Abstract: Cells derived from postpartum tissue and methods for their isolation and induction to differentiate to cells of a chondrogenic or osteogenic phenotype are provided by the invention. The invention further provides cultures and compositions of the postpartum-derived cells and products such as lysates related thereto. The postpartum-derived cells of the invention and products related thereto have a plethora of uses, including but not limited to research, diagnostic, and therapeutic applications, for example, in the treatment of bone and cartilage conditions such as osteoarthritis.

Abstract: The disclosure extends to methods, systems, and computer program products for widening dynamic range within an image in a light deficient environment.

Abstract: Methods and systems including an expandable stent and achieving, by the expandable stent, a reduction in odds of 12-month inpatient readmission and/or a reduction in total cost of care for a plurality of patients.

Abstract: A delivery member is provided for delivering and deploying an implantable medical device. The delivery member includes a distal hypotube, a flexible tubular section, a proximal hypotube, a lumen extending through the distal hypotube, flexible tubular section, and proximal hypotube, a stretch resistant member, and a flexible sleeve. The stretch resistant tube can be positioned outside of the lumen, affixed to the proximal and distal hypotubes, and extending along at least a portion of an outer surface of the flexible tubular section. The flexible sleeve can comprise one or more stretch resistant fibers positioned within a wall of the flexible sleeve. The flexible sleeve can cover at least a majority of an outer surface of the flexible tubular section.

Abstract: A C-arm, or a mobile intensifier device, is one example of a medical imaging device that is based on X-ray technology. Because a C-arm device can display high-resolution X-ray images in real time, a physician can monitor progress at any time during an operation, and thus can take appropriate actions based on the displayed images. Monitoring the images, however, is often challenging during certain procedures, for instance during procedures in which attention must be paid to the patient's anatomy as well as a medical imaging device display. In an example, a surgical instrument assembly includes a processor, a surgical instrument configured to operate on an anatomical structure, and a display coupled to the processor and attached to the surgical instrument. The display can be configured to display visual information comprising X-ray images generated by a medical imaging device.

Abstract: In one embodiment, a strike instrument that couples to an insertion handle of an intramedullary nail has a shaft that extends along a shaft axis, and an abutment that extends outward relative to the shaft. The abutment is rotationally fixed to the shaft such that the shaft can rotate the abutment between a first orientation, where the abutment can be removed or inserted into the insertion handle, and a second orientation, where the abutment forms an interference with the insertion handle that prevents the abutment from being removed from the handle. The strike instrument includes a strike surface that can transfer an impaction force to the insertion handle, and a lock that engages the insertion handle so as to prevent the abutment from rotating from the second orientation to the first orientation after the abutment is rotated within the insertion handle from the first orientation to the second orientation.

Abstract: The invention relates to a medical assembly, preferably a sterilized one, comprising a medical article (5) and a package containing said article, said package comprising a hollow support element (2) inside which said article (5) is free, a first protective element (3), called a stopper, which can be coupled to the support element (2) of said article, such that the support element (2) has a grip part (20) that protrudes from said stopper (3), and a second hollow protective element (4), called a cover. Said cover can be coupled to the stopper (3) in such a way as to delimit, in cooperation with said stopper (3), a chamber (8) inside which there extends said grip part (20) of the support element, and, in the state when the cover is coupled to the stopper, a part of the stopper (3) protrudes from the cover (4).

Abstract: A medical package containing a medical article, including: a support element comprising a hollow support tube and a support cap, wherein the support element includes a first chamber configured to enclose the medical article and wherein the support cap includes a support structure configured to hold the medical article captive; a stopper configured to be coupled to the hollow support tube in such a way that the support element has a grip part that protrudes from the stopper, the grip part of the support element configured to be held by a hand of a person; a hollow protective cover configured to be coupled to the stopper in such a way as to delimit, in cooperation with the stopper, a second chamber inside which there extends the grip part of the support element, the hollow protective cover configured to be separated from the stopper, wherein when the hollow protective cover is coupled to the stopper, a part of the stopper protrudes from the hollow protective cover, and is configured to form a grip end of the st

Abstract: The disclosure extends to methods, systems, and computer program products for producing an image in light deficient environments with luminance and chrominance emitted from a controlled light source.

Abstract: A double layered braid for treating an aneurysm is provided. The braid can include a first radially expandable segment having a first plurality of wire segments with a first braid wire diameter. The braid can include a second radially expandable segment having a second plurality of wire segments with a second braid wire diameter, the second braid wire diameter being greater than the first braid wire diameter. The first segment can radially expand to form an outer occlusive sack that seals across a neck of the aneurysm. The second segment can radially expand within the outer occlusive sack to form an inner occlusive sack. The greater second braid wire diameter can allow the inner occlusive sack to exert a force against the outer occlusive sack and the walls of the aneurysm. The force can minimize movement of the outer occlusive sack from the neck of the aneurysm.

Abstract: An embolic coil implant having a stretch resistant fiber therethrough and dual-functional engagement feature at its proximal end is provided. The stretch resistant fiber can be effective to limiting separation of windings of the embolic coil. The engagement feature can provide an attachment for securing the embolic coil to an engagement system of a delivery tube and for securing the stretch resistant fiber at the proximal end of the embolic coil. The engagement feature can have two engagement surfaces affixed to a proximal end of the embolic coil that are longitudinally offset from each other by a distance that is about half of a diameter of a wire of the embolic coil.

