-reticulated polyurethane foam, and is formed by compressing a thick sheet of foam against a plate with a shaped hole or cavity in it, and slicing off the protruding mass of material.

Abstract: A topical anthralin cream composition in which the anthralin demonstrates improved stability, comprises from about 0.05% to about 5% by weight of anthralin in a water: fluid hydrocarbon emulsion having a weight ratio of at least about 5:1, at least one anionic emulsifying agent, at least one oil soluble anti-oxidant, at least one water soluble acidic material, and at least one bifunctional sequestering agent.