Abstract: Systems and methods are provided for ranking and querying statistical analysis results of database contents for the purpose of populating search engine query results with novel content.

Abstract: The present patent application relates to a process for preparing cinacalcet or a pharmaceutically acceptable salt thereof, which comprises reacting 3-trifluoromethylbenzaldehyde having the following formula (II) with the phosphorus-comprising derivative having the following formula (III) in which R1 and R2, which may be identical or different, are each a (C1-C6)alkyl group. The present invention also relates to the phosphorus-comprising derivative having the formula (III), to the use thereof and to the process for preparing same. The present invention also relates to the phosphate salt of cinacalcet and to uses thereof.

Abstract: The present patent application relates to a process for preparing cinacalcet or a pharmaceutically acceptable salt thereof, which comprises reacting 3-trifluoromethylbenzaldehyde having the following formula (II) with the phosphorus-comprising derivative having the following formula (III) in which R1 and R2, which may be identical or different, are each a (C1-C6)alkyl group. The present invention also relates to the phosphorus-comprising derivative having the formula (III), to the use thereof and to the process for preparing same. The present invention also relates to the phosphate salt of cinacalcet and to uses thereof.

Abstract: The present patent application relates to a process for preparing, cinacalcet or a pharmaceutically acceptable salt thereof, which comprises reacting 3-trifluoromethylbenzaldehyde having the following formula (II) with the phosphorus-comprising derivative having the following formula (III) in which R1 and R2, which may be identical or different, are each a (C1-C6)alkyl group. The present invention also relates to the phosphorus-comprising derivative having the formula (III), to the use thereof and to the process for preparing same. The present invention also relates to the phosphate salt of cinacalcet and to uses thereof.

Abstract: An implant inserter for use in ALIF spine surgery, wherein the inserter has a flexible bracket, biased closed, onto which two long blades can be removably attached.

Abstract: The invention relates to novel guanidine derivatives in the cinnamic series of general formula (I): The invention also relates to the process for preparing said guanidine derivatives and also to synthetic intermediates. Finally, the invention relates to the use of the guanidine derivatives for the preparation of compositions with anti-glycation properties, especially in cosmetology.

Abstract: An implantable medical device delivery system is provided with a carrier member having a proximal portion, a distal portion, and a frangible portion intermediate the proximal and distal portions. The frangible portion includes at least one notch providing a break hinge. A locking member is fixedly secured to the proximal portion of the carrier member and is releasably connected to an implantable medical device at or adjacent to the distal portion of the carrier member. In use, the implantable medical device is positioned generally adjacent to a target location of a body vessel and the frangible portion is broken about the break hinge. The proximal portion of the carrier member is then moved away from the distal portion to retract the locking member, thereby deploying the implantable medical device.

Abstract: A rapidly dissolving film is provided for delivery of an active agent to a moist body surface, e.g., mucosal tissue. The film comprises a film-forming binder, a rapidly dissolving polymeric material, and an active agent.

Abstract: A precursor phase of the magnesium tetrahydrate salt of an omeprazole enantiomer, and also processes for preparing it and its use for the preparation of the magnesium tetrahydrate salt are described. Crystals of the magnesium tetrahydrate salt thus obtained, and their uses, especially in the synthesis of the dihydrate form A of the magnesium salt of the enantiomer or as medicament are also disclosed.

Abstract: The invention relates to novel guanidine derivatives in the cinnamic series of general formula (I): The invention also relates to the process for preparing said guanidine derivatives and also to synthetic intermediates. Finally, the invention relates to the use of the guanidine derivatives for the preparation of compositions with anti-glycation properties, especially in cosmetology.

Abstract: Spinal rod reduction apparatuses, systems, and methods are provided. In various examples, a rod reduction apparatus includes a first threaded member (130, 210, 330) including an engagement feature (138A, 138B, 220, 332, 334) configured to selectively anchor the first threaded member to the implantable screw assembly. A second threaded member (110, 230, 310) is configured to threadably engage with the first threaded member. The second threaded member is axially movable with respect to the first threaded member with rotation of the second threaded member. A spinal rod urging member (120, 240, 320) is axially movable with the second threaded member. The urging member includes a bearing surface (126, 242, 320) that is configured to selectively abut the spinal rod and selectively urge the spinal rod toward the implantable screw assembly with rotation of the second threaded member in a first rotational direction.

Abstract: A precursor phase of the magnesium tetrahydrate salt of an omeprazole enantiomer, and also processes for preparing it and its use for the preparation of the magnesium tetrahydrate salt are described. Crystals of the magnesium tetrahydrate salt thus obtained, and their uses, especially in the synthesis of the dihydrate form A of the magnesium salt of the enantiomer or as medicament are also disclosed.

Abstract: A subject matter of the present invention is novel intermediates for the synthesis of (R)-tamsulosin and of its pharmaceutically acceptable salts, and also the associated preparation process.

Abstract: The invention relates to a process for preparing modafinil having a defined granulometry which comprises the steps of: a) preparing a solution of DMSAM; b) contacting the solution obtained with NH3 at a predetermined temperature and a predetermined stirring; and c) isolating the modafinil formed, wherein said temperature and said stirring are predetermined in order to obtain said defined granulometry.

Abstract: Modafinil polymorphic forms of modafinil racemate, methods of preparation thereof, pharmaceutical compositions and methods of therapeutic treatment involving modafinil polymorphic forms.

Abstract: The invention relates to a process for the preparation of crystalline forms of the optical enantiomers of modafinil, comprising stages comprising: i) dissolving one of the optical enantiomers of modafinil in a solvent other than ethanol, ii) crystallising the modafinil enantiomer, iii) recovering the crystalline form of the modafinil enantiomer so obtained. The invention also relates to a process for the preparation of the optical enantiomers of modafinil.

Abstract: The invention relates to a process for the preparation of crystalline forms of the optical enantiomers of modafinil, comprising stages comprising: i) dissolving one of the optical enantiomers of modafinil in a solvent other than ethanol, ii) crystallising the modafinil enantiomer, iii) recovering the crystalline form of the modafinil enantiomer so obtained. The invention also relates to a process for the preparation of the optical enantiomers of modafinil.

Abstract: Modafinil polymorphic forms of modafinil racemate, methods of preparation thereof, pharmaceutical compositions and methods of therapeutic treatment involving modafinil polymorphic forms.

Abstract: The invention concerns a fast transfer yoke for the cranium-calculated transfer of a maxilla plaster model from a patient into a dental articulator as well as for the recording of axis-related individual mandibular joint geometry of the patient in question. The invention is to create a fast transfer yoke that, with easy handling, facilitates fast recording of patient data, i.e., of the mandible movements as well as of the patient axis and their transfer into a dental articulator or to an mounting apparatus.

Abstract: The present invention related to an implant (1) for an intervertebral space consists of a frame (2) which is closed at the sides but open without restriction at the top and bottom and provided with an anterior lead-in face (3) and a posterior manipulation face (4). The upper (5) and lower boundary (6) of the frame (2) is convex, so that the implant (1) has an overall lens shape in the midplane (8) of the frame (2) containing the longitudinal axis (7) of the implant (1). The inner cavity (15) which is open without restriction at the top and bottom can be filled with a compressible material. The posterior manipulation face (4) of the frame (2) is provided with an aperture (9) to allow the introduction of a compression element (10) with which the compressible material can be forced out of the inner cavity (15).