Abstract: Electronic devices that detect their position and/or orientation with respect to earth's frame of reference are described. A coupler can removeably maintain the electronic devices in physical proximity of one another. Each electronic device can have a housing and the coupler can be included on the housing and arranged to physically connect the housing of the electronic device to the housing of at least one other electronic device. Alternatively, the coupler can be a packaging that maintains the electronic devices in physical proximity of one another. Each electronic device can be calibrated using the orientation or position information obtained by other electronic devices maintained by the coupler. Further, each electronic device can include a power source that remains inactive until the device is ready for use.

Abstract: An intervertebral implant for insertion into an intervertebral disc space between adjacent vertebral bodies or between two bone portions. The implant includes a spacer portion, a plate portion operatively coupled to the spacer portion and one or more blades for securing the implant to the adjacent vertebral bodies. The blades preferably include superior and inferior cylindrical pins for engaging the adjacent vertebral bodies. The implant may be configured to be inserted via a direct lateral trans-psoas approach. Alternatively, the implant may be configured for insertion via an anterior approach.

Abstract: An occlusion device suitable for endovasculature treatment of an aneurysm in a blood vessel in a patient, including a substantially tubular structure having a proximal end region and a distal end region, having a first, expanded condition and a second, collapsed condition. The device has dimensions in the second, collapsed condition suitable for insertion through vasculature of the patient and through a neck of the aneurysm. The device further includes a control ring having a substantially annular body disposed on the proximal end region of the structure and at least substantially circumscribing the proximal end region to prevent radial expansion of the proximal end region and to provide an engagement feature during manipulation of the occlusion device.

Abstract: A method of performing joint arthroplasty includes accessing a surface on a bone and supporting a stop with the accessed surface. The method includes positioning an instrument at least partially within the stop, the instrument having a body and a punch, the punch including a portion thereof having a shape similar to a shape of a stem of an implant, and rotating the stop with respect to the accessed surface based upon an indicia on one of the body and the stop so as to position the punch rotationally with respect to the accessed surface at a first orientation. The method further includes moving the body axially with respect to the stop to form a cavity in the bone with the punch at the first rotational orientation, the formed cavity having a shape similar to the stem of the implant, and implanting the stem of the implant into the cavity.

Abstract: A single-use handle is disclosed for releasably engaging an orthopedic device. The handle includes an elongate body that has a first portion that, in turn, defines a connection end adapted for connection to an upper end portion of a broach. The handle includes a second end portion adapted to be griped by a user. The handle further includes a cylindrical bore at the connection end. The bore is configured to receive a corresponding male portion of a surgical instrument. The handle further includes a button that is adapted to releasably connect the instrument in the bore. The handle further includes a plurality of sizing cavities that have a predetermined size and shape that corresponds to the size and shape of an orthopedic implant. The handle is of a biocompatible, disposable material.

Abstract: Methods and devices are provided for anchoring suture to tissue, incorporating anchoring devices constructed substantially from suture. The anchoring devices are constructed as longitudinally extended, preformed knot configurations that upon deployment are reconfigured to form anchoring knots having an increased cross-section relative to the preformed knot configuration, for secure lodging in tissue. The anchoring devices are suitable for single and multi-anchor surgical procedures in soft tissue or bone, and multiple anchors can be delivered using a single delivery device.

Abstract: An endovascular surgical tool may include a flexible, electrically-conductive delivery tube, a return conductor, a resistive heating element attached to the distal end of the delivery tube, and a therapeutic payload attached to a loop of the resistive heating element by a coil connecting member. The delivery tube may include at least one segment at its distal end which includes a plurality of transverse slots. Each slot of the plurality of slots includes an origin on the perimeter of the delivery tube, a terminus closer to a central axis of the delivery tube than the origin, and a depth between the origin and terminus. The origins of at least two slots of the plurality of slots may be located at different angular positions relative to the central axis. The return conductor may be electrically insulated from and positioned within the delivery tube.

Abstract: A novel posterolateral inter-muscular approach has been developed to access the cervical spine. The approach includes elevating the splenius capitis and trapezios muscles dorsally to create a window for deep spine access, wherein the window comprises: i) an anterior superior border of the trapezius muscle; ii) an anterior inferior border of the splenius capitis muscle, and iii) a posterior superior border of the levator scapulae muscle. Preferably, a device such as an implant or an instrument is then passed through the window to manipulate the spine.

Abstract: The present invention is directed an anchor assembly for use in spinal fixation to interconnect a longitudinal spinal rod with a patient's vertebra. The anchor assembly preferably includes a bone anchor, a body with a rod-receiving channel, an insert member (preferably a bushing), and a locking cap with a saddle. The anchor assembly preferably enables in-situ assembly where the bone anchor may be secured to the patient's vertebra prior to being received within the body of the bone anchor assembly. Accordingly, the anchor assembly enables a surgeon to implant the bone anchor without the body to maximize visibility and access around the anchoring site. Once the bone anchor has been secured to the patient's vertebra, the body may be snapped onto the bone anchor and a spinal rod may be inserted into the rod-receiving channel.