Abstract: Methods for treating Alzheimer's disease, or the symptoms of Alzheimer's disease, are provided. Some embodiments are to methods for treatment comprising administering cells obtained from human umbilical cord tissue, or administering pharmaceutical compositions comprising such cells or prepared from such cells, such as cell derivatives. Some embodiments are to methods for treatment comprising hUTC. Pharmaceutical compositions for use in the inventive methods, as well as kits for practicing the methods are also provided.

Abstract: A perfusion device and method is provided. In one embodiment, the device includes a container having a first internal chamber configured to hold the material; a port for introducing the liquid into the chamber; a vent for releasing gas and liquid from the chamber; and a means for sealing the vent to allow a vacuum to be drawn on the first chamber The material may be biomaterial, such as a bone graft material in any form. In one embodiment, the container is a syringe that defines the internal material chamber and includes an end cap and a plunger. The vent may be formed by a venting passageway in plunger and/or cap in some embodiments. In one embodiment, the vacuum may be created by a medical syringe coupled to the container, and which in some embodiments may also be used to deliver the liquid into the container. The liquid may be bone marrow aspirate in some embodiments.

Abstract: Methods and devices are shown for forming polymer fasteners into bone by expelling the polymer from a cannula. Devices and methods shown allow a user to form multiple fasteners of various sizes without re-loading a device. Devices and methods shown further provide temperature profiles during fastener formation that reduce or eliminate thermal necrosis. Devices and methods shown further provide fasteners with increased strength.

Abstract: A shoulder prosthesis kit includes a first metaglene component including (i) a first body defining an outer diameter, (ii) a first augment extending medially from the first body, and (iii) a first void defined by a portion of the first body and a portion of the first augment, and a plurality of bearing components, each of the plurality of bearing components defining a cavity configured to couple with the first body, and having a bearing surface that is sized differently from the size of another of the plurality of bearing components.

Abstract: A orthopaedic implant comprises an acetabular cup and a wireless communication device. The wireless communication device is coupled to a rim surface of the acetabular cup. In one embodiment, a recess is defined in the rim surface and the wireless communication device is positioned therein. In another embodiment, the wireless communication device is positioned in an annular ring formed of a biocompatible material. The annular ring is coupled to the rim surface of the acetabular cup. The wireless communication device may be, for example, a radio frequency identification (RFID) tag or device.

Abstract: Customized patient-specific orthopaedic surgical instruments are disclosed. Methods for fabricating and using such instruments are also disclosed.

Abstract: A prosthetic ball for use in a ball and cup joint system includes a spherical cap articulation portion defined by a first radius of curvature, and a toroidal articulation portion defined by a second radius of curvature having a circular origin such that the toroidal articulation portion is defined by a portion of the inner surface of a spindle torus.

Abstract: An enhanced adipose tissue containing native adipose tissue and a concentrated amount of an active agent derived from adipose tissue, wherein the enhanced adipose tissue is preferably injected into the intervertebral disc of a patient suffering from degenerative disc disease.

Abstract: A joint prosthesis device comprises a head configured to fit within a cup. The cup includes a concave cup surface defined by at least one radius of curvature RC. The head includes a convex head surface defined by at least one radius of curvature RH. The convex head surface is configured to engage the concave cup surface. The convex head surface provides an articulation zone where the head surface engages the cup surface. RC differs from RH in the articulation zone by a first amount. The convex head surface also provide a peripheral zone outside of the articulation zone. RC differs from RH in the peripheral zone by a second amount that is greater than the first amount. The peripheral zone generally extends over an area subtended by a minimum angle having a vertex at a center of the head.

Abstract: An intervertebral implant includes a three-dimensional body and a securing plate. The three-dimensional body includes a front surface and a rear surface. The three-dimensional body further includes a plurality of boreholes for accommodating fixation elements. The intervertebral implant also includes a front plate disposed at the front surface of the three-dimensional body and having a plurality of boreholes. A securing plate can be fastened to the front plate.

Abstract: Synthetic polymer substrates comprising a hierarchical surface structure of multiple domes and multiple pillars on said domes, wherein said substrate is a synthetic polymer film, said domes have diameters in the range from about 5 ?m to about 400 ?m, heights in the range from about 2.5 ?m and about 500 ?m, and said pillars have diameters in the range from about 20 nm to about 5 ?m and aspect ratios of from about 2 to about 50, and methods of making and using them.

Abstract: The present invention relates to a bone plating system and method for fracture fixation of bone. The bone plating system includes a bone plate, at least one locking screw, and at least one non-locking screw. The bone plate has locking holes with threads and non-locking holes. The locking screws have a shaft with a thread for engaging bone and a head with a thread configured and dimensioned to mate with the thread of the locking holes. The non-locking screws have a thread for engaging bone and a non-threaded head. Both the locking and non-locking screws remain seated in their respective holes for substantially as long as the bone plate is implanted. The non-locking screws compress the bone plate against the bone and hold fracture reduction while the locking screws are secured to the plate at a fixed angular relationship. The mixed fixation achieved by this bone plating system and method is particularly useful for treatment of per-articular fractures.

Abstract: A method for manipulating a vertebra includes connecting a first bone anchor to a first vertebra, connecting a second bone anchor to a second bone anchor, positioning a spinal rod in a receiving member of the first bone anchor and in a receiving member of the second bone anchor, connecting a first instrument to the receiving member of the first bone anchor, and manipulating the first instrument to rotate first bone anchor and the first vertebra relative to the second vertebra.

Abstract: An intervertebral implant includes a three-dimensional body and a securing plate. The three-dimensional body includes a front surface and a rear surface. The three-dimensional body further includes a plurality of boreholes for accommodating fixation elements. The intervertebral implant also includes a front plate disposed at the front surface of the three-dimensional body and having a plurality of boreholes. A securing plate can be fastened to the front plate.

Abstract: An anti-adhesion sheet for placement upon the anterior wall of a vertebral body, wherein the sheet has a radius of curvature that is less than that of the anterior wall of the vertebral body.

Abstract: A tibial insert includes a platform defining an upper bearing surface and a bottom surface. A keel of the tibial insert is coupled to the bottom surface of the platform. A surgical method for knee anthroplasty is also disclosed.

Abstract: The disclosed embodiments provide a system including an implant assembly and an instrument configured to work in conjunction to manipulate vertebral bodies to affect derotation. The implant assemblies include a removable attachment element that allows for the attachment of the instrument. The instrument is configured to attach to two implant assemblies that have been inserted bilaterally into a vertebral body. When the instrument is attached to the implant assemblies, forces applied to the instrument are translated and transferred to the implant assemblies and the vertebral body into which the implant assemblies have been inserted thereby providing a rotational force on the vertebral body.

Abstract: Various methods and devices for inserting a guidewire into the body are provided. In one embodiment, a guidewire insertion device is provided and includes and outer sheath having an outer surface and an inner lumen extending therethrough, and a dilator having an inner lumen extending therethrough and having a length greater than a length of the outer sheath. A guidewire can be configured to extend through the inner lumen of the dilator such that the guidewire is removably and replaceably disposable within the dilator and coupled thereto. A locking mechanism can be effective to selectively configure the guidewire between a locked position in which the guidewire is stationary relative to the dilator and an unlocked position in which the guidewire is movable relative to the dilator.

Abstract: A distractible intervertebral implant configured to be inserted in an insertion direction into an intervertebral space that is defined between a first vertebral body and a second vertebral body is disclosed. The implant may include a first body and a second body. The first body may define an outer surface that is configured to engage the first vertebral body, and an opposing inner surface that defines a rail. The second body may define an outer surface that is configured to engage the second vertebral body, and an inner surface that defines a recess configured to receive the rail of the first body. The second body moves in a vertical direction toward the second vertebral body as the second body is slid over the first body and the rail is received in the recess.

Abstract: An interspinous process spacer for implantation in an interspinous space between a superior spinous process and an inferior spinous process includes a balloon-like body, a first deployable protrusion and a second deployable protrusion. The body has a distal end, a proximal end and a longitudinal axis extending between the proximal and distal ends. The spacer is arrangeable in an unexpanded configuration and an expanded configuration. The first deployable protrusion is mounted proximate the proximal end and the second deployable protrusion is mounted proximate the distal end. The first and second deployable protrusions are oriented generally parallel to the longitudinal axis in the unexpanded configuration and generally perpendicular to the longitudinal axis in the expanded configuration